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Joshus Radke,

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Email: jradke@health.usf.edu
Phone: (813) 974-5796
Office: IDRB, 325
Mailing address 3705 Spectrum Blvd. Suite 325
Tampa, FL 33612
  • MS, Molecular Biosciences, University of South Florida, USA - 2012.
  • BS, Chemistry, Belmont University, USA - 2003.
Interdisciplinary & Emerging Signature Programs
Allergy, Immunology & Infectious Disease.
Research Summary

Research in the White lab is focused on the malaria-related protzoan parasite Toxoplasma gondii. T.gondii is an obligate intracellular parasite that causes severe disease in people with underdeveloped or compromised immune systems. Toxoplasmosis can be a lethal infection for people with AIDS, those undergoing chemotherapy and recent transplant recipients. Pathogenesis in this disease is the result of uncontrolled parasite growth in conjunction with significant tissue damage and inflammation. Given that parasite growth and division is critical to disease, it is important to understand the mechanisms that regulate the progression through the parasite cell cycle. Approximately ~2500 mRNAs show cyclic patterns of expression during parasite division, however, the transcriptional mechanisms that regulate periodic gene expression are largely uncharacterized. The recent discovery of a class of plant-like transcription factors in Apicomplexa has revealed an important set of proteins that play a critical role in parasite development and division. My project centers on the characterization of these plant-like transcription factors, specifially those that lie in S-phase of the cell division cycle, a very critical and unique step in these parasites. What these factors regulate and how they are regulated is critical to our understanding of the progression of the cell division cycle in Toxoplasma gondii.


  • Outstanding Poster:Allergy, Immunology and Infectious Disease (USF Research Day - 2010)

Profile last modified on 03/14/2014