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Chad Dickey,  Ph.D.
Associate Professor, Molecular Medicine Byrd Alzheimer's Institute


Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

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Contacts
Email: cdickey@health.usf.edu
Phone: (813) 396-0639
Office: ALZ, 310
Mailing address 4001 E. Fletcher Ave. Rm# 338 USF Health Byrd Alzheimer's Insititute
Tampa, FL 33613
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Education
  • PHD, Pharmacology/Neuroscience, University Of South Florida , Tampa, United States - 2004.
  • B.S., Microbiology, University of South Florida ,USA - 1998.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cellular and Molecular Biology, Neurodegenerative Disease, Neuroscience, Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine.
     
    Research Summary

    Human cells, including neurons in the brain, contain thousands of proteins that must work in concert to produce or perform our actions. Breathing, running, talking, remembering….all of these things are coordinated by thousands of proteins every second in our cells. This is what we work on in the lab. Hidden among those thousands of proteins is a group of sentinels called chaperones that, by definition, ensure propriety of all of these other proteins in the cell. Without chaperones, nothing would work properly. In fact, our lab and others have begun to show that many if not all of human disease is in some way affected by chaperones. There are approximately 150 chaperones in humans and each of these could be a drug target for human diseases. In particular, our lab has focused on a group of more than 15 neurological degenerative diseases collectively termed “tauopathies", the most common being Alzheimer’s disease. We have also seen our work move into glaucoma and depression.

     
    Links

    Lab Link:  http://health.usf.edu/medicine/molecularmedicine/dickey_lab/index.htm


    Selected Publications
  • Karagöz, GE.Duarte, AM.Akoury, E.Ippel, H.Biernat, J.Morán Luengo, T.Radli, M.Didenko, T.Nordhues, BA.Veprintsev, DB.Dickey, CA.Mandelkow, E.Zweckstetter, M.Boelens, R.Madl, T.Rüdiger, SG. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 156(5): 963-74, 2014.
  • Orwig, SD.Chi, PV.Du, Y.Hill, SE.Cavitt, MA.Suntharalingam, A.Turnage, KC.Dickey, CA.France, S.Fu, H.Lieberman, RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. ACS chemical biology. 9(2): 517-25, 2014.
  • Blair, LJ.Zhang, B.Dickey, CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's research & therapy. 5(5): 41, 2013.
  • Smith, MC.Scaglione, KM.Assimon, VA.Patury, S.Thompson, AD.Dickey, CA.Southworth, DR.Paulson, HL.Gestwicki, JE.Zuiderweg, ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52(32): 5354-64, 2013.
  • Jinwal, UK.Koren, J.Dickey, CA. Reconstructing the Hsp90/Tau Machine. Current enzyme inhibition. 9(1): 41-45, 2013.
  • Abisambra, JF.Jinwal, UK.Blair, LJ.O'Leary, JC.Li, Q.Brady, S.Wang, L.Guidi, CE.Zhang, B.Nordhues, BA.Cockman, M.Suntharalingham, A.Li, P.Jin, Y.Atkins, CA.Dickey, CA. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(22): 9498-507, 2013.
  • Abisambra, J.Jinwal, UK.Miyata, Y.Rogers, J.Blair, L.Li, X.Seguin, SP.Wang, L.Jin, Y.Bacon, J.Brady, S.Cockman, M.Guidi, C.Zhang, J.Koren, J.Young, ZT.Atkins, CA.Zhang, B.Lawson, LY.Weeber, EJ.Brodsky, JL.Gestwicki, JE.Dickey, CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. 74(5): 367-74, 2013.
  • Lee, DC.Ruiz, CR.Lebson, L.Selenica, ML.Rizer, J.Hunt, JB.Rojiani, R.Reid, P.Kammath, S.Nash, K.Dickey, CA.Gordon, M.Morgan, D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of aging. 34(6): 1610-20, 2013.
  • Miyata, Y.Li, X.Lee, HF.Jinwal, UK.Srinivasan, SR.Seguin, SP.Young, ZT.Brodsky, JL.Dickey, CA.Sun, D.Gestwicki, JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS chemical neuroscience. 4(6): 930-9, 2013.
  • Braswell, K.Dickey, CA.Jinwal, UK. A commentary on: Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Experimental neurology. 241(): 122-4, 2013.
  • Chiosis, G.Dickey, CA.Johnson, JL. A global view of Hsp90 functions. Nature structural & molecular biology. 20(1): 1-4, 2013.
  • Jinwal, UK.Akoury, E.Abisambra, JF.O'Leary, JC.Thompson, AD.Blair, LJ.Jin, Y.Bacon, J.Nordhues, BA.Cockman, M.Zhang, J.Li, P.Zhang, B.Borysov, S.Uversky, VN.Biernat, J.Mandelkow, E.Gestwicki, JE.Zweckstetter, M.Dickey, CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4): 1450-9, 2013.
  • Selenica, ML.Brownlow, M.Jimenez, JP.Lee, DC.Pena, G.Dickey, CA.Gordon, MN.Morgan, D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neuro-degenerative diseases. 11(4): 165-81, 2013.
  • Blair, LJ.Nordhues, BA.Hill, SE.Scaglione, KM.O'Leary, JC.Fontaine, SN.Breydo, L.Zhang, B.Li, P.Wang, L.Cotman, C.Paulson, HL.Muschol, M.Uversky, VN.Klengel, T.Binder, EB.Kayed, R.Golde, TE.Berchtold, N.Dickey, CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation. 123(10): 4158-69, 2013.
  • O'Leary, JC.Zhang, B.Koren, J.Blair, L.Dickey, CA. The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. CNS & neurological disorders drug targets. 12(8): 1157-62, 2013.
  • Jinwal, UK.Abisambra, JF.Zhang, J.Dharia, S.O'Leary, JC.Patel, T.Braswell, K.Jani, T.Gestwicki, JE.Dickey, CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. The Journal of biological chemistry. 287(29): 24814-20, 2012.
  • Thompson, AD.Scaglione, KM.Prensner, J.Gillies, AT.Chinnaiyan, A.Paulson, HL.Jinwal, UK.Dickey, CA.Gestwicki, JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS chemical biology. 7(10): 1677-86, 2012.
  • Calcul, L.Zhang, B.Jinwal, UK.Dickey, CA.Baker, BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future medicinal chemistry. 4(13): 1751-61, 2012.
  • Suntharalingam, A.Abisambra, JF.O'Leary, JC.Koren, J.Zhang, B.Joe, MK.Blair, LJ.Hill, SE.Jinwal, UK.Cockman, M.Duerfeldt, AS.Tomarev, S.Blagg, BS.Lieberman, RL.Dickey, CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of biological chemistry. 287(48): 40661-9, 2012.
  • Miyata, Y.Rauch, JN.Jinwal, UK.Thompson, AD.Srinivasan, S.Dickey, CA.Gestwicki, JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & biology. 19(11): 1391-9, 2012.
  • Abisambra, JF.Jinwal, UK.Suntharalingam, A.Arulselvam, K.Brady, S.Cockman, M.Jin, Y.Zhang, B.Dickey, CA. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. Journal of molecular biology. 421(4-5): 653-61, 2012.
  • Congdon, EE.Wu, JW.Myeku, N.Figueroa, YH.Herman, M.Marinec, PS.Gestwicki, JE.Dickey, CA.Yu, WH.Duff, KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8(4): 609-22, 2012.
  • Koren, J.Miyata, Y.Kiray, J.O'Leary, JC.Nguyen, L.Guo, J.Blair, LJ.Li, X.Li, X.Jinwal, UK.Cheng, JQ.Gestwicki, JE.Dickey, CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PloS one. 7(4): e35566, 2012.
  • Daily, JL.Nash, K.Jinwal, U.Golde, T.Rogers, J.Peters, MM.Burdine, RD.Dickey, C.Banko, JL.Weeber, EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PloS one. 6(12): e27221, 2011.
  • Jinwal, UK.Dickey, CA. Cell-based assays for regulators of tau biology. Methods in molecular biology (Clifton, N.J.). 670(): 93-108, 2011.
  • Evans, CG.Jinwal, UK.Makley, LN.Dickey, CA.Gestwicki, JE. Identification of dihydropyridines that reduce cellular tau levels. Chemical communications (Cambridge, England). 47(1): 529-31, 2011.
  • Jones, JR.Lebar, MD.Jinwal, UK.Abisambra, JF.Koren, J.Blair, L.O'Leary, JC.Davey, Z.Trotter, J.Johnson, AG.Weeber, E.Eckman, CB.Baker, BJ.Dickey, CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. Journal of natural products. 74(1): 38-44, 2011.
  • Jinwal, UK.Trotter, JH.Abisambra, JF.Koren, J.Lawson, LY.Vestal, GD.O'Leary, JC.Johnson, AG.Jin, Y.Jones, JR.Li, Q.Weeber, EJ.Dickey, CA. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. The Journal of biological chemistry. 286(19): 16976-83, 2011.
  • Koren, J.Jinwal, UK.Davey, Z.Kiray, J.Arulselvam, K.Dickey, CA. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular neurobiology. 44(1): 65-70, 2011.
  • O'Leary, JC.Koren, J.Dickey, CA. Neuronal life span versus health span: principles of natural selection at work in the degenerating brain. Journal of molecular neuroscience : MN. 45(3): 467-72, 2011.
  • Rousaki, A.Miyata, Y.Jinwal, UK.Dickey, CA.Gestwicki, JE.Zuiderweg, ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology. 411(3): 614-32, 2011.
  • Miyata, Y.Koren, J.Kiray, J.Dickey, CA.Gestwicki, JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future medicinal chemistry. 3(12): 1523-37, 2011.
  • Storer, CL.Dickey, CA.Galigniana, MD.Rein, T.Cox, MB. FKBP51 and FKBP52 in signaling and disease. Trends in endocrinology and metabolism: TEM. 22(12): 481-90, 2011.
  • Abisambra, JF.Jinwal, UK.Jones, JR.Blair, LJ.Koren, J.Dickey, CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current neuropharmacology. 9(4): 623-31, 2011.
  • Trotter, JH.Klein, M.Jinwal, UK.Abisambra, JF.Dickey, CA.Tharkur, J.Masiulis, I.Ding, J.Locke, KG.Rickman, CB.Birch, DG.Weeber, EJ.Herz, J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(40): 14413-23, 2011.
  • Voss, K.Koren, J.Dickey, CA. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. The American journal of pathology. 179(5): 2148-51, 2011.
  • O'Leary, JC.Dharia, S.Blair, LJ.Brady, S.Johnson, AG.Peters, M.Cheung-Flynn, J.Cox, MB.de Erausquin, G.Weeber, EJ.Jinwal, UK.Dickey, CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PloS one. 6(9): e24840, 2011.
  • Lebson, L.Nash, K.Kamath, S.Herber, D.Carty, N.Lee, DC.Li, Q.Szekeres, K.Jinwal, U.Koren, J.Dickey, CA.Gottschall, PE.Morgan, D.Gordon, MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(29): 9651-8, 2010.
  • Lee, DC.Rizer, J.Selenica, ML.Reid, P.Kraft, C.Johnson, A.Blair, L.Gordon, MN.Dickey, CA.Morgan, D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of neuroinflammation. 7(): 56, 2010.
  • Carty, N.Lee, D.Dickey, C.Ceballos-Diaz, C.Jansen-West, K.Golde, TE.Gordon, MN.Morgan, D.Nash, K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of neuroscience methods. 194(1): 144-53, 2010.
  • Jinwal, UK.Koren, J.Borysov, SI.Schmid, AB.Abisambra, JF.Blair, LJ.Johnson, AG.Jones, JR.Shults, CL.O'Leary, JC.Jin, Y.Buchner, J.Cox, MB.Dickey, CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(2): 591-9, 2010.
  • Koren, J.Jinwal, UK.Jin, Y.O'Leary, J.Jones, JR.Johnson, AG.Blair, LJ.Abisambra, JF.Chang, L.Miyata, Y.Cheng, AM.Guo, J.Cheng, JQ.Gestwicki, JE.Dickey, CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of biological chemistry. 285(4): 2498-505, 2010.
  • Azorsa, DO.Robeson, RH.Frost, D.Meec hoovet, B.Brautigam, GR.Dickey, C.Beaudry, C.Basu, GD.Holz, DR.Hernandez, JA.Bisanz, KM.Gwinn, L.Grover, A.Rogers, J.Reiman, EM.Hutton, M.Stephan, DA.Mousses, S.Dunckley, T. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC genomics. 11(): 25, 2010.
  • Abisambra, JF.Blair, LJ.Hill, SE.Jones, JR.Kraft, C.Rogers, J.Koren, J.Jinwal, UK.Lawson, L.Johnson, AG.Wilcock, D.O'Leary, JC.Jansen-West, K.Muschol, M.Golde, TE.Weeber, EJ.Banko, J.Dickey, CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46): 15374-82, 2010.
  • Jinwal, UK.O'Leary, JC.Borysov, SI.Jones, JR.Li, Q.Koren, J.Abisambra, JF.Vestal, GD.Lawson, LY.Johnson, AG.Blair, LJ.Jin, Y.Miyata, Y.Gestwicki, JE.Dickey, CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of biological chemistry. 285(22): 16798-805, 2010.
  • Jinwal, UK.Koren, J.O'Leary, JC.Jones, JR.Abisambra, JF.Dickey, CA. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and cellular pharmacology. 2(2): 43-46, 2010.
  • O'Leary, JC.Li, Q.Marinec, P.Blair, LJ.Congdon, EE.Johnson, AG.Jinwal, UK.Koren, J.Jones, JR.Kraft, C.Peters, M.Abisambra, JF.Duff, KE.Weeber, EJ.Gestwicki, JE.Dickey, CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5(): 45, 2010.
  • Jinwal, UK.Miyata, Y.Koren, J.Jones, JR.Trotter, JH.Chang, L.O'Leary, J.Morgan, D.Lee, DC.Shults, CL.Rousaki, A.Weeber, EJ.Zuiderweg, ER.Gestwicki, JE.Dickey, CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39): 12079-88, 2009.
  • Koren, J.Jinwal, UK.Lee, DC.Jones, JR.Shults, CL.Johnson, AG.Anderson, LJ.Dickey, CA. Chaperone signalling complexes in Alzheimer's disease. Journal of cellular and molecular medicine. 13(4): 619-30, 2009.
  • Dickey, C.Kraft, C.Jinwal, U.Koren, J.Johnson, A.Anderson, L.Lebson, L.Lee, D.Dickson, D.de Silva, R.Binder, LI.Morgan, D.Lewis, J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. 174(1): 228-38, 2009.
  • Dickey, CA.Koren, J.Zhang, YJ.Xu, YF.Jinwal, UK.Birnbaum, MJ.Monks, B.Sun, M.Cheng, JQ.Patterson, C.Bailey, RM.Dunmore, J.Soresh, S.Leon, C.Morgan, D.Petrucelli, L. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105(9): 3622-7, 2008.
  • Dickey, CA.Patterson, C.Dickson, D.Petrucelli, L. Brain CHIP: removing the culprits in neurodegenerative disease. Trends in molecular medicine. 13(1): 32-8, 2007.
  • Dickey, CA.Kamal, A.Lundgren, K.Klosak, N.Bailey, RM.Dunmore, J.Ash, P.Shoraka, S.Zlatkovic, J.Eckman, CB.Patterson, C.Dickson, DW.Nahman, NS.Hutton, M.Burrows, F.Petrucelli, L. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of clinical investigation. 117(3): 648-58, 2007.
  • Zhang, YJ.Xu, YF.Dickey, CA.Buratti, E.Baralle, F.Bailey, R.Pickering-Brown, S.Dickson, D.Petrucelli, L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(39): 10530-4, 2007.
  • Dickey, CA.Yue, M.Lin, WL.Dickson, DW.Dunmore, JH.Lee, WC.Zehr, C.West, G.Cao, S.Clark, AM.Caldwell, GA.Caldwell, KA.Eckman, C.Patterson, C.Hutton, M.Petrucelli, L. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(26): 6985-96, 2006.
  • Baker, M.Mackenzie, IR.Pickering-Brown, SM.Gass, J.Rademakers, R.Lindholm, C.Snowden, J.Adamson, J.Sadovnick, AD.Rollinson, S.Cannon, A.Dwosh, E.Neary, D.Melquist, S.Richardson, A.Dickson, D.Berger, Z.Eriksen, J.Robinson, T.Zehr, C.Dickey, CA.Crook, R.McGowan, E.Mann, D.Boeve, B.Feldman, H.Hutton, M. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442(7105): 916-9, 2006.
  • Dickey, CA.Ash, P.Klosak, N.Lee, WC.Petrucelli, L.Hutton, M.Eckman, CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular neurodegeneration. 1(): 6, 2006.
  • Dickey, CA.Petrucelli, L. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. 10(5): 665-76, 2006.
  • Lee, WC.Tsoi, YK.Dickey, CA.Delucia, MW.Dickson, DW.Eckman, CB. Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD). Neurobiology of disease. 23(2): 273-80, 2006.
  • Dickey, CA.Dunmore, J.Lu, B.Wang, JW.Lee, WC.Kamal, A.Burrows, F.Eckman, C.Hutton, M.Petrucelli, L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(6): 753-5, 2006.
  • Lee, WC.Courtenay, A.Troendle, FJ.Stallings-Mann, ML.Dickey, CA.DeLucia, MW.Dickson, DW.Eckman, CB. Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(11): 1549-51, 2005.
  • Dickey, CA.Eriksen, J.Kamal, A.Burrows, F.Kasibhatla, S.Eckman, CB.Hutton, M.Petrucelli, L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer research. 2(2): 231-8, 2005.
  • Dickey, CA.Gordon, MN.Wilcock, DM.Herber, DL.Freeman, MJ.Morgan, D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. BMC neuroscience. 6(): 7, 2005.
  • Dickey, CA.De Mesquita, DD.Morgan, D.Pennypacker, KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neuroscience letters. 366(1): 10-4, 2004.
  • Garcia, MF.Gordon, MN.Hutton, M.Lewis, J.McGowan, E.Dickey, CA.Morgan, D.Arendash, GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15(1): 73-7, 2004.
  • Dickey, CA.Gordon, MN.Mason, JE.Wilson, NJ.Diamond, DM.Guzowski, JF.Morgan, D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. Journal of neurochemistry. 88(2): 434-42, 2004.
  • Dickey, CA.Loring, JF.Montgomery, J.Gordon, MN.Eastman, PS.Morgan, D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(12): 5219-26, 2003.
  • Dickey, CA.Morgan, DG.Kudchodkar, S.Weiner, DB.Bai, Y.Cao, C.Gordon, MN.Ugen, KE. Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA and cell biology. 20(11): 723-9, 2001.

  • Positions Held


    Memberships
  • American Society for Cell Biology (Member, 2007 - Present)
  • Society for Neuroscience (Member, 2002 - Present)
  • University of South Florida Alumni Association (Member, 1998 - Present)
  • Institute for Biomolecular Sciences (USF) (Member, 2000 - 2002)


  • Awards/Honors
  • Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Awards in Alzheimer's Disease ( - 2007)
  • Smith Award Recipient (Mayo Clinic Jacksonville - 2006)
  • ADRC Pilot Study Award Recipient ( - 2006)
  • University of South Florida Department of Pharmacology Stipend Award (University of South Florida - 2004)
  • Institute for Biomolecular Sciences Competitive Stipend Award ( University of South Florida - 2002)


  • Lectures
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" Medical College of Georgia. GA, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity" ASNTR. NC, United States - 2010.
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" International Conference on Frontotemporal Dementias. IN, United States - 2010.
  • "Rapid folding of tau by Hsc70 after microtubule destabilization is prevented by distinct phosphorylation events" ICAD. HI, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity"  American Federation for Aging Research. CA, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Hsp90 Meeting. Switzerland - 2010.
  • "Folding and aggregation of the intrinsically disordered tau protein are selectively regulated by chaperones" Cold Springs Harbor Laboratories. NY, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Aging, Tau Protein and Dementias. Japan - 2010.
  • "The twists and turns of the intrinsically disordered tau protein" University of Kansas . KS, United States - 2010.
  • "Hsp90 cochaperone FKBP51 regulates tau and polymerizes microtubules"  Midwest Stress Response Meeting. IL, United States - 2010.
  • "Akt Clearance Through Hsp70 Regulation" Midwest Stress Response Meeting . IL, United States - 2010.
  • "Heat Shock Protein 27-mediated disruption of tau aggregation reduces intraneuronal tau inclusions and improves hippocampal plasticity" Midwest Stress Response Meeting. IL, United States - 2010.
  • "The Duality of Heat Shock Proteins in Tau Pathogenesis" Midwest Stress Response Meeting . IL, United States - 2010.
  • "FKBP51 regulates tau phosphorylation and degradation" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "The Effect of Hsp27 on Phosphorylated Tau" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Tau Processing Regulated through Hsp70 Manipulation by Methylene Blue" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Akts Effect on Chaperone Machinery and Related Clients" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "In vivo Administration of Heat Shock Protein 27 Variants; Implications for Tauopathies" . Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" International Research Conference for PSP. IL, United States - 2009.
  • "Emerging therapeutic strategies for Alzheimers disease and other neurological disorders" AFAR Florida Affiliate Program. FL, United States - 2009.
  • "Chemical manipulation of Hsp70 activity regulates tau processing" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" AFAR Grantee Conference. CA, United States - 2009.
  • "Tau and the chaperone interface" University of Florida . FL, United States - 2009.
  • "The unstructured protein tau as a chaperone client; a common vector for diseases of aging?" Cedars-Sinai Hospital at UCLA. CA, United States - 2009.
  • "Chemically tuning tau Fate with Chaperone Modulators" Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "Kinases and chaperones converge to regulate tau proteotoxicity" Cold Springs Harbor Laboratories. NY, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" University of Alabama at Birmingham. AL, United States - 2008.
  • "Akt and CHIP converge to regulate tau degradation" International Conference on Alzheimers Disease. IL, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" AFAR Conference. CA, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity" University of Michigan. MI, United States - 2008.
  • "" Akt and CHIP co-regulate tau through coordinated interactions" Midwest Stress Meeting . FL, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity"  Society for Neuroscience. DC, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers Disease"  Integrated Neuroscience Symposium. FL, United States - 2008.

  • Profile last modified on 01/17/2015