Login here to update your profile  
My Profile

Stephen Liggett,  MD

Administrative Appointment: Assoc Vice President
Primary Department: USF HEALTH PERSONALIZED MEDICINE

Assoc VP, USF Health & Prof
USF HEALTH PERSONALIZED MEDICINE

Professor
COLLEGE OF MEDICINE INTERNAL MEDICINE

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

profile Image
Contacts
Email: sliggett@health.usf.edu
Phone: (813) 974-7715
Office: CMS, 3014
Mailing address 12901 Bruce B. Downs Blvd., MDC02
Tampa, FL 33612
View My C. V.
 
Education
  • MD, Medicine, Unviersity Of Miami School Of Medicine , Miami, United States - 1982.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease, Cardiovascular.
     
    Research Summary

    Dr. Stephen B. Liggett's laboratory has several major interrelated initiatives: The study of the molecular basis of G-protein coupled receptor structure and function Delineation and characterization of human genetic variants within this receptor signaling network Association studies of genetic variants with heart and lung disease and their response to treatment to develop a platform for genetically-based personalized medicine Creation of genetically modified mice to define the mechanisms of heart and lung disease and "humanized mice" to explore the effects of genetic variation of human genes Determination of the full genome sequences of human Rhinoviruses using high throughput next-generation sequencing technologies; analysis of the relationships between viral genomes and asthma phenotypes Genomic-based drug discovery, most recently identifying bitter taste receptors on airway smooth muscle and showing that they act to bronchodilate, thus being a potential new therapy for asthma and COPD

     
    Links

    Lab Link:  http://health.usf.edu/research/personalized_medicine/index.htm


    Selected Publications
  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2): , 2014.
  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus C isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2): , 2014.
  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus B isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2): , 2014.
  • Liggett, SB. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert opinion on therapeutic targets. 17(6): 721-31, 2013.
  • Duan, QL.Du, R.Lasky-Su, J.Klanderman, BJ.Partch, AB.Peters, SP.Irvin, CG.Hanrahan, JP.Lima, JJ.Blake, KV.Liggett, SB.Litonjua, AA.Tantisira, KG. A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. The pharmacogenomics journal. 13(2): 130-6, 2013.
  • Aleong, RG.Sauer, WH.Davis, G.Murphy, GA.Port, JD.Anand, IS.Fiuzat, M.O'Connor, CM.Abraham, WT.Liggett, SB.Bristow, MR. Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta1389 Arg/Gly Adrenergic Receptor Polymorphism. JACC. Heart failure. 1(4): 338-344, 2013.
  • Robinett, KS.Koziol-White, CJ.Akoluk, A.An, SS.Panettieri Jr, RA.Liggett, SB. Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells. American journal of respiratory cell and molecular biology. (): , 2013.
  • Aleong, RG.Sauer, WH.Robertson, AD.Liggett, SB.Bristow, MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circulation. Arrhythmia and electrophysiology. 6(1): 137-43, 2013.
  • Vandell, AG.Lobmeyer, MT.Gawronski, BE.Langaee, TY.Gong, Y.Gums, JG.Beitelshees, AL.Turner, ST.Chapman, AB.Cooper-DeHoff, RM.Bailey, KR.Boerwinkle, E.Pepine, CJ.Liggett, SB.Johnson, JA. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension. 60(4): 957-64, 2012.
  • An, SS.Wang, WC.Koziol-White, CJ.Ahn, K.Lee, DY.Kurten, RC.Panettieri, RA.Liggett, SB. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. American journal of physiology. Lung cellular and molecular physiology. 303(4): L304-11, 2012.
  • An, SS.Robinett, KS.Deshpande, DA.Wang, WC.Liggett, SB. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nature medicine. 18(5): 650-1, 2012.
  • Clark, AA.Liggett, SB.Munger, SD. Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(12): 4827-31, 2012.
  • O'Connor, CM.Fiuzat, M.Carson, PE.Anand, IS.Plehn, JF.Gottlieb, SS.Silver, MA.Lindenfeld, J.Miller, AB.White, M.Walsh, R.Nelson, P.Medway, A.Davis, G.Robertson, AD.Port, JD.Carr, J.Murphy, GA.Lazzeroni, LC.Abraham, WT.Liggett, SB.Bristow, MR. Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. PloS one. 7(10): e44324, 2012.
  • Duan, QL.Gaume, BR.Hawkins, GA.Himes, BE.Bleecker, ER.Klanderman, B.Irvin, CG.Peters, SP.Meyers, DA.Hanrahan, JP.Lima, JJ.Litonjua, AA.Tantisira, KG.Liggett, SB. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. American journal of respiratory and critical care medicine. 183(4): 449-54, 2011.
  • Johnson, JA.Liggett, SB. Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions. Clinical pharmacology and therapeutics. 89(3): 366-78, 2011.
  • Parsa, A.Chang, YP.Kelly, RJ.Corretti, MC.Ryan, KA.Robinson, SW.Gottlieb, SS.Kardia, SL.Shuldiner, AR.Liggett, SB. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clinical and translational science. 4(1): 17-23, 2011.
  • Wang, WC.Juan, AH.Panebra, A.Liggett, SB. MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108(15): 6246-51, 2011.
  • Bochkov, YA.Palmenberg, AC.Lee, WM.Rathe, JA.Amineva, SP.Sun, X.Pasic, TR.Jarjour, NN.Liggett, SB.Gern, JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature medicine. 17(5): 627-32, 2011.
  • Trian, T.Burgess, JK.Niimi, K.Moir, LM.Ge, Q.Berger, P.Liggett, SB.Black, JL.Oliver, BG. β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. PloS one. 6(5): e20000, 2011.
  • Robinett, KS.Deshpande, DA.Malone, MM.Liggett, SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. American journal of respiratory cell and molecular biology. 45(5): 1069-74, 2011.
  • Liggett, SB. Phosphorylation barcoding as a mechanism of directing GPCR signaling. Science signaling. 4(185): pe36, 2011.
  • Nagele, P.Liggett, SB. Genetic variation, β-blockers, and perioperative myocardial infarction. Anesthesiology. 115(6): 1316-27, 2011.
  • Dockstader, K.Nunley, K.Karimpour-Fard, A.Medway, A.Nelson, P.Port, JD.Liggett, SB.Bristow, MR.Sucharov, CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. Physiological genomics. 43(23): 1294-306, 2011.
  • Wang, WC.Schillinger, RM.Malone, MM.Liggett, SB. Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. American journal of physiology. Lung cellular and molecular physiology. 300(3): L472-8, 2011.
  • Deshpande, DA.Wang, WC.McIlmoyle, EL.Robinett, KS.Schillinger, RM.An, SS.Sham, JS.Liggett, SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature medicine. 16(11): 1299-304, 2010.
  • Rajan, S.Jagatheesan, G.Karam, CN.Alves, ML.Bodi, I.Schwartz, A.Bulcao, CF.D'Souza, KM.Akhter, SA.Boivin, GP.Dube, DK.Petrashevskaya, N.Herr, AB.Hullin, R.Liggett, SB.Wolska, BM.Solaro, RJ.Wieczorek, DF. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation. 121(3): 410-8, 2010.
  • Liggett, SB. Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. Heart failure clinics. 6(1): 27-33, 2010.
  • Rathe, JA.Liu, X.Tallon, LJ.Gern, JE.Liggett, SB. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. Archives of virology. 155(1): 83-7, 2010.
  • Bristow, MR.Murphy, GA.Krause-Steinrauf, H.Anderson, JL.Carlquist, JF.Thaneemit-Chen, S.Krishnan, V.Abraham, WT.Lowes, BD.Port, JD.Davis, GW.Lazzeroni, LC.Robertson, AD.Lavori, PW.Liggett, SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circulation. Heart failure. 3(1): 21-8, 2010.
  • Palmenberg, AC.Rathe, JA.Liggett, SB. Analysis of the complete genome sequences of human rhinovirus. The Journal of allergy and clinical immunology. 125(6): 1190-9; quiz 1200-1, 2010.
  • Panebra, A.Wang, WC.Malone, MM.Pitter, DR.Weiss, ST.Hawkins, GA.Liggett, SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. PloS one. 5(7): e11819, 2010.
  • Jagatheesan, G.Rajan, S.Ahmed, RP.Petrashevskaya, N.Boivin, G.Arteaga, GM.Tae, HJ.Liggett, SB.Solaro, RJ.Wieczorek, DF. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. Journal of muscle research and cell motility. 31(3): 227-39, 2010.
  • Palmenberg, AC.Spiro, D.Kuzmickas, R.Wang, S.Djikeng, A.Rathe, JA.Fraser-Liggett, CM.Liggett, SB. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science (New York, N.Y.). 324(5923): 55-9, 2009.
  • Jagatheesan, G.Rajan, S.Schulz, EM.Ahmed, RP.Petrashevskaya, N.Schwartz, A.Boivin, GP.Arteaga, GM.Wang, T.Wang, YG.Ashraf, M.Liggett, SB.Lorenz, J.Solaro, RJ.Wieczorek, DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. American journal of physiology. Heart and circulatory physiology. 297(1): H181-90, 2009.
  • Dorn, GW.Liggett, SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular pharmacology. 76(3): 466-80, 2009.
  • Wang, WC.Mihlbachler, KA.Brunnett, AC.Liggett, SB. Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling. Proceedings of the National Academy of Sciences of the United States of America. 106(35): 15007-12, 2009.
  • Liggett, SB. alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes. Science translational medicine. 1(12): 12ps15, 2009.
  • Dorn, GW.Liggett, SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clinical and translational science. 1(3): 255-62, 2008.
  • Petrashevskaya, N.Gaume, BR.Mihlbachler, KA.Dorn, GW.Liggett, SB. Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy. Clinical and translational science. 1(3): 221-7, 2008.
  • Wang, WC.Mihlbachler, KA.Bleecker, ER.Weiss, ST.Liggett, SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and genomics. 18(8): 729-32, 2008.
  • Swift, SM.Gaume, BR.Small, KM.Aronow, BJ.Liggett, SB. Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiological genomics. 35(1): 123-31, 2008.
  • Litonjua, AA.Lasky-Su, J.Schneiter, K.Tantisira, KG.Lazarus, R.Klanderman, B.Lima, JJ.Irvin, CG.Peters, SP.Hanrahan, JP.Liggett, SB.Hawkins, GA.Meyers, DA.Bleecker, ER.Lange, C.Weiss, ST. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. American journal of respiratory and critical care medicine. 178(7): 688-94, 2008.
  • Liggett, SB.Cresci, S.Kelly, RJ.Syed, FM.Matkovich, SJ.Hahn, HS.Diwan, A.Martini, JS.Sparks, L.Parekh, RR.Spertus, JA.Koch, WJ.Kardia, SL.Dorn, GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature medicine. 14(5): 510-7, 2008.
  • Einstein, R.Jordan, H.Zhou, W.Brenner, M.Moses, EG.Liggett, SB. Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proceedings of the National Academy of Sciences of the United States of America. 105(13): 5230-5, 2008.
  • Small, KM.Mialet-Perez, J.Liggett, SB. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. Journal of cardiovascular pharmacology. 51(1): 106-10, 2008.
  • Panebra, A.Schwarb, MR.Swift, SM.Weiss, ST.Bleecker, ER.Hawkins, GA.Liggett, SB. Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. American journal of physiology. Lung cellular and molecular physiology. 294(2): L190-5, 2008.
  • Sehnert, AJ.Daniels, SE.Elashoff, M.Wingrove, JA.Burrow, CR.Horne, B.Muhlestein, JB.Donahue, M.Liggett, SB.Anderson, JL.Kraus, WE. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology. 52(8): 644-51, 2008.
  • Kardia, SL.Kelly, RJ.Keddache, MA.Aronow, BJ.Grabowski, GA.Hahn, HS.Case, KL.Wagoner, LE.Dorn, GW.Liggett, SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. BMC medical genetics. 9(): 93, 2008.
  • Liggett, SB. Long-distance affair with adrenal GRK2 hangs up heart failure. Nature medicine. 13(3): 246-8, 2007.
  • Swift, SM.Schwarb, MR.Mihlbachler, KA.Liggett, SB. Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. American journal of respiratory cell and molecular biology. 36(2): 236-43, 2007.
  • Panebra, A.Schwarb, MR.Glinka, CB.Liggett, SB. Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. American journal of respiratory cell and molecular biology. 36(6): 654-60, 2007.
  • Rajan, S.Ahmed, RP.Jagatheesan, G.Petrashevskaya, N.Boivin, GP.Urboniene, D.Arteaga, GM.Wolska, BM.Solaro, RJ.Liggett, SB.Wieczorek, DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circulation research. 101(2): 205-14, 2007.
  • Panebra, A.Schwarb, MR.Glinka, CB.Liggett, SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 293(2): L453-62, 2007.
  • Petrashevskaya, N.Liggett, SB. Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. Cardiovascular research. 75(4): 631-3, 2007.
  • Jagatheesan, G.Rajan, S.Petrashevskaya, N.Schwartz, A.Boivin, G.Arteaga, GM.Solaro, RJ.Liggett, SB.Wieczorek, DF. Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. American journal of physiology. Heart and circulatory physiology. 293(2): H949-58, 2007.
  • McGraw, DW.Elwing, JM.Fogel, KM.Wang, WC.Glinka, CB.Mihlbachler, KA.Rothenberg, ME.Liggett, SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of clinical investigation. 117(5): 1391-8, 2007.
  • Liggett, SB.Kelly, RJ.Parekh, RR.Matkovich, SJ.Benner, BJ.Hahn, HS.Syed, FM.Galvez, AS.Case, KL.McGuire, N.Odley, AM.Sparks, L.Kardia, SL.Dorn, GW. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Human molecular genetics. 16(22): 2740-50, 2007.
  • Liggett, SB. Genetic variability of the beta2 adrenergic receptor and asthma exacerbations. Thorax. 61(11): 925-7, 2006.
  • Hawkins, GA.Tantisira, K.Meyers, DA.Ampleford, EJ.Moore, WC.Klanderman, B.Liggett, SB.Peters, SP.Weiss, ST.Bleecker, ER. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. American journal of respiratory and critical care medicine. 174(10): 1101-9, 2006.
  • Mialet-Perez, J.Liggett, SB. Pharmacogenetics of beta1-adrenergic receptors in heart failure and hypertension. Archives des maladies du coeur et des vaisseaux. 99(6): 616-20, 2006.
  • McGraw, DW.Fogel, KM.Kong, S.Litonjua, AA.Kranias, EG.Aronow, BJ.Liggett, SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological genomics. 27(2): 171-7, 2006.
  • Liggett, SB.Mialet-Perez, J.Thaneemit-Chen, S.Weber, SA.Greene, SM.Hodne, D.Nelson, B.Morrison, J.Domanski, MJ.Wagoner, LE.Abraham, WT.Anderson, JL.Carlquist, JF.Krause-Steinrauf, HJ.Lazzeroni, LC.Port, JD.Lavori, PW.Bristow, MR. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proceedings of the National Academy of Sciences of the United States of America. 103(30): 11288-93, 2006.
  • Small, KM.Schwarb, MR.Glinka, C.Theiss, CT.Brown, KM.Seman, CA.Liggett, SB. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. 45(15): 4760-7, 2006.
  • Liggett, SB. Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. The Journal of clinical investigation. 116(4): 875-7, 2006.
  • Small, KM.Brown, KM.Seman, CA.Theiss, CT.Liggett, SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 103(14): 5472-7, 2006.
  • Akhter, SA.D'Souza, KM.Petrashevskaya, NN.Mialet-Perez, J.Liggett, SB. Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. American journal of physiology. Heart and circulatory physiology. 290(4): H1427-32, 2006.
  • Zhao, W.Yuan, Q.Qian, J.Waggoner, JR.Pathak, A.Chu, G.Mitton, B.Sun, X.Jin, J.Braz, JC.Hahn, HS.Marreez, Y.Syed, F.Pollesello, P.Annila, A.Wang, HS.Schultz, Jel J.Molkentin, JD.Liggett, SB.Dorn, GW.Kranias, EG. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113(7): 995-1004, 2006.
  • McGraw, DW.Mihlbachler, KA.Schwarb, MR.Rahman, FF.Small, KM.Almoosa, KF.Liggett, SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of clinical investigation. 116(5): 1400-9, 2006.
  • Liggett, SB. Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. Circulation. 113(15): 1818-20, 2006.
  • McGraw, DW.Liggett, SB. Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society. 2(4): 292-6; discussion 311-2, 2005.
  • Liggett, SB. Lymphocyte GRK levels as biomarkers in heart failure. European heart journal. 26(17): 1695-6, 2005.
  • Tantisira, KG.Small, KM.Litonjua, AA.Weiss, ST.Liggett, SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. Human molecular genetics. 14(12): 1671-7, 2005.
  • Liggett, SB. Polymorphisms of beta-adrenergic receptors in heart failure. The American journal of medicine. 117(7): 525-7, 2004.
  • Liggett, SB. Genetically modified mouse models for pharmacogenomic research. Nature reviews. Genetics. 5(9): 657-63, 2004.
  • Liggett, SB. The two-timing thyroid. Nature medicine. 10(6): 582-3, 2004.
  • Mialet-Perez, J.Green, SA.Miller, WE.Liggett, SB. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of biological chemistry. 279(37): 38603-7, 2004.
  • Israel, E.Chinchilli, VM.Ford, JG.Boushey, HA.Cherniack, R.Craig, TJ.Deykin, A.Fagan, JK.Fahy, JV.Fish, J.Kraft, M.Kunselman, SJ.Lazarus, SC.Lemanske, RF.Liggett, SB.Martin, RJ.Mitra, N.Peters, SP.Silverman, E.Sorkness, CA.Szefler, SJ.Wechsler, ME.Weiss, ST.Drazen, JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 364(9444): 1505-12, 2004.
  • Braz, JC.Gregory, K.Pathak, A.Zhao, W.Sahin, B.Klevitsky, R.Kimball, TF.Lorenz, JN.Nairn, AC.Liggett, SB.Bodi, I.Wang, S.Schwartz, A.Lakatta, EG.DePaoli-Roach, AA.Robbins, J.Hewett, TE.Bibb, JA.Westfall, MV.Kranias, EG.Molkentin, JD. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature medicine. 10(3): 248-54, 2004.
  • Small, KM.Mialet-Perez, J.Seman, CA.Theiss, CT.Brown, KM.Liggett, SB. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proceedings of the National Academy of Sciences of the United States of America. 101(35): 13020-5, 2004.
  • Tantisira, KG.Lake, S.Silverman, ES.Palmer, LJ.Lazarus, R.Silverman, EK.Liggett, SB.Gelfand, EW.Rosenwasser, LJ.Richter, B.Israel, E.Wechsler, M.Gabriel, S.Altshuler, D.Lander, E.Drazen, J.Weiss, ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human molecular genetics. 13(13): 1353-9, 2004.
  • Lalchandani, SG.Zhang, X.Hong, SS.Liggett, SB.Li, W.Moore, BM.Miller, DD.Feller, DR. Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical pharmacology. 67(1): 87-96, 2004.
  • Small, KM.McGraw, DW.Liggett, SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual review of pharmacology and toxicology. 43(): 381-411, 2003.
  • Rathz, DA.Gregory, KN.Fang, Y.Brown, KM.Liggett, SB. Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. The Journal of biological chemistry. 278(12): 10784-9, 2003.
  • Liggett, SB. Polymorphisms of adrenergic receptors: variations on a theme. Assay and drug development technologies. 1(2): 317-26, 2003.
  • Gaussin, V.Tomlinson, JE.Depre, C.Engelhardt, S.Antos, CL.Takagi, G.Hein, L.Topper, JN.Liggett, SB.Olson, EN.Lohse, MJ.Vatner, SF.Vatner, DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108(23): 2926-33, 2003.
  • Hahn, HS.Marreez, Y.Odley, A.Sterbling, A.Yussman, MG.Hilty, KC.Bodi, I.Liggett, SB.Schwartz, A.Dorn, GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation research. 93(11): 1111-9, 2003.
  • McGraw, DW.Almoosa, KF.Paul, RJ.Kobilka, BK.Liggett, SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of clinical investigation. 112(4): 619-26, 2003.
  • Haghighi, K.Kolokathis, F.Pater, L.Lynch, RA.Asahi, M.Gramolini, AO.Fan, GC.Tsiapras, D.Hahn, HS.Adamopoulos, S.Liggett, SB.Dorn, GW.MacLennan, DH.Kremastinos, DT.Kranias, EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of clinical investigation. 111(6): 869-76, 2003.
  • Cuajungco, MP.Ando, Y.Axelrod, FB.Biaggioni, I.Goldstein, DS.Guttmacher, AE.Gwinn-Hardy, K.Hahn, MK.Hilz, MJ.Jacob, G.Jens, J.Kennedy, WR.Liggett, SB.O'Connor, DT.Peltzer, SR.Robertson, D.Rubin, BY.Scudder, Q.Smith, LJ.Sonenshein, GE.Svejstrup, JQ.Xu, Y.Slaugenhaupt, SA. Hereditary dysautonomias: current knowledge and collaborations for the future. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 13(3): 180-95, 2003.
  • Gerson, MC.Wagoner, LE.McGuire, N.Liggett, SB. Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 10(6): 583-9, 2003.
  • Mialet Perez, J.Rathz, DA.Petrashevskaya, NN.Hahn, HS.Wagoner, LE.Schwartz, A.Dorn, GW.Liggett, SB. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature medicine. 9(10): 1300-5, 2003.
  • Small, KM.Brown, KM.Theiss, CT.Seman, CA.Weiss, ST.Liggett, SB. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 13(9): 535-41, 2003.
  • Small, KM.Tanguay, DA.Nandabalan, K.Zhan, P.Stephens, JC.Liggett, SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. 3(1): 65-71, 2003.
  • Liggett, SB. Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. The Journal of allergy and clinical immunology. 110(6 Suppl): S223-7, 2002.
  • Small, KM.Rathz, DA.Liggett, SB. Identification of adrenergic receptor polymorphisms. Methods in enzymology. 343(): 459-75, 2002.
  • Small, KM.Wagoner, LE.Levin, AM.Kardia, SL.Liggett, SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. The New England journal of medicine. 347(15): 1135-42, 2002.
  • Rathz, DA.Brown, KM.Kramer, LA.Liggett, SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. Journal of cardiovascular pharmacology. 39(2): 155-60, 2002.
  • Liggett, SB. Polymorphisms of the beta2-adrenergic receptor. The New England journal of medicine. 346(7): 536-8, 2002.
  • Lalchandani, SG.Lei, L.Zheng, W.Suni, MM.Moore, BM.Liggett, SB.Miller, DD.Feller, DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of pharmacology and experimental therapeutics. 303(3): 979-84, 2002.
  • Wagoner, LE.Craft, LL.Zengel, P.McGuire, N.Rathz, DA.Dorn, GW.Liggett, SB. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. American heart journal. 144(5): 840-6, 2002.
  • Small, KM.Seman, CA.Castator, A.Brown, KM.Liggett, SB. False positive non-synonymous polymorphisms of G-protein coupled receptor genes. FEBS letters. 516(1-3): 253-6, 2002.
  • Liang, M.Eason, MG.Theiss, CT.Liggett, SB. Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. European journal of pharmacology. 437(1-2): 41-6, 2002.
  • Small, KM.Brown, KM.Forbes, SL.Liggett, SB. Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. The Journal of biological chemistry. 276(34): 31596-601, 2001.
  • Green, SA.Rathz, DA.Schuster, AJ.Liggett, SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). European journal of pharmacology. 421(3): 141-7, 2001.
  • Small, KM.Liggett, SB. Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms. Trends in pharmacological sciences. 22(9): 471-7, 2001.
  • McGraw, DW.Fukuda, N.James, PF.Forbes, SL.Woo, AL.Lingrel, JB.Witte, DP.Matthay, MA.Liggett, SB. Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology. 281(4): L895-903, 2001.
  • Small, KM.Brown, KM.Forbes, SL.Liggett, SB. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. The Journal of biological chemistry. 276(7): 4917-22, 2001.
  • Dash, R.Kadambi, V.Schmidt, AG.Tepe, NM.Biniakiewicz, D.Gerst, MJ.Canning, AM.Abraham, WT.Hoit, BD.Liggett, SB.Lorenz, JN.Dorn, GW.Kranias, EG. Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation. 103(6): 889-96, 2001.
  • Liggett, SB. Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown. The Journal of clinical investigation. 107(8): 947-8, 2001.
  • Israel, E.Drazen, JM.Liggett, SB.Boushey, HA.Cherniack, RM.Chinchilli, VM.Cooper, DM.Fahy, JV.Fish, JE.Ford, JG.Kraft, M.Kunselman, S.Lazarus, SC.Lemanske, RF.Martin, RJ.McLean, DE.Peters, SP.Silverman, EK.Sorkness, CA.Szefler, SJ.Weiss, ST.Yandava, CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. International archives of allergy and immunology. 124(1-3): 183-6, 2001.
  • Liang, M.Freedman, NJ.Theiss, CT.Liggett, SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40(49): 15031-7, 2001.
  • Silverman, ES.Liggett, SB.Gelfand, EW.Rosenwasser, LJ.Baron, RM.Bolk, S.Weiss, ST.Drazen, JM. The pharmacogenetics of asthma: a candidate gene approach. The pharmacogenomics journal. 1(1): 27-37, 2001.
  • Liggett, SB. Pharmacogenetic applications of the Human Genome project. Nature medicine. 7(3): 281-3, 2001.
  • Liggett, SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology. 61(3): 167-73, 2000.
  • Small, KM.Forbes, SL.Brown, KM.Liggett, SB. An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. The Journal of biological chemistry. 275(49): 38518-23, 2000.
  • Tepe, NM.Liggett, SB. Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. Journal of receptor and signal transduction research. 20(1): 75-85, 2000.
  • McGraw, DW.Forbes, SL.Mak, JC.Witte, DP.Carrigan, PE.Leikauf, GD.Liggett, SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American journal of physiology. Lung cellular and molecular physiology. 279(2): L379-89, 2000.
  • Israel, E.Drazen, JM.Liggett, SB.Boushey, HA.Cherniack, RM.Chinchilli, VM.Cooper, DM.Fahy, JV.Fish, JE.Ford, JG.Kraft, M.Kunselman, S.Lazarus, SC.Lemanske, RF.Martin, RJ.McLean, DE.Peters, SP.Silverman, EK.Sorkness, CA.Szefler, SJ.Weiss, ST.Yandava, CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. American journal of respiratory and critical care medicine. 162(1): 75-80, 2000.
  • Jewell-Motz, EA.Small, KM.Theiss, CT.Liggett, SB. alpha 2A/alpha 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation. The Journal of biological chemistry. 275(37): 28989-93, 2000.
  • Wagoner, LE.Craft, LL.Singh, B.Suresh, DP.Zengel, PW.McGuire, N.Abraham, WT.Chenier, TC.Dorn, GW.Liggett, SB. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. Circulation research. 86(8): 834-40, 2000.
  • Liggett, SB.Tepe, NM.Lorenz, JN.Canning, AM.Jantz, TD.Mitarai, S.Yatani, A.Dorn, GW. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 101(14): 1707-14, 2000.
  • Liggett, SB. beta(2)-adrenergic receptor pharmacogenetics. American journal of respiratory and critical care medicine. 161(3 Pt 2): S197-201, 2000.
  • Small, KM.Forbes, SL.Rahman, FF.Bridges, KM.Liggett, SB. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. The Journal of biological chemistry. 275(30): 23059-64, 2000.
  • Yan, L.Galinsky, RE.Bernstein, JA.Liggett, SB.Weinshilboum, RM. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics. 10(3): 261-6, 2000.
  • Small, KM.Forbes, SL.Rahman, FF.Liggett, SB. Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. Biochemistry. 39(10): 2815-21, 2000.
  • Hoit, BD.Suresh, DP.Craft, L.Walsh, RA.Liggett, SB. beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. American heart journal. 139(3): 537-42, 2000.
  • Liggett, SB. The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma. The Journal of allergy and clinical immunology. 105(2 Pt 2): S487-92, 2000.
  • Dorn, GW.Tepe, NM.Wu, G.Yatani, A.Liggett, SB. Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. Molecular pharmacology. 57(2): 278-87, 2000.
  • Drysdale, CM.McGraw, DW.Stack, CB.Stephens, JC.Judson, RS.Nandabalan, K.Arnold, K.Ruano, G.Liggett, SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America. 97(19): 10483-8, 2000.
  • Liggett, SB. Plastic adenylyl cyclase. American journal of respiratory cell and molecular biology. 21(5): 564-6, 1999.
  • Tepe, NM.Liggett, SB. Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. FEBS letters. 458(2): 236-40, 1999.
  • Mason, DA.Moore, JD.Green, SA.Liggett, SB. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. The Journal of biological chemistry. 274(18): 12670-4, 1999.
  • Dorn, GW.Tepe, NM.Lorenz, JN.Koch, WJ.Liggett, SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96(11): 6400-5, 1999.
  • Tepe, NM.Lorenz, JN.Yatani, A.Dash, R.Kranias, EG.Dorn, GW.Liggett, SB. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry. 38(50): 16706-13, 1999.
  • McGraw, DW.Liggett, SB. Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 29 Suppl 4(): 43-5, 1999.
  • Small, K.Feng, JF.Lorenz, J.Donnelly, ET.Yu, A.Im, MJ.Dorn, GW.Liggett, SB. Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation. The Journal of biological chemistry. 274(30): 21291-6, 1999.
  • McGraw, DW.Forbes, SL.Kramer, LA.Witte, DP.Fortner, CN.Paul, RJ.Liggett, SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry. 274(45): 32241-7, 1999.
  • Liggett, SB. Molecular and genetic basis of beta2-adrenergic receptor function. The Journal of allergy and clinical immunology. 104(2 Pt 2): S42-6, 1999.
  • Moore, JD.Mason, DA.Green, SA.Hsu, J.Liggett, SB. Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C. Human mutation. 14(3): 271, 1999.
  • McGraw, DW.Donnelly, ET.Eason, MG.Green, SA.Liggett, SB. Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular signalling. 10(3): 197-204, 1998.
  • Liang, M.Eason, MG.Jewell-Motz, EA.Williams, MA.Theiss, CT.Dorn, GW.Liggett, SB. Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. Molecular pharmacology. 54(1): 44-9, 1998.
  • Liggett, SB.Wagoner, LE.Craft, LL.Hornung, RW.Hoit, BD.McIntosh, TC.Walsh, RA. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. The Journal of clinical investigation. 102(8): 1534-9, 1998.
  • Liggett, SB. Pharmacogenetics of relevant targets in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 28 Suppl 1(): 77-9; discussion 80-1, 1998.
  • Adams, JW.Sakata, Y.Davis, MG.Sah, VP.Wang, Y.Liggett, SB.Chien, KR.Brown, JH.Dorn, GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95(17): 10140-5, 1998.
  • Weir, TD.Mallek, N.Sandford, AJ.Bai, TR.Awadh, N.Fitzgerald, JM.Cockcroft, D.James, A.Liggett, SB.Paré, PD. beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. American journal of respiratory and critical care medicine. 158(3): 787-91, 1998.
  • Jewell-Motz, EA.Donnelly, ET.Eason, MG.Liggett, SB. Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. Biochemistry. 37(45): 15720-5, 1998.
  • Liggett, SB. Structural determinants of alpha 2-adrenergic receptor regulation. Advances in pharmacology (San Diego, Calif.). 42(): 438-42, 1998.
  • Sakata, Y.Hoit, BD.Liggett, SB.Walsh, RA.Dorn, GW. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation. 97(15): 1488-95, 1998.
  • McGraw, DW.Forbes, SL.Kramer, LA.Liggett, SB. Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. The Journal of clinical investigation. 102(11): 1927-32, 1998.
  • Jewell-Motz, EA.Donnelly, ET.Eason, MG.Liggett, SB. Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor. Biochemistry. 36(29): 8858-63, 1997.
  • D'Angelo, DD.Sakata, Y.Lorenz, JN.Boivin, GP.Walsh, RA.Liggett, SB.Dorn, GW. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proceedings of the National Academy of Sciences of the United States of America. 94(15): 8121-6, 1997.
  • McGraw, DW.Liggett, SB. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of biological chemistry. 272(11): 7338-44, 1997.
  • Dewar, JC.Wilkinson, J.Wheatley, A.Thomas, NS.Doull, I.Morton, N.Lio, P.Harvey, JF.Liggett, SB.Holgate, ST.Hall, IP. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. The Journal of allergy and clinical immunology. 100(2): 261-5, 1997.
  • Hoit, BD.Khoury, SF.Shao, Y.Gabel, M.Liggett, SB.Walsh, RA. Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. Circulation. 96(2): 592-8, 1997.
  • Liggett, SB. Polymorphisms of the beta2-adrenergic receptor and asthma. American journal of respiratory and critical care medicine. 156(4 Pt 2): S156-62, 1997.
  • Kiss, E.Edes, I.Sato, Y.Luo, W.Liggett, SB.Kranias, EG. beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. The American journal of physiology. 272(2 Pt 2): H785-90, 1997.
  • Dorn, GW.Oswald, KJ.McCluskey, TS.Kuhel, DG.Liggett, SB. Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. Biochemistry. 36(21): 6415-23, 1997.
  • Turki, J.Lorenz, JN.Green, SA.Donnelly, ET.Jacinto, M.Liggett, SB. Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 93(19): 10483-8, 1996.
  • Eason, MG.Liggett, SB. Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains. The Journal of biological chemistry. 271(22): 12826-32, 1996.
  • Jewell-Motz, EA.Liggett, SB. G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes. The Journal of biological chemistry. 271(30): 18082-7, 1996.
  • Green, SA.Spasoff, AP.Coleman, RA.Johnson, M.Liggett, SB. Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor. The Journal of biological chemistry. 271(39): 24029-35, 1996.
  • Green, SA.Turki, J.Hall, IP.Liggett, SB. Implications of genetic variability of human beta 2-adrenergic receptor structure. Pulmonary pharmacology. 8(1): 1-10, 1995.
  • Eason, MG.Moreira, SP.Liggett, SB. Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. The Journal of biological chemistry. 270(9): 4681-8, 1995.
  • Turki, J.Pak, J.Green, SA.Martin, RJ.Liggett, SB. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. The Journal of clinical investigation. 95(4): 1635-41, 1995.
  • Turki, J.Liggett, SB. Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma. American journal of respiratory cell and molecular biology. 12(5): 531-9, 1995.
  • Hall, IP.Wheatley, A.Wilding, P.Liggett, SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet. 345(8959): 1213-4, 1995.
  • Green, SA.Turki, J.Bejarano, P.Hall, IP.Liggett, SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. American journal of respiratory cell and molecular biology. 13(1): 25-33, 1995.
  • Liggett, SB.Levi, R.Metzger, H. G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. American journal of respiratory and critical care medicine. 152(1): 394-402, 1995.
  • Freedman, NJ.Liggett, SB.Drachman, DE.Pei, G.Caron, MG.Lefkowitz, RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. The Journal of biological chemistry. 270(30): 17953-61, 1995.
  • Eason, MG.Liggett, SB. Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. The Journal of biological chemistry. 270(42): 24753-60, 1995.
  • Jewell-Motz, EA.Liggett, SB. An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization. Biochemistry. 34(37): 11946-53, 1995.
  • Turki, J.Green, SA.Newman, KB.Meyers, MA.Liggett, SB. Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist. The American journal of physiology. 269(5 Pt 1): L709-14, 1995.
  • Liggett, SB. Genetics of beta 2-adrenergic receptor variants in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 25 Suppl 2(): 89-94; discussion 95-6, 1995.
  • Green, SA.Liggett, SB. A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration. The Journal of biological chemistry. 269(42): 26215-9, 1994.
  • Eason, MG.Jacinto, MT.Theiss, CT.Liggett, SB. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Proceedings of the National Academy of Sciences of the United States of America. 91(23): 11178-82, 1994.
  • Eason, MG.Jacinto, MT.Liggett, SB. Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. Molecular pharmacology. 45(4): 696-702, 1994.
  • Green, SA.Turki, J.Innis, M.Liggett, SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 33(32): 9414-9, 1994.
  • Thomas, RF.Liggett, SB. Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Molecular pharmacology. 43(3): 343-8, 1993.
  • Reihsaus, E.Innis, M.MacIntyre, N.Liggett, SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. American journal of respiratory cell and molecular biology. 8(3): 334-9, 1993.
  • Green, SA.Cole, G.Jacinto, M.Innis, M.Liggett, SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. The Journal of biological chemistry. 268(31): 23116-21, 1993.
  • Eason, MG.Liggett, SB. Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. Molecular pharmacology. 44(1): 70-5, 1993.
  • Eason, MG.Liggett, SB. Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. Biochemical and biophysical research communications. 193(1): 318-23, 1993.
  • Liggett, SB.Freedman, NJ.Schwinn, DA.Lefkowitz, RJ. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 90(8): 3665-9, 1993.
  • Liggett, SB.Raymond, JR. Pharmacology and molecular biology of adrenergic receptors. Baillière's clinical endocrinology and metabolism. 7(2): 279-306, 1993.
  • Thomas, RF.Holt, BD.Schwinn, DA.Liggett, SB. Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. Proceedings of the National Academy of Sciences of the United States of America. 89(10): 4490-4, 1992.
  • Liggett, SB.Ostrowski, J.Chesnut, LC.Kurose, H.Raymond, JR.Caron, MG.Lefkowitz, RJ. Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. The Journal of biological chemistry. 267(7): 4740-6, 1992.
  • Eason, MG.Liggett, SB. Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2. The Journal of biological chemistry. 267(35): 25473-9, 1992.
  • Liggett, SB. Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. Molecular pharmacology. 42(4): 634-7, 1992.
  • Eason, MG.Kurose, H.Holt, BD.Raymond, JR.Liggett, SB. Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. The Journal of biological chemistry. 267(22): 15795-801, 1992.
  • Green, SA.Holt, BD.Liggett, SB. Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. Molecular pharmacology. 41(5): 889-93, 1992.
  • Saffitz, JE.Liggett, SB. Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circulation research. 70(6): 1320-5, 1992.
  • Kraus, WE.Longabaugh, JP.Liggett, SB. Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. The American journal of physiology. 263(2 Pt 1): E226-30, 1992.
  • Schwinn, DA.Leone, BJ.Spahn, DR.Chesnut, LC.Page, SO.McRae, RL.Liggett, SB. Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation. Circulation. 84(6): 2559-67, 1991.
  • Schwinn, DA.Page, SO.Middleton, JP.Lorenz, W.Liggett, SB.Yamamoto, K.Lapetina, EG.Caron, MG.Lefkowitz, RJ.Cotecchia, S. The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. Molecular pharmacology. 40(5): 619-26, 1991.
  • Liggett, SB. Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases. Pharmacological research : the official journal of the Italian Pharmacological Society. 24 Suppl 1(): 29-41, 1991.
  • Liggett, SB.Caron, MG.Lefkowitz, RJ.Hnatowich, M. Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. The Journal of biological chemistry. 266(8): 4816-21, 1991.
  • Bates, MD.Senogles, SE.Bunzow, JR.Liggett, SB.Civelli, O.Caron, MG. Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. Molecular pharmacology. 39(1): 55-63, 1991.
  • Liggett, SB.Ostrowski, J.Chesnut, LC.Caron, MG.Lefkowitz, RJ. Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. Transactions of the Association of American Physicians. 104(): 40-7, 1991.
  • Liggett, SB.Schwinn, DA. Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor. DNA sequence : the journal of DNA sequencing and mapping. 2(1): 61-3, 1991.
  • Dejgaard, A.Liggett, SB.Christensen, NJ.Cryer, PE.Hilsted, J. Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity. Scandinavian journal of clinical and laboratory investigation. 51(8): 659-66, 1991.
  • Hausdorff, WP.Lohse, MJ.Bouvier, M.Liggett, SB.Caron, MG.Lefkowitz, RJ. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symposia of the Society for Experimental Biology. 44(): 225-40, 1990.
  • Liggett, SB.Renfro, AD. Energy expenditures of mechanically ventilated nonsurgical patients. Chest. 98(3): 682-6, 1990.
  • Liggett, SB.Bouvier, M.O'Dowd, BF.Caron, MG.Lefkowitz, RJ.DeBlasi, A. Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochemical and biophysical research communications. 165(1): 257-63, 1989.
  • Liggett, SB.Bouvier, M.Hausdorff, WP.O'Dowd, B.Caron, MG.Lefkowitz, RJ. Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. Molecular pharmacology. 36(4): 641-6, 1989.
  • Liggett, SB. Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages. The American review of respiratory disease. 139(2): 552-5, 1989.
  • Liggett, SB. Beta-adrenoceptor-effector system of the human macrophage U937 cell line. European journal of pharmacology. 163(1): 171-4, 1989.
  • Liggett, SB.Shah, SD.Cryer, PE. Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. The Journal of clinical investigation. 83(3): 803-9, 1989.
  • Liggett, SB.Shah, SD.Cryer, PE. Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo. The American journal of physiology. 256(5 Pt 1): E600-9, 1989.
  • Liggett, SB.Daughaday, CC.Senior, RM. Ipratropium in patients with COPD receiving cholinesterase inhibitors. Chest. 94(1): 210-2, 1988.
  • Liggett, SB.Marker, JC.Shah, SD.Roper, CL.Cryer, PE. Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. The Journal of clinical investigation. 82(1): 48-56, 1988.
  • Liggett, SB.Shah, SD.Cryer, PE. Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy. The American journal of physiology. 254(6 Pt 1): E795-8, 1988.
  • Boyle, PJ.Liggett, SB.Shah, SD.Cryer, PE. Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. The Journal of clinical investigation. 82(2): 445-9, 1988.

  • Profile last modified on 04/02/2014