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Gloria Ferreira, Ph.D.

Primary Department: COLLEGE OF MEDICINE MOLECULAR MEDICINE

Professor, COLLEGE OF MEDICINE MOLECULAR MEDICINE

Member, Florida Center of Excellence for Biomolecular Identification and Targeted Therapeutics (FCoE-BITT)

Affiliated Professor, Department of Chemistry

Professor, Department of Molecular Medicine, College of Medicine

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Contacts
Email: gferreir@health.usf.edu
Phone: (813) 974-5797
Office: MDC, 2152
Mailing address 12901 Bruce B. Downs Blvd. MDC 7
Tampa, FL 33612
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Education
  • PHD, Biochemistry, University Of Georgia, Athens, United States - 1986.
 
Interdisciplinary & Emerging Signature Programs
Cancer Biology, Cardiovascular.
 
Research Summary

Our main research interest is defining the reaction and regulatory mechanisms of the first and terminal heme biosynthetic pathway enzymes, 5-aminolevulinate synthase (ALAS) and ferrochelatase (FC). Iron overload is a clinically important feature of sideroblastic anemia, X-linked SA, and myelodysplastic syndrome, which often results from either ineffective hematopoiesis or the repeated transfusions undergone by the patients to manage their erythropoietic defects. The pathological consequences of mitochondrial mishandling of iron and heme synthesis are also evident in erythropoietic porphyrias. There is no cure for the above disorders, and thus understanding the mechanisms of the terminal stages of erythropoiesis becomes necessary for discovering novel therapeutic targets. Towards this goal, our on-going research focuses on establishing 1) whether succinyl-CoA synthetase b-subunit allosterically fine-tunes the activity of erythroid ALAS and 2) the mechanism of Fe2+ delivery to FC.

 
Links

Lab Link:  


Selected Publications

Positions Held

Memberships
  • American Society for Biochemistry and Molecular Biology (Member, 2007 - Present)
  • Biophysical Society (Member, 2007 - Present)
  • Protein Society (Member, 2007 - Present)
  • American Association for Advancement of Science (Member, 2007 - Present)
  • Sociedade Portuguesa de Bioquimica (Member, 2007 - Present)
  • American Society for Hematology (Member, 2007 - Present)
  • American Porphyria Foundation (Member, 2007 - Present)
  • Society of Porphyrins & Phatlocyanines (Member, 2007 - Present)
  • American Chemical Society (Member, 2007 - Present)


Awards/Honors
  • Elected Member (Nominating Committee of the Division of Biological Chemistry, American Chemical Society 2002 - 2004)
  • Elected Vice-Chair (Year 2000) and Chair (Year 2002) (Gordon Research Conference, The Chemistry and Biology of Tetrapyrroles - 2000)
  • National Science Foundation Young Investigator Award (1992 - 1997)
  • Presidential Young Faculty Award (University of South Florida 1995 - 1996)



Profile last modified on 07/07/2014