University of South Florida

University of South Florida


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David E. Kang, PhD

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Fleming Endowed Chair in Alzheimer's Disease, Morsani College of Medicine

Director, Byrd Alzheimer's Center, Division of Basic Research

Professor, Morsani College of Medicine, Molecular Medicine

Academic Email : dkang@usf.edu

Office : ALZ, 304

Mailing address : 4001 E. Fletcher Ave - MDC36
Tampa, FL 33613

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Education

  • PhD, Neurosciences, University Of California, San Diego, San Diego, United States - 1999.
  • BA, Natural Science / Psychology, Illinois Wesleyan University, USA - 1993.

Research summary

  • Research in the Kang lab (http://www.kang-lab.com/) focuses on the mechanisms of neurodegeneration in Alzheimer’s disease (AD) and related neurological disorders such as FTD, ALS, and PD. Specifically, we are interested in 1) mechanisms of Abeta production and neurotoxicity in AD; 2) signal transduction mechanisms between Abeta and tau in AD; 3) interplay between pathogenic proteins such as tau and the UPR activation in neurodegenerative processes; 4) tau triaging and aggregation mechanisms via scaffolding proteins, RanBP9, ubiquitin specific proteases, and beta-arrestins, as well as their interplay with the Hsp90/Hsc70 chaperone system in proteinopathies; 5) mechanisms underlying mitochondrial dysfunction in AD, FTD/ALS, and PD; 6) role of selective autophagy and mitophagy in the accumulation of toxic components in neurodegenerative processes; and 7) the study of extracellular vesicles (i.e. exosomes) as neurodegenerative disease biomarkers and agents of neurodegeneration.

Selected Publications

Positions Held

  • Associate Professor (Dept. of Neurosciences, University of California, San Diego 2010 - 2012)
  • Assistant Professor (Dept. of Neurosciences, University of California, San Diego 2004 - 2010)

Interdisciplinary and Emerging Signature Programs

  • Cellular and Molecular Biology, Metabolic Regulation and Disorders, Neurodegenerative Disease, Neuroscience, Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine.

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Profile last modified on 03/03/2020