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Emmanuel W. Smith, PhD

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE
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Contacts
Email: esmith3@health.usf.edu
Phone: (813) 396-9188
Office: MDC, 3524
Mailing address 12901 Bruce B. Downs Blvd ,MDC07
Tampa, FL 33612
 
Education
  • PhD, Medical Sciences, University Of South Florida, Tampa, United States - 2014.
  • PhD, Medical Sciences, University of South Florida, USA - 2014.
  • MS, Molecular Medicine, University of South Florida, USA - 2012.
  • BS, Biology, University of South Florida, USA - 2009.
 
 
Research Summary

Our lab focuses on structure-based drug discovery through the use of X-ray crystallography and molecular docking. My main focus has been on chemokine proteins CXCL12 and CCL21 and their implication in cancer metastasis, but also on P.aeruginosa proteins LpxA and LpxD. X-ray crystallography is a tool used to determine the atomic and molecular structure of protein crystals. This provides invaluable information about the protein, such as structural characterization of active sites. Once an active site is characterized, a rational drug design approach can be used. Molecular docking is a computational tool that can be used to predict the binding orientation of small molecules to proteins. This can be used to study possible conformations a molecule might take in a protein active site, but can also be used to computationally screen millions of compounds in search of potential drug candidates.

 


Selected Publications






Profile last modified on 12/28/2014