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Jinyi Zhu, Ph.D.

Primary Department:

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Email: jzhu1@health.usf.edu
Office: MDC, 3023A
Mailing address 12901 Bruce B. Downs Blvd. MDC07
Tampa, FL 33612
  • Ph.D., Chemistry, University of Georgia, USA - 2008.
  • B.S., Chemistry, Nanjing University, Nanjing, People's Republic of China - 2002.
    Interdisciplinary & Emerging Signature Programs
    Research Summary

    The Core is focused on providing a cost-effective resource to the USF and neighborhood community for expression and purification of recombinant proteins, utilizing E. coli, yeast and insect cell expression systems. A matrix buffer screening system would be applied to select suitable buffer conditions for proteins which have limited solubility. Our services also include biophysical characterization of structural and functional properties of proteins.


    Selected Publications
  • Zhu JY, Yang Y, Han H, Betzi S, Olesen SH, Marsilio F, Schönbrunn E. Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). The Journal of biological chemistry. 287(16) : 12657-67, 2012.
  • Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. Journal of medicinal chemistry. 55(5) : 2474-8, 2012.
  • Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E. A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS chemical biology. 7(4) : 698-706, 2012.
  • Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of organic chemistry. 77(7) : 3082-98, 2012.
  • Lawrence H, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng J, Sebti SM, Schonbrunn E, Lawrence NJ. Development of ortho-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora A Inhibitors. Journal of medicinal chemistry. 55(17) : 7392-416, 2012.
  • Zhu JY, Fu ZQ, Chen L, Xu H, Chrzas J, Rose J, Wang BC. Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. Acta crystallographica. Section D, Biological crystallography. 68(Pt 9) : 1242-52, 2012.
  • Pireddu, R. Forinash, KD. Sun, N. Martin, MP. Sung, SS. Alexander, B. Zhu, JY. Guida, WC. Schönbrunn, E. Sebti, SM. Lawrence, NJ. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) MedChemComm. 3(6) : 699-709, 2012.
  • Martin MP, Alam R, Betzi S, Ingles DJ, Zhu JY, Schönbrunn E. A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem : a European journal of chemical biology. 13(14) : 2128-36, 2012.
  • Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Proteins. 71(4) : 2109-13, 2008.
  • Zhu, JY.Liu, L.Lu, CS.Meng, QJ. Inclusion compound of beta-cyclodextrin with p-azidobenzoic acid CHINESE JOURNAL OF ORGANIC CHEMISTRY. 23(11) : 1303-05, 2003.

  • Positions Held
  • Postdoctoral Fellow (Dept. of Drug Discovery, H. Lee Moffitt Cancer Center 2008 - 2012)

  • Awards/Honors
  • Travel Grant (American Crystallographic Association - 2008)
  • Young Scientist Travel Award (International Structural Genomics Organization / the NIH Protein Structure Initiative - 2006)

  • Profile last modified on 08/20/2012