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Niketa Patel, PH.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Associate Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE

Associate Professor, Molecular Medicine

Research Biologist, Research Service

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Contacts
Email: npatel@health.usf.edu
Phone: (813) 972-2000 ext. 7283
Office: VAH, 115a
Mailing address JAH VA, Res Ser VAR 151 13000 Bruce B Downs
Tampa, 33612
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Education
  • PHD, Molecular Biology, University Of South Florida, Tampa, United States - 1998.
 
Interdisciplinary & Emerging Signature Programs
Cardiovascular, Cellular and Molecular Biology, Neuroscience, Other.
 
Research Summary

Obesity continues to escalate as a significant public health problem and as the leading preventable cause of death. Genetic, environmental, behavioral, and socioeconomic factors cause excess weight gain and obesity. Increased proliferation and differentiation of pre-adipocytes to mature adipocytes (adipogenesis) within the fat tissues are central to obesity. Apoptosis, or programmed cell death, is an integral part of the cell cycle. Research from our laboratory involves elucidation of the biochemical and molecular mechanisms in the study of adipogenesis. Protein kinase C (PKC)d, a member of the novel PKC (nPKC) subfamily, plays an important role in the regulation of cell apoptosis. The focus of this laboratory is to decipher the molecular mechanisms regulating alternative expression of PKC´ isoforms. Our laboratory has recently identified a new human PKCdelta isoform generated by alternative splicing. Alternative splicing is now acknowledged as being pivotal in generating the protein diversity required to fine tune the cellular functions. Regulation of alternative splicing involves interplay of the cis-elements with the trans-acting factors such as SR proteins and hnRNPs. This is currently being investigated using molecular biology techniques and cloning of minigenes to facilitate the identification of the splicing components in this system.

 


Selected Publications

Positions Held
  • Assistant Professor (Dept. of Molecular Medicine, College of Medicine, USF 2004 - 2012)

Memberships
  • Endocrine Society (member, 1998 - Present)


Awards/Honors
  • Chair, RNA and Disease (Endocrine Society - 2007)


Patents & Licensing
  • Compositions and Methods for Detecting Intracellular Glucose and Analogs Thereof (Patel NA - 2011)
  • Glucose-regulated mRNA instability element (Patel NA - 2005)


Lectures
  • "SC35 mediates alternative splicing of PKCdVIII" Endocrine Society . FL, United States - 2008.
  • "Alternative splicing of PKCd" Endocrine Society. Canada - 2007.
  • "Alternative splicing" TIFR, India. India - 2006.
  • "Insulin regulates alternative splicing of PKCbII" ISIS Pharm. FL, United States - 2005.

Profile last modified on 10/31/2014