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Subhra Mohapatra, PHD

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Associate Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: smohapa2@health.usf.edu
Phone: (813) 974-4127
Office: MDC, 2525
Mailing address 12901 Bruce B Downs Blvd. MDC 7, Rm# 2523
Tampa, FL 33612
View My C.V.
 
Education
  • PHD, Immunology, University Of Manitoba, Winnipeg, Canada - 1993.
  • MS, Chemistry, Ravenshaw College, Utkal University, Cuttack, India - 1983.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease, Cancer Biology.
     
    Research Summary

    Research in my lab focuses on understanding the fundamental mechanisms of tumor-stroma interaction that plays a critical role in tumor growth and metastasis. To this end, we have developed a novel nanofiber scaffold platform, which allows study of tumor progression in vitro and it is being exploited for research involving anti-cancer drug discovery and the mechanism of drug resistance. We are also exploring the role of cancer-associated fibroblasts, a key player in the tumor microenvironment in modulating tumor growth and cancer stem cell expansion, especially evaluating the role of the atrial natriuretic peptide receptor A signaling pathway as a target. My lab is also investigating the effects of a combined nano- and cell-therapy for the treatment of traumatic brain injury.

     


    Selected Publications
  • Devkota J, Howell M, Mukherjee P, Srikanth H, Mohapatra S* and Phan MH. Magneto-reactance based detection of MnO nanoparticle-embedded Lewis lung carcinoma cells J. Appl. Phys.. 117: 17D123, 2015.
  • Wong TM, Boyapalle S, Sampayo V, Nguyen HD, Bedi R, Kamath SG, Moore ML, Mohapatra S, Mohapatra SS. Respiratory syncytial virus (RSV) infection in elderly mice results in altered antiviral gene expression and enhanced pathology. PloS one. 9(2) : e88764, 2014.
  • Das M, Wang C, Bedi R, Mohapatra SS, Mohapatra S. Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury. Nanomedicine : nanotechnology, biology, and medicine. 10(7) : 1539-48, 2014.
  • Howell M, Mallela J, Wang C, Ravi S, Dixit S, Garapati U, Mohapatra S. Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs. Journal of controlled release : official journal of the Controlled Release Society. 167(2) : 210-8, 2013.
  • Mallela J, Ravi S, Jean Louis F, Mulaney B, Cheung M, Sree Garapati U, Chinnasamy V, Wang C, Nagaraj S, Mohapatra SS, Mohapatra S. Natriuretic Peptide receptor a signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis. Stem cells (Dayton, Ohio). 31(7) : 1321-9, 2013.
  • Wang C, Mallela J, Garapati US, Ravi S, Chinnasamy V, Girard Y, Howell M, Mohapatra S. A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine : nanotechnology, biology, and medicine. 9(7) : 903-11, 2013.
  • Howell M, Wang C, Mahmoud A, Hellermann G, Mohapatra SS, Mohapatra S. Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases. Drug delivery and translational research. 3(4) : 352-363, 2013.
  • Girard YK, Wang C, Ravi S, Howell MC, Mallela J, Alibrahim M, Green R, Hellermann G, Mohapatra SS, Mohapatra S. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PloS one. 8(10) : e75345, 2013.
  • Wang C, Ravi S, Martinez GV, Chinnasamy V, Raulji P, Howell M, Davis Y, Mallela J, Seehra MS, Mohapatra S. Dual-purpose magnetic micelles for MRI and gene delivery. Journal of controlled release : official journal of the Controlled Release Society. 163(1) : 82-92, 2012.
  • Wang X, Raulji P, Mohapatra SS, Patel R, Hellermann G, Kong X, Vera PL, Meyer-Siegler KL, Coppola D, Mohapatra S. Natriuretic peptide receptor a as a novel target for prostate cancer. Molecular cancer. 10: 56, 2011.
  • Wang JW, Li K, Hellermann G, Lockey RF, Mohapatra S, Mohapatra S. Regulating the Regulators: microRNA and Asthma. The World Allergy Organization journal. 4(6) : 94-103, 2011.
  • Wang C, Howell M, Raulji P, Davis Y, Mohapatra S. Preparation and Characterization of Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic Peptide (ANP). Advanced functional materials. 21(23) : 4423-4429, 2011.
  • Zhang W, Cao X, Chen D, Wang JW, Yang H, Wang W, Mohapatra S, Hellermann G, Kong X, Lockey RF, Mohapatra SS. Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells. Genetic vaccines and therapy. 9(1) : 3, 2011.
  • Kumar A, Jena PK, Behera S, Lockey RF, Mohapatra S, Mohapatra S. Multifunctional magnetic nanoparticles for targeted delivery. Nanomedicine : nanotechnology, biology, and medicine. 6(1) : 64-9, 2010.
  • Kandasamy R, Park SJ, Boyapalle S, Mohapatra S, Hellermann GR, Lockey RF, Mohapatra SS. Isatin down-regulates expression of atrial natriuretic peptide receptor A and inhibits airway inflammation in a mouse model of allergic asthma. International immunopharmacology. 10(2) : 218-25, 2010.
  • Bagui TK, Cui D, Roy S, Mohapatra S, Shor AC, Ma L, Pledger WJ. Inhibition of p27Kip1 gene transcription by mitogens. Cell cycle (Georgetown, Tex.). 8(1) : 115-24, 2009.
  • Wang X, Xu W, Kong X, Chen D, Hellermann G, Ahlert TA, Giaimo JD, Cormier SA, Li X, Lockey RF, Mohapatra S, Mohapatra SS. Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. Respiratory research. 10: 66, 2009.
  • Mohapatra S, Chu B, Zhao X, Djeu J, Cheng JQ, Pledger WJ. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. The international journal of biochemistry & cell biology. 41(3) : 595-602, 2009.
  • Kong X, Wang X, Xu W, Behera S, Hellermann G, Kumar A, Lockey RF, Mohapatra S, Mohapatra SS. Natriuretic peptide receptor a as a novel anticancer target. Cancer research. 68(1) : 249-56, 2008.
  • Wang X, Xu W, Mohapatra S, Kong X, Li X, Lockey RF, Mohapatra SS. Prevention of airway inflammation with topical cream containing imiquimod and small interfering RNA for natriuretic peptide receptor. Genetic vaccines and therapy. 6: 7, 2008.
  • Mohapatra S, Coppola D, Riker AI, Pledger WJ. Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma. Molecular cancer research : MCR. 5(2) : 145-51, 2007.
  • Mohapatra S, Chu B, Zhao X, Pledger WJ. Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer research. 65(17) : 7717-23, 2005.
  • Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. The Journal of biological chemistry. 280(13) : 12339-43, 2005.
  • Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, Hellermann G, Behera S, Singam R, Lockey RF, Mohapatra SS. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nature medicine. 11(1) : 56-62, 2005.
  • Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer research. 63(23) : 8523-30, 2003.
  • Bagui TK, Mohapatra S, Haura E, Pledger WJ. P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Molecular and cellular biology. 23(20) : 7285-90, 2003.
  • Mohapatra S, Agrawal D, Pledger WJ. p27Kip1 regulates T cell proliferation. The Journal of biological chemistry. 276(24) : 21976-83, 2001.
  • Mohapatra S, Pledger WJ. Interdependence of cdk2 activation and interleukin-2Ralpha accumulation in T cells. The Journal of biological chemistry. 276(24) : 21984-9, 2001.
  • Mohapatra S, Yang X, Wright JA, Turley EA, Greenberg AH. Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression. The Journal of experimental medicine. 183(4) : 1663-8, 1996.
  • Chen Y, Takata M, Maiti PK, Mohapatra S, Mohapatra SS, Sehon AH. The suppressor factor of T suppressor cells induced by tolerogenic conjugates of ovalbumin and monomethoxypolyethylene glycol is serologically and physicochemically related to the alpha beta heterodimer of the T cell receptor. Journal of immunology (Baltimore, Md. : 1950). 152(1) : 3-11, 1994.
  • Mohapatra SS, Mohapatra S, Yang M, Ansari AA, Parronchi P, Maggi E, Romagnani S. Molecular basis of cross-reactivity among allergen-specific human T cells: T-cell receptor V alpha gene usage and epitope structure. Immunology. 81(1) : 15-20, 1994.
  • Chen Y, Mohapatra S, Mohapatra SS, Sehon AH. Cytokine gene expression of CD8+ suppressor T cells induced by tolerogenic conjugates of antigen and mPEG. Cellular immunology. 149(2) : 409-21, 1993.
  • Mohapatra S, Chen Y, Takata M, Mohapatra SS, Sehon AH. Analysis of T-cell receptor alpha beta chains of CD8+ suppressor T cells induced by tolerogenic conjugates of antigen and monomethoxypolyethylene glycol. Involvement of TCR alpha-CDR3 domain in immunosuppression. Journal of immunology (Baltimore, Md. : 1950). 151(2) : 688-98, 1993.
  • Venugopal G, Mohapatra S, Salo D, Mohapatra S. Multiple mismatch annealing: basis for random amplified polymorphic DNA fingerprinting. Biochemical and biophysical research communications. 197(3) : 1382-7, 1993.

  • Memberships
  • National Academic of Inventors (Member, 2014 - Present)
  • USF Senate (Member, 2014 - Present)
  • National Academic of Inventors USF Chapter (Member, 2014 - Present)
  • American Association of Cancer Research (Member, 2001 - Present)


  • Awards/Honors
  • Excellence in Innovation Award (USF - 2014)
  • Academic Editor (PLOS One - 2014)
  • International Travel Grant (USF - 2013)
  • SIPAIID Travel Grant (SIPAIID - 2011)
  • Organotypic Culture Training Program Award (NIH/NCI - 2007)
  • Young Investigator Travel Award (AACR - 1996)
  • Junior Research Fellowship (NCI-Canada - 1994)
  • Postdoctoral Fellowship (• Manitoba Health Research Council - 1994)
  • Travel grant (• Canadian Society of Immunology - 1993)
  • Graduate Student Fellowship (Manitoba Health Research Council - 1991)
  • Graduate Student Fellowship (University of Manitoba - 1990)


  • Patents & Licensing
  • 2. Methods of predicting sensitivity to prostate cancer therapy (University of south florida - 2015)
  • 1. XIAP targeted prostate cancer therapy (University of south florida - 2014)


  • Profile last modified on 08/17/2015