Login here to update your profile  
My Profile

Chad Dickey, Ph.D.
Associate Professor, Molecular Medicine Byrd Alzheimer's Institute

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

profile Image
Contacts
Email: cdickey@health.usf.edu
Phone: (813) 396-0639
Office: ALZ, 310
Mailing address 4001 E. Fletcher Ave. Rm# 338 USF Health Byrd Alzheimer's Insititute
Tampa, FL 33613
View My C.V.
 
Education
  • PHD, Pharmacology/Neuroscience, University Of South Florida, Tampa, United States - 2004.
  • B.S., Microbiology, University of South Florida, USA - 1998.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cellular and Molecular Biology, Neurodegenerative Disease, Neuroscience, Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine.
     
    Research Summary

    Human cells, including neurons in the brain, contain thousands of proteins that must work in concert to produce or perform our actions. Breathing, running, talking, remembering….all of these things are coordinated by thousands of proteins every second in our cells. This is what we work on in the lab. Hidden among those thousands of proteins is a group of sentinels called chaperones that, by definition, ensure propriety of all of these other proteins in the cell. Without chaperones, nothing would work properly. In fact, our lab and others have begun to show that many if not all of human disease is in some way affected by chaperones. There are approximately 150 chaperones in humans and each of these could be a drug target for human diseases. In particular, our lab has focused on a group of more than 15 neurological degenerative diseases collectively termed “tauopathies", the most common being Alzheimer’s disease. We have also seen our work move into glaucoma and depression.

     
    Links

    Lab Link:  http://health.usf.edu/medicine/molecularmedicine/dickey_lab/index.htm


    Selected Publications
  • Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 156(5) : 963-74, 2014.
  • Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. ACS chemical biology. 9(2) : 517-25, 2014.
  • Blair LJ, Zhang B, Dickey CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's research & therapy. 5(5) : 41, 2013.
  • Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52(32) : 5354-64, 2013.
  • Jinwal UK, Koren J, Dickey CA. Reconstructing the Hsp90/Tau Machine. Current enzyme inhibition. 9(1) : 41-45, 2013.
  • Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(22) : 9498-507, 2013.
  • Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. 74(5) : 367-74, 2013.
  • Lee DC, Ruiz CR, Lebson L, Selenica ML, Rizer J, Hunt JB, Rojiani R, Reid P, Kammath S, Nash K, Dickey CA, Gordon M, Morgan D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiology of aging. 34(6) : 1610-20, 2013.
  • Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS chemical neuroscience. 4(6) : 930-9, 2013.
  • Braswell K, Dickey CA, Jinwal UK. A commentary on: Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Experimental neurology. 241: 122-4, 2013.
  • Chiosis G, Dickey CA, Johnson JL. A global view of Hsp90 functions. Nature structural & molecular biology. 20(1) : 1-4, 2013.
  • Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4) : 1450-9, 2013.
  • Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neuro-degenerative diseases. 11(4) : 165-81, 2013.
  • Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation. 123(10) : 4158-69, 2013.
  • O'Leary JC, Zhang B, Koren J, Blair L, Dickey CA. The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. CNS & neurological disorders drug targets. 12(8) : 1157-62, 2013.
  • Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. The Journal of biological chemistry. 287(29) : 24814-20, 2012.
  • Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS chemical biology. 7(10) : 1677-86, 2012.
  • Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future medicinal chemistry. 4(13) : 1751-61, 2012.
  • Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of biological chemistry. 287(48) : 40661-9, 2012.
  • Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & biology. 19(11) : 1391-9, 2012.
  • Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. Journal of molecular biology. 421(4-5) : 653-61, 2012.
  • Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8(4) : 609-22, 2012.
  • Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PloS one. 7(4) : e35566, 2012.
  • Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PloS one. 6(12) : e27221, 2011.
  • Jinwal UK, Dickey CA. Cell-based assays for regulators of tau biology. Methods in molecular biology (Clifton, N.J.). 670: 93-108, 2011.
  • Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chemical communications (Cambridge, England). 47(1) : 529-31, 2011.
  • Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. Journal of natural products. 74(1) : 38-44, 2011.
  • Jinwal UK, Trotter JH, Abisambra JF, Koren J, Lawson LY, Vestal GD, O'Leary JC, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. The Journal of biological chemistry. 286(19) : 16976-83, 2011.
  • Koren J, Jinwal UK, Davey Z, Kiray J, Arulselvam K, Dickey CA. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular neurobiology. 44(1) : 65-70, 2011.
  • O'Leary JC, Koren J, Dickey CA. Neuronal life span versus health span: principles of natural selection at work in the degenerating brain. Journal of molecular neuroscience : MN. 45(3) : 467-72, 2011.
  • Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology. 411(3) : 614-32, 2011.
  • Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future medicinal chemistry. 3(12) : 1523-37, 2011.
  • Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. FKBP51 and FKBP52 in signaling and disease. Trends in endocrinology and metabolism: TEM. 22(12) : 481-90, 2011.
  • Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J, Dickey CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current neuropharmacology. 9(4) : 623-31, 2011.
  • Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(40) : 14413-23, 2011.
  • Voss K, Koren J, Dickey CA. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. The American journal of pathology. 179(5) : 2148-51, 2011.
  • O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PloS one. 6(9) : e24840, 2011.
  • Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee DC, Li Q, Szekeres K, Jinwal U, Koren J, Dickey CA, Gottschall PE, Morgan D, Gordon MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(29) : 9651-8, 2010.
  • Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of neuroinflammation. 7: 56, 2010.
  • Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of neuroscience methods. 194(1) : 144-53, 2010.
  • Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(2) : 591-9, 2010.
  • Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of biological chemistry. 285(4) : 2498-505, 2010.
  • Azorsa DO, Robeson RH, Frost D, Meec hoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, Hutton M, Stephan DA, Mousses S, Dunckley T. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation. BMC genomics. 11: 25, 2010.
  • Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46) : 15374-82, 2010.
  • Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of biological chemistry. 285(22) : 16798-805, 2010.
  • Jinwal UK, Koren J, O'Leary JC, Jones JR, Abisambra JF, Dickey CA. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and cellular pharmacology. 2(2) : 43-46, 2010.
  • O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5: 45, 2010.
  • Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(39) : 12079-88, 2009.
  • Koren J, Jinwal UK, Lee DC, Jones JR, Shults CL, Johnson AG, Anderson LJ, Dickey CA. Chaperone signalling complexes in Alzheimer's disease. Journal of cellular and molecular medicine. 13(4) : 619-30, 2009.
  • Dickey C, Kraft C, Jinwal U, Koren J, Johnson A, Anderson L, Lebson L, Lee D, Dickson D, de Silva R, Binder LI, Morgan D, Lewis J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. 174(1) : 228-38, 2009.
  • Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105(9) : 3622-7, 2008.
  • Dickey CA, Patterson C, Dickson D, Petrucelli L. Brain CHIP: removing the culprits in neurodegenerative disease. Trends in molecular medicine. 13(1) : 32-8, 2007.
  • Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Hutton M, Burrows F, Petrucelli L. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of clinical investigation. 117(3) : 648-58, 2007.
  • Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(39) : 10530-4, 2007.
  • Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(26) : 6985-96, 2006.
  • Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442(7105) : 916-9, 2006.
  • Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular neurodegeneration. 1: 6, 2006.
  • Dickey CA, Petrucelli L. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert opinion on therapeutic targets. 10(5) : 665-76, 2006.
  • Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB. Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD). Neurobiology of disease. 23(2) : 273-80, 2006.
  • Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(6) : 753-5, 2006.
  • Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(11) : 1549-51, 2005.
  • Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer research. 2(2) : 231-8, 2005.
  • Dickey CA, Gordon MN, Wilcock DM, Herber DL, Freeman MJ, Morgan D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. BMC neuroscience. 6: 7, 2005.
  • Dickey CA, De Mesquita DD, Morgan D, Pennypacker KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neuroscience letters. 366(1) : 10-4, 2004.
  • Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15(1) : 73-7, 2004.
  • Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski JF, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. Journal of neurochemistry. 88(2) : 434-42, 2004.
  • Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(12) : 5219-26, 2003.
  • Dickey CA, Morgan DG, Kudchodkar S, Weiner DB, Bai Y, Cao C, Gordon MN, Ugen KE. Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA and cell biology. 20(11) : 723-9, 2001.

  • Positions Held


    Memberships
  • American Society for Cell Biology (Member, 2007 - Present)
  • Society for Neuroscience (Member, 2002 - Present)
  • University of South Florida Alumni Association (Member, 1998 - Present)
  • Institute for Biomolecular Sciences (USF) (Member, 2000 - 2002)


  • Awards/Honors
  • Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Awards in Alzheimer's Disease ( - 2007)
  • Smith Award Recipient (Mayo Clinic Jacksonville - 2006)
  • ADRC Pilot Study Award Recipient ( - 2006)
  • University of South Florida Department of Pharmacology Stipend Award (University of South Florida - 2004)
  • Institute for Biomolecular Sciences Competitive Stipend Award ( University of South Florida - 2002)


  • Lectures
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" Medical College of Georgia. GA, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity" ASNTR. NC, United States - 2010.
  • "Exploiting the Diversity of the Chaperone Repertoire to Treat Tauopathies" International Conference on Frontotemporal Dementias. IN, United States - 2010.
  • "Rapid folding of tau by Hsc70 after microtubule destabilization is prevented by distinct phosphorylation events" ICAD. HI, United States - 2010.
  • "Functionally intact Hsp27 links tau aggregate disassembly to neuronal activity"  American Federation for Aging Research. CA, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Hsp90 Meeting. Switzerland - 2010.
  • "Folding and aggregation of the intrinsically disordered tau protein are selectively regulated by chaperones" Cold Springs Harbor Laboratories. NY, United States - 2010.
  • "Deconstructing the Hsp90/tau machine reveals important roles for FKBP51 and Cdc37" Aging, Tau Protein and Dementias. Japan - 2010.
  • "The twists and turns of the intrinsically disordered tau protein" University of Kansas . KS, United States - 2010.
  • "Hsp90 cochaperone FKBP51 regulates tau and polymerizes microtubules"  Midwest Stress Response Meeting. IL, United States - 2010.
  • "Akt Clearance Through Hsp70 Regulation" Midwest Stress Response Meeting . IL, United States - 2010.
  • "Heat Shock Protein 27-mediated disruption of tau aggregation reduces intraneuronal tau inclusions and improves hippocampal plasticity" Midwest Stress Response Meeting. IL, United States - 2010.
  • "The Duality of Heat Shock Proteins in Tau Pathogenesis" Midwest Stress Response Meeting . IL, United States - 2010.
  • "FKBP51 regulates tau phosphorylation and degradation" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "The Effect of Hsp27 on Phosphorylated Tau" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Tau Processing Regulated through Hsp70 Manipulation by Methylene Blue" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Akts Effect on Chaperone Machinery and Related Clients" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy" Midwest Stress Response and Molecular Chaperone Meeting. IL, United States - 2009.
  • "In vivo Administration of Heat Shock Protein 27 Variants; Implications for Tauopathies" . Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" International Research Conference for PSP. IL, United States - 2009.
  • "Emerging therapeutic strategies for Alzheimers disease and other neurological disorders" AFAR Florida Affiliate Program. FL, United States - 2009.
  • "Chemical manipulation of Hsp70 activity regulates tau processing" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" ICAD. Austria - 2009.
  • "The Hsp90 cochaperone, FKBP51, increases tau stability and polymerizes microtubules" AFAR Grantee Conference. CA, United States - 2009.
  • "Tau and the chaperone interface" University of Florida . FL, United States - 2009.
  • "The unstructured protein tau as a chaperone client; a common vector for diseases of aging?" Cedars-Sinai Hospital at UCLA. CA, United States - 2009.
  • "Chemically tuning tau Fate with Chaperone Modulators" Society for Neuroscience Annual Meeting. IL, United States - 2009.
  • "Kinases and chaperones converge to regulate tau proteotoxicity" Cold Springs Harbor Laboratories. NY, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" University of Alabama at Birmingham. AL, United States - 2008.
  • "Akt and CHIP converge to regulate tau degradation" International Conference on Alzheimers Disease. IL, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers disease" AFAR Conference. CA, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity" University of Michigan. MI, United States - 2008.
  • "" Akt and CHIP co-regulate tau through coordinated interactions" Midwest Stress Meeting . FL, United States - 2008.
  • "Chaperones and Kinases Converge to Regulate Tau Proteotoxicity"  Society for Neuroscience. DC, United States - 2008.
  • "Novel Chaperones and Modifiers of Tau Degradation in Alzheimers Disease"  Integrated Neuroscience Symposium. FL, United States - 2008.

  • Profile last modified on 01/17/2015