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Bin Xue,  PhD


Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assistant Professor
NON USF HEALTH

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Contacts
Email: bxue@health.usf.edu
Phone: (813) 974-1905
Office: MDC, 3523
Mailing address 12901 Bruce B Downs Blvd MDC 7
Tampa, FL 33612
 
Education
  • PhD, Physics, Nanjing University , Nanjing, People'S Republic Of China - 2005.
  • PhD, Condensed Matter Physics, Nanjing University , Nanjing, People's Republic of China - 2005.
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    Research Summary

    I am fascinated by questions related to protein sequence-conformation-function and roles of protein molecules and their interactions in the process of development, evolution, and human diseases. In all these questions, protein conformation and conformational changes play key roles. Many proteins have specific 3-dimensional structures to perform their functions. Meanwhile, more proteins have been found without rigid 3-dimensional structures under physiological conditions. These two types of proteins are usually called structured proteins and intrinsically disordered proteins. I am using various computational tools to study these two types of proteins. Current projects include: - Machine-learning based prediction of protein intrinsic disorder and structural properties; - Molecular simulation of proteins; - Docking; - Protein interaction pathways and networks; - Molecular mechanisms of diseases; - Theoretical topics on computational molecular biology and biophysics; - etc.

     


    Selected Publications
  • Xue, B.Soeria-Atmadja, D.Gustafsson, MG.Hammerling, U.Dunker, AK.Uversky, VN. Abundance and functional roles of intrinsic disorder in allergenic proteins and allergen representative peptides. Proteins. (): , 2011.
  • Xue, B.Oldfield, CJ.Van, YY.Dunker, AK.Uversky, VN. Protein intrinsic disorder and induced pluripotent stem cells. Molecular bioSystems. (): , 2011.
  • Xue, B.Williams, RW.Oldfield, CJ.Dunker, AK.Uversky, VN. Archaic chaos: intrinsically disordered proteins in Archaea. BMC systems biology. 4 Suppl 1(): S1, 2010.
  • Xue, B.Dunker, AK.Uversky, VN. Retro-MoRFs: Identifying Protein Binding Sites by Normal and Reverse Alignment and Intrinsic Disorder Prediction. International journal of molecular sciences. 11(10): 3725-47, 2010.
  • Xue, B.Hsu, WL.Lee, JH.Lu, H.Dunker, AK.Uversky, VN. SPA: Short peptide analyzer of intrinsic disorder status of short peptides. Genes to cells : devoted to molecular & cellular mechanisms. 15(6): 635-46, 2010.
  • Xue, B.Dunbrack, RL.Williams, RW.Dunker, AK.Uversky, VN. PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochimica et biophysica acta. 1804(4): 996-1010, 2010.
  • Xue, B.Williams, RW.Oldfield, CJ.Goh, GK.Dunker, AK.Uversky, VN. Viral disorder or disordered viruses: do viral proteins possess unique features? Protein and peptide letters. 17(8): 932-51, 2010.
  • Xue, B.Li, L.Meroueh, SO.Uversky, VN.Dunker, AK. Analysis of structured and intrinsically disordered regions of transmembrane proteins. Molecular bioSystems. 5(12): 1688-1702, 2009.
  • Xue, B.Dor, O.Faraggi, E.Zhou, Y. Real-value prediction of backbone torsion angles. Proteins. 72(1): 427-33, 2008.
  • Xue, B; Su, Y; Wang, W. Permeation of particle through a four-helix-bundle model channel J. Chem. Phys.. 122(10): 104703, 2005.

  • Profile last modified on 03/20/2012