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Robert Haire , PHD

Primary Department: COLLEGE OF MEDICINE PEDIATRICS
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Contacts
Email:
Phone: (727) 797-6932 ext. 33604
Office: XXX, XXX
 
Education
  • PHD, University Of Minnesota , United States - 1987.
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    Selected Publications
  • Haire, RN.Ohta, Y.Litman, RT.Amemiya, CT.Litman, GW. The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of families. Nucleic acids research. 19(11): 3061-6, 1991.
  • Litman, GW.Haire, RN.Hinds, KR.Amemiya, CT.Rast, JP.Hulst, M. Evolutionary development of the B-cell repertoire. Annals of the New York Academy of Sciences. 651(): 360-8, 1992.
  • Litman, GW.Rast, JP.Shamblott, MJ.Haire, RN.Hulst, M.Roess, W.Litman, RT.Hinds-Frey, KR.Zilch, A.Amemiya, CT. Phylogenetic diversification of immunoglobulin genes and the antibody repertoire. Molecular biology and evolution. 10(1): 60-72, 1993.
  • Haire, RN.Buell, RD.Litman, RT.Ohta, Y.Fu, SM.Honjo, T.Matsuda, F.de la Morena, M.Carro, J.Good, RA. Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome. The Journal of experimental medicine. 178(3): 825-34, 1993.
  • Amemiya, CT.Ohta, Y.Litman, RT.Rast, JP.Haire, RN.Litman, GW. VH gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications. Proceedings of the National Academy of Sciences of the United States of America. 90(14): 6661-5, 1993.
  • Ohta, Y.Haire, RN.Litman, RT.Fu, SM.Nelson, RP.Kratz, J.Kornfeld, SJ.de la Morena, M.Good, RA.Litman, GW. Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia. Proceedings of the National Academy of Sciences of the United States of America. 91(19): 9062-6, 1994.
  • Haire, RN.Ohta, Y.Lewis, JE.Fu, SM.Kroisel, P.Litman, GW. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. Human molecular genetics. 3(6): 897-901, 1994.
  • de la Morena, M.Haire, RN.Ohta, Y.Nelson, RP.Litman, RT.Day, NK.Good, RA.Litman, GW. Predominance of sterile immunoglobulin transcripts in a female phenotypically resembling Bruton's agammaglobulinemia. European journal of immunology. 25(3): 809-15, 1995.
  • Rast, JP.Haire, RN.Litman, RT.Pross, S.Litman, GW. Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species. Immunogenetics. 42(3): 204-12, 1995.
  • Kornfeld, SJ.Kratz, J.Haire, RN.Litman, GW.Good, RA. X-linked agammaglobulinemia presenting as transient hypogammaglobulinemia of infancy. The Journal of allergy and clinical immunology. 95(4): 915-7, 1995.
  • Haire, RN.Litman, GW. The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5. Mammalian genome : official journal of the International Mammalian Genome Society. 6(7): 476-80, 1995.
  • Haire, RN.Ota, T.Rast, JP.Litman, RT.Chan, FY.Zon, LI.Litman, GW. A third Ig light chain gene isotype in Xenopus laevis consists of six distinct VL families and is related to mammalian lambda genes. Journal of immunology (Baltimore, Md. : 1950). 157(4): 1544-50, 1996.
  • Ohta, Y.Haire, RN.Amemiya, CT.Litman, RT.Träger, T.Riess, O.Litman, GW. Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. Oncogene. 12(4): 937-42, 1996.
  • Kornfeld, SJ.Haire, RN.Strong, SJ.Tang, H.Sung, SS.Fu, SM.Litman, GW. A novel mutation (Cys145-->Stop) in Bruton's tyrosine kinase is associated with newly diagnosed X-linked agammaglobulinemia in a 51-year-old male. Molecular medicine (Cambridge, Mass.). 2(5): 619-23, 1996.
  • Haire, RN.Strong, SJ.Litman, GW. Identification and characterization of a homologue of Bruton's tyrosine kinase, a Tec kinase involved in B-cell development, in a modern representative of a phylogenetically ancient vertebrate. Immunogenetics. 46(4): 349-51, 1997.
  • Haire, RN.Ohta, Y.Strong, SJ.Litman, RT.Liu, Y.Prchal, JT.Cooper, MD.Litman, GW. Unusual patterns of exon skipping in Bruton tyrosine kinase are associated with mutations involving the intron 17 3' splice site. American journal of human genetics. 60(4): 798-807, 1997.
  • Kornfeld, SJ.Haire, RN.Strong, SJ.Brigino, EN.Tang, H.Sung, SS.Fu, SM.Litman, GW. Extreme variation in X-linked agammaglobulinemia phenotype in a three-generation family. The Journal of allergy and clinical immunology. 100(5): 702-6, 1997.
  • Hawke, NA.Strong, SJ.Haire, RN.Litman, GW. Vector for positive selection of in-frame genetic sequences. BioTechniques. 23(4): 619-21, 1997.
  • Haire, RN.Strong, SJ.Litman, GW. Tec-family non-receptor tyrosine kinase expressed in zebrafish kidney. Immunogenetics. 47(4): 336-7, 1998.
  • Icard-Liepkalns, C.Haire, RN.Strong, SJ.Litman, GW. Cloning of a cDNA encoding a Pim1 homologue in zebrafish, Danio rerio. Immunogenetics. 49(4): 351-3, 1999.
  • Yoder, JA.Haire, RN.Litman, GW. Cloning of two zebrafish cDNAs that share domains with the MHC class II-associated invariant chain. Immunogenetics. 50(1-2): 84-8, 1999.
  • Strong, SJ.Mueller, MG.Litman, RT.Hawke, NA.Haire, RN.Miracle, AL.Rast, JP.Amemiya, CT.Litman, GW. A novel multigene family encodes diversified variable regions. Proceedings of the National Academy of Sciences of the United States of America. 96(26): 15080-5, 1999.
  • Haire, RN.Rast, JP.Litman, RT.Litman, GW. Characterization of three isotypes of immunoglobulin light chains and T-cell antigen receptor alpha in zebrafish. Immunogenetics. 51(11): 915-23, 2000.
  • Haire, RN.Miracle, AL.Rast, JP.Litman, GW. Members of the Ikaros gene family are present in early representative vertebrates. Journal of immunology (Baltimore, Md. : 1950). 165(1): 306-12, 2000.
  • Hawke, NA.Yoder, JA.Haire, RN.Mueller, MG.Litman, RT.Miracle, AL.Stuge, T.Shen, L.Miller, N.Litman, GW. Extraordinary variation in a diversified family of immune-type receptor genes. Proceedings of the National Academy of Sciences of the United States of America. 98(24): 13832-7, 2001.
  • Haire, RN.Kitzan Haindfield, MK.Turpen, JB.Litman, GW. Structure and diversity of T-lymphocyte antigen receptors alpha and gamma in Xenopus. Immunogenetics. 54(6): 431-8, 2002.
  • Litman, GW.Yoder, JA.Cannon, JP.Haire, RN. Novel Immune-type Receptor Genes and the Origins of Adaptive and Innate Immune Recognition. Integrative and comparative biology. 43(2): 331-7, 2003.
  • Eason, DD.Cannon, JP.Haire, RN.Rast, JP.Ostrov, DA.Litman, GW. Mechanisms of antigen receptor evolution. Seminars in immunology. 16(4): 215-26, 2004.
  • Cannon, JP.Haire, RN.Mueller, MG.Litman, RT.Eason, DD.Tinnemore, D.Amemiya, CT.Ota, T.Litman, GW. Ancient divergence of a complex family of immune-type receptor genes. Immunogenetics. 58(5-6): 362-73, 2006.
  • Litman, GW.Cannon, JP.Dishaw, LJ.Haire, RN.Eason, DD.Yoder, JA.Prada, JH.Ostrov, DA. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic research. 38(1-3): 294-304, 2007.
  • Cannon, JP.Haire, RN.Magis, AT.Eason, DD.Winfrey, KN.Hernandez Prada, JA.Bailey, KM.Jakoncic, J.Litman, GW.Ostrov, DA. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity. 29(2): 228-37, 2008.
  • Cannon, JP.Dishaw, LJ.Haire, RN.Litman, RT.Ostrov, DA.Litman, GW. Recognition of additional roles for immunoglobulin domains in immune function. Seminars in immunology. 22(1): 17-24, 2010.
  • Dishaw, LJ.Mueller, MG.Haire, RN.Litman, GW. Transfection-based genomic readout for identifying rare transcriptional splice variants. Methods in molecular biology (Clifton, N.J.). 748(): 243-54, 2011.
  • Dishaw, LJ.Giacomelli, S.Melillo, D.Zucchetti, I.Haire, RN.Natale, L.Russo, NA.De Santis, R.Litman, GW.Pinto, MR. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proceedings of the National Academy of Sciences of the United States of America. 108(40): 16747-52, 2011.
  • Dishaw, LJ.Haire, RN.Litman, GW. The amphioxus genome provides unique insight into the evolution of immunity. Briefings in functional genomics. 11(2): 167-76, 2012.
  • Haire, RN.Cannon, JP.O'Driscoll, ML.Ostrov, DA.Mueller, MG.Turner, PM.Litman, RT.Litman, GW.Yoder, JA. Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family. Genomics. 99(5): 282-91, 2012.

    • Profile last modified on 05/15/2012
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