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Srinivas Bharadwaj,  PhD
Assistant Professor, Internal Medicine, Morsani College of Medicine
Assistant Professor, Molecular Medicine, Morsani College of Medicine
Assistant Professor, Division of Pharmaceutical Sciences, College of Pharmacy
Member, H. Lee Moffitt Cancer Center & Research Institute


Primary Department: COLLEGE OF MEDICINE INTERNAL MEDICINE

Assistant Professor
COLLEGE OF MEDICINE INTERNAL MEDICINE

Assistant Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assistant Professor
COP DEPT OF PHARMACEUTICAL SCIENCE

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Contacts
Email: snagaraj@health.usf.edu
Phone: (813) 974-4585
Office: MDC, 4161
Mailing address Division of Translational Medicine 12901 Bruce B. Downs Blvd., MDC 19
Tampa, FL 33612
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Education
  • PhD, Anatomy, Bangalore University , Bangalore, India - 2001.
  • Ph.D, Anatomy/Medicine, St.Johns Medical College , Bangalore , India - 2001.
  • M.S, Human Anatomy, Kasturba Medical College , Manipal , India - 1995.
  • B.S, Microbiology, St.Josephs College , Bangalore, India - 1992.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine, Cancer Biology.
     
    Links

    Lab Link:  http://www.usfinternalmedicine.com


    Selected Publications
  • Nagaraj, S.Youn, JI.Gabrilovich, DI. Reciprocal relationship between myeloid-derived suppressor cells and T cells. Journal of immunology (Baltimore, Md. : 1950). 191(1): 17-23, 2013.
  • Mallela, J.Ravi, S.Jean Louis, F.Mulaney, B.Cheung, M.Sree Garapati, U.Chinnasamy, V.Wang, C.Nagaraj, S.Mohapatra, SS.Mohapatra, S. Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis. Stem cells (Dayton, Ohio). 31(7): 1321-9, 2013.
  • Wang, D.Yu, Y.Haarberg, K.Fu, J.Kaosaard, K.Nagaraj, S.Anasetti, C.Gabrilovich, D.Yu, XZ. Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(5): 692-702, 2013.
  • Brar, T.Nagaraj, S.Mohapatra, S. Microbes and asthma: the missing cellular and molecular links. Current opinion in pulmonary medicine. 18(1): 14-22, 2012.
  • Nagaraj, S.Gabrilovich, DI. Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells. Seminars in cancer biology. 22(4): 282-8, 2012.
  • Nagaraj, S.Nelson, A.Youn, JI.Cheng, P.Quiceno, D.Gabrilovich, DI. Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Cancer research. 72(4): 928-38, 2012.
  • Nelson, A.Nair, S.Nagaraj, S. CD4(+) T cells suppress immune response to cancer: novel targets for antitumor efforts. Expert review of clinical immunology. 8(5): 401-3, 2012.
  • Herber, DL.Cao, W.Nefedova, Y.Novitskiy, SV.Nagaraj, S.Tyurin, VA.Corzo, A.Cho, HI.Celis, E.Lennox, B.Knight, SC.Padhya, T.McCaffrey, TV.McCaffrey, JC.Antonia, S.Fishman, M.Ferris, RL.Kagan, VE.Gabrilovich, DI. Lipid accumulation and dendritic cell dysfunction in cancer. Nature medicine. 16(8): 880-6, 2010.
  • Nagaraj, S.Youn, JI.Weber, H.Iclozan, C.Lu, L.Cotter, MJ.Meyer, C.Becerra, CR.Fishman, M.Antonia, S.Sporn, MB.Liby, KT.Rawal, B.Lee, JH.Gabrilovich, DI. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 16(6): 1812-23, 2010.
  • Nagaraj, S.Schrum, AG.Cho, HI.Celis, E.Gabrilovich, DI. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. Journal of immunology (Baltimore, Md. : 1950). 184(6): 3106-16, 2010.
  • Ramakrishnan, R.Assudani, D.Nagaraj, S.Hunter, T.Cho, HI.Antonia, S.Altiok, S.Celis, E.Gabrilovich, DI. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. The Journal of clinical investigation. 120(4): 1111-24, 2010.
  • Nagaraj, S.Gabrilovich, DI. Myeloid-derived suppressor cells in human cancer. Cancer journal (Sudbury, Mass.). 16(4): 348-53, 2010.
  • Nagaraj, S.Collazo, M.Corzo, CA.Youn, JI.Ortiz, M.Quiceno, D.Gabrilovich, DI. Regulatory myeloid suppressor cells in health and disease. Cancer research. 69(19): 7503-6, 2009.
  • Gabrilovich, DI.Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nature reviews. Immunology. 9(3): 162-74, 2009.
  • Ziske, C.Tiemann, K.Schmidt, T.Nagaraj, S.Märten, A.Schmitz, V.Clarenbach, R.Sauerbruch, T.Schmidt-Wolf, IG. Real-time high-resolution compound imaging allows percutaneous initiation and surveillance in an orthotopic murine pancreatic cancer model. Pancreas. 36(2): 146-52, 2008.
  • Nagaraj, S.Gabrilovich, DI. Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer research. 68(8): 2561-3, 2008.
  • Nagaraj, S.Neumann, J.Winzen, B.Frank, S.Ziske, C.Sievers, E.Koch, N.Schmidt-Wolf, IG. Pancreas carcinoma antigen fused to invariant chain elicits T-cell response and tumor growth inhibition. Pancreas. 37(3): 321-7, 2008.
  • Cheng, P.Corzo, CA.Luetteke, N.Yu, B.Nagaraj, S.Bui, MM.Ortiz, M.Nacken, W.Sorg, C.Vogl, T.Roth, J.Gabrilovich, DI. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. The Journal of experimental medicine. 205(10): 2235-49, 2008.
  • Youn, JI.Nagaraj, S.Collazo, M.Gabrilovich, DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. Journal of immunology (Baltimore, Md. : 1950). 181(8): 5791-802, 2008.
  • Nagaraj, S.Pisarev, V.Kinarsky, L.Sherman, S.Muro-Cacho, C.Altieri, DC.Gabrilovich, DI. Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors. Journal of immunotherapy (Hagerstown, Md. : 1997). 30(2): 169-79, 2007.
  • Nagaraj, S.Gupta, K.Pisarev, V.Kinarsky, L.Sherman, S.Kang, L.Herber, DL.Schneck, J.Gabrilovich, DI. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nature medicine. 13(7): 828-35, 2007.
  • Herber, DL.Nagaraj, S.Djeu, JY.Gabrilovich, DI. Mechanism and therapeutic reversal of immune suppression in cancer. Cancer research. 67(11): 5067-9, 2007.
  • Delano, MJ.Scumpia, PO.Weinstein, JS.Coco, D.Nagaraj, S.Kelly-Scumpia, KM.O'Malley, KA.Wynn, JL.Antonenko, S.Al-Quran, SZ.Swan, R.Chung, CS.Atkinson, MA.Ramphal, R.Gabrilovich, DI.Reeves, WH.Ayala, A.Phillips, J.Laface, D.Heyworth, PG.Clare-Salzler, M.Moldawer, LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. The Journal of experimental medicine. 204(6): 1463-74, 2007.
  • Kusmartsev, S.Nagaraj, S.Gabrilovich, DI. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. Journal of immunology (Baltimore, Md. : 1950). 175(7): 4583-92, 2005.
  • Nefedova, Y.Nagaraj, S.Rosenbauer, A.Muro-Cacho, C.Sebti, SM.Gabrilovich, DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer research. 65(20): 9525-35, 2005.
  • Ziske, C.Nagaraj, S.Märten, A.Gorschlüter, M.Strehl, J.Sauerbruch, T.Abraham, NG.Schmidt-Wolf, IG. Retroviral IFN-alpha gene transfer combined with gemcitabine acts synergistically via cell cycle alteration in human pancreatic carcinoma cells implanted orthotopically in nude mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 24(8): 490-6, 2004.
  • Nagaraj, S.Ziske, C.Schmidt-Wolf, IG. Human cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer. Genetic vaccines and therapy. 2(1): 12, 2004.
  • Gross, C.Schmidt-Wolf, IG.Nagaraj, S.Gastpar, R.Ellwart, J.Kunz-Schughart, LA.Multhoff, G. Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells. Cell stress & chaperones. 8(4): 348-60, 2003.

  • Positions Held
  • Research Assistant Professor (H. Lee Moffitt Cancer Center & Research Institute, . 2007 - 2009)
  • Postdoctoral Fellow (H. Lee Moffitt Cancer Center & Research Institute, . 2004 - 2007)
  • Scientist (Immune and Gene Therapy Lab, Internal Medicine, Uni-Clinic 2001 - 2004)
  • Lecturer (Anatomy, St. John's Medical College 1995 - 2001)


  • Memberships
  • American Association for Advancement of Science (., 2014 - Present)
  • American Association of Immunologists ( Full member, 2006 - Present)
  • American Association of Cancer Research ( Full member, 2005 - Present)


  • Awards/Honors
  • Junior faculty award (American Association of Immunologists - 2012)
  • Scholarship (Keystone Symposia - 2010)


  • Lectures
  • "MHC II retrograde signaling in MDSC" American Association of Immunologists. FL, United States - 2012.
  • "Role of NPRA in MDSC" American Association of Immunologists. FL, United States - 2011.
  • "Myeloid Derived Suppressor Cells" SIPAIID, USF Health. FL, United States - 2011.
  • "Regulation of Myeloid Derived Suppressor Cell Activity in Cancer by CD4+ T cells" Keystone Symposia. FL, United States - 2010.
  • "Mechanism of MDSC induced tolerance in cancer" American Association of Immunologists. WA, United States - 2009.

  • Profile last modified on 01/21/2014