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Laura Pendleton,  MS



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Email: lpendlet@health.usf.edu
Phone: (813) 974-6631
Office: MDC, 3005
Mailing address 12901 Bruce B Downs Blvd MDC 7
Tampa, FL 33612
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  • MS, Medical Sciences/Biochemistry, University Of South Florida , United States - 1992.
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology.
    Research Summary

    Current research projects focus on the process of palmitoylation, a post-translational lipid modification that plays an important role in stability and trafficking of several important proteins such as Ras, as well as other proteins responsible for a variety of human diseases.


    Selected Publications
  • Haines, RJ.Corbin, KD.Pendleton, LC.Meininger, CJ.Eichler, DC. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochemical and biophysical research communications. 421(1): 9-14, 2012.
  • Haines, RJ.Corbin, KD.Pendleton, LC.Eichler, DC. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. The Journal of biological chemistry. 287(31): 26168-76, 2012.
  • Pilon-Thomas, S.Nelson, N.Vohra, N.Jerald, M.Pendleton, L.Szekeres, K.Ghansah, T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PloS one. 6(11): e27729, 2011.
  • Haines, RJ.Pendleton, LC.Eichler, DC. Argininosuccinate synthase: at the center of arginine metabolism. International journal of biochemistry and molecular biology. 2(1): 8-23, 2011.
  • Corbin, KD.Pendleton, LC.Solomonson, LP.Eichler, DC. Phosphorylation of argininosuccinate synthase by protein kinase A. Biochemical and biophysical research communications. 377(4): 1042-6, 2008.
  • Goodwin, BL.Corbin, KD.Pendleton, LC.Levy, MM.Solomonson, LP.Eichler, DC. Troglitazone up-regulates vascular endothelial argininosuccinate synthase. Biochemical and biophysical research communications. 370(2): 254-8, 2008.
  • Goodwin, BL.Pendleton, LC.Levy, MM.Solomonson, LP.Eichler, DC. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. American journal of physiology. Heart and circulatory physiology. 293(2): H1115-21, 2007.
  • Pendleton, LC.Goodwin, BL.Solomonson, LP.Eichler, DC. Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame. The Journal of biological chemistry. 280(25): 24252-60, 2005.
  • Ness, GC.Pendleton, LC.McCreery, MJ. Target size analysis by radiation inactivation: the use of free radical scavengers. Experimental biology and medicine (Maywood, N.J.). 230(7): 455-63, 2005.
  • Solomonson, LP.Flam, BR.Pendleton, LC.Goodwin, BL.Eichler, DC. The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells. The Journal of experimental biology. 206(Pt 12): 2083-7, 2003.
  • Pendleton, LC.Goodwin, BL.Flam, BR.Solomonson, LP.Eichler, DC. Endothelial argininosuccinate synthase mRNA 5'-untranslated region diversity. Infrastructure for tissue-specific expression. The Journal of biological chemistry. 277(28): 25363-9, 2002.

  • Patents & Licensing
  • Polynucleotides Targeted Against the Extended 5´-UTR of Argininosuccinate Synthase and Uses Thereof (US Patent Number 7,718,625 - 2010)

  • Profile last modified on 06/27/2014