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Santo V. Nicosia,  MD
Collaborator Member, Chemical Biology and Molecular Medicine
Distinguished University Professor, Pathology and cell Biology, USF Morsani School of Medicine
Member, Clinical Investigation Program
Professor, Interdisciplinary Oncology Program
Professor, Department of Obstetrics and Gynecology, College of Medicine


Distinguished Professor


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Email: snicosia@health.usf.edu
Phone: (813) 974-0529
Office: SHR, 233A
Mailing address Pathology and Cell Biology MDC11 12901 Bruce B. Downs Blvd
Tampa, 33612
View My C. V.
  • MSc, Pathology, University of Illinois at the Medical Center ,USA - 1971.
  • MD, Medicine, Catholic University Of The Sacred Heart , Rome, Italy - 1967.
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology, Women & Children's Health.
    Academic Philosophy

    An academic medical career is about service to the profession and the public through education, service and scientific discovery. I have tried to live by this overriding principle throughout my own career, first at the University of Pennsylvania Scho

    Research Summary

    Basic research: My basic research focuses on the regulation of cell growth and development in epithelial ovarian cancer (EOC), the most frequent and lethal gynecologic malignancy. Using a gene discovery approach, a number of molecules that regulate blood vessel formation (angiogenesis) and tissue architecture have been identified as significantly up-regulated or down-regulated in the main tissue component of EOC. Development of tumor structures is also being re-constructed and investigated in vitro utilizing recombinant cultures of EOC cells, blood vessel lining cells and fibroblasts grown in extracellular matrix. Translational research: My laboratory has shown that EOC development is regulated in a “Yin and Yang” fashion by factors that promote or suppress formation and growth of blood vessels, structures integral to tumor development. Some of these factors are dramatically elevated in the cyst fluid of EOCs consistent with the hypothesis that cytokines may play an important role in ovarian cancer related-angiogenesis and tumor progression. Translating these results to the bedside, the laboratory has shown that seriousness of clinical status correlates with urinary angiostatin, an angiogenesis inhibitor that independently discriminates EOC patients from volunteer controls and patients with benign ovarian masses. A second potential biomarker under current study is the protein product of the High Motility Group A2 gene, an architectural transcription factor that is over-expressed in high grade serous ovarian and tubal carcinomas. Discovery and validation of urinary biomarkers of EOC continue to be main aims of our funded research. Pathology: Over 35 years of experience in a variety of morphological methods including 12 years as the Director of the Electron Microscopy Core at the University of Pennsylvania School of Medicine in a NIH funded Program Project in Reproductive Biology and over 10 years as Scientific Director of the Experimental Pathology and Histology/Immunocytochemistry facilities at USF Health and the Comprehensive Moffitt Cancer Center.

    Personal Page:   http://www.linkedin.com/pub/santo-nicosia/33/89a/90b/

    Selected Publications
  • Zhang M, Xiang S, Joo HY, Wang L, et al. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Mol Cell. (oi:10.1016/j.molcel.2014.04.028. Epub 2014 May 29.): , 2014.
  • Lee JH, Cragun D, Thompson Z, Coppola D, Nicosia SV, et al. Association Between IHC and MSI Testing to Identify Mismatch Repair-Deficient Patients with Ovarian Cancer. Genet Test Mol Biomarkers. . (): 229-35, 2014.
  • Dobrinski K, Esposito NN, Kruk PA, Hoffman M, Coppola D, Bai W, Zhang X, Nicosia SV. Procurement and Cytological Features of Human Fallopian Tube Fimbrial Cells by Ex-Vivo Imprinting and Washing. JASC (Published online: August 28, 2014). Journal American Society Cytopathology. (): , 2014.
  • Malaney P, Nicosia SV, Davé V. One mouse, one patient paradigm: new avatars of personalized cancer therapy Cancer Letters. (): , 2013.
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration The Journal of biological chemistry. (): , 2013.
  • Xu, CX.Xu, M.Tan, L.Yang, H.Permuth-Wey, J.Kruk, PA.Wenham, RM.Nicosia, SV.Lancaster, JM.Sellers, TA.Cheng, JQ. MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. The Journal of biological chemistry. 287(42): 34970-8, 2012.
  • Wang, L.Xiang, S.Williams, KA.Dong, H.Bai, W.Nicosia, SV.Khochbin, S.Bepler, G.Zhang, X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. 7(9): e44265, 2012.
  • Shan, L.Chen, YA.Davis, L.Han, G.Zhu, W.Molina, AD.Arango, H.LaPolla, JP.Hoffman, MS.Sellers, T.Kirby, T.Nicosia, SV.Sutphen, R. Measurement of phospholipids may improve diagnostic accuracy in ovarian cancer. PloS one. 7(10): e46846, 2012.
  • Coppola, D.Nicosia, SV.Doty, A.Sellers, TA.Lee, JH.Fulp, J.Thompson, Z.Galeb, S.McLaughlin, J.Narod, SA.Schildkraut, J.Pal, T. Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. Anticancer research. 32(11): 4963-9, 2012.
  • Kasiappan, R.Shen, Z.Tse, AK.Jinwal, U.Tang, J.Lungchukiet, P.Sun, Y.Kruk, P.Nicosia, SV.Zhang, X.Bai, W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. The Journal of biological chemistry. 287(49): 41297-309, 2012.
  • Khoor, A.Byrd-Gloster, AL.Nicosia, SV. Expression of thyroid transcription factor-1 in malignant pleural effusions. Pathology oncology research : POR. 17(2): 263-7, 2011.
  • Shen, Z.Zhang, X.Tang, J.Kasiappan, R.Jinwal, U.Li, P.Hann, S.Nicosia, SV.Wu, J.Zhang, X.Bai, W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells. Molecular and cellular endocrinology. 338(1-2): 58-67, 2011.
  • Yang, Y.Tse, AK.Li, P.Ma, Q.Xiang, S.Nicosia, SV.Seto, E.Zhang, X.Bai, W. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 30(19): 2207-18, 2011.
  • Drenberg, CD.Saunders, BO.Wilbanks, GD.Chen, R.Nicosia, RF.Kruk, PA.Nicosia, SV. Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer. Gynecologic oncology. 117(1): 117-24, 2010.
  • Zhang, Y.Dong, H.Li, Z.Xiang, S.Zhu, Y.Zhang, M.Liu, J.Bai, W.Nicosia, SV.Chen, J.Zhao, RJ.Zhang, X. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Frontiers in bioscience (Elite edition). 2(): 221-30, 2010.
  • Drenberg, CD.Livingston, S.Chen, R.Kruk, PA.Nicosia, SV. Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues. Obstetrics and gynecology international. 2009(): 730739, 2009.
  • Permuth-Wey, J.Boulware, D.Valkov, N.Livingston, S.Nicosia, S.Lee, JH.Sutphen, R.Schildkraut, J.Narod, S.Parker, A.Coppola, D.Sellers, T.Pal, T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(1): 28-34, 2009.
  • Zhang, Y.Zhang, M.Dong, H.Yong, S.Li, X.Olashaw, N.Kruk, PA.Cheng, JQ.Bai, W.Chen, J.Nicosia, SV.Zhang, X. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 28(3): 445-60, 2009.
  • Ma, Q.Fu, W.Li, P.Nicosia, SV.Jenster, G.Zhang, X.Bai, W. FoxO1 mediates PTEN suppression of androgen receptor N- and C-terminal interactions and coactivator recruitment. Molecular endocrinology (Baltimore, Md.). 23(2): 213-25, 2009.
  • Fu, W.Ma, Q.Chen, L.Li, P.Zhang, M.Ramamoorthy, S.Nawaz, Z.Shimojima, T.Wang, H.Yang, Y.Shen, Z.Zhang, Y.Zhang, X.Nicosia, SV.Zhang, Y.Pledger, JW.Chen, J.Bai, W. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. The Journal of biological chemistry. 284(21): 13987-4000, 2009.
  • Guo, JP.Shu, SK.He, L.Lee, YC.Kruk, PA.Grenman, S.Nicosia, SV.Mor, G.Schell, MJ.Coppola, D.Cheng, JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. The American journal of pathology. 175(1): 324-33, 2009.
  • Anderson, NS.Turner, L.Livingston, S.Chen, R.Nicosia, SV.Kruk, PA. Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation. Journal of ovarian research. 2(): 16, 2009.
  • Anderson, NS.Bermudez, Y.Badgwell, D.Chen, R.Nicosia, SV.Bast, RC.Kruk, PA. Urinary levels of Bcl-2 are elevated in ovarian cancer patients. Gynecologic oncology. 112(1): 60-7, 2009.
  • Yang, H.Kong, W.He, L.Zhao, JJ.O'Donnell, JD.Wang, J.Wenham, RM.Coppola, D.Kruk, PA.Nicosia, SV.Cheng, JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer research. 68(2): 425-33, 2008.
  • Yang, Y.Fu, W.Chen, J.Olashaw, N.Zhang, X.Nicosia, SV.Bhalla, K.Bai, W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature cell biology. 9(11): 1253-62, 2007.
  • Yang, L.Sun, M.Sun, XM.Cheng, GZ.Nicosia, SV.Cheng, JQ. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. The Journal of biological chemistry. 282(15): 10981-7, 2007.
  • Lee, H.Kim, D.Dan, HC.Wu, EL.Gritsko, TM.Cao, C.Nicosia, SV.Golemis, EA.Liu, W.Coppola, D.Brem, SS.Testa, JR.Cheng, JQ. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Molecular and cellular biology. 27(6): 2103-19, 2007.
  • Bao, J.Cao, C.Zhang, X.Jiang, F.Nicosia, SV.Bai, W. Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65. Molecular and cellular biology. 27(4): 1321-33, 2007.
  • Garbuzova-Davis, S.Haller, E.Saporta, S.Kolomey, I.Nicosia, SV.Sanberg, PR. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain research. 1157(): 126-37, 2007.
  • Bermudez, Y.Yang, H.Saunders, BO.Cheng, JQ.Nicosia, SV.Kruk, PA. VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent. Gynecologic oncology. 106(3): 526-37, 2007.
  • Zhang, X.Nicosia, SV.Bai, W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Current cancer drug targets. 6(3): 229-44, 2006.
  • Yang, H.He, L.Kruk, P.Nicosia, SV.Cheng, JQ. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. International journal of cancer. Journal international du cancer. 119(10): 2304-12, 2006.
  • Zhang, X.Li, P.Bao, J.Nicosia, SV.Wang, H.Enkemann, SA.Bai, W. Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. The Journal of biological chemistry. 280(42): 35458-68, 2005.
  • Kim, D.Dan, HC.Park, S.Yang, L.Liu, Q.Kaneko, S.Ning, J.He, L.Yang, H.Sun, M.Nicosia, SV.Cheng, JQ. AKT/PKB signaling mechanisms in cancer and chemoresistance. Frontiers in bioscience : a journal and virtual library. 10(): 975-87, 2005.
  • Zhang, X.Jiang, F.Li, P.Li, C.Ma, Q.Nicosia, SV.Bai, W. Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clinical cancer research : an official journal of the American Association for Cancer Research. 11(1): 323-8, 2005.
  • Yang, Y.Hou, H.Haller, EM.Nicosia, SV.Bai, W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. The EMBO journal. 24(5): 1021-32, 2005.
  • Yuan, ZQ.Kim, D.Kaneko, S.Sussman, M.Bokoch, GM.Kruh, GD.Nicosia, SV.Testa, JR.Cheng, JQ. ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival. The Journal of biological chemistry. 280(22): 21483-90, 2005.
  • Cheng, JQ.Lindsley, CW.Cheng, GZ.Yang, H.Nicosia, SV. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene. 24(50): 7482-92, 2005.
  • Park, S.Kim, D.Kaneko, S.Szewczyk, KM.Nicosia, SV.Yu, H.Jove, R.Cheng, JQ. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. The Journal of biological chemistry. 280(47): 38932-41, 2005.
  • Reed, J.Hakam, A.Nicosia, SV.Coppola, D. Significance of Fas receptor protein expression in epithelial ovarian cancer. Human pathology. 36(9): 971-6, 2005.
  • Jiang, F.Bao, J.Li, P.Nicosia, SV.Bai, W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. The Journal of biological chemistry. 279(51): 53213-21, 2004.
  • Liu, Q.Kaneko, S.Yang, L.Feldman, RI.Nicosia, SV.Chen, J.Cheng, JQ. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. The Journal of biological chemistry. 279(50): 52175-82, 2004.
  • Yang, L.Dan, HC.Sun, M.Liu, Q.Sun, XM.Feldman, RI.Hamilton, AD.Polokoff, M.Nicosia, SV.Herlyn, M.Sebti, SM.Cheng, JQ. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer research. 64(13): 4394-9, 2004.
  • Li, P.Li, C.Zhao, X.Zhang, X.Nicosia, SV.Bai, W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. The Journal of biological chemistry. 279(24): 25260-7, 2004.
  • Nicosia, SV.Wilbanks, GD.Saunders, B.Mayer, J.Cardosi, RJ.Kruk, PA.Cheng, J.Bai, W.Coppola, D.Fiorica, J. Cytology of human ovarian surface epithelial brushings. Cancer. 102(1): 1-10, 2004.
  • Yang, H.Ou, CC.Feldman, RI.Nicosia, SV.Kruk, PA.Cheng, JQ. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer research. 64(2): 463-7, 2004.
  • Dan, HC.Jiang, K.Coppola, D.Hamilton, A.Nicosia, SV.Sebti, SM.Cheng, JQ. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene. 23(3): 706-15, 2004.
  • Dan, HC.Sun, M.Kaneko, S.Feldman, RI.Nicosia, SV.Wang, HG.Tsang, BK.Cheng, JQ. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). The Journal of biological chemistry. 279(7): 5405-12, 2004.
  • Jiang, F.Li, P.Fornace, AJ.Nicosia, SV.Bai, W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. The Journal of biological chemistry. 278(48): 48030-40, 2003.
  • Tsibris, JC.Maas, S.Segars, JH.Nicosia, SV.Enkemann, SA.O'Brien, WF.Spellacy, WN. New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochemical and biophysical research communications. 312(1): 249-54, 2003.
  • Nicosia, SV.Bai, W.Cheng, JQ.Coppola, D.Kruk, PA. Oncogenic pathways implicated in ovarian epithelial cancer. Hematology/oncology clinics of North America. 17(4): 927-43, 2003.
  • Sun, M.Yang, L.Feldman, RI.Sun, XM.Bhalla, KN.Jove, R.Nicosia, SV.Cheng, JQ. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. The Journal of biological chemistry. 278(44): 42992-3000, 2003.
  • Yuan, ZQ.Feldman, RI.Sussman, GE.Coppola, D.Nicosia, SV.Cheng, JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. The Journal of biological chemistry. 278(26): 23432-40, 2003.
  • Gritsko, TM.Coppola, D.Paciga, JE.Yang, L.Sun, M.Shelley, SA.Fiorica, JV.Nicosia, SV.Cheng, JQ. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4): 1420-6, 2003.
  • Yuan, ZQ.Feldman, RI.Sun, M.Olashaw, NE.Coppola, D.Sussman, GE.Shelley, SA.Nicosia, SV.Cheng, JQ. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. The Journal of biological chemistry. 277(33): 29973-82, 2002.
  • Dan, HC.Sun, M.Yang, L.Feldman, RI.Sui, XM.Ou, CC.Nellist, M.Yeung, RS.Halley, DJ.Nicosia, SV.Pledger, WJ.Cheng, JQ. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. The Journal of biological chemistry. 277(38): 35364-70, 2002.
  • Kaneko, S.Feldman, RI.Yu, L.Wu, Z.Gritsko, T.Shelley, SA.Nicosia, SV.Nobori, T.Cheng, JQ. Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter. The Journal of biological chemistry. 277(26): 23230-5, 2002.
  • Naidu, KA.Tang, JL.Naidu, KA.Prockop, LD.Nicosia, SV.Coppola, D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression. Journal of neuro-oncology. 54(1): 15-22, 2001.
  • Sun, M.Paciga, JE.Feldman, RI.Yuan , Z.Coppola, D.Lu, YY.Shelley, SA.Nicosia, SV.Cheng, JQ. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer research. 61(16): 5985-91, 2001.
  • Sun, M.Wang, G.Paciga, JE.Feldman, RI.Yuan, ZQ.Ma, XL.Shelley, SA.Jove, R.Tsichlis, PN.Nicosia, SV.Cheng, JQ. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. The American journal of pathology. 159(2): 431-7, 2001.
  • Li, P.Nicosia, SV.Bai, W. Antagonism between PTEN/MMAC1/TEP-1 and androgen receptor in growth and apoptosis of prostatic cancer cells. The Journal of biological chemistry. 276(23): 20444-50, 2001.
  • Adnane, J.Jackson, RJ.Nicosia, SV.Cantor, AB.Pledger, WJ.Sebti, SM. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene. 19(47): 5338-47, 2000.
  • Lee, H.Jiang, F.Wang, Q.Nicosia, SV.Yang, J.Su, B.Bai, W. MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Molecular endocrinology (Baltimore, Md.). 14(11): 1882-96, 2000.
  • Yuan, ZQ.Sun, M.Feldman, RI.Wang, G.Ma, X.Jiang, C.Coppola, D.Nicosia, SV.Cheng, JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene. 19(19): 2324-30, 2000.
  • Jiang, K.Coppola, D.Crespo, NC.Nicosia, SV.Hamilton, AD.Sebti, SM.Cheng, JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Molecular and cellular biology. 20(1): 139-48, 2000.
  • Diaz, JI.Mora, LB.Austin, PF.Muro-Cacho, CA.Cantor, AB.Nicosia, SV.Pow-Sang, JM. Predictability of PSA failure in prostate cancer by computerized cytometric assessment of tumoral cell proliferation. Urology. 53(5): 931-8, 1999.
  • Hazelton, D.Nicosia, RF.Nicosia, SV. Vascular endothelial growth factor levels in ovarian cyst fluid correlate with malignancy. Clinical cancer research : an official journal of the American Association for Cancer Research. 5(4): 823-9, 1999.
  • Coppola, D.Saunders, B.Fu, L.Mao, W.Nicosia, SV. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer research. 59(13): 3264-70, 1999.
  • Hakam, A.Yeatman, TJ.Lu, L.Mora, L.Marcet, G.Nicosia, SV.Karl, RC.Coppola, D. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Human pathology. 30(10): 1128-33, 1999.
  • Coppola, D.Catalano, E.Nicosia, SV. Significance of p53 and Bcl-2 Protein Expression in Human Breast Ductal Carcinoma. Cancer control : journal of the Moffitt Cancer Center. 6(2): 181-187, 1999.
  • Cavanagh, D.Fiorica, JV.Hoffman, MS.Durfee, J.Nicosia, SV. Adenocarcinoma of the Endometrium: An Institutional Review. Cancer control : journal of the Moffitt Cancer Center. 6(4): 354-360, 1999.
  • Cox, CE.Pendas, S.Ku, NN.Reintgen, DS.Greenberg, HS.Nicosia, SV. Local recurrence of breast cancer after cytological evaluation of lumpectomy margins. The American surgeon. 64(6): 533-7; discussion 537-8, 1998.
  • Coppola, D.Lu, L.Fruehauf, JP.Kyshtoobayeva, A.Karl, RC.Nicosia, SV.Yeatman, TJ. Analysis of p53, p21WAF1, and TGF-beta1 in human ductal adenocarcinoma of the pancreas: TGF-beta1 protein expression predicts longer survival. American journal of clinical pathology. 110(1): 16-23, 1998.
  • Liu, AX.Testa, JR.Hamilton, TC.Jove, R.Nicosia, SV.Cheng, JQ. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer research. 58(14): 2973-7, 1998.
  • Porter, KB.Tsibris, JC.Porter, GW.Fuchs-Young, R.Nicosia, SV.O'Brien, WF.Spellacy, WN. Effects of raloxifene in a guinea pig model for leiomyomas. American journal of obstetrics and gynecology. 179(5): 1283-7, 1998.
  • Coppola, D.Hyacinthe, M.Fu, L.Cantor, AB.Karl, R.Marcet, J.Cooper, DL.Nicosia, SV.Cooper, HS. CD44V6 expression in human colorectal carcinoma. Human pathology. 29(6): 627-35, 1998.
  • Cowper, SE.Fiorica, JV.Haller, EM.Nicosia, SV.Jones, M.Coppola, D. Papillary Squamous Cell Carcinoma. Cancer control : journal of the Moffitt Cancer Center. 5(2): 179-1183, 1998.
  • Coppola, D.Fu, L.Nicosia, SV.Kounelis, S.Jones, M. Prognostic significance of p53, bcl-2, vimentin, and S100 protein-positive Langerhans cells in endometrial carcinoma. Human pathology. 29(5): 455-62, 1998.
  • Cox, CE.Hyacinthe, M.Gonzalez, RJ.Lyman, G.Reintgen, D.Ku, NN.Miller, MS.Greenberg, H.Nicosia, SV. Cytologic evaluation of lumpectomy margins in patients with ductal carcinoma in situ: clinical outcome. Annals of surgical oncology. 4(8): 644-9, 1997.
  • Ku, NN.Mela, N.Cox, CE.Reintgen, DS.Nicosia, SV. Diagnostic Pitfalls in Aspiration Biopsy Cytology of Papillary Breast Lesions. Cancer control : journal of the Moffitt Cancer Center. 4(5): 451-457, 1997.
  • Mora, LB.Nicosia, SV.Pow-Sang, JM.Ku, NK.Diaz, JI.Lockhart, J.Einstein, A. Ancillary techniques in the followup of transitional cell carcinoma: a comparison of cytology, histology and deoxyribonucleic acid image analysis cytometry in 91 patients. The Journal of urology. 156(1): 49-54; discussion 54-5, 1996.
  • Diaz, JI.Nicosia, SV.Szakacs, J.Powsang, J.Saba, HI. Metastatic seminoma simulating malignant lymphoma in an HIV infected hemophiliac. Leukemia & lymphoma. 23(1-2): 165-71, 1996.
  • Pierro, E.Nicosia, SV.Saunders, B.Fultz, CB.Nicosia, RF.Mancuso, S. Influence of growth factors on proliferation and morphogenesis of rabbit ovarian mesothelial cells in vitro. Biology of reproduction. 54(3): 660-9, 1996.
  • Pinelli, DM.Fiorica, JV.Roberts, WS.Hoffman, MS.Nicosia, SV.Cavanagh, D. Chemotherapy plus sequential hormonal therapy for advanced and recurrent endometrial carcinoma: a phase II study. Gynecologic oncology. 60(3): 462-7, 1996.
  • Nicosia, SV. Ovarian and Peritoneal Borderline Neoplasms: Histopathology, Diagnostic Pitfalls, and Prognostication. Cancer control : journal of the Moffitt Cancer Center. 3(1): 58-65, 1996.
  • Morgan, MB.Nicosia, SV.Shabaik, A.Mela, N.Cox, CC. Fine Needle Aspiration Biopsy Cytology of Argyrophilic Carcinoma (Carcinoid Tumor) of the Breast. Cancer control : journal of the Moffitt Cancer Center. 2(3): 245-249, 1995.
  • Nicosia, SV.Sowinski, JM. Cytological analysis of the urn cell complex of Sipunculus nudus before and after serum-induced secretion. The Biological bulletin. 188(3): 267-80, 1995.
  • Cox, CE.Reintgen, DS.Nicosia, SV.Ku, NN.Baekey, P.Carey, LC. Analysis of residual cancer after diagnostic breast biopsy: an argument for fine-needle aspiration cytology. Annals of surgical oncology. 2(3): 201-6, 1995.
  • Porter, KB.Tsibris, JC.Nicosia, SV.Murphy, JM.O'Brien, WF.Rao, PS.Spellacy, WN. Estrogen-induced guinea pig model for uterine leiomyomas: do the ovaries protect? Biology of reproduction. 52(4): 824-32, 1995.
  • Giacomini, G.Nicosia, SV.Saunders, BO.Fultz, C.Sun, X.Jasonni, VM. Ovarian mesothelial and extramesothelial cells in interactive culture. In vitro cellular & developmental biology. Animal. 31(4): 300-9, 1995.
  • Ku, NN.Mela, NJ.Fiorica, JV.Cox, CE.Reintgen, DS.Greenberg, HM.Clark, RA.Nicosia, SV. Role of fine needle aspiration cytology after lumpectomy. Acta cytologica. 38(6): 927-32, 1994.
  • Nicosia, RF.Nicosia, SV.Smith, M. Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. The American journal of pathology. 145(5): 1023-9, 1994.
  • Nicosia, SV. The Role of Fine Needle Aspiration Biopsy in Gynecologic Oncology. Cancer control : journal of the Moffitt Cancer Center. 1(2): 160-165, 1994.
  • Ku, NN.Nicosia, SV.Reintgen, DS.Cox, CE. Role of Cytopathology in the Management of Breast Cancer. Cancer control : journal of the Moffitt Cancer Center. 1(4): 402-408, 1994.
  • Nicosia, SV.Narconis, RJ.Saunders, BO. Influence of a corpus luteum tissue extract on rabbit ovarian mesothelial cells. Scanning microscopy. 8(2): 393-401; discussion 401-2, 1994.
  • Barton, DP.Blanchard, DK.Wells, AF.Nicosia, SV.Roberts, WS.Cavanagh, D.Djeu, JY. Expression of interleukin-2 receptor alpha (IL-2R alpha) mRNA and protein in advanced epithelial ovarian cancer. Anticancer Research. 14(3A): 761-72, 1993.
  • Setrakian, S.Oliveros-Saunders, B.Nicosia, SV. Growth stimulation of ovarian and extraovarian mesothelial cells by corpus luteum extract. In vitro cellular & developmental biology. Animal. 29A(11): 879-83, 1993.
  • Nicosia, SV.Williams, JA.Horowitz, SA.Ku, NN.Shabaik, AS.Mela, N.Reintgen, DS.Cox, CE. Fine needle aspiration biopsy of palpable breast lesions. Review and statistical analysis of 1875 cases. Surgical oncology. 2(3): 145-60, 1993.
  • Barton, DP.Blanchard, DK.Michelini-Norris, B.Nicosia, SV.Cavanagh, D.Djeu, JY. High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer. Blood. 81(2): 424-9, 1993.
  • Shabaik, AS.Pow-Sang, JM.Lockhart, J.Nicosia, SV. Role of DNA image cytometry in the follow-up of patients with urinary tract transitional cell carcinoma. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology. 15(2): 115-23, 1993.
  • Gleeson, NC.Nicosia, SV.Mark, JE.Hoffman, MS.Cavanagh, D. Abdominal wall metastases from ovarian cancer after laparoscopy. American journal of obstetrics and gynecology. 169(3): 522-3, 1993.
  • Mourad, WA.Erkman-Balis, B.Livingston, S.Shoukri, M.Cox, CE.Nicosia, SV.Rowlands, DT. Argyrophilic nucleolar organizer regions in breast carcinoma. Correlation with DNA flow cytometry, histopathology, and lymph node status. Cancer. 69(7): 1739-44, 1992.
  • Cox, CE.Ku, NN.Reintgen, DS.Greenberg, HM.Nicosia, SV.Wangensteen, S. Touch preparation cytology of breast lumpectomy margins with histologic correlation. Archives of surgery (Chicago, Ill. : 1960). 126(4): 490-3, 1991.
  • Brown, HK.Stoll, BS.Nicosia, SV.Fiorica, JV.Hambley, PS.Clarke, LP.Silbiger, ML. Uterine junctional zone: correlation between histologic findings and MR imaging. Radiology. 179(2): 409-13, 1991.
  • Nicosia, SV.Narconis, RJ.Saunders, BO. Regulation and temporal sequence of surface epithelium morphogenesis in the postovulatory rabbit ovary. Progress in clinical and biological research. 296(): 111-9, 1989.
  • Quinn, SF.Bodne, DJ.Clark, RA.Karl, RC.Nicosia, SV. Upper abdomen: CT findings following partial hepatectomy. Radiology. 168(3): 879-80, 1988.
  • Bodne, D.Quinn, SF.Nicosia, SV.King, PA.Clark, RA. Comparison study of the efficacy of the 22-gauge Vacu-Cut needle for biopsy. AJR. American journal of roentgenology. 150(2): 468-9, 1988.
  • Haas, GG.Nicosia, SV.Wolf, DP. Influence of estrogens on vascular transudation and mucus production in the rabbit endocervix. Fertility and sterility. 48(6): 1036-42, 1987.
  • Nicosia, SV. The aging ovary. The Medical clinics of North America. 71(1): 1-9, 1987.
  • Nicosia, SV. Pathology of the oviducts and embryonal remnants. Obstetrics and gynecology annual. 14(): 382-410, 1985.
  • Matus-Ridley, M.Nicosia, SV.Meadows, AT. Gonadal effects of cancer therapy in boys. Cancer. 55(10): 2353-63, 1985.
  • Nicosia, SV.Matus-Ridley, M.Meadows, AT. Gonadal effects of cancer therapy in girls. Cancer. 55(10): 2364-72, 1985.
  • Osterholzer, HO.Streibel, EJ.Nicosia, SV. Growth effects of protein hormones on cultured rabbit ovarian surface epithelial cells. Biology of reproduction. 33(1): 247-58, 1985.
  • Osterholzer, HO.Johnson, JH.Nicosia, SV. An autoradiographic study of rabbit ovarian surface epithelium before and after ovulation. Biology of reproduction. 33(3): 729-38, 1985.
  • Nicosia, SV.Johnson, JH.Streibel, EJ. Growth characteristics of rabbit ovarian mesothelial (surface epithelial) cells. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 4(1): 58-74, 1985.
  • Chilton, BS.Nicosia, SV.Sowinski, JM. Enrichment of lysozyme-containing cells from the rabbit endocervix by unit gravity sedimentation. The Anatomical record. 209(4): 481-9, 1984.
  • Nicosia, SV.Sowinski, JM.Chilton, BS.Streibel, EJ. Ultrastructural immunocytochemical localization of lysozyme in the mucociliary epithelium of the rabbit endocervix in different hormonal states. The Anatomical record. 209(4): 469-80, 1984.
  • Nicosia, SV.Johnson, JH.Streibel, EJ. Morphology of rabbit endocervical mucosa after mating. Scanning electron microscopy. (Pt 3): 1321-8, 1984.
  • Nicosia, SV.Johnson, JH. Surface morphology of ovarian mesothelium (surface epithelium) and of other pelvic and extrapelvic mesothelial sites in the rabbit. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 3(3): 249-60, 1984.
  • Nicosia, SV.Johnson, JH.Streibel, EJ. Isolation and ultrastructure of rabbit ovarian mesothelium (surface epithelium). International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 3(4): 348-60, 1984.
  • Nicosia, SV.Johnson, JH. Effects of two international union against cancer standard reference samples of asbestos on cultured rabbit ovarian surface epithelial cells. Scanning electron microscopy. (Pt 3): 1329-36, 1984.
  • Chilton, BS.Nicosia, SV.Lyttle, CR. Cytosol and nuclear estrogen and progesterone receptors in the rabbit endocervix. Journal of steroid biochemistry. 17(4): 363-9, 1982.
  • Chilton, BS.Kennedy, JR.Nicosia, SV. Isolation of basal and mucous cell populations from rabbit trachea. The American review of respiratory disease. 124(6): 723-7, 1981.
  • Chilton, BS.Nicosia, SV.Sowinski, JM.Wolf, DP. Isolation and characterization of rabbit endocervical cells. The Journal of cell biology. 86(1): 172-80, 1980.
  • Chilton, BS.Nicosia, SV.Laufer, MR. Effect of estradiol-17 beta on endocervical cytodifferentiation and glycoprotein biosynthesis in the ovariectomized rabbit. Biology of reproduction. 23(3): 677-86, 1980.
  • Nicosia, SV.Tojo, R. Morphogenetic reaggregation and luteinization of mouse preantral follicle cells. The American journal of anatomy. 156(3): 401-27, 1979.
  • Nicosia, SV. Lectin-Induced Mucus Release in the Urn Cell Complex of the Marine Invertebrate Sipunculus nudus (Linnaeus). Science (New York, N.Y.). 206(4419): 698-700, 1979.
  • Wolf, DP.Nicosia, SV.Hamada, M. Premature cortical granule loss does not prevent sperm penetration of mouse eggs. Developmental biology. 71(1): 22-32, 1979.
  • Nicosia, SV.Wolf, DP.Inoue, M. Cortical granule distribution and cell surface characteristics in mouse eggs. Developmental biology. 57(1): 56-74, 1977.
  • Nicosia, SV.Evangelista, I.Batta, SK. Rabbit ovarian follicles. I. Isolation technique and characterization at different stages of development. Biology of reproduction. 13(4): 423-47, 1975.
  • Schenker, JG.Nicosia, SV.Polishuk, WZ.Garcia, CR. An in vitro fibroblast-enriched sponge preparation for induction of intrauterine adhesions. Israel journal of medical sciences. 11(8): 849-51, 1975.
  • Nicosia, SV.Mikhail, G. Cumuli oophori in tissue culture: hormone production, ultrastructure, and morphometry of early luteinization. Fertility and sterility. 26(5): 427-48, 1975.
  • Nicosia, SV. Luteinization of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. I. Growth characteristics and progestin biosynthesis. Fertility and sterility. 23(11): 791-801, 1972.
  • Nicosia, SV. Luteinization of rabbit preovulatory granulosa cells cultured in vitro in presence of follicular oocytes. II. Histochemical and electron microscopic observations. Fertility and sterility. 23(11): 802-16, 1972.
  • Presman, D.Ross, LS.Nicosia, SV. Fibromuscular hyperplasia of the posterior urethra: a cause for lower urinary tract obstruction in male children. The Journal of urology. 107(1): 149-53, 1972.
  • Nicosia, SV. [Anatomo-clinical considerations on a case of utero-ureteral fibroleiomyomatosis] Rivista di anatomia patologica e di oncologia. 31(6): 686-705, 1967.

  • Positions Held
  • Chairman (Department of Pathology and Cell Biology, College of Medicine, University of South Florida 2006 - 2012)
  • Professor (Department of Pathology, College of Medicine, University of South Florida 1984 - 2006)
  • Director (Histopathology Core Laboratory, NCI-Comprehensive H. Lee Moffitt Cancer Center and University of South Florida-College of Medicine 2002 - 2002)

  • Memberships
  • American Association for Cancer Research (Member, 2002 - Present)
  • College of American Pathologists (Member, 1995 - Present)
  • American Society of Cytopathology (Member, 1982 - Present)
  • International Society of Gynecological Pathologists (Member, 1981 - Present)
  • American Society for Cell Biology (Member, 1977 - Present)
  • United States and Canadian Academy of Pathology (Member, 1972 - Present)
  • Hillsborough County Medical Association (Member, 2005 - 2010)
  • Florida Society of Pathologists (Member, 2005 - 2010)
  • Society for In Vitro Biology (Member, 1971 - 2006)

  • Awards/Honors
  • Best Doctors in America: Southeast Region ( - 2008)
  • America's Top Physicians (Consumer Research Council of America - 2007)
  • Distinguished USF Professor (University of South Florida - 2007)
  • President (Pathology History Society, United States-Canadian Academy of Pathology - 2005)
  • Hill Lecturer (American Association of Clinician Scientists - 2001)
  • New Frontiers in Cytology Research (American Society of Cytopathology - 1998)
  • James A. Reagan Memorial Lecturer (Case Western Reserve University - 1994)
  • Keynote Speaker - Lectio Magistralis (Congress of Italian Society of Obsterics and Gynecology - 1990)
  • Honorary Member (Sociedad de Obstetricia y Gynecologia de Rosario - Argentina - 1979)

  • Patents & Licensing
  • HMGA2 as a Biomarker of Epithelial Ovarian Cancer - Filed (Nicosia, Santo - 2013)
  • Guinea Pig Model for Leiomyoma Development (US94B34 WO/CP - 2008)

  • Lectures
  • ""Intraoperative Imprint Cytology: A Method for Rapid Assessment of FallopianTube Pathology and Molecular Signature"." Early Ovarian Cancer Symposium. USC/Norris Comprehensive Cancer Center, Los Angeles . CA, United States - 2009.
  • "Brown Memorial Lecture on Frontiers of Ovarian Cancer" nnual Meeting of Association of Clinical Scientists, 129th Meeting of the Association of Clinical Scientists, Tampa, . FL, United States - 2009.
  • ""George Papanicolaou: The origin of diagnostic cytology and cancer screening"" 12th Annual Educational Forum of the American Foundation for Greek Language and Culture (AFGLC).. FL, United States - 2007.
  • ""Historical Perspectives on Ovarian Cancer"" Nelly Auersperg Symposium, University of British Columbia Cancer Center. Canada - 2007.
  • ""Anatomical Waxes in 18th Century Italy" History of Pathology Symposium" 95th Annual Meeting United States Canadian Academy of Pathology. GA, United States - 2006.
  • ""Ovarian Epithelial CancerPathobiology program at the University of South Florida College of Medicine" " 1st Top Executive Italy-US Pharma Meeting. Italian Embassy. DC, United States - 2006.
  • ""Angioregulators as Markers of Ovarian Epithelial Cancer" 1st Italy Americans Medical Congress: Project Florida Congress Center" Miller School of Medicine University of Miami. FL, United States - 2005.

  • Profile last modified on 10/21/2014