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Radouil Tzekov,  Ph.D.
Adjunct Assistant Professor, Ophthalmology
Senior Research Scientist III, Vision Research Program in neurodegenerative diseases


Primary Department: COLLEGE OF MEDICINE OPHTHALMOLOGY

Assistant Professor
COLLEGE OF MEDICINE OPHTHALMOLOGY

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Contacts
Email: rtzekov@health.usf.edu
Phone: (813) 974-1530
Office: MDO, 1036
Mailing address 12901 Bruce B. Downs Blvd. MDC 21
Tampa, FL 33612
 
Education
  • Certificate, Clinical Sciences, PERI ,USA - 2008.
  • Postdoctoral fellowship, Visual function testing, Smith-Kettlewell Eye Research Institute ,USA - 2002.
  • Postdoctoral fellowship, Visual function testing , Stanford University ,USA - 2001.
  • Postdoctoral fellowship, Applied Vision Research, Retina Foundation of the SW ,USA - 2000.
  • Postgraduate fellowship, Applied Vision Research, City University , London, United Kingdom - 1997.
  • PhD, Ophthalmology, Medical University , Sofia, Bulgaria - 1996.
  • MD, Medicine, Medical Academy , Sofia, Bulgaria - 1984.
  •  
    Interdisciplinary & Emerging Signature Programs
    Biomedical Engineering & Nanomedicine, Allergy, Immunology & Infectious Disease, Neurodegenerative Disease.
     
    Research Summary

    Clinical visual electrophysiology and psychophysics; traumatic brain injury; retinal degenerative diseases; visual function in neuro-degenerative disease.

     
    Links

    Lab Link:  EyeHealth.usf.edu/testing


    Selected Publications
  • Tzekov, R.Quezada, A.Gautier, M.Biggins, D.Frances, C.Mouzon, B.Jamison, J.Mullan, M.Crawford, F. Repetitive Mild Traumatic Brain Injury Causes Optic Nerve and Retinal Damage in a Mouse Model. Journal of neuropathology and experimental neurology. (): , 2014.
  • Lei, L.Tzekov, R.McDowell, JH.Smith, WC.Tang, S.Kaushal, S. Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Experimental eye research. 112(): 57-67, 2013.
  • Byrne, M.Tzekov, R.Wang, Y.Rodgers, A.Cardia, J.Ford, G.Holton, K.Pandarinathan, L.Lapierre, J.Stanney, W.Bulock, K.Shaw, S.Libertine, L.Fettes, K.Khvorova, A.Kaushal, S.Pavco, P. Novel Hydrophobically Modified Asymmetric RNAi Compounds (sd-rxRNA) Demonstrate Robust Efficacy in the Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 29(10): 855-64, 2013.
  • Tzekov, R.Mullan, M. Vision function abnormalities in Alzheimer disease. Survey of ophthalmology. (): , 2013.
  • Zheng Q., Ren, Y.,Tzekov, R., Zhang, Y.Chen, B.Hou, J.Zhao, C.Zhu, J.Zhang, Y.Dai, X.Ma, S.Li, J.Pang, J.Qu, J.Li, W. Differential Proteomics and Functional Research following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis. PloS one. 7(8): e44855, 2012.
  • Lei, L., Tzekov, R., Tang,, S.Kaushal, S. Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells. Molecular vision. 18(): 103-13, 2012.
  • Meklenburg, J.Clancy, EA.Tzekov, R. Signal processing techniques for oscillatory potential extraction in the electroretinogram: automated highpass cutoff frequency estimation. Documenta ophthalmologica. Advances in ophthalmology. 125(2): 101-11, 2012.
  • Kleinberg, TT.Tzekov, RT.Stein, L.Ravi, N.Kaushal, S. Vitreous substitutes: a comprehensive review. Survey of ophthalmology. 56(4): 300-23, 2011.
  • Tzekov, R.Stein, L.Kaushal, S. Protein misfolding and retinal degeneration. Cold Spring Harbor perspectives in biology. 3(11): a007492, 2011.
  • Clemson, CM.Tzekov, R.Krebs, M.Checchi, JM.Bigelow, C.Kaushal, S. Therapeutic potential of valproic acid for retinitis pigmentosa. The British journal of ophthalmology. 95(1): 89-93, 2011.
  • Akula, JD.Hansen, RM.Tzekov, R.Favazza, TL.Vyhovsky, TC.Benador, IY.Mocko, JA.McGee, D.Kubota, R.Fulton, AB. Visual cycle modulation in neurovascular retinopathy. Experimental eye research. 91(2): 153-61, 2010.
  • Messias, A.Zrenner, E.Tzekov, R.McGee, D.Peters, T.Wilhelm, B.Baryluk, A.Kubota, R.Gekeler, F. Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats. Documenta ophthalmologica. Advances in ophthalmology. 120(2): 165-74, 2010.
  • Tzekov, R., Lin, T., Zhang, KM., Jackson, B., Oyejide, A., Orilla, W.Kulkarni, AD.Kuppermann, BD.Wheeler, L.Burke, J. Ocular changes after photodynamic therapy. Investigative ophthalmology & visual science. 47(1): 377-85, 2006.
  • Tzekov, R. Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates. Documenta ophthalmologica. Advances in ophthalmology. 110(1): 111-20, 2005.
  • Brigell, M.Dong, CJ.Rosolen, S.Tzekov, R. An overview of drug development with special emphasis on the role of visual electrophysiological testing. Documenta ophthalmologica. Advances in ophthalmology. 110(1): 3-13, 2005.
  • Kulkarni, AD.Kuppermann, BD.Tzekov, RT.Lin, T.Burke, JA. Vitreous surgery in pigmented rabbits using the new, noncontact wide-field viewing system. American journal of ophthalmology. 137(1): 212-3; author reply 213, 2004.
  • Tzekov, RT., Serrato, A., Marmor, MF. ERG findings in patients using hydroxychloroquine. Documenta ophthalmologica. Advances in ophthalmology. 108(1): 87-97, 2004.
  • Tzekov, RT., Gerth, C., Werner, JS. Senescence of human multifocal electroretinogram components: a localized approach. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 242(7): 549-60, 2004.
  • Tzekov, RT, .Locke, KG., Hood, DC., Birch, DG. Cone and rod ERG phototransduction parameters in retinitis pigmentosa. Investigative ophthalmology & visual science. 44(9): 3993-4000, 2003.
  • Marmor, MF.Serrato, A.Tzekov, R. Comparison of conventional ERG parameters and high-intensity A-wave analysis in a clinical setting. Documenta ophthalmologica. Advances in ophthalmology. 106(3): 281-7, 2003.
  • Penrose, PJ., Tzekov, RT., Sutter, EE.Fu, AD.Allen, AW.Fung, WE.Oxford, KW. Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine. Retina (Philadelphia, Pa.). 23(4): 503-12, 2003.
  • Serrato, A., Tzekov, R., Marmor, MF. The lens-coating agent and the electroretinogram. Documenta ophthalmologica. Advances in ophthalmology. 106(3): 225-30, 2003.
  • Birch, DG.Hood, DC.Locke, KG.Hoffman, DR.Tzekov, RT. Quantitative electroretinogram measures of phototransduction in cone and rod photoreceptors: normal aging, progression with disease, and test-retest variability. Archives of ophthalmology. 120(8): 1045-51, 2002.
  • Pham, RT., Tzekov, RT., Biesman, BS., Marmor, MF. Retinal evaluation after 810 nm Dioderm laser removal of eyelashes. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 28(9): 836-40, 2002.
  • Tzekov, RT., Liu, Y., Sohocki, MM., Zack, DJ., Daiger, SP., Heckenlively, JR., Birch, DG. Autosomal dominant retinal degeneration and bone loss in patients with a 12-bp deletion in the CRX gene. Investigative ophthalmology & visual science. 42(6): 1319-27, 2001.
  • Tzekov, RT.Sohocki, MM.Daiger, SP.Birch, DG. Visual phenotype in patients with Arg41Gln and ala196+1bp mutations in the CRX gene. Ophthalmic genetics. 21(2): 89-99, 2000.
  • Yankov, E.Nakova, A.Tzekov, R. Spectral sensitivity of the visual system as revealed by evoked potentials in normal and anomalous trichomats. Acta physiologica et pharmacologica Bulgarica. 24(4): 91-100, 1999.
  • Arden, G.Wolf, J.Berninger, T.Hogg, CR.Tzekov, R.Holder, GE. S-cone ERGs elicited by a simple technique in normals and in tritanopes. Vision research. 39(3): 641-50, 1999.
  • Weng, J.Mata, NL.Azarian, SM.Tzekov, RT.Birch, DG.Travis, GH. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell. 98(1): 13-23, 1999.
  • Tzekov, R.Arden, GB. The electroretinogram in diabetic retinopathy. Survey of ophthalmology. 44(1): 53-60, 1999.

  • Positions Held


    Memberships
  • American Association for the Advancement of Science (AAAS) (Member, 2001 - Present)
  • New York Academy of Sciences (NYAS) (Member, 2001 - Present)
  • International Society for Clinical Electrophysiology of Vision (ISCEV) (Member, 1998 - Present)
  • Association for Research in Vision and Ophthalmology (ARVO) (Member, 1997 - Present)


  • Profile last modified on 11/07/2013