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Santo V. Nicosia, MD




Collaborator Member, Chemical Biology and Molecular Medicine

Distinguished University Professor, Pathology and cell Biology, USF Morsani School of Medicine

Member, Clinical Investigation Program

Professor, Interdisciplinary Oncology Program

Professor, Department of Obstetrics and Gynecology, College of Medicine

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Email: snicosia@health.usf.edu
Phone: (813) 974-0529
Office: SHR, 233A
Mailing address Pathology and Cell Biology MDC11 12901 Bruce B. Downs Blvd
Tampa, 33612
View My C.V.
  • MSc, Pathology, University of Illinois at the Medical Center, USA - 1971.
  • MD, Medicine, Catholic University Of The Sacred Heart, Rome, Italy - 1967.
Interdisciplinary & Emerging Signature Programs
Cancer Biology, Women & Children's Health.
Academic Philosophy

An academic medical career is about service to the profession and the public through education, service and scientific discovery. I have tried to live by this overriding principle throughout my own career, first at the University of Pennsylvania Scho

Research Summary

Basic research: My basic research focuses on the regulation of cell growth and development in epithelial ovarian cancer (EOC), the most frequent and lethal gynecologic malignancy. Using a gene discovery approach, a number of molecules that regulate blood vessel formation (angiogenesis) and tissue architecture have been identified as significantly up-regulated or down-regulated in the main tissue component of EOC. Development of tumor structures is also being re-constructed and investigated in vitro utilizing recombinant cultures of EOC cells, blood vessel lining cells and fibroblasts grown in extracellular matrix. Translational research: My laboratory has shown that EOC development is regulated in a “Yin and Yang” fashion by factors that promote or suppress formation and growth of blood vessels, structures integral to tumor development. Some of these factors are dramatically elevated in the cyst fluid of EOCs consistent with the hypothesis that cytokines may play an important role in ovarian cancer related-angiogenesis and tumor progression. Translating these results to the bedside, the laboratory has shown that seriousness of clinical status correlates with urinary angiostatin, an angiogenesis inhibitor that independently discriminates EOC patients from volunteer controls and patients with benign ovarian masses. A second potential biomarker under current study is the protein product of the High Motility Group A2 gene, an architectural transcription factor that is over-expressed in high grade serous ovarian and tubal carcinomas. Discovery and validation of urinary biomarkers of EOC continue to be main aims of our funded research. Pathology: Over 35 years of experience in a variety of morphological methods including 12 years as the Director of the Electron Microscopy Core at the University of Pennsylvania School of Medicine in a NIH funded Program Project in Reproductive Biology and over 10 years as Scientific Director of the Experimental Pathology and Histology/Immunocytochemistry facilities at USF Health and the Comprehensive Moffitt Cancer Center.

Personal Page:   http://www.linkedin.com/pub/santo-nicosia/33/89a/90b/

Selected Publications

Positions Held
  • Chairman (Department of Pathology and Cell Biology, College of Medicine, University of South Florida 2006 - 2012)
  • Professor (Department of Pathology, College of Medicine, University of South Florida 1984 - 2006)
  • Director (Histopathology Core Laboratory, NCI-Comprehensive H. Lee Moffitt Cancer Center and University of South Florida-College of Medicine 2002 - 2002)

  • American Association for Cancer Research (Member, 2002 - Present)
  • College of American Pathologists (Member, 1995 - Present)
  • American Society of Cytopathology (Member, 1982 - Present)
  • International Society of Gynecological Pathologists (Member, 1981 - Present)
  • American Society for Cell Biology (Member, 1977 - Present)
  • United States and Canadian Academy of Pathology (Member, 1972 - Present)
  • Hillsborough County Medical Association (Member, 2005 - 2010)
  • Florida Society of Pathologists (Member, 2005 - 2010)
  • Society for In Vitro Biology (Member, 1971 - 2006)

  • Best Doctors in America: Southeast Region ( - 2008)
  • America's Top Physicians (Consumer Research Council of America - 2007)
  • Distinguished USF Professor (University of South Florida - 2007)
  • President (Pathology History Society, United States-Canadian Academy of Pathology - 2005)
  • Hill Lecturer (American Association of Clinician Scientists - 2001)
  • New Frontiers in Cytology Research (American Society of Cytopathology - 1998)
  • James A. Reagan Memorial Lecturer (Case Western Reserve University - 1994)
  • Keynote Speaker - Lectio Magistralis (Congress of Italian Society of Obsterics and Gynecology - 1990)
  • Honorary Member (Sociedad de Obstetricia y Gynecologia de Rosario - Argentina - 1979)

Patents & Licensing
  • HMGA2 as a Biomarker of Epithelial Ovarian Cancer - Filed (Nicosia, Santo - 2013)
  • Guinea Pig Model for Leiomyoma Development (US94B34 WO/CP - 2008)

  • ""Intraoperative Imprint Cytology: A Method for Rapid Assessment of FallopianTube Pathology and Molecular Signature"." Early Ovarian Cancer Symposium. USC/Norris Comprehensive Cancer Center, Los Angeles . CA, United States - 2009.
  • "Brown Memorial Lecture on Frontiers of Ovarian Cancer" nnual Meeting of Association of Clinical Scientists, 129th Meeting of the Association of Clinical Scientists, Tampa, . FL, United States - 2009.
  • ""George Papanicolaou: The origin of diagnostic cytology and cancer screening"" 12th Annual Educational Forum of the American Foundation for Greek Language and Culture (AFGLC).. FL, United States - 2007.
  • ""Historical Perspectives on Ovarian Cancer"" Nelly Auersperg Symposium, University of British Columbia Cancer Center. Canada - 2007.
  • ""Anatomical Waxes in 18th Century Italy" History of Pathology Symposium" 95th Annual Meeting United States Canadian Academy of Pathology. GA, United States - 2006.
  • ""Ovarian Epithelial CancerPathobiology program at the University of South Florida College of Medicine" " 1st Top Executive Italy-US Pharma Meeting. Italian Embassy. DC, United States - 2006.
  • ""Angioregulators as Markers of Ovarian Epithelial Cancer" 1st Italy Americans Medical Congress: Project Florida Congress Center" Miller School of Medicine University of Miami. FL, United States - 2005.

Profile last modified on 10/21/2014