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Laura Pendleton, MS

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Instructor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: lpendlet@health.usf.edu
Phone: (813) 974-6631
Office: MDC, 3005
Mailing address 12901 Bruce B Downs Blvd MDC 7
Tampa, FL 33612
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Education
  • MS, Medical Sciences/Biochemistry, University Of South Florida, United States - 1992.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology.
     
    Research Summary

    Current research projects focus on the process of palmitoylation, a post-translational lipid modification that plays an important role in stability and trafficking of several important proteins such as Ras, as well as other proteins responsible for a variety of human diseases.

     


    Selected Publications
  • Haines RJ, Corbin KD, Pendleton LC, Meininger CJ, Eichler DC. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochemical and biophysical research communications. 421(1) : 9-14, 2012.
  • Haines RJ, Corbin KD, Pendleton LC, Eichler DC. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. The Journal of biological chemistry. 287(31) : 26168-76, 2012.
  • Pilon-Thomas S, Nelson N, Vohra N, Jerald M, Pendleton L, Szekeres K, Ghansah T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PloS one. 6(11) : e27729, 2011.
  • Haines RJ, Pendleton LC, Eichler DC. Argininosuccinate synthase: at the center of arginine metabolism. International journal of biochemistry and molecular biology. 2(1) : 8-23, 2011.
  • Corbin KD, Pendleton LC, Solomonson LP, Eichler DC. Phosphorylation of argininosuccinate synthase by protein kinase A. Biochemical and biophysical research communications. 377(4) : 1042-6, 2008.
  • Goodwin BL, Corbin KD, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Troglitazone up-regulates vascular endothelial argininosuccinate synthase. Biochemical and biophysical research communications. 370(2) : 254-8, 2008.
  • Goodwin BL, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. American journal of physiology. Heart and circulatory physiology. 293(2) : H1115-21, 2007.
  • Pendleton LC, Goodwin BL, Solomonson LP, Eichler DC. Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame. The Journal of biological chemistry. 280(25) : 24252-60, 2005.
  • Ness GC, Pendleton LC, McCreery MJ. Target size analysis by radiation inactivation: the use of free radical scavengers. Experimental biology and medicine (Maywood, N.J.). 230(7) : 455-63, 2005.
  • Solomonson LP, Flam BR, Pendleton LC, Goodwin BL, Eichler DC. The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells. The Journal of experimental biology. 206(Pt 12) : 2083-7, 2003.
  • Pendleton LC, Goodwin BL, Flam BR, Solomonson LP, Eichler DC. Endothelial argininosuccinate synthase mRNA 5'-untranslated region diversity. Infrastructure for tissue-specific expression. The Journal of biological chemistry. 277(28) : 25363-9, 2002.

  • Patents & Licensing
  • Polynucleotides Targeted Against the Extended 5´-UTR of Argininosuccinate Synthase and Uses Thereof (US Patent Number 7,718,625 - 2010)


  • Profile last modified on 06/27/2014