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Peter Medveczky, MD

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: pmedvecz@health.usf.edu
Phone: (813) 974-2372
Office: MDC, 4159
Mailing address 12901 Bruce B. Downs Blvd. MDC 7
Tampa, FL 33612
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Education
  • MD, Medicine, Semmelweis Medical University, Budapest, Hungary - 1970.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease.
     
    Research Summary

    We are virologists and molecular biologists interested in oncogenic and neurotropic herpesviruses. These large DNA viruses cause cancer and neurodegenerative diseases.

    Project 1 involves experiments on the Kaposi's sarcoma Associated Herpesvirus (KSHV) related to latency and oncogenic transformation. In this context we also study the role of marijuanas major compound THC and its receptors in modulation of oncogenic herpesviruses. Project is funded by a 5 year NIH grant.

    Project 2 is molecular biology of the viral interleukin-6 (vIL-6) of KSHV that is possibly involved in the oncogenic transformation process. Funding is pending.

    Project 3 Identification novel oncogenic viruses in AIDS lymphomas (50% has no known etiology). Funding is pending.

    Project 4 Human herpesvirus 6 (HHV-6) is implicated in the pathogenesis of multiple sclerosis (M.S.). Recent data show that variant HHV-6A infected marmosets develop an MS-like disease but variant B infected animals remain healthy suggesting that variant A virus encodes specific genes responsible for this phenotype. About 65 genes of the two variant genomes are highly homologous; however, about 15 genes show significant sequence divergence. Currently we are developing a system to identify genes of interest e.g. involved in neurotropism and M.S. Funded by a small grant and other grants are pending.

    Project 5 HHV-6 is a unique human virus as we discovered that its genome integrates into telomeres of human chromosomes. We have identified families with integrated HHV-6 in chromosomes 17 and 18. These patients are diagnosed with various CNS conditions and show weakened immune responses.

     


    Selected Publications
  • Medveczky MM, Sherwood TA, Klein TW, Friedman H, Medveczky PG. Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro. BMC medicine. 2: 34, 2004.
  • Meads MB, Medveczky PG. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. The Journal of biological chemistry. 279(50) : 51793-803, 2004.
  • Fej√©r G, Medveczky MM, Horvath E, Lane B, Chang Y, Medveczky PG. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. The Journal of general virology. 84(Pt 6) : 1451-62, 2003.
  • Collins CM, Medveczky MM, Lund T, Medveczky PG. The terminal repeats and latency-associated nuclear antigen of herpesvirus saimiri are essential for episomal persistence of the viral genome. The Journal of general virology. 83(Pt 9) : 2269-78, 2002.
  • Kjellen P, Amdjadi K, Lund TC, Medveczky PG, Sefton BM. The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. Virology. 297(2) : 281-8, 2002.
  • Collins CM, Medveczky PG. Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes. Advances in cancer research. 84: 155-74, 2002.
  • Hartley DA, Amdjadi K, Hurley TR, Lund TC, Medveczky PG, Sefton BM. Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions. Virology. 276(2) : 339-48, 2000.
  • Lund TC, Coleman C, Horvath E, Sefton BM, Jove R, Medveczky MM, Medveczky PG. The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. Cellular signalling. 11(11) : 789-96, 1999.
  • Lund TC, Prator PC, Medveczky MM, Medveczky PG. The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. Journal of virology. 73(2) : 1689-94, 1999.
  • Lund TC, Medveczky MM, Medveczky PG. Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. Cellular immunology. 192(2) : 133-9, 1999.
  • Hartley DA, Hurley TR, Hardwick JS, Lund TC, Medveczky PG, Sefton BM. Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation. The Journal of biological chemistry. 274(29) : 20056-9, 1999.
  • Medveczky MM, Horvath E, Lund T, Medveczky PG. In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus. AIDS (London, England). 11(11) : 1327-32, 1997.
  • Lund T, Medveczky MM, Medveczky PG. Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells. Journal of virology. 71(1) : 378-82, 1997.
  • Lund TC, Garcia R, Medveczky MM, Jove R, Medveczky PG. Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. Journal of virology. 71(9) : 6677-82, 1997.
  • Kung SH, Medveczky PG. Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells. Journal of virology. 70(3) : 1738-44, 1996.
  • Lund T, Medveczky MM, Neame PJ, Medveczky PG. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. Journal of virology. 70(1) : 600-6, 1996.
  • Williams L, Moscinski LC, Medveczky PG. Immunoglobulin germline mu transcripts in acute myelogenous leukemia cells vary in splicing pattern and are heterogeneous. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 9(12) : 2016-22, 1995.
  • Chou CS, Geck P, Medveczky MM, Hernandez OM, Medveczky PG. Induction of a herpesvirus saimiri small RNA AU binding factor (AUBF70) activity and lymphokine mRNAs by T cell mitogens. Archives of virology. 140(3) : 415-35, 1995.
  • Whitaker S, Geck P, Medveczky MM, Cus J, Kung SH, Lund T, Medveczky PG. A polycistronic transcript in transformed cells encodes the dihydrofolate reductase of herpesvirus saimiri. Virus genes. 10(2) : 163-72, 1995.
  • Chou CS, Medveczky MM, Geck P, Vercelli D, Medveczky PG. Expression of IL-2 and IL-4 in T lymphocytes transformed by herpesvirus saimiri. Virology. 208(2) : 418-26, 1995.
  • Lund T, Medveczky MM, Geck P, Medveczky PG. A herpesvirus saimiri protein required for interleukin-2 independence is associated with membranes of transformed T cells. Journal of virology. 69(7) : 4495-9, 1995.
  • Geck P, Medveczky MM, Chou CS, Brown A, Cus J, Medveczky PG. Herpesvirus saimiri small RNA and interleukin-4 mRNA AUUUA repeats compete for sequence-specific factors including a novel 70K protein. The Journal of general virology. 75 ( Pt 9): 2293-301, 1994.
  • Geck P, Whitaker SA, Medveczky MM, Last TJ, Medveczky PG. Small RNA expression from the oncogenic region of a highly oncogenic strain of herpesvirus saimiri. Virus genes. 8(1) : 25-34, 1994.
  • Medveczky MM, Geck P, Vassallo R, Medveczky PG. Expression of the collagen-like putative oncoprotein of Herpesvirus saimiri in transformed T cells. Virus genes. 7(4) : 349-65, 1993.
  • Medveczky MM, Geck P, Sullivan JL, Serbousek D, Djeu JY, Medveczky PG. IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology. 196(2) : 402-12, 1993.
  • Medveczky PG. Western blotting and polymerase chain reaction for diagnosis of HIV infection. The Journal of the Florida Medical Association. 79(1) : 47-50, 1992.
  • Geck P, Whitaker SA, Medveczky MM, Medveczky PG. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. Journal of virology. 65(12) : 7084, 1991.
  • Sairenji T, Bertoni G, Medveczky MM, Medveczky PG, Humphreys RE. Inhibition of Epstein-Barr virus production in P3HR-1 cells by Epstein-Barr virus-seropositive human serum. Intervirology. 32(1) : 37-51, 1991.
  • Geck P, Whitaker SA, Medveczky MM, Medveczky PG. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. Journal of virology. 64(7) : 3509-15, 1990.
  • Medveczky PG, Medveczky MM. Expression of interleukin 2 receptors in T cells transformed by strains of Herpesvirus saimiri representing three DNA subgroups. Intervirology. 30(4) : 213-26, 1989.
  • Medveczky MM, Geck P, Clarke C, Byrnes J, Sullivan JL, Medveczky PG. Arrangement of repetitive sequences in the genome of herpesvirus Sylvilagus. Journal of virology. 63(2) : 1010-4, 1989.
  • Medveczky MM, Szomolanyi E, Hesselton R, DeGrand D, Geck P, Medveczky PG. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits. Journal of virology. 63(9) : 3601-11, 1989.
  • Sairenji T, Bertoni G, Medveczky MM, Medveczky PG, Nguyen QV, Humphreys RE. Inhibition of Epstein-Barr virus (EBV) release from P3HR-1 and B95-8 cell lines by monoclonal antibodies to EBV membrane antigen gp350/220. Journal of virology. 62(8) : 2614-21, 1988.

  • Positions Held
  • Associate Professor (Department of Microbiology and Immunology, University of South Florida 1990 - 2006)
  • Assistant Professor (Department of Pharmacology and Molecular Genetics and Microbiology, University of Massachusetts Medical School 1982 - 1990)
  • Assistant, then Associate Professor (Dept. of Microbiology, Semmelweis Medical University 1973 - 1982)


  • Memberships
  • Clinical and Diagnostic Laboratory Immunology (Member Editorial Board, 2000 - Present)
  • NIH Immunological Sciences Immunity and Host Defense (Member, 2004 - 2006)
  • NIH Immunological Sciences Study Section Innate Immunity/Host Defense (Member, 2001 - 2003)


  • Lectures
  • "Tumor Virology seminar" Johns Hopkins School of Medicine, Sidney Kimmel Cancer Center. MD, United States - 2004.
  • "invited speaker" NATO Advanced Workshop on Emerging Biological Threats. Belgium - 2003.
  • "Immunology and Virology Seminar" University of Massachusetts Medical School . MA, United States - 2002.

  • Profile last modified on 10/07/2013