University of South Florida

University of South Florida


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Kevin Nash, Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Assistant Professor, Dept. of Molecular Pharmacology and Physiology, College of Medicine

Assoc Professor, COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Academic Email : knash@health.usf.edu

Phone : (813) 974-3788

Office : ALZ, 421

Mailing address : 12901 Bruce B. Downs Blvd. MDC 8
Tampa, FL 33612

Education

  • Ph.D. , Biochemistry, University of Queensland, Queensland, Australia - 1996.
  • PHD, Biochemistry, University Of Queensland, Australia - 1996.
  • B.S., Biochemistry and Microbiology, University of Queensland, Queensland, Australia - 1991.

Research summary

  • My research focus is now targeted towards using recombinant Adeno-associated virus (rAAV) to study of neurological disorders. We have examined the use of rAAV to over express proteases including neprilysin (NEP), insulin degrading enzyme (IDE; also known as insulysin) and endothelin converting enzyme (ECE) to remove beta-amyloid which is deposited in Alzhiemer disease. To facilitate the diffusion of the protease enzymes to the amyloid plaques, we have engineered the proteins with a signal peptide triggering secretion. We have successfully observed a reduction in amyloid plaques with both NEP and ECE in APP+PS1 transgenic Alzheimer mice models. We are also using rAAV to study an inflammatory molecule known as Fractalkine. Fractalkine reduces the pro-inflammatory response that is observed in many neurological diseases. We are examining whether this reduction in inflammation would be beneficial in Alzheimer and Parkinson’s diseases.

Selected Publications

Positions Held

  • Research Assistant Professor (Powell Centre for Gene Therapy, University of Florida 2002 - 2007)

Interdisciplinary and Emerging Signature Programs

  • Neurodegenerative Disease, Neuroscience.

Memberships

  • The American Association for the Advancement of Science (Member, 2008 - Present)
  • American Society of Gene Therapy (Member, 2008 - Present)
  • Society for Neuroscience (Member, 2008 - Present)

Patents & Licensing

  • Pseudotyping of recombinant AAV verions (Snyder et al.) Patent pending (US Application No. 60/385,864 - 2008)



Profile last modified on 09/01/2017