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Peter Medveczky, MD



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Email: pmedvecz@health.usf.edu
Phone: (813) 974-2372
Office: MDC, 4159
Mailing address 12901 Bruce B. Downs Blvd. MDC 7
Tampa, FL 33612
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  • MD, Medicine, Semmelweis Medical University, Budapest, Hungary - 1970.
Interdisciplinary & Emerging Signature Programs
Allergy, Immunology & Infectious Disease.
Research Summary

We are virologists and molecular biologists interested in oncogenic and neurotropic herpesviruses. These large DNA viruses cause cancer and neurodegenerative diseases.

Project 1 involves experiments on the Kaposi's sarcoma Associated Herpesvirus (KSHV) related to latency and oncogenic transformation. In this context we also study the role of marijuanas major compound THC and its receptors in modulation of oncogenic herpesviruses. Project is funded by a 5 year NIH grant.

Project 2 is molecular biology of the viral interleukin-6 (vIL-6) of KSHV that is possibly involved in the oncogenic transformation process. Funding is pending.

Project 3 Identification novel oncogenic viruses in AIDS lymphomas (50% has no known etiology). Funding is pending.

Project 4 Human herpesvirus 6 (HHV-6) is implicated in the pathogenesis of multiple sclerosis (M.S.). Recent data show that variant HHV-6A infected marmosets develop an MS-like disease but variant B infected animals remain healthy suggesting that variant A virus encodes specific genes responsible for this phenotype. About 65 genes of the two variant genomes are highly homologous; however, about 15 genes show significant sequence divergence. Currently we are developing a system to identify genes of interest e.g. involved in neurotropism and M.S. Funded by a small grant and other grants are pending.

Project 5 HHV-6 is a unique human virus as we discovered that its genome integrates into telomeres of human chromosomes. We have identified families with integrated HHV-6 in chromosomes 17 and 18. These patients are diagnosed with various CNS conditions and show weakened immune responses.


Selected Publications

Positions Held
  • Associate Professor (Department of Microbiology and Immunology, University of South Florida 1990 - 2006)
  • Assistant Professor (Department of Pharmacology and Molecular Genetics and Microbiology, University of Massachusetts Medical School 1982 - 1990)
  • Assistant, then Associate Professor (Dept. of Microbiology, Semmelweis Medical University 1973 - 1982)

  • Clinical and Diagnostic Laboratory Immunology (Member Editorial Board, 2000 - Present)
  • NIH Immunological Sciences Immunity and Host Defense (Member, 2004 - 2006)
  • NIH Immunological Sciences Study Section Innate Immunity/Host Defense (Member, 2001 - 2003)

  • "Tumor Virology seminar" Johns Hopkins School of Medicine, Sidney Kimmel Cancer Center. MD, United States - 2004.
  • "invited speaker" NATO Advanced Workshop on Emerging Biological Threats. Belgium - 2003.
  • "Immunology and Virology Seminar" University of Massachusetts Medical School . MA, United States - 2002.

Profile last modified on 10/07/2013