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Jaya Padmanabhan, PH.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assistant Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assistant Professor, Molecular Medicne, COM

Assistant Professor, Department of Molecular Medicine, USF College of Medicine

Assistant Professor/Courtesy, CMMB, College of Arts and Sciences

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Contacts
Email: jpadmana@health.usf.edu
Phone: (813) 396-0721
Office: ALZ, 440
Mailing address USF Health Byrd Alzheimer's Institute 4001 E. Fletcher Ave.
Tampa, FL 33613
View My C.V.
 
Education
  • PHD, Biochemistry, University Of Kerala, India - 1989.
  • M.Sc., Biochemistry, University of Kerala, , India - 1982.
  • B.Sc., Chemistry, University of Kerala, , India - 1980.
 
Interdisciplinary & Emerging Signature Programs
Allergy, Immunology & Infectious Disease, Biomedical Engineering & Nanomedicine, Neurodegenerative Disease.
 
Academic Philosophy

Conduct high quality research, mentor and educate future generation

 
Research Summary

Our lab is interested in understanding the molecular mechanisms involved in neurodegeneration and cancer, especially those linked to inflammation and cell cycle deregulation. While aberrant cell cycle activation promotes cell proliferation and tumor growth, these signaling events induce mitotic catastrophe and neurodegeneration in differentiated neurons. Recently, by conducting biochemical and molecular level analyses combined with proteomic approach, we showed that the Alzheimer’s disease (AD)-associated amyloid precursor protein (APP) plays a central role in cell cycle deregulation, which have implications in both neurodegeneration and cancer. We are currently analyzing the regulatory role of APP, secretases and calcium in AD and pancreatic cancer, expecting to elucidate if targeted inhibition of specific signaling events can effectively combat both diseases. The experimental systems include primary neurons, transformed cells, mouse models of AD, and tumor xenograft models.

 


Selected Publications

Positions Held
  • Associate Professor ( , Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2007 - 2008)
  • Assistant Professor/Courtesy Faculty (Department of Molecular Medicine, College of Medicine, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2006 - 2007)
  • Co-appointment as Assistant Professor (Department of Biochemistry and Molecular Biology, USF College of Medicine, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2004 - 2006)
  • Research Assistant Professor (Department of Biochemistry and Molecular Biology, University of South Florida 2002 - 2004)
  • Post Doctoral Staff Associate (Department of Pathology, Columbia University 1992 - 2001)
  • Post Doctoral Training (Division of Cardiology, Dept. of Medicine, Duke University 1991 - 1992)
  • Post Doctoral Training (Division of Geriatrics, Dept. of Medicine, Duke University 1988 - 1991)

Memberships
  • AACR (Member, 2012 - Present)
  • Society for Neuroscience (Member, 2008 - Present)
  • AAAS (Member, 2006 - Present)




Lectures
  • "Functional role of amyloid precursor protein in neurodegeneration and oncogenesis" Wayne State University. DE, United States - 2013.
  • "Cell cycle-dependent regulatory mechanisms in neurodegenration and Alzheimer’s disease" Dept Pathology and Cell Biology. FL, United States - 2013.
  • "SILAC-based proteomic approach to determine role of APP in Alzheimer’s disease" Proteomic Workshop, CMMB. FL, United States - 2013.
  • "SILAC-based proteomic approach to determine the impact of amyloid precursor protein expression in ne" SFN, New Orleans. FL, United States - 2012.
  • "Cell cycle-dependent regulatory mechanisms in neurodegenration and Alzheimer's disease" CMMB, USF. FL, United States - 2011.
  • "Molecular Mechanisms of Neurodegeneration" Department of Biochemistry, University of Kerala. India - 2011.
  • "Molecular Mechanisms of Neurodegenration in Alzheinmers disease" College of Medicine. FL, United States - 2010.
  • "Mitosis specific modifications in APP and tau: Implications in Alzheimers disease" USF-MINDS, Byrd Institute. FL, United States - 2009.
  • "Mitotic arrest induces APP and tau phosphorylation: Implications in AD" Molecular Medicine, USF. FL, United States - 2009.
  • "Signaling pathways in Alzheimers disease: Cell cycle and infammation-dependent mechanisms" Molecular Medicine, USF. FL, United States - 2009.
  • "Molecular Mechanisms of Neurodegeneration in Alzheimers Disease: Cell Cycle and Inflammation-Dependent Phosphorylation of APP and Tau" University of Alabama, Birmingham. AL, United States - 2009.
  • "Cell cycle dependent modifications in tau; Implications in Alzheimer's disease" Society for Neuroscience (SFN) . IL, United States - 2009.
  • "Molecular Mechanisms of Neurodegeneration in Alzheimers Disease: Cell Cycle and Inflammation-Dependent Phosphorylation of APP and Tau" Virginia Commonwealth University. VA, United States - 2008.
  • "Induction Of Tau Hyperphosphorylation By Inflammatory Proteins Associated With Alzheimer's Disease." University of South Florida. FL, United States - 2008.
  • "In vivo induction of Tau hyperphosphorylation by the inflammatory protein alpha 1-antichymotrypsin." University of South Florida. FL, United States - 2008.
  • "Inflammation Promotes Amyloid and Tau Pathology" UK-US Symposia: Byrd Alzheimers Institute. FL, United States - 2008.
  • "Cell cycle dependent phosphorylation and processing of amyloid precursor protein" University of South Florida. FL, United States - 2007.

Profile last modified on 03/27/2016