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Huntington Potter, Ph.D.
Director,
Chair, Alzheimer's Disease Strategic Planning Committee
Professor and Eric Pfeiffer Chair for Research on Alzheimer's Disease, Suncoast Gerontology and Alzheimer's Center

Administrative Appointment: Endowed Chair
Primary Department: USF HEALTH ALZHEIMER'S

Professor
NON USF HEALTH

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Contacts
Email: hpotter@health.usf.edu
Phone: (813) 974-5369
Office: ALZ, 308
 
Education
  • PHD, Harvard University, United States - 1979.
  • MA, Harvard University, United States - 1975.
  •  
    Interdisciplinary & Emerging Signature Programs
    Neuroscience.
     
    Research Summary

    Molecular genetics and biochemistry of Alzheimer's Disease. Biotechnology. DNA recombination, rearrangement. Electroporation. mRNA localization at the synapse. Gene expression in differentiating neurons and glia. Role of chromosome mis-segregation in human disease.

    Dr. Potter is credited with the discovery of the essential role of inflammation in the pathogenesis of Alzheimer's disease and has been investigating the relationship between classical Alzheimer's disease and Down syndrome, which invariably leads to Alzheimer's by age 30-40.

     


    Selected Publications
  • Ma J, Brewer HB, Potter H. Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides. Neurobiology of aging. 17(5) : 773-80, .
  • Potter H. On keys and correlations in Alzheimer's disease. Neurobiology of aging. 17(6) : 943-4; discussion 945-7, .
  • Nilsson LN, Das S, Potter H. Effect of cytokines, dexamethasone and the A/T-signal peptide polymorphism on the expression of alpha(1)-antichymotrypsin in astrocytes: significance for Alzheimer's disease. Neurochemistry international. 39(5-6) : 361-70, .
  • Potter H, Wefes IM, Nilsson LN. The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation. Neurobiology of aging. 22(6) : 923-30, .
  • Koo EH, Abraham CR, Potter H, Cork LC, Price DL. Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis. Neurobiology of aging. 12(5) : 495-501, .
  • Abraham CR, Shirahama T, Potter H. Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiology of aging. 11(2) : 123-9, .
  • Hollis GF, Mitchell KF, Battey J, Potter H, Taub R, Lenoir GM, Leder P. A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma. Nature. 307(5953) : 752-5, .
  • Abisambra JF, Fiorelli T, Padmanabhan J, Neame P, Wefes I, Potter H. LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease. PloS one. 5(1) : e8556, 2010.
  • Duara R, Loewenstein DA, Greig M, Acevedo A, Potter E, Appel J, Raj A, Schinka J, Schofield E, Barker W, Wu Y, Potter H. Reliability and validity of an algorithm for the diagnosis of normal cognition, mild cognitive impairment, and dementia: implications for multicenter research studies. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 18(4) : 363-70, 2010.
  • Duara R, Loewenstein DA, Greig-Custo MT, Raj A, Barker W, Potter E, Schofield E, Small B, Schinka J, Wu Y, Potter H. Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR. International journal of geriatric psychiatry. 25(3) : 282-9, 2010.
  • Potter H, Heller R. Transfection by electroporation. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]. Chapter 9: Unit9.3, 2010.
  • Boyd TD, Bennett SP, Mori T, Governatori N, Runfeldt M, Norden M, Padmanabhan J, Neame P, Wefes I, Sanchez-Ramos J, Arendash GW, Potter H. GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice. Journal of Alzheimer's disease : JAD. 21(2) : 507-18, 2010.
  • Schinka JA, Raj A, Loewenstein DA, Small BJ, Duara R, Potter H. The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition. International journal of geriatric psychiatry. 25(3) : 266-74, 2010.
  • Schinka JA, Raj A, Loewenstein DA, Small BJ, Duara R, Potter H. Cross-validation of the Florida Cognitive Activities Scale (FCAS) in an Alzheimer's disease research center sample. Journal of geriatric psychiatry and neurology. 23(1) : 9-14, 2010.
  • Cao C, Cirrito JR, Lin X, Wang L, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice. Journal of Alzheimer's disease : JAD. 17(3) : 681-97, 2009.
  • Arendash GW, Mori T, Cao C, Mamcarz M, Runfeldt M, Dickson A, Rezai-Zadeh K, Tane J, Citron BA, Lin X, Echeverria V, Potter H. Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice. Journal of Alzheimer's disease : JAD. 17(3) : 661-80, 2009.
  • Bennett SP, Boyd TD, Norden M, Padmanabhan J, Neame P, Wefes I, Potter H. A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. Journal of neuroscience methods. 184(2) : 320-6, 2009.
  • Soule S, Florkowski C, Potter H, Pattison D, Swan M, Hunt P, George P. Intermittent severe, symptomatic hyponatraemia due to the nephrogenic syndrome of inappropriate antidiuresis. Annals of clinical biochemistry. 45(Pt 5) : 520-3, 2008.
  • Leighty RE, Runfeldt MJ, Berndt DJ, Schleif WS, Cracchiolo JR, Potter H, Arendash GW. Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice. Journal of neuroscience methods. 167(2) : 358-66, 2008.
  • Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H. Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiology of aging. 29(3) : 319-28, 2008.
  • Cao C, Lin X, Zhang C, Wahi MM, Wefes I, Arendash G, Potter H. Mutant amyloid-beta-sensitized dendritic cells as Alzheimer's disease vaccine. Journal of neuroimmunology. 200(1-2) : 1-10, 2008.
  • Cao C, Lin X, Wahi MM, Jackson EA, Potter H. Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid beta peptides. BMC neuroscience. 9: 25, 2008.
  • Costa DA, Cracchiolo JR, Bachstetter AD, Hughes TF, Bales KR, Paul SM, Mervis RF, Arendash GW, Potter H. Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Neurobiology of aging. 28(6) : 831-44, 2007.
  • Garbuzova-Davis S, Saporta S, Haller E, Kolomey I, Bennett SP, Potter H, Sanberg PR. Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS ONE. 2(11) : e1205, 2007.
  • Arendash GW, Jensen MT, Salem N, Hussein N, Cracchiolo J, Dickson A, Leighty R, Potter H. A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice. Neuroscience. 149(2) : 286-302, 2007.
  • Cracchiolo JR, Mori T, Nazian SJ, Tan J, Potter H, Arendash GW. Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity. Neurobiology of learning and memory. 88(3) : 277-94, 2007.
  • Padmanabhan J, Levy M, Dickson DW, Potter H. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. 129(Pt 11) : 3020-34, 2006.
  • Leighty RE, Nilsson LN, Potter H, Costa DA, Low MA, Bales KR, Paul SM, Arendash GW. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behavioural brain research. 153(1) : 107-21, 2004.
  • Costa DA, Nilsson LN, Bales KR, Paul SM, Potter H. Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 6(5) : 509-14, 2004.
  • Nilsson LN, Arendash GW, Leighty RE, Costa DA, Low MA, Garcia MF, Cracciolo JR, Rojiani A, Wu X, Bales KR, Paul SM, Potter H. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiology of aging. 25(9) : 1153-67, 2004.
  • Arendash GW, Garcia MF, Costa DA, Cracchiolo JR, Wefes IM, Potter H. Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport. 15(11) : 1751-4, 2004.
  • Potter H. Transfection by electroporation. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]. Chapter 9: Unit 9.3, 2003.
  • Potter H. Transfection by electroporation. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.]. Chapter 20: Unit 20.5, 2003.
  • Nilsson LN, Bales KR, DiCarlo G, Gordon MN, Morgan D, Paul SM, Potter H. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(5) : 1444-51, 2001.
  • Potter H. Transfection by electroporation. Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 10: Unit 10.15, 2001.
  • Potter H, Dressler D. The potential of BACE inhibitors for Alzheimer's therapy. Nature biotechnology. 18(2) : 125-6, 2000.
  • Scinto LF, Rentz DM, Potter H, Daffner KR. Pupil assay and Alzheimer's disease: a critical analysis. Neurology. 52(3) : 673-4, 1999.
  • Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. The Journal of biological chemistry. 274(10) : 6421-31, 1999.
  • Geller LN, Potter H. Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiology of disease. 6(3) : 167-79, 1999.
  • DeFranco C, Chicurel ME, Potter H. A general RNA-binding protein complex that includes the cytoskeleton-associated protein MAP 1A. Molecular biology of the cell. 9(7) : 1695-708, 1998.
  • Nilsson L, Rogers J, Potter H. The essential role of inflammation and induced gene expression in the pathogenic pathway of Alzheimer's disease. Frontiers in bioscience : a journal and virtual library. 3: d436-46, 1998.
  • Li J, Xu M, Zhou H, Ma J, Potter H. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell. 90(5) : 917-27, 1997.
  • Kayyali US, Zhang W, Yee AG, Seidman JG, Potter H. Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. Journal of neurochemistry. 68(4) : 1668-78, 1997.
  • Prihar G, Fuldner RA, Perez-Tur J, Lincoln S, Duff K, Crook R, Hardy J, Philips CA, Venter C, Talbot C, Clark RF, Goate A, Li J, Potter H, Karran E, Roberts GW, Hutton M, Adams MD. Structure and alternative splicing of the presenilin-2 gene. Neuroreport. 7(10) : 1680-4, 1996.
  • Potter H, Geller LN. Alzheimer's disease, Down's syndrome, and chromosome segregation. Lancet. 348(9019) : 66, 1996.
  • Das S, Potter H. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron. 14(2) : 447-56, 1995.
  • Li J, Ma J, Potter H. Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3. Proceedings of the National Academy of Sciences of the United States of America. 92(26) : 12180-4, 1995.
  • Scinto LF, Daffner KR, Dressler D, Ransil BI, Rentz D, Weintraub S, Mesulam M, Potter H. Response. Science (New York, N.Y.). 267(5204) : 1580-1581, 1995.
  • Scinto LF, Daffner KR, Dressler D, Ransil BI, Rentz D, Weintraub S, Mesulam M, Potter H. A potential noninvasive neurobiological test for Alzheimer's disease. Science (New York, N.Y.). 266(5187) : 1051-4, 1994.
  • Potter H, Ma J, Das S, Kayyali U. The involvement of amyloid associated proteins in the formation of beta-protein filaments in Alzheimer's disease. Progress in clinical and biological research. 390: 57-71, 1994.
  • Ma J, Yee A, Brewer HB, Das S, Potter H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. 372(6501) : 92-4, 1994.
  • Potter H. Application of electroporation in recombinant DNA technology. Methods in enzymology. 217: 461-78, 1993.
  • Polak M, Scharfmann R, Seilheimer B, Eisenbarth G, Dressler D, Verma IM, Potter H. Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic beta cell line. Proceedings of the National Academy of Sciences of the United States of America. 90(12) : 5781-5, 1993.
  • Nelson RB, Siman R, Iqbal MA, Potter H. Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein. Journal of neurochemistry. 61(2) : 567-77, 1993.
  • Chicurel ME, Terrian DM, Potter H. mRNA at the synapse: analysis of a synaptosomal preparation enriched in hippocampal dendritic spines. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13(9) : 4054-63, 1993.
  • Potter H, Nelson RB, Das S, Siman R, Kayyali US, Dressler D. The involvement of proteases, protease inhibitors, and an acute phase response in Alzheimer's disease. Annals of the New York Academy of Sciences. 674: 161-73, 1992.
  • Potter H. The involvement of astrocytes and an acute phase response in the amyloid deposition of Alzheimer's disease. Progress in brain research. 94: 447-58, 1992.
  • Abraham CR, Driscoll J, Potter H, Van Nostrand WE, Tempst P. A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochemical and biophysical research communications. 174(2) : 790-6, 1991.
  • Benjamin MB, Potter H, Yandell DW, Little JB. A system for assaying homologous recombination at the endogenous human thymidine kinase gene. Proceedings of the National Academy of Sciences of the United States of America. 88(15) : 6652-6, 1991.
  • Potter H. Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders. American journal of human genetics. 48(6) : 1192-200, 1991.
  • Abraham CR, Potter H. The protease inhibitor, alpha 1-antichymotrypsin, is a component of the brain amyloid deposits in normal aging and Alzheimer's disease. Annals of medicine. 21(2) : 77-81, 1989.
  • Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 32(3) : 715-20, 1989.
  • Abraham CR, Potter H. Alpha 1-antichymotrypsin in brain aging and disease. Progress in clinical and biological research. 317: 1037-48, 1989.
  • Pasternack JM, Abraham CR, Van Dyke BJ, Potter H, Younkin SG. Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA. The American journal of pathology. 135(5) : 827-34, 1989.
  • Potter H. Electroporation in biology: methods, applications, and instrumentation. Analytical biochemistry. 174(2) : 361-73, 1988.
  • Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 52(4) : 487-501, 1988.
  • Igarashi T, Okazaki T, Potter H, Gaz R, Kronenberg HM. Cell-specific expression of the human parathyroid hormone gene in rat pituitary cells. Molecular and cellular biology. 6(5) : 1830-3, 1986.
  • Potter H, Weir L, Leder P. Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proceedings of the National Academy of Sciences of the United States of America. 81(22) : 7161-5, 1984.
  • Battey J, Moulding C, Taub R, Murphy W, Stewart T, Potter H, Lenoir G, Leder P. The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma. Cell. 34(3) : 779-87, 1983.
  • Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R. Translocations among antibody genes in human cancer. Science (New York, N.Y.). 222(4625) : 765-71, 1983.
  • Potter H, Dressler D. Mechanisms in generalized genetic recombination. Progress in clinical and biological research. 102 Pt C: 109-26, 1982.
  • Dressler D, Potter H. Molecular mechanisms in genetic recombination. Annual review of biochemistry. 51: 727-61, 1982.
  • Potter H, Dressler D. Genome fusion. Cold Spring Harbor symposia on quantitative biology. 45 Pt 1: 371-83, 1981.
  • Potter H, Dressler D. DNA synaptase: an enzyme that fuses DNA molecules at a region of homology. Proceedings of the National Academy of Sciences of the United States of America. 77(5) : 2390-4, 1980.
  • Potter H, Dressler D. Biochemical assay designed to detect formation of recombination intermediates in vitro. Proceedings of the National Academy of Sciences of the United States of America. 76(3) : 1084-8, 1979.
  • Potter H, Dressler D. DNA recombination: in vivo and in vitro studies. Cold Spring Harbor symposia on quantitative biology. 43 Pt 2: 969-85, 1979.
  • Potter H, Dressler D. In vitro system from Escherichia coli that catalyzes generalized genetic recombination. Proceedings of the National Academy of Sciences of the United States of America. 75(8) : 3698-702, 1978.
  • Potter H, Dressler D. On the mechanism of genetic recombination: the maturation of recombination intermediates. Proceedings of the National Academy of Sciences of the United States of America. 74(10) : 4168-72, 1977.
  • Potter H, Dressler D. On the mechanism of genetic recombination: electron microscopic observation of recombination intermediates. Proceedings of the National Academy of Sciences of the United States of America. 73(9) : 3000-4, 1976.
  • Dressler D, Potter H. Transfer factor: warning on uncertainty of results. Annals of internal medicine. 82(2) : 279, 1975.
  • Dressler D, Potter H. Authors' statement: the existence and nature of "transfer factor/be/. Proceedings of the National Academy of Sciences of the United States of America. 72(1) : 409, 1975.

  • Positions Held
  • Chief Executive Officer and Scientific Director (USF-Health, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2004 - 2008)


  • Memberships
  • American Society for Cell Biology (Member, 1993 - Present)
  • American Society of Human Genetics (Member, 1993 - Present)
  • Society for Neuroscience (Member, 1986 - Present)
  • American Society for Microbiology (Member, 1986 - Present)
  • American Association for the Advancement of Science (Member, 1985 - Present)


  • Awards/Honors
  • designation of Alzheimers' Awareness Week (by Tampa Mayor Pam Iorio - 2008)
  • Proclamation of Alzheimer's Awareness Month (from Florida Governor Christ and the Florida Cabinet - 2007)
  • Health Care Heroes Award - Health Care Innovation & Research (Tampa Bay Business Journal - 2005)
  • Award for Excellence and a gift of $100,000 for outstanding achievements in the field of neurobiolog (Kaul Foundation - 2000)


  • Lectures
  • "Poster: Role of microtubule defects and chromosome mis-segregation in neurodegenerative diseases" International Conference on Alzheimers Disease. HI, United States - 2010.
  • "Update on Alzheimers Research" Oster Life Long Learning Instititute. CA, United States - 2010.
  • "Recent Advances in Alzheimers Disease Research" Arden Court. FL, United States - 2010.
  • "The Next Generation of Alzheimers Disease Therapies" The Chairmans Leadership Forum. FL, United States - 2010.
  • "Interdisciplinary, University-wide meetings for the discussion of recent advances in science and engineering at the University of South Florida " University of South Florida . FL, United States - 2010.
  • "Recent Research on Alzheimers Disease" Florida Annual Grand Masons meeting. FL, United States - 2010.
  • "Recent Advances in Alzheimers Disease Research" United Methodist Church. FL, United States - 2010.
  • "Recent Advances in Alzheimers Disease Research" Tampa Rotary North. FL, United States - 2010.
  • "Toward More Effective Treatments for Alzheimers Disease Through Harnessing Natural Anti-inflammatory Molecules " USF Research One. FL, United States - 2010.
  • "Interdisciplinary, University-wide meetings for the discussion of recent advances in science and engineering at the University of South Florida " University of South Florida . FL, United States - 2009.
  • "MINDS -Interdisciplinary, University-wide meetings for the discussion of recent advances in science and engineering at the University of South Florida " University of South Florida . FL, United States - 2008.
  • "UK Consulate/Byrd Institute International Workshop on Alzheimer's Disease " . FL, United States - 2008.
  • "Symposium on Alzheimer's Disease" Florida Alzheimer Center and Research Institute at USF. FL, United States - 2003.

  • Profile last modified on 02/24/2012