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Radouil Tzekov, Ph.D.
Adjunct Assistant Professor, Ophthalmology
Senior Research Scientist III, Vision Research Program in neurodegenerative diseases


Assistant Professor

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Email: rtzekov@health.usf.edu
Phone: (813) 974-1530
Office: MDO, 1036
Mailing address 12901 Bruce B. Downs Blvd. MDC 21
Tampa, FL 33612
  • Certificate, Clinical Sciences, PERI, USA - 2008.
  • Postdoctoral fellowship, Visual function testing, Smith-Kettlewell Eye Research Institute, USA - 2002.
  • Postdoctoral fellowship, Visual function testing , Stanford University, USA - 2001.
  • Postdoctoral fellowship, Applied Vision Research, Retina Foundation of the SW, USA - 2000.
  • Postgraduate fellowship, Applied Vision Research, City University, London, United Kingdom - 1997.
  • PhD, Ophthalmology, Medical University, Sofia, Bulgaria - 1996.
  • MD, Medicine, Medical Academy, Sofia, Bulgaria - 1984.
    Interdisciplinary & Emerging Signature Programs
    Biomedical Engineering & Nanomedicine, Allergy, Immunology & Infectious Disease, Neurodegenerative Disease.
    Research Summary

    Clinical visual electrophysiology and psychophysics; traumatic brain injury; retinal degenerative diseases; visual function in neuro-degenerative disease.


    Lab Link:  EyeHealth.usf.edu/testing

    Selected Publications
  • Ojo JO, Bachmeier C, Mouzon BC, Tzekov R, Mullan M, Davies H, Stewart MG, Crawford F. Ultrastructural Changes in the White and Gray Matter of Mice at Chronic Time Points After Repeated Concussive Head Injury. Journal of neuropathology and experimental neurology. 74(10) : 1012-35, 2015.
  • Chen G, Tzekov R, Li W, Jiang F, Mao S, Tong Y. Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis. Scientific reports. 5: 14517, 2015.
  • Zheng Q Ren Y Tzekov R Hua S Li M Pang J Qu J Li W. iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery. J Ophthalmol.. 2015: 918473, 2015.
  • McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M. Erratum to: ISCEV Standard for full-field clinical electroretinography (2015 update). Documenta ophthalmologica. Advances in ophthalmology. 131(1) : 81-3, 2015.
  • Tzekov R, Madow B. Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy. Journal of ophthalmology. 2015: 680215, 2015.
  • Tzekov R. Full-field ERG in diabetic retinopathy: a screening tool? Graefe's archive for clinical and experimental ophthalmology. 253(7) : 987-988, 2015.
  • Chen G, Li, W; Tzekov R; Jiang F; Mao S; Tong Y. BEVACIZUMAB VERSUS RANIBIZUMAB FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Meta-analysis of Randomized Controlled Trials. Retina. 35(2) : 187-193, 2015.
  • McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M. ISCEV Standard for full-field clinical electroretinography (2015 update). Documenta ophthalmologica. Advances in ophthalmology. 130(1) : 1-12, 2015.
  • Chen G, Li W, Tzekov R, Jiang F, Mao S, Tong Y. Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema: a meta-analysis of randomized controlled trials. PloS one. 9(12) : e115797, 2014.
  • Tzekov R, Quezada A, Gautier M, Biggins D, Frances C, Mouzon B, Jamison J, Mullan M, Crawford F. Repetitive Mild Traumatic Brain Injury Causes Optic Nerve and Retinal Damage in a Mouse Model. Journal of neuropathology and experimental neurology. 73(4) : 345-61, 2014.
  • Tzekov R, Mullan M. Vision function abnormalities in Alzheimer disease. Survey of ophthalmology. 59(4) : 414-33, 2014.
  • Lei L, Tzekov R, McDowell JH, Smith WC, Tang S, Kaushal S. Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Experimental eye research. 112(7) : 57-67, 2013.
  • Byrne M, Tzekov R, Wang Y, Rodgers A, Cardia J, Ford G, Holton K, Pandarinathan L, Lapierre J, Stanney W, Bulock K, Shaw S, Libertine L, Fettes K, Khvorova A, Kaushal S, Pavco P. Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 29(10) : 855-64, 2013.
  • Meklenburg J, Clancy EA, Tzekov R. Signal processing techniques for oscillatory potential extraction in the electroretinogram: automated highpass cutoff frequency estimation. Documenta ophthalmologica. Advances in ophthalmology. 125(2) : 101-11, 2012.
  • Lei L, Tzekov R, Tang S, Kaushal S. Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells. Molecular vision. 18: 103-13, 2012.
  • Zheng Q, Ren Y, Tzekov R, Zhang Y, Chen B, Hou J, Zhao C, Zhu J, Zhang Y, Dai X, Ma S, Li J, Pang J, Qu J, Li W. Differential Proteomics and Functional Research following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis. PloS one. 7(8) : e44855, 2012.
  • Kleinberg TT, Tzekov RT, Stein L, Ravi N, Kaushal S. Vitreous substitutes: a comprehensive review. Survey of ophthalmology. 56(4) : 300-23, 2011.
  • Tzekov R, Stein L, Kaushal S. Protein misfolding and retinal degeneration. Cold Spring Harbor perspectives in biology. 3(11) : a007492, 2011.
  • Clemson CM, Tzekov R, Krebs M, Checchi JM, Bigelow C, Kaushal S. Therapeutic potential of valproic acid for retinitis pigmentosa. The British journal of ophthalmology. 95(1) : 89-93, 2011.
  • Akula JD, Hansen RM, Tzekov R, Favazza TL, Vyhovsky TC, Benador IY, Mocko JA, McGee D, Kubota R, Fulton AB. Visual cycle modulation in neurovascular retinopathy. Experimental eye research. 91(2) : 153-61, 2010.
  • Messias A, Zrenner E, Tzekov R, McGee D, Peters T, Wilhelm B, Baryluk A, Kubota R, Gekeler F. Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats. Documenta ophthalmologica. Advances in ophthalmology. 120(2) : 165-74, 2010.
  • Tzekov R, Lin T, Zhang KM, Jackson B, Oyejide A, Orilla W, Kulkarni AD, Kuppermann BD, Wheeler L, Burke J. Ocular changes after photodynamic therapy. Investigative ophthalmology & visual science. 47(1) : 377-85, 2006.
  • Tzekov R. Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates. Documenta ophthalmologica. Advances in ophthalmology. 110(1) : 111-20, 2005.
  • Brigell M, Dong CJ, Rosolen S, Tzekov R. An overview of drug development with special emphasis on the role of visual electrophysiological testing. Documenta ophthalmologica. Advances in ophthalmology. 110(1) : 3-13, 2005.
  • Tzekov RT, Gerth C, Werner JS. Senescence of human multifocal electroretinogram components: a localized approach. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 242(7) : 549-60, 2004.
  • Kulkarni AD, Kuppermann BD, Tzekov RT, Lin T, Burke JA. Vitreous surgery in pigmented rabbits using the new, noncontact wide-field viewing system. American journal of ophthalmology. 137(1) : 212-3; author reply 213, 2004.
  • Tzekov RT, Serrato A, Marmor MF. ERG findings in patients using hydroxychloroquine. Documenta ophthalmologica. Advances in ophthalmology. 108(1) : 87-97, 2004.
  • Marmor MF, Serrato A, Tzekov R. Comparison of conventional ERG parameters and high-intensity A-wave analysis in a clinical setting. Documenta ophthalmologica. Advances in ophthalmology. 106(3) : 281-7, 2003.
  • Tzekov RT , Locke KG, Hood DC, Birch DG. Cone and rod ERG phototransduction parameters in retinitis pigmentosa. Investigative ophthalmology & visual science. 44(9) : 3993-4000, 2003.
  • Penrose PJ, Tzekov RT, Sutter EE, Fu AD, Allen AW, Fung WE, Oxford KW. Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine. Retina (Philadelphia, Pa.). 23(4) : 503-12, 2003.
  • Serrato A, Tzekov R, Marmor MF. The lens-coating agent and the electroretinogram. Documenta ophthalmologica. Advances in ophthalmology. 106(3) : 225-30, 2003.
  • Pham RT, Tzekov RT, Biesman BS, Marmor MF. Retinal evaluation after 810 nm Dioderm laser removal of eyelashes. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 28(9) : 836-40, 2002.
  • Birch DG, Hood DC, Locke KG, Hoffman DR, Tzekov RT. Quantitative electroretinogram measures of phototransduction in cone and rod photoreceptors: normal aging, progression with disease, and test-retest variability. Archives of ophthalmology. 120(8) : 1045-51, 2002.
  • Mata NL Tzekov RT Liu X Weng J Birch DG Travis G. Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration Invest Ophthalmol Vis Sci. 42(8) : 1685-1690, 2001.
  • Tzekov RT, Liu Y, Sohocki MM, Zack DJ, Daiger SP, Heckenlively JR, Birch DG. Autosomal dominant retinal degeneration and bone loss in patients with a 12-bp deletion in the CRX gene. Investigative ophthalmology & visual science. 42(6) : 1319-27, 2001.
  • Tzekov RT, Sohocki MM, Daiger SP, Birch DG. Visual phenotype in patients with Arg41Gln and ala196+1bp mutations in the CRX gene. Ophthalmic genetics. 21(2) : 89-99, 2000.
  • Tzekov R, Arden GB. The electroretinogram in diabetic retinopathy. Survey of ophthalmology. 44(1) : 53-60, 1999.
  • Weng J, Mata NL, Azarian SM, Tzekov RT, Birch DG, Travis GH. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell. 98(1) : 13-23, 1999.
  • Arden G, Wolf J, Berninger T, Hogg CR, Tzekov R, Holder GE. S-cone ERGs elicited by a simple technique in normals and in tritanopes. Vision research. 39(3) : 641-50, 1999.
  • Yankov E, Nakova A, Tzekov R. Spectral sensitivity of the visual system as revealed by evoked potentials in normal and anomalous trichomats. Acta physiologica et pharmacologica Bulgarica. 24(4) : 91-100, 1999.

  • Positions Held

  • American Association for the Advancement of Science (AAAS) (Member, 2001 - Present)
  • New York Academy of Sciences (NYAS) (Member, 2001 - Present)
  • International Society for Clinical Electrophysiology of Vision (ISCEV) (Member, 1998 - Present)
  • Association for Research in Vision and Ophthalmology (ARVO) (Member, 1997 - Present)

  • Profile last modified on 10/10/2015