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Chad Dickey, Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE

Associate Professor, Molecular Medicine Byrd Alzheimer's Institute

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Contacts
Email: cdickey@health.usf.edu
Phone: (813) 396-0639
Office: ALZ, 310
Mailing address 4001 E. Fletcher Ave. Rm# 338 USF Health Byrd Alzheimer's Insititute
Tampa, FL 33613
View My C.V.
 
Education
  • PHD, Pharmacology/Neuroscience, University Of South Florida, Tampa, United States - 2004.
  • B.S., Microbiology, University of South Florida, USA - 1998.
 
Interdisciplinary & Emerging Signature Programs
Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine, Neuroscience, Cellular and Molecular Biology, Neurodegenerative Disease.
 
Research Summary

Human cells, including neurons in the brain, contain thousands of proteins that must work in concert to produce or perform our actions. Breathing, running, talking, remembering….all of these things are coordinated by thousands of proteins every second in our cells. This is what we work on in the lab. Hidden among those thousands of proteins is a group of sentinels called chaperones that, by definition, ensure propriety of all of these other proteins in the cell. Without chaperones, nothing would work properly. In fact, our lab and others have begun to show that many if not all of human disease is in some way affected by chaperones. There are approximately 150 chaperones in humans and each of these could be a drug target for human diseases. In particular, our lab has focused on a group of more than 15 neurological degenerative diseases collectively termed “tauopathies", the most common being Alzheimer’s disease. We have also seen our work move into glaucoma and depression.

 
Links

Lab Link:  http://health.usf.edu/medicine/molecularmedicine/dickey_lab/index.htm


Selected Publications

Positions Held

Memberships
  • American Society for Cell Biology (Member, 2007 - Present)
  • Society for Neuroscience (Member, 2002 - Present)
  • University of South Florida Alumni Association (Member, 1998 - Present)
  • Institute for Biomolecular Sciences (USF) (Member, 2000 - 2002)


Awards/Honors
  • Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Awards in Alzheimer's Disease ( - 2007)
  • Smith Award Recipient (Mayo Clinic Jacksonville - 2006)
  • ADRC Pilot Study Award Recipient ( - 2006)
  • University of South Florida Department of Pharmacology Stipend Award (University of South Florida - 2004)
  • Institute for Biomolecular Sciences Competitive Stipend Award ( University of South Florida - 2002)



Lectures
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" Medical College of Georgia. GA, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity" ASNTR. NC, United States - 2010.
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" International Conference on Frontotemporal Dementias. IN, United States - 2010.
  • "Rapid folding of tau by Hsc70 after microtubule destabilization is prevented by distinct phosphorylation events" ICAD. HI, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity"  American Federation for Aging Research. CA, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Hsp90 Meeting. Switzerland - 2010.
  • "Folding and aggregation of the intrinsically disordered tau protein are selectively regulated by chaperones" Cold Springs Harbor Laboratories. NY, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Aging, Tau Protein and Dementias. Japan - 2010.
  • "The twists and turns of the intrinsically disordered tau protein" University of Kansas . KS, United States - 2010.
  • "Hsp90 cochaperone FKBP51 regulates tau and polymerizes microtubules"  Midwest Stress Response Meeting. IL, United States - 2010.
  • "Akt Clearance Through Hsp70 Regulation" Midwest Stress Response Meeting . IL, United States - 2010.
  • "Heat Shock Protein 27-mediated disruption of tau aggregation reduces intraneuronal tau inclusions and improves hippocampal plasticity" Midwest Stress Response Meeting. IL, United States - 2010.
  • "The Duality of Heat Shock Proteins in Tau Pathogenesis" Midwest Stress Response Meeting . IL, United States - 2010.
  • "FKBP51 regulates tau phosphorylation and degradation" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "The Effect of Hsp27 on Phosphorylated Tau" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Tau Processing Regulated through Hsp70 Manipulation by Methylene Blue" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Akts Effect on Chaperone Machinery and Related Clients" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "In vivo Administration of Heat Shock Protein 27 Variants; Implications for Tauopathies" . Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" International Research Conference for PSP. IL, United States - 2009.
  • "Emerging therapeutic strategies for Alzheimers disease and other neurological disorders" AFAR Florida Affiliate Program. FL, United States - 2009.
  • "Chemical manipulation of Hsp70 activity regulates tau processing" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" AFAR Grantee Conference. CA, United States - 2009.
  • "Tau and the chaperone interface" University of Florida . FL, United States - 2009.
  • "The unstructured protein tau as a chaperone client; a common vector for diseases of aging?" Cedars-Sinai Hospital at UCLA. CA, United States - 2009.
  • "Chemically tuning tau Fate with Chaperone Modulators" Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "Kinases and chaperones converge to regulate tau proteotoxicity" Cold Springs Harbor Laboratories. NY, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" University of Alabama at Birmingham. AL, United States - 2008.
  • "Akt and CHIP converge to regulate tau degradation" International Conference on Alzheimers Disease. IL, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" AFAR Conference. CA, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity" University of Michigan. MI, United States - 2008.
  • "" Akt and CHIP co-regulate tau through coordinated interactions" Midwest Stress Meeting . FL, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity"  Society for Neuroscience. DC, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers Disease"  Integrated Neuroscience Symposium. FL, United States - 2008.

Profile last modified on 01/17/2015