University of South Florida

University of South Florida


Login here to update your profile  
profile Image

Patricia Kruk, Ph.D.

Primary Department: COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Professor, COLLEGE OF MEDICINE OBSTETRICS & GYNECOLOGY

Professor, DEPARTMENT OF ONCOLOGIC SCIENCES

Vice Chair, Pathology & Cell Biology

Professor, Department of Pathology and Cell Biology, College of Medicine

Professor, COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Academic Email : pkruk@health.usf.edu

Phone : (813) 974-0548

Office : MDC, 2040A

Mailing address : Dept. Path & Cell Biol, MDC 11 12901 Bruce B. Downs Blvd
Tampa, 33612

View My C.V.

Education

  • PHD, Medical Sciences/Anatomy, University Of British Columbia, Vancouver, British Columbia - 1992.
  • MS, Zoology, University of Alberta, Edmonton, Canada - 1983.
  • BS, Biological Sciences, Concorida University, Montreal, Canada - 1980.

Research summary

  • As part of the Ovarian Epithelial Cancer Pathobiology program in the Department of Pathology at USF, the research focus in my lab is on early molecular changes responsible for ovarian epithelial transformation. In particular, we are interested in the molecular regulation of telomerase, DNA repair and apoptosis associated with a familial risk for ovarian cancer. Our research concerns the signal transduction pathways involved in early stages of ovarian oncogenesis. We are examining the molecular mechanism(s) that regulate telomerase, a ribonucleoprotein expressed in over 90% of all cancers. Studies in this laboratory also indicate that telomerase re-expression appears to confer increased cancer cell survival and resistance to chemotherapeutic-mediated apoptosis associated with elevated levels of anti-apopototic proteins including survivin and Bcl-2. Consequently, a recent translational study revealed Bcl-2 present at levels 10x greater in urine samples from women with ovarian cancer compared to normal controls or women with benign gynecologic disease. Lastly, in agreement with clinical reports that certain women with hereditary ovarian cancer initially respond better to chemotherapy, other studies in this laboratory are directed at understanding the molecular mechanism(s) by which BRCA1 amino-terminal mutations result in enhanced cellular apoptosis following genotoxic stress. Thus, while elevated urinary levels of Bcl-2 may provide a novel, safe, sensitive and economic method ovarian cancer detection, inhibition of the signaling pathways regulating telomerase activity or activation of cellular BRCA1 amino-terminal mutation targets may be beneficial for the treatment of ovarian cancer, an insipid disease with the highest mortality of all gynecological cancers.

Selected Publications

Positions Held

  • Associate Professor (Pathology & Cell Biology, University of South Florida 2003 - 2008)
  • Assistant Professor (Pathology, Univeristy of South Florida 1996 - 2003)

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology, Women & Children's Health, Biomedical Engineering & Nanomedicine.

Memberships

  • National Academy of Inventors (Member, 2012 - Present)
  • Minorities in Cancer Research, American Association for Cancer Research (Member, 2005 - Present)
  • Women in Cancer Research, American Association for Cancer Research (Member, 2005 - Present)
  • American Association for Cancer Research (Member, 1991 - Present)
  • Women in Academic medicine, USF Health (Member, 2007 - 2009)
  • American Society for Investigative Pathology (Member, 2005 - 2007)

Awards/Honors

  • Robert J. Grasso Award (University of South Florida - 2012)
  • Excellence in Innovation Award (National Academy of Inventors - 2010)
  • University of South Florida Women in Leadership and Philanthropy Faculty Research Award (University of South Florida - 2008)
  • Robert J. Grasso Award (University of South Florida - 1999)
  • Upjohn Travel Award (Upjohn Company - 1993)
  • Outstanding Dissertation Award (American Association of Anatomists - 1992)
  • Student Travel Award (University of British Columbia - 1990)
  • Student Travel Award (American Society of Cell Biology - 1990)
  • Student Travel Award (American Association of Anatomists - 1990)
  • University of British Columbia Graduate Fellowship (University of British Columbia - 1987)
  • Evelyn Martin Memorial Fellowship (British Columbia Fouhdation for Non-Animal Research - 1987)
  • University of British Columbia MacMillan Family Fellowship (University of British Columbia - 1985)

Patents & Licensing

  • Detection of Ovarian Cancer by Elevated Urinary Levels of Bcl-2 (Patent serial number 60/771,677, USF Ref. No. 05B108PR - 2007)

Lectures

  • "Roles of IL-10 and I-309 cytokines in reproductive cancers(co-presenter)" USF Health Research Day. FL, United States - 2014.
  • "Up-regulated Bcl-2 production and secretion by ovarian cancer cells modulates the tumor microenviron" 9th Biennial Ovarian Cancer Research Symposium. WA, United States - 2012.
  • "Ovarian Cancer: Identifying early events" University of Alberta. Canada - 2011.
  • "Ovarian Cancer: Early Changes" University of South Florida. FL, United States - 2010.
  • "Lysophosphatidic acid-dependent Bcl-2 production and secretion modulates antiogenesis" 8th Biennial Ovarian Cancer Research Symposium. WA, United States - 2010.
  • "Telomerase and Ovarian Cancer." Plenary Speaker for 2nd Annual Ovarian Cancer Research Symposium, Medical University of South Carolina Hollings Cancer Center.. SC, United States - 2008.
  • "Detection of ovarian cancer by elevated urinary levels of Bcl-2" 7th Biennial Ovarian Cancer Research Symposium. WA, United States - 2008.
  • "Telomerase Regulation in Ovarian Cancer." Department of Cellular and Molecular Medicine, University of Ottawa,. Canada - 2007.
  • "Role of telomerase in ovarian cancer" Auersperg Ovarian Cancer Symposium, University of British Columbia. Canada - 2007.
  • "Analysis of biomarkers in ovarian cancer" University of South Florida. FL, United States - 2006.
  • "Detection of Ovarian Cancer by Elevated Urinary Levels of Bcl-2." 6th Biennial Ovarian Cancer Research Symposium. WA, United States - 2006.
  • "Telomerase in ovarian cancer" Florida Society of Pathologists. FL, United States - 2004.
  • "The anti-apoptotic role of telomerase in ovarian cancer" University of South Florida. FL, United States - 2004.
  • "Telomerase in ovarian cancer: friend or foe?" University of British Columbia. Canada - 2003.
  • "Telomerase in ovarian cancer" Fox Chase Cancer Center. PA, United States - 2003.
  • "Telomerase activity in ovarian cancer" H. Lee Moffitt Cancer Center. FL, United States - 2002.
  • "Telomerase activity in ovarian cancer" University of South Florida. FL, United States - 2001.
  • "Telomeric instabiity and telomerase activity in ovarian cancer" H. Lee Moffitt Cancer Center. FL, United States - 2001.
  • "Telomeric instability in ovarian cancer" University of British Columbia. Canada - 2000.
  • "DNA damage and repari in human ovarina cacner" University of South Florida. FL, United States - 1999.



Profile last modified on 08/29/2016