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Tomar Ghansah,  Ph.D.


Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assistant Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: tghansah@health.usf.edu
Phone: (813) 974-1825
Office: MDC, 3030
Mailing address 12901 Bruce B. Downs Blvd MDC07
Tampa, FL 33612
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Education
  • PHD, Microbiolgy, Meharry Medical College , United States - 1999.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology.
     
    Research Summary

    My specific research area is Tumor Immunology with an emphasis on Signal Transduction. Pancreatic cancer is one of the most aggressive and lethal cancers in humans. Current therapy modalities are less effective in treating solid tumors partly due to immunosuppression associated with the expansion of regulatory Myeloid Derived Suppressor Cells (MDSC) and T Cells (Tregs). Currently, in my lab, we have several pancreatic cancer mouse models that we use to investigate how the host immune system responds to tumors, as well as the effects of a variety of immunomodulatory drugs on restoring immune homeostasis, thus enhancing anti-tumor responses in vivo and in vitro.

     


    Selected Publications
  • Ghansah, TJ.Ager, EC.Freeman-Junior, P.Villalta, F.Lima, MF. Epidermal growth factor binds to a receptor on Trypanosoma cruzi amastigotes inducing signal transduction events and cell proliferation. The Journal of eukaryotic microbiology. 49(5): 383-90, .
  • Nelson, N.Szekeres, K.Cooper, D.Ghansah, T. Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS). Journal of visualized experiments : JoVE. (64): , 2012.
  • Pilon-Thomas, S.Nelson, N.Vohra, N.Jerald, M.Pendleton, L.Szekeres, K.Ghansah, T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PloS one. 6(11): e27729, 2011.
  • Kleiman, E.Carter, G.Ghansah, T.Patel, NA.Cooper, DR. Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport. Biochemical and biophysical research communications. 388(3): 554-9, 2009.
  • Jiang, K.Apostolatos, AH.Ghansah, T.Watson, JE.Vickers, T.Cooper, DR.Epling-Burnette, PK.Patel, NA. Identification of a novel antiapoptotic human protein kinase C delta isoform, PKCdeltaVIII in NT2 cells. Biochemistry. 47(2): 787-97, 2008.
  • Paraiso, KH.Ghansah, T.Costello, A.Engelman, RW.Kerr, WG. Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950). 178(5): 2893-900, 2007.
  • Ghansah, T.Paraiso, KH.Highfill, S.Desponts, C.May, S.McIntosh, JK.Wang, JW.Ninos, J.Brayer, J.Cheng, F.Sotomayor, E.Kerr, WG. Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. Journal of immunology (Baltimore, Md. : 1950). 173(12): 7324-30, 2004.
  • Cheng, F.Wang, HW.Cuenca, A.Huang, M.Ghansah, T.Brayer, J.Kerr, WG.Takeda, K.Akira, S.Schoenberger, SP.Yu, H.Jove, R.Sotomayor, EM. A critical role for Stat3 signaling in immune tolerance. Immunity. 19(3): 425-36, 2003.
  • Wang, JW.Howson, JM.Ghansah, T.Desponts, C.Ninos, JM.May, SL.Nguyen, KH.Toyama-Sorimachi, N.Kerr, WG. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science (New York, N.Y.). 295(5562): 2094-7, 2002.
  • Tu, Z.Ninos, JM.Ma, Z.Wang, JW.Lemos, MP.Desponts, C.Ghansah, T.Howson, JM.Kerr, WG. Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood. 98(7): 2028-38, 2001.

  • Profile last modified on 10/07/2013