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Vladimir Uversky,  PhD, DSc


Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Associate Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: vuversky@health.usf.edu
Phone: (813) 974-5816
Office: MDC, 3540
Mailing address 12901 Bruce B. Downs Blvd. MDC07
Tampa, FL 33647
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Education
  • DSc, Biophysics, Russian Academy Of Sciences , Russia - 1998.
  • PhD, Biophysics, Moscow Institute Of Technical Physics , Russia - 1991.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cardiovascular Sciences, Cancer Biology, Cellular and Molecular Biology, Metabolic Regulation and Disorders, Neurodegenerative Disease, Other.
     
    Academic Philosophy

    Progress of modern science is defined by the collaboration and team-based research. Students should be prepared for the reality of team science. This goes in parallel with creativity, critical and integrative thinking, and interdisciplinarity.

     
    Research Summary

    Our scientific interests are broadly defined as everything related to protein folding, misfolding and non-folding. However, the passion is definitely the field of protein non-folding , which is related to the discovery of intrinsically disordered proteins (IDPs), analysis of their abundance in nature, characterization of their exceptional structural and functional plasticity, understanding of their vital roles in various biological processes, and establishing their involvement in the pathogenesis of multiple human diseases. These and related aspects of IDPs are analyzed by a combination of a wide spectrum of computational, bioinformatics, and experimental approaches of modern protein biophysics. Due to the high abundance of IDPs in various proteomes, the exceptional structural and functional plasticity of these proteins, and their intimate relations to the maladies' pathogenesis, it is almost impossible to find an area of protein science where IDPs would not play a noticeable role.

     


    Selected Publications
  • Varadi, M.Kosol, S.Lebrun, P.Valentini, E.Blackledge, M.Dunker, AK.Felli, IC.Forman-Kay, JD.Kriwacki, RW.Pierattelli, R.Sussman, J.Svergun, DI.Uversky, VN.Vendruscolo, M.Wishart, D.Wright, PE.Tompa, P. pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic acids research. 42(1): D326-35, 2014.
  • Kutyshenko, VP.Prokhorov, DA.Molochkov, NV.Sharapov, MG.Kolesnikov, I.Uversky, VN. Dancing retro: solution structure and micelle interactions of the retro-SH3-domain, retro-SHH-'Bergerac'. Journal of biomolecular structure & dynamics. 32(2): 257-72, 2014.
  • Uversky, VN. The triple power of D³: Protein intrinsic disorder in degenerative diseases. Frontiers in bioscience (Landmark edition). 19(): 181-258, 2014.
  • Rae, GM.Uversky, VN.David, K.Wood, M. DRM1 and DRM2 expression regulation: potential role of splice variants in response to stress and environmental factors in Arabidopsis. Molecular genetics and genomics : MGG. (): , 2014.
  • Ferreira, L.Fan, X.Mikheeva, LM.Madeira, PP.Kurgan, L.Uversky, VN.Zaslavsky, BY. Structural features important for differences in protein partitioning in aqueous dextran-polyethylene glycol two-phase systems of different ionic composition. Biochimica et biophysica acta. (): , 2014.
  • Breydo, L.Reddy, KD.Piai, A.Felli, IC.Pierattelli, R.Uversky, VN. The crowd you're in with: Effects of different types of crowding agents on protein aggregation. Biochimica et biophysica acta. 1844(2): 346-57, 2014.
  • Lee, C.Kalmar, L.Xue, B.Tompa, P.Daughdrill, GW.Uversky, VN.Han, KH. Contribution of proline to the pre-structuring tendency of transient helical secondary structure elements in intrinsically disordered proteins. Biochimica et biophysica acta. 1840(3): 993-1003, 2014.
  • Uversky, VN. The most important thing is the tail: multitudinous functionalities of intrinsically disordered protein termini. FEBS letters. 587(13): 1891-901, 2013.
  • Yan, J.Mizianty, MJ.Filipow, PL.Uversky, VN.Kurgan, L. RAPID: fast and accurate sequence-based prediction of intrinsic disorder content on proteomic scale. Biochimica et biophysica acta. 1834(8): 1671-80, 2013.
  • Xue, B.Ganti, K.Rabionet, A.Banks, L.Uversky, VN. Disordered Interactome of Human Papillomavirus. Current pharmaceutical design. (): , 2013.
  • Malaney, P.Uversky, VN.Davé, V. The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy. Molecular bioSystems. 9(11): 2877-88, 2013.
  • Marín, M.Uversky, VN.Ott, T. Intrinsic disorder in pathogen effectors: protein flexibility as an evolutionary hallmark in a molecular arms race. The Plant cell. 25(9): 3153-7, 2013.
  • Na, I.Redmon, D.Kopa, M.Qin, Y.Xue, B.Uversky, VN. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. PloS one. 8(8): e73476, 2013.
  • Choi, UB.Kazi, R.Stenzoski, N.Wollmuth, LP.Uversky, VN.Bowen, ME. Modulating the intrinsic disorder in the cytoplasmic domain alters the biological activity of the N-methyl-D-aspartate-sensitive glutamate receptor. The Journal of biological chemistry. 288(31): 22506-15, 2013.
  • Peng, Z.Xue, B.Kurgan, L.Uversky, VN. Resilience of death: intrinsic disorder in proteins involved in the programmed cell death. Cell death and differentiation. 20(9): 1257-67, 2013.
  • Madeira, PP.Bessa, A.Alvares-Ribeiro, L.Raquel Aires-Barros, M.Rodrigues, AE.Uversky, VN.Zaslavsky, BY. Amino acid/water interactions study: a new amino acid scale. Journal of biomolecular structure & dynamics. (): , 2013.
  • Uversky, AV.Xue, B.Peng, Z.Kurgan, L.Uversky, VN. On the intrinsic disorder status of the major players in programmed cell death pathways. F1000Research. 2(): 190, 2013.
  • Goh, GK.Dunker, AK.Uversky, V. Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission. PLoS currents. 5(): , 2013.
  • Blair, LJ.Nordhues, BA.Hill, SE.Scaglione, KM.O'Leary, JC.Fontaine, SN.Breydo, L.Zhang, B.Li, P.Wang, L.Cotman, C.Paulson, HL.Muschol, M.Uversky, VN.Klengel, T.Binder, EB.Kayed, R.Golde, TE.Berchtold, N.Dickey, CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation. 123(10): 4158-69, 2013.
  • Ferreira, L.Madeira, PP.Mikheeva, L.Uversky, VN.Zaslavsky, B. Effect of salt additives on protein partition in polyethylene glycol-sodium sulfate aqueous two-phase systems. Biochimica et biophysica acta. 1834(12): 2859-66, 2013.
  • Uversky, VN. The UBE2E proteins as conjugating dispersers: extending function with extended extensions. Journal of molecular biology. 425(22): 4067-70, 2013.
  • Peng, Z.Oldfield, CJ.Xue, B.Mizianty, MJ.Dunker, AK.Kurgan, L.Uversky, VN. A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome. Cellular and molecular life sciences : CMLS. (): , 2013.
  • Xue, B.Brown, CJ.Dunker, AK.Uversky, VN. Intrinsically disordered regions of p53 family are highly diversified in evolution. Biochimica et biophysica acta. 1834(4): 725-38, 2013.
  • Uversky, VN.Dunker, AK. The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure. F1000 biology reports. 5(): 1, 2013.
  • Sun, X.Rikkerink, EH.Jones, WT.Uversky, VN. Multifarious roles of intrinsic disorder in proteins illustrate its broad impact on plant biology. The Plant cell. 25(1): 38-55, 2013.
  • Coelho Ribeiro, Mde L.Espinosa, J.Islam, S.Martinez, O.Thanki, JJ.Mazariegos, S.Nguyen, T.Larina, M.Xue, B.Uversky, VN. Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome. PeerJ. 1(): e2, 2013.
  • Lapteva, YS.Uversky, VN.Permyakov, SE. Sequence microheterogeneity of parvalbumin, the major fish allergen. Biochimica et biophysica acta. 1834(8): 1607-14, 2013.
  • Xue, B.Romero, PR.Noutsou, M.Maurice, MM.Rüdiger, SG.William, AM.Mizianty, MJ.Kurgan, L.Uversky, VN.Dunker, AK. Stochastic machines as a colocalization mechanism for scaffold protein function. FEBS letters. 587(11): 1587-91, 2013.
  • Wood, M.Rae, GM.Wu, RM.Walton, EF.Xue, B.Hellens, RP.Uversky, VN. Actinidia DRM1--an intrinsically disordered protein whose mRNA expression is inversely correlated with spring budbreak in kiwifruit. PloS one. 8(3): e57354, 2013.
  • Uversky, VN. A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein science : a publication of the Protein Society. 22(6): 693-724, 2013.
  • Uversky, VN. MultIDIMensionality of IDIMs: intrinsic disorder in autoinhibition. Structure (London, England : 1993). 21(3): 315-6, 2013.
  • Ortiz, JF.MacDonald, ML.Masterson, P.Uversky, VN.Siltberg-Liberles, J. Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses. Genome biology and evolution. 5(3): 504-13, 2013.
  • Xue, B.Jeffers, V.Sullivan, WJ.Uversky, VN. Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Molecular bioSystems. 9(4): 645-57, 2013.
  • Hsu, WL.Oldfield, CJ.Xue, B.Meng, J.Huang, F.Romero, P.Uversky, VN.Dunker, AK. Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding. Protein science : a publication of the Protein Society. 22(3): 258-73, 2013.
  • Oldfield, CJ.Xue, B.Van, YY.Ulrich, EL.Markley, JL.Dunker, AK.Uversky, VN. Utilization of protein intrinsic disorder knowledge in structural proteomics. Biochimica et biophysica acta. 1834(2): 487-98, 2013.
  • Oates, ME.Romero, P.Ishida, T.Ghalwash, M.Mizianty, MJ.Xue, B.Dosztányi, Z.Uversky, VN.Obradovic, Z.Kurgan, L.Dunker, AK.Gough, J. D²P²: database of disordered protein predictions. Nucleic acids research. 41(Database issue): D508-16, 2013.
  • Zaslavsky, A.Madeira, P.Breydo, L.Uversky, VN.Chait, A.Zaslavsky, B. High throughput characterization of structural differences between closely related proteins in solution. Biochimica et biophysica acta. 1834(2): 583-92, 2013.
  • Uversky, VN. Intrinsic disorder-based protein interactions and their modulators. Current pharmaceutical design. 19(23): 4191-213, 2013.
  • Silva, BA.Breydo, L.Uversky, VN. Targeting the chameleon: a focused look at α-synuclein and its roles in neurodegeneration. Molecular neurobiology. 47(2): 446-59, 2013.
  • Silva, BA.Breydo, L.Fink, AL.Uversky, VN. Agrochemicals, α-synuclein, and Parkinson's disease. Molecular neurobiology. 47(2): 598-612, 2013.
  • Moroz, NA.Novak, SM.Azevedo, R.Colpan, M.Uversky, VN.Gregorio, CC.Kostyukova, AS. Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes. The Journal of biological chemistry. 288(7): 4899-907, 2013.
  • Jinwal, UK.Akoury, E.Abisambra, JF.O'Leary, JC.Thompson, AD.Blair, LJ.Jin, Y.Bacon, J.Nordhues, BA.Cockman, M.Zhang, J.Li, P.Zhang, B.Borysov, S.Uversky, VN.Biernat, J.Mandelkow, E.Gestwicki, JE.Zweckstetter, M.Dickey, CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4): 1450-9, 2013.
  • Malaney, P.Pathak, RR.Xue, B.Uversky, VN.Davé, V. Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility. Scientific reports. 3(): 2035, 2013.
  • Shivu, B.Seshadri, S.Li, J.Oberg, KA.Uversky, VN.Fink, AL. Distinct β-sheet structure in protein aggregates determined by ATR-FTIR spectroscopy. Biochemistry. 52(31): 5176-83, 2013.
  • Kutyshenko, VP.Beskaravayny, PM.Molchanov, MV.Paskevich, SI.Prokhorov, DA.Uversky, VN. Looking at microbial metabolism by high-resolution (2)H-NMR spectroscopy. PeerJ. 1(): e101, 2013.
  • Breydo, L.Mikheeva, LM.Madeira, PP.Zaslavsky, BY.Uversky, VN. Solvent interaction analysis of intrinsically disordered proteins in aqueous two-phase systems. Molecular bioSystems. 9(12): 3068-79, 2013.
  • Xue, B.Uversky, VN. Intrinsic Disorder in Proteins Involved in the Innate Antiviral Immunity: Another Flexible Side of a Molecular Arms Race. Journal of molecular biology. (): , 2013.
  • Uversky, VN. Unusual biophysics of intrinsically disordered proteins. Biochimica et biophysica acta. 1834(5): 932-51, 2013.
  • Bhat-Nakshatri, P.Song, EK.Collins, NR.Uversky, VN.Dunker, AK.O'Malley, BW.Geistlinger, TR.Carroll, JS.Brown, M.Nakshatri, H. Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing. BMC medical genomics. 6(): 21, 2013.
  • Uversky, VN. Under-folded proteins: Conformational ensembles and their roles in protein folding, function, and pathogenesis. Biopolymers. 99(11): 870-87, 2013.

  • Memberships
  • ASBMB (Member, 2012 - Present)
  • Biophysical Society (Member, 2006 - Present)


  • Patents & Licensing
  • Artificial entropic bristle domain sequences and their use in recombinant protein production (Molecular Kinetics, Inc. - 2013)
  • Artificial entropic bristle domain sequences and their use in recombinant protein production (Molecular Kinetics, Inc. - 2011)
  • Entropic bristle domain sequences and their use in recombinant protein production. (Molecular Kinetics, Inc. - 2009)


  • Profile last modified on 02/05/2014