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Santo V. Nicosia, MD
Collaborator Member, Chemical Biology and Molecular Medicine
Distinguished University Professor, Pathology and cell Biology, USF Morsani School of Medicine
Member, Clinical Investigation Program
Professor, Interdisciplinary Oncology Program
Professor, Department of Obstetrics and Gynecology, College of Medicine

Primary Department: COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Distinguished Professor
COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Professor
DEPARTMENT OF ONCOLOGIC SCIENCES

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Contacts
Email: snicosia@health.usf.edu
Phone: (813) 974-0529
Office: SHR, 233A
Mailing address Pathology and Cell Biology MDC11 12901 Bruce B. Downs Blvd
Tampa, 33612
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Education
  • MSc, Pathology, University of Illinois at the Medical Center, USA - 1971.
  • MD, Medicine, Catholic University Of The Sacred Heart, Rome, Italy - 1967.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology, Women & Children's Health.
     
    Academic Philosophy

    An academic medical career is about service to the profession and the public through education, service and scientific discovery. I have tried to live by this overriding principle throughout my own career, first at the University of Pennsylvania Scho

     
    Research Summary

    Basic research: My basic research focuses on the regulation of cell growth and development in epithelial ovarian cancer (EOC), the most frequent and lethal gynecologic malignancy. Using a gene discovery approach, a number of molecules that regulate blood vessel formation (angiogenesis) and tissue architecture have been identified as significantly up-regulated or down-regulated in the main tissue component of EOC. Development of tumor structures is also being re-constructed and investigated in vitro utilizing recombinant cultures of EOC cells, blood vessel lining cells and fibroblasts grown in extracellular matrix. Translational research: My laboratory has shown that EOC development is regulated in a “Yin and Yang” fashion by factors that promote or suppress formation and growth of blood vessels, structures integral to tumor development. Some of these factors are dramatically elevated in the cyst fluid of EOCs consistent with the hypothesis that cytokines may play an important role in ovarian cancer related-angiogenesis and tumor progression. Translating these results to the bedside, the laboratory has shown that seriousness of clinical status correlates with urinary angiostatin, an angiogenesis inhibitor that independently discriminates EOC patients from volunteer controls and patients with benign ovarian masses. A second potential biomarker under current study is the protein product of the High Motility Group A2 gene, an architectural transcription factor that is over-expressed in high grade serous ovarian and tubal carcinomas. Discovery and validation of urinary biomarkers of EOC continue to be main aims of our funded research. Pathology: Over 35 years of experience in a variety of morphological methods including 12 years as the Director of the Electron Microscopy Core at the University of Pennsylvania School of Medicine in a NIH funded Program Project in Reproductive Biology and over 10 years as Scientific Director of the Experimental Pathology and Histology/Immunocytochemistry facilities at USF Health and the Comprehensive Moffitt Cancer Center.

     
    Links
    Personal Page:   http://www.linkedin.com/pub/santo-nicosia/33/89a/90b/


    Selected Publications
  • Zhang M, Xiang S, Joo HY, Wang L, et al. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell. (oi:10.1016/j.molcel.2014.04.028. Epub 2014 May 29.) : , 2014.
  • Lee JH, Cragun D, Thompson Z, Coppola D, Nicosia SV, et al. Association Between IHC and MSI Testing to Identify Mismatch Repair-Deficient Patients with Ovarian Cancer. Genet Test Mol Biomarkers.. : 229-35, 2014.
  • Dobrinski K, Esposito NN, Kruk PA, Hoffman M, Coppola D, Bai W, Zhang X, Nicosia SV. Procurement and Cytological Features of Human Fallopian Tube Fimbrial Cells by Ex-Vivo Imprinting and Washing. JASC (Published online: August 28, 2014). Journal American Society Cytopathology. : , 2014.
  • Malaney P, Nicosia SV, Davé V. One mouse, one patient paradigm: new avatars of personalized cancer therapy Cancer Letters. : , 2013.
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai. Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration The Journal of biological chemistry. : , 2013.
  • Xu CX, Xu M, Tan L, Yang H, Permuth-Wey J, Kruk PA, Wenham RM, Nicosia SV, Lancaster JM, Sellers TA, Cheng JQ. MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. The Journal of biological chemistry. 287(42) : 34970-8, 2012.
  • Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia SV, Khochbin S, Bepler G, Zhang X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. 7(9) : e44265, 2012.
  • Shan L, Chen YA, Davis L, Han G, Zhu W, Molina AD, Arango H, LaPolla JP, Hoffman MS, Sellers T, Kirby T, Nicosia SV, Sutphen R. Measurement of phospholipids may improve diagnostic accuracy in ovarian cancer. PloS one. 7(10) : e46846, 2012.
  • Coppola D, Nicosia SV, Doty A, Sellers TA, Lee JH, Fulp J, Thompson Z, Galeb S, McLaughlin J, Narod SA, Schildkraut J, Pal T. Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. Anticancer research. 32(11) : 4963-9, 2012.
  • Kasiappan R, Shen Z, Tse AK, Jinwal U, Tang J, Lungchukiet P, Sun Y, Kruk P, Nicosia SV, Zhang X, Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. The Journal of biological chemistry. 287(49) : 41297-309, 2012.
  • Khoor A, Byrd-Gloster AL, Nicosia SV. Expression of thyroid transcription factor-1 in malignant pleural effusions. Pathology oncology research : POR. 17(2) : 263-7, 2011.
  • Shen Z, Zhang X, Tang J, Kasiappan R, Jinwal U, Li P, Hann S, Nicosia SV, Wu J, Zhang X, Bai W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells. Molecular and cellular endocrinology. 338(1-2) : 58-67, 2011.
  • Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 30(19) : 2207-18, 2011.
  • Drenberg CD, Saunders BO, Wilbanks GD, Chen R, Nicosia RF, Kruk PA, Nicosia SV. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecologic oncology. 117(1) : 117-24, 2010.
  • Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J, Zhao RJ, Zhang X. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Frontiers in bioscience (Elite edition). 2: 221-30, 2010.
  • Drenberg CD, Livingston S, Chen R, Kruk PA, Nicosia SV. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstetrics and gynecology international. 2009: 730739, 2009.
  • Permuth-Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee JH, Sutphen R, Schildkraut J, Narod S, Parker A, Coppola D, Sellers T, Pal T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(1) : 28-34, 2009.
  • Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 28(3) : 445-60, 2009.
  • Ma Q, Fu W, Li P, Nicosia SV, Jenster G, Zhang X, Bai W. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Molecular endocrinology (Baltimore, Md.). 23(2) : 213-25, 2009.
  • Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. The Journal of biological chemistry. 284(21) : 13987-4000, 2009.
  • Guo JP, Shu SK, He L, Lee YC, Kruk PA, Grenman S, Nicosia SV, Mor G, Schell MJ, Coppola D, Cheng JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. The American journal of pathology. 175(1) : 324-33, 2009.
  • Anderson NS, Turner L, Livingston S, Chen R, Nicosia SV, Kruk PA. Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation. Journal of ovarian research. 2: 16, 2009.
  • Anderson NS, Bermudez Y, Badgwell D, Chen R, Nicosia SV, Bast RC, Kruk PA. Urinary levels of Bcl-2 are elevated in ovarian cancer patients. Gynecologic oncology. 112(1) : 60-7, 2009.
  • Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer research. 68(2) : 425-33, 2008.
  • Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature cell biology. 9(11) : 1253-62, 2007.
  • Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. The Journal of biological chemistry. 282(15) : 10981-7, 2007.
  • Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao C, Nicosia SV, Golemis EA, Liu W, Coppola D, Brem SS, Testa JR, Cheng JQ. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Molecular and cellular biology. 27(6) : 2103-19, 2007.
  • Bao J, Cao C, Zhang X, Jiang F, Nicosia SV, Bai W. Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65. Molecular and cellular biology. 27(4) : 1321-33, 2007.
  • Garbuzova-Davis S, Haller E, Saporta S, Kolomey I, Nicosia SV, Sanberg PR. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain research. 1157: 126-37, 2007.
  • Bermudez Y, Yang H, Saunders BO, Cheng JQ, Nicosia SV, Kruk PA. VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent. Gynecologic oncology. 106(3) : 526-37, 2007.
  • Zhang X, Nicosia SV, Bai W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Current cancer drug targets. 6(3) : 229-44, 2006.
  • Yang H, He L, Kruk P, Nicosia SV, Cheng JQ. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. International journal of cancer. Journal international du cancer. 119(10) : 2304-12, 2006.
  • Zhang X, Li P, Bao J, Nicosia SV, Wang H, Enkemann SA, Bai W. Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. The Journal of biological chemistry. 280(42) : 35458-68, 2005.
  • Kim D, Dan HC, Park S, Yang L, Liu Q, Kaneko S, Ning J, He L, Yang H, Sun M, Nicosia SV, Cheng JQ. AKT/PKB signaling mechanisms in cancer and chemoresistance. Frontiers in bioscience : a journal and virtual library. 10: 975-87, 2005.
  • Zhang X, Jiang F, Li P, Li C, Ma Q, Nicosia SV, Bai W. Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clinical cancer research : an official journal of the American Association for Cancer Research. 11(1) : 323-8, 2005.
  • Yang Y, Hou H, Haller EM, Nicosia SV, Bai W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. The EMBO journal. 24(5) : 1021-32, 2005.
  • Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ. ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. The Journal of biological chemistry. 280(22) : 21483-90, 2005.
  • Cheng JQ, Lindsley CW, Cheng GZ, Yang H, Nicosia SV. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene. 24(50) : 7482-92, 2005.
  • Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. The Journal of biological chemistry. 280(47) : 38932-41, 2005.
  • Reed J, Hakam A, Nicosia SV, Coppola D. Significance of Fas receptor protein expression in epithelial ovarian cancer. Human pathology. 36(9) : 971-6, 2005.
  • Jiang F, Bao J, Li P, Nicosia SV, Bai W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. The Journal of biological chemistry. 279(51) : 53213-21, 2004.
  • Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. The Journal of biological chemistry. 279(50) : 52175-82, 2004.
  • Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer research. 64(13) : 4394-9, 2004.
  • Li P, Li C, Zhao X, Zhang X, Nicosia SV, Bai W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. The Journal of biological chemistry. 279(24) : 25260-7, 2004.
  • Nicosia SV, Wilbanks GD, Saunders B, Mayer J, Cardosi RJ, Kruk PA, Cheng J, Bai W, Coppola D, Fiorica J. Cytology of human ovarian surface epithelial brushings. Cancer. 102(1) : 1-10, 2004.
  • Yang H, Ou CC, Feldman RI, Nicosia SV, Kruk PA, Cheng JQ. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer research. 64(2) : 463-7, 2004.
  • Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene. 23(3) : 706-15, 2004.
  • Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. 279(7) : 5405-12, 2004.
  • Jiang F, Li P, Fornace AJ, Nicosia SV, Bai W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. The Journal of biological chemistry. 278(48) : 48030-40, 2003.
  • Tsibris JC, Maas S, Segars JH, Nicosia SV, Enkemann SA, O'Brien WF, Spellacy WN. New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochemical and biophysical research communications. 312(1) : 249-54, 2003.
  • Nicosia SV, Bai W, Cheng JQ, Coppola D, Kruk PA. Oncogenic pathways implicated in ovarian epithelial cancer. Hematology/oncology clinics of North America. 17(4) : 927-43, 2003.
  • Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. The Journal of biological chemistry. 278(44) : 42992-3000, 2003.
  • Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. The Journal of biological chemistry. 278(26) : 23432-40, 2003.
  • Gritsko TM, Coppola D, Paciga JE, Yang L, Sun M, Shelley SA, Fiorica JV, Nicosia SV, Cheng JQ. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4) : 1420-6, 2003.
  • Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. The Journal of biological chemistry. 277(33) : 29973-82, 2002.
  • Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. The Journal of biological chemistry. 277(38) : 35364-70, 2002.
  • Kaneko S, Feldman RI, Yu L, Wu Z, Gritsko T, Shelley SA, Nicosia SV, Nobori T, Cheng JQ. Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter. The Journal of biological chemistry. 277(26) : 23230-5, 2002.
  • Naidu KA, Tang JL, Naidu KA, Prockop LD, Nicosia SV, Coppola D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression. Journal of neuro-oncology. 54(1) : 15-22, 2001.
  • Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer research. 61(16) : 5985-91, 2001.
  • Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma XL, Shelley SA, Jove R, Tsichlis PN, Nicosia SV, Cheng JQ. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. The American journal of pathology. 159(2) : 431-7, 2001.
  • Li P, Nicosia SV, Bai W. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. The Journal of biological chemistry. 276(23) : 20444-50, 2001.
  • Adnane J, Jackson RJ, Nicosia SV, Cantor AB, Pledger WJ, Sebti SM. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene. 19(47) : 5338-47, 2000.
  • Lee H, Jiang F, Wang Q, Nicosia SV, Yang J, Su B, Bai W. MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Molecular endocrinology (Baltimore, Md.). 14(11) : 1882-96, 2000.
  • Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene. 19(19) : 2324-30, 2000.
  • Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Molecular and cellular biology. 20(1) : 139-48, 2000.
  • Diaz JI, Mora LB, Austin PF, Muro-Cacho CA, Cantor AB, Nicosia SV, Pow-Sang JM. Predictability of PSA failure in prostate cancer by computerized cytometric assessment of tumoral cell proliferation. Urology. 53(5) : 931-8, 1999.
  • Hazelton D, Nicosia RF, Nicosia SV. Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy. Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4) : 823-9, 1999.
  • Coppola D, Saunders B, Fu L, Mao W, Nicosia SV. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer research. 59(13) : 3264-70, 1999.
  • Hakam A, Yeatman TJ, Lu L, Mora L, Marcet G, Nicosia SV, Karl RC, Coppola D. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Human pathology. 30(10) : 1128-33, 1999.
  • Coppola D, Catalano E, Nicosia SV. Significance of p53 and Bcl-2 Protein Expression in Human Breast Ductal Carcinoma. Cancer control : journal of the Moffitt Cancer Center. 6(2) : 181-187, 1999.
  • Cavanagh D, Fiorica JV, Hoffman MS, Durfee J, Nicosia SV. Adenocarcinoma of the Endometrium: An Institutional Review. Cancer control : journal of the Moffitt Cancer Center. 6(4) : 354-360, 1999.
  • Cox CE, Pendas S, Ku NN, Reintgen DS, Greenberg HS, Nicosia SV. Local recurrence of breast cancer after cytological evaluation of lumpectomy margins. The American surgeon. 64(6) : 533-7; discussion 537-8, 1998.
  • Coppola D, Lu L, Fruehauf JP, Kyshtoobayeva A, Karl RC, Nicosia SV, Yeatman TJ. Analysis of p53, p21WAF1, and TGF-beta1 in human ductal adenocarcinoma of the pancreas: TGF-beta1 protein expression predicts longer survival. American journal of clinical pathology. 110(1) : 16-23, 1998.
  • Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer research. 58(14) : 2973-7, 1998.
  • Porter KB, Tsibris JC, Porter GW, Fuchs-Young R, Nicosia SV, O'Brien WF, Spellacy WN. Effects of raloxifene in a guinea pig model for leiomyomas. American journal of obstetrics and gynecology. 179(5) : 1283-7, 1998.
  • Coppola D, Hyacinthe M, Fu L, Cantor AB, Karl R, Marcet J, Cooper DL, Nicosia SV, Cooper HS. CD44V6 expression in human colorectal carcinoma. Human pathology. 29(6) : 627-35, 1998.
  • Cowper SE, Fiorica JV, Haller EM, Nicosia SV, Jones M, Coppola D. Papillary Squamous Cell Carcinoma. Cancer control : journal of the Moffitt Cancer Center. 5(2) : 179-1183, 1998.
  • Coppola D, Fu L, Nicosia SV, Kounelis S, Jones M. Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma. Human pathology. 29(5) : 455-62, 1998.
  • Cox CE, Hyacinthe M, Gonzalez RJ, Lyman G, Reintgen D, Ku NN, Miller MS, Greenberg H, Nicosia SV. Cytologic evaluation of lumpectomy margins in patients with ductal carcinoma in situ: clinical outcome. Annals of surgical oncology. 4(8) : 644-9, 1997.
  • Ku NN, Mela N, Cox CE, Reintgen DS, Nicosia SV. Diagnostic Pitfalls in Aspiration Biopsy Cytology of Papillary Breast Lesions. Cancer control : journal of the Moffitt Cancer Center. 4(5) : 451-457, 1997.
  • Mora LB, Nicosia SV, Pow-Sang JM, Ku NK, Diaz JI, Lockhart J, Einstein A. Ancillary techniques in the followup of transitional cell carcinoma: a comparison of cytology, histology and deoxyribonucleic acid image analysis cytometry in 91 patients. The Journal of urology. 156(1) : 49-54; discussion 54-5, 1996.
  • Diaz JI, Nicosia SV, Szakacs J, Powsang J, Saba HI. Metastatic seminoma simulating malignant lymphoma in an HIV infected hemophiliac. Leukemia & lymphoma. 23(1-2) : 165-71, 1996.
  • Pierro E, Nicosia SV, Saunders B, Fultz CB, Nicosia RF, Mancuso S. Influence of growth factors on proliferation and morphogenesis of rabbit ovarian mesothelial cells in vitro. Biology of reproduction. 54(3) : 660-9, 1996.
  • Pinelli DM, Fiorica JV, Roberts WS, Hoffman MS, Nicosia SV, Cavanagh D. Chemotherapy plus sequential hormonal therapy for advanced and recurrent endometrial carcinoma: a phase II study. Gynecologic oncology. 60(3) : 462-7, 1996.
  • Nicosia SV. Ovarian and Peritoneal Borderline Neoplasms: Histopathology, Diagnostic Pitfalls, and Prognostication. Cancer control : journal of the Moffitt Cancer Center. 3(1) : 58-65, 1996.
  • Morgan MB, Nicosia SV, Shabaik A, Mela N, Cox CC. Fine Needle Aspiration Biopsy Cytology of Argyrophilic Carcinoma (Carcinoid Tumor) of the Breast. Cancer control : journal of the Moffitt Cancer Center. 2(3) : 245-249, 1995.
  • Nicosia SV, Sowinski JM. Cytological analysis of the urn cell complex of Sipunculus nudus before and after serum-induced secretion. The Biological bulletin. 188(3) : 267-80, 1995.
  • Cox CE, Reintgen DS, Nicosia SV, Ku NN, Baekey P, Carey LC. Analysis of residual cancer after diagnostic breast biopsy: an argument for fine-needle aspiration cytology. Annals of surgical oncology. 2(3) : 201-6, 1995.
  • Porter KB, Tsibris JC, Nicosia SV, Murphy JM, O'Brien WF, Rao PS, Spellacy WN. Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect? Biology of reproduction. 52(4) : 824-32, 1995.
  • Giacomini G, Nicosia SV, Saunders BO, Fultz C, Sun X, Jasonni VM. Ovarian mesothelial and extramesothelial cells in interactive culture. In vitro cellular & developmental biology. Animal. 31(4) : 300-9, 1995.
  • Ku NN, Mela NJ, Fiorica JV, Cox CE, Reintgen DS, Greenberg HM, Clark RA, Nicosia SV. Role of fine needle aspiration cytology after lumpectomy. Acta cytologica. 38(6) : 927-32, 1994.
  • Nicosia RF, Nicosia SV, Smith M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. The American journal of pathology. 145(5) : 1023-9, 1994.
  • Nicosia SV. The Role of Fine Needle Aspiration Biopsy in Gynecologic Oncology. Cancer control : journal of the Moffitt Cancer Center. 1(2) : 160-165, 1994.
  • Ku NN, Nicosia SV, Reintgen DS, Cox CE. Role of Cytopathology in the Management of Breast Cancer. Cancer control : journal of the Moffitt Cancer Center. 1(4) : 402-408, 1994.
  • Nicosia SV, Narconis RJ, Saunders BO. Influence of a corpus luteum tissue extract on rabbit ovarian mesothelial cells. Scanning microscopy. 8(2) : 393-401; discussion 401-2, 1994.
  • Barton DP, Blanchard DK, Wells AF, Nicosia SV, Roberts WS, Cavanagh D, Djeu JY. Expression of interleukin-2 receptor alpha (IL-2R alpha) mRNA and protein in advanced epithelial ovarian cancer. Anticancer Research. 14(3A) : 761-72, 1993.
  • Setrakian S, Oliveros-Saunders B, Nicosia SV. Growth stimulation of ovarian and extraovarian mesothelial cells by corpus luteum extract. In vitro cellular & developmental biology. Animal. 29A(11) : 879-83, 1993.
  • Nicosia SV, Williams JA, Horowitz SA, Ku NN, Shabaik AS, Mela N, Reintgen DS, Cox CE. Fine needle aspiration biopsy of palpable breast lesions. Review and statistical analysis of 1875 cases. Surgical oncology. 2(3) : 145-60, 1993.
  • Barton DP, Blanchard DK, Michelini-Norris B, Nicosia SV, Cavanagh D, Djeu JY. High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer. Blood. 81(2) : 424-9, 1993.
  • Shabaik AS, Pow-Sang JM, Lockhart J, Nicosia SV. Role of DNA image cytometry in the follow-up of patients with urinary tract transitional cell carcinoma. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology. 15(2) : 115-23, 1993.
  • Gleeson NC, Nicosia SV, Mark JE, Hoffman MS, Cavanagh D. Abdominal wall metastases from ovarian cancer after laparoscopy. American journal of obstetrics and gynecology. 169(3) : 522-3, 1993.
  • Mourad WA, Erkman-Balis B, Livingston S, Shoukri M, Cox CE, Nicosia SV, Rowlands DT. Argyrophilic nucleolar organizer regions in breast carcinoma. Correlation with DNA flow cytometry, histopathology, and lymph node status. Cancer. 69(7) : 1739-44, 1992.
  • Cox CE, Ku NN, Reintgen DS, Greenberg HM, Nicosia SV, Wangensteen S. Touch preparation cytology of breast lumpectomy margins with histologic correlation. Archives of surgery (Chicago, Ill. : 1960). 126(4) : 490-3, 1991.
  • Brown HK, Stoll BS, Nicosia SV, Fiorica JV, Hambley PS, Clarke LP, Silbiger ML. Uterine junctional zone: correlation between histologic findings and MR imaging. Radiology. 179(2) : 409-13, 1991.
  • Nicosia SV, Narconis RJ, Saunders BO. Regulation and temporal sequence of surface epithelium morphogenesis in the postovulatory rabbit ovary. Progress in clinical and biological research. 296: 111-9, 1989.
  • Quinn SF, Bodne DJ, Clark RA, Karl RC, Nicosia SV. Upper abdomen: CT findings following partial hepatectomy. Radiology. 168(3) : 879-80, 1988.
  • Bodne D, Quinn SF, Nicosia SV, King PA, Clark RA. Comparison study of the efficacy of the 22-gauge Vacu-Cut needle for biopsy. AJR. American journal of roentgenology. 150(2) : 468-9, 1988.
  • Haas GG, Nicosia SV, Wolf DP. Influence of estrogens on vascular transudation and mucus production in the rabbit endocervix. Fertility and sterility. 48(6) : 1036-42, 1987.
  • Nicosia SV. The aging ovary. The Medical clinics of North America. 71(1) : 1-9, 1987.
  • Nicosia SV. Pathology of the oviducts and embryonal remnants. Obstetrics and gynecology annual. 14: 382-410, 1985.
  • Matus-Ridley M, Nicosia SV, Meadows AT. Gonadal effects of cancer therapy in boys. Cancer. 55(10) : 2353-63, 1985.
  • Nicosia SV, Matus-Ridley M, Meadows AT. Gonadal effects of cancer therapy in girls. Cancer. 55(10) : 2364-72, 1985.
  • Osterholzer HO, Streibel EJ, Nicosia SV. Growth effects of protein hormones on cultured rabbit ovarian surface epithelial cells. Biology of reproduction. 33(1) : 247-58, 1985.
  • Osterholzer HO, Johnson JH, Nicosia SV. An autoradiographic study of rabbit ovarian surface epithelium before and after ovulation. Biology of reproduction. 33(3) : 729-38, 1985.
  • Nicosia SV, Johnson JH, Streibel EJ. Growth characteristics of rabbit ovarian mesothelial (surface epithelial) cells. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 4(1) : 58-74, 1985.
  • Chilton BS, Nicosia SV, Sowinski JM. Enrichment of lysozyme-containing cells from the rabbit endocervix by unit gravity sedimentation. The Anatomical record. 209(4) : 481-9, 1984.
  • Nicosia SV, Sowinski JM, Chilton BS, Streibel EJ. Ultrastructural immunocytochemical localization of lysozyme in the mucociliary epithelium of the rabbit endocervix in different hormonal states. The Anatomical record. 209(4) : 469-80, 1984.
  • Nicosia SV, Johnson JH, Streibel EJ. Morphology of rabbit endocervical mucosa after mating. Scanning electron microscopy. (Pt 3) : 1321-8, 1984.
  • Nicosia SV, Johnson JH. Surface morphology of ovarian mesothelium (surface epithelium) and of other pelvic and extrapelvic mesothelial sites in the rabbit. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 3(3) : 249-60, 1984.
  • Nicosia SV, Johnson JH, Streibel EJ. Isolation and ultrastructure of rabbit ovarian mesothelium (surface epithelium). International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 3(4) : 348-60, 1984.
  • Nicosia SV, Johnson JH. Effects of two international union against cancer standard reference samples of asbestos on cultured rabbit ovarian surface epithelial cells. Scanning electron microscopy. (Pt 3) : 1329-36, 1984.
  • Chilton BS, Nicosia SV, Lyttle CR. Cytosol and nuclear estrogen and progesterone receptors in the rabbit endocervix. Journal of steroid biochemistry. 17(4) : 363-9, 1982.
  • Chilton BS, Kennedy JR, Nicosia SV. Isolation of basal and mucous cell populations from rabbit trachea. The American review of respiratory disease. 124(6) : 723-7, 1981.
  • Chilton BS, Nicosia SV, Sowinski JM, Wolf DP. Isolation and characterization of rabbit endocervical cells. The Journal of cell biology. 86(1) : 172-80, 1980.
  • Chilton BS, Nicosia SV, Laufer MR. Effect of estradiol-17 beta on endocervical cytodifferentiation and glycoprotein biosynthesis in the ovariectomized rabbit. Biology of reproduction. 23(3) : 677-86, 1980.
  • Nicosia SV, Tojo R. Morphogenetic reaggregation and luteinization of mouse preantral follicle cells. The American journal of anatomy. 156(3) : 401-27, 1979.
  • Nicosia SV. Lectin-Induced Mucus Release in the Urn Cell Complex of the Marine Invertebrate Sipunculus nudus (Linnaeus). Science (New York, N.Y.). 206(4419) : 698-700, 1979.
  • Wolf DP, Nicosia SV, Hamada M. Premature cortical granule loss does not prevent sperm penetration of mouse eggs. Developmental biology. 71(1) : 22-32, 1979.
  • Nicosia SV, Wolf DP, Inoue M. Cortical granule distribution and cell surface characteristics in mouse eggs. Developmental biology. 57(1) : 56-74, 1977.
  • Nicosia SV, Evangelista I, Batta SK. Rabbit ovarian follicles. I. Isolation technique and characterization at different stages of development. Biology of reproduction. 13(4) : 423-47, 1975.
  • Schenker JG, Nicosia SV, Polishuk WZ, Garcia CR. An in vitro fibroblast-enriched sponge preparation for induction of intrauterine adhesions. Israel journal of medical sciences. 11(8) : 849-51, 1975.
  • Nicosia SV, Mikhail G. Cumuli oophori in tissue culture: hormone production, ultrastructure, and morphometry of early luteinization. Fertility and sterility. 26(5) : 427-48, 1975.
  • Nicosia SV. Luteinization of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. I. Growth characteristics and progestin biosynthesis. Fertility and sterility. 23(11) : 791-801, 1972.
  • Nicosia SV. Luteinization of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. II. Histochemical and electron microscopic observations. Fertility and sterility. 23(11) : 802-16, 1972.
  • Presman D, Ross LS, Nicosia SV. Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. The Journal of urology. 107(1) : 149-53, 1972.
  • Nicosia SV. [Anatomo-clinical considerations on a case of utero-ureteral fibroleiomyomatosis] Rivista di anatomia patologica e di oncologia. 31(6) : 686-705, 1967.

  • Positions Held
  • Chairman (Department of Pathology and Cell Biology, College of Medicine, University of South Florida 2006 - 2012)
  • Professor (Department of Pathology, College of Medicine, University of South Florida 1984 - 2006)
  • Director (Histopathology Core Laboratory, NCI-Comprehensive H. Lee Moffitt Cancer Center and University of South Florida-College of Medicine 2002 - 2002)


  • Memberships
  • American Association for Cancer Research (Member, 2002 - Present)
  • College of American Pathologists (Member, 1995 - Present)
  • American Society of Cytopathology (Member, 1982 - Present)
  • International Society of Gynecological Pathologists (Member, 1981 - Present)
  • American Society for Cell Biology (Member, 1977 - Present)
  • United States and Canadian Academy of Pathology (Member, 1972 - Present)
  • Hillsborough County Medical Association (Member, 2005 - 2010)
  • Florida Society of Pathologists (Member, 2005 - 2010)
  • Society for In Vitro Biology (Member, 1971 - 2006)


  • Awards/Honors
  • Best Doctors in America: Southeast Region ( - 2008)
  • America's Top Physicians (Consumer Research Council of America - 2007)
  • Distinguished USF Professor (University of South Florida - 2007)
  • President (Pathology History Society, United States-Canadian Academy of Pathology - 2005)
  • Hill Lecturer (American Association of Clinician Scientists - 2001)
  • New Frontiers in Cytology Research (American Society of Cytopathology - 1998)
  • James A. Reagan Memorial Lecturer (Case Western Reserve University - 1994)
  • Keynote Speaker - Lectio Magistralis (Congress of Italian Society of Obsterics and Gynecology - 1990)
  • Honorary Member (Sociedad de Obstetricia y Gynecologia de Rosario - Argentina - 1979)


  • Patents & Licensing
  • HMGA2 as a Biomarker of Epithelial Ovarian Cancer - Filed (Nicosia, Santo - 2013)
  • Guinea Pig Model for Leiomyoma Development (US94B34 WO/CP - 2008)


  • Lectures
  • ""Intraoperative Imprint Cytology: A Method for Rapid Assessment of FallopianTube Pathology and Molecular Signature"." Early Ovarian Cancer Symposium. USC/Norris Comprehensive Cancer Center, Los Angeles . CA, United States - 2009.
  • "Brown Memorial Lecture on Frontiers of Ovarian Cancer" nnual Meeting of Association of Clinical Scientists, 129th Meeting of the Association of Clinical Scientists, Tampa, . FL, United States - 2009.
  • ""George Papanicolaou: The origin of diagnostic cytology and cancer screening"" 12th Annual Educational Forum of the American Foundation for Greek Language and Culture (AFGLC).. FL, United States - 2007.
  • ""Historical Perspectives on Ovarian Cancer"" Nelly Auersperg Symposium, University of British Columbia Cancer Center. Canada - 2007.
  • ""Anatomical Waxes in 18th Century Italy" History of Pathology Symposium" 95th Annual Meeting United States Canadian Academy of Pathology. GA, United States - 2006.
  • ""Ovarian Epithelial CancerPathobiology program at the University of South Florida College of Medicine" " 1st Top Executive Italy-US Pharma Meeting. Italian Embassy. DC, United States - 2006.
  • ""Angioregulators as Markers of Ovarian Epithelial Cancer" 1st Italy Americans Medical Congress: Project Florida Congress Center" Miller School of Medicine University of Miami. FL, United States - 2005.

  • Profile last modified on 10/21/2014