My Profile
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Umesh Jinwal
, PHD
Primary Department: COP DEPT OF PHARMACEUTICAL SCIENCE
Assistant Professor
COP DEPT OF PHARMACEUTICAL SCIENCE
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| Contacts |
| Email: |
ujinwal@health.usf.edu
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| Phone: |
(813) 396-0673 |
| Office: |
ALZ, 308 |
| Mailing address |
Pharmaceutical Sciences, USF College of Pharmacy, USF Health Byrd Alzheimer’s Institute, University of South Florida, ,4001 E. Fletcher Ave, MDC36,
Tampa, FL 33613
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Education |
| PHD, Biotechnology, Institute Of Microbiology & Biotechnology, Barkatullah Univ , Bhopal, India - 2003. |
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Research Summary |
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My research interest includes Drug discovery, Molecular Chaperone proteins, Neurodegenerative Diseases and Cancer. |
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Selected Publications
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Chowdhury, A.R., Tripathi, M.K., Jinwal, U.K., Roy, U., Kumar, V.V., Bhaduri, A.P. and P.K. Roy Chemoselective hydrolysis of esters by fungal lipase
Journal of Chemical Research. (): , 1999.
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Tripathi, MK, Jinwal, U.K., Roy, U., Patra, A., Roy, P.K., Batra, S. and A.P. Bhaduri Effect of different strains of yeast on stereo-controlled reduction of 5-acetylisoxazolines
Bio-organic Chemistry. (): , 2002.
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Jinwal, U.K., Roy, U., Chowdhury, A.R., Bhadhuri, A.P. and P.K. Roy Purification and characterization of an alkaline lipase from a newly isolated Pseudomonas mendocina PK-12CS and chemoselective hydrolysis of fatty acid ester (dagger)
Bioorganic Medicinal Chemistry. (): , 2003.
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Tripathi, M.K., Roy, U., Jinwal, U.K., Jain, S.K. and P.K. Roy Cloning, sequencing and structural features of a novel Streptococcus lipase
Enzyme and Microbial Technology. (): , 2004.
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Zakharkin, S.O., Willis, R.L., Litvinova, O.V., Jinwal, U.K., Headley, V.V. and H. Beneš Identification of two mariner-like elements in the genome of the mosquito Ochlerotatus atropalpus
Insect Biochemistry and Molecular Biology. (): , 2004.
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Jinwal, U.K., Zakharkin, S.O., Litvinova, O.V., Jain, S., and H. Beneš Sex, stage and tissue-specific regulation by a mosquito hexamerin promoter
Insect Molecular Biology. (): , 2006.
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Dickey, C.A., Koren, J., Zhang, Y.J., Xu, Y.F., Jinwal, U.K., Birnbaum, M.J., Monks, B., Sun, M., Cheng, J.Q., Patterson, C., Bailey, R.M., Dunmore, J., Soresh, S., Leon, C., Morgan, D., Petrucelli, L. Akt and CHIP coregulate tau degradation through coordinated interactions
Proceedings of the National Academy of Sciences of the United States of America. (): , 2008.
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Dickey, C. A., Kraft, C., Jinwal U.K., Koren, J., Johnson, A., Anderson, L., Lebson, L., Lee, D., Dickson, D., De Silva, R., Binder, L., I., Morgan, D. and Lewis, J. Aging analysis reveals slowed Tau turnover and enhanced stress response in Mouse model of Tauopathy
American Journal of Pathology. (): , 2009.
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Jinwal, U.K., O’Leary, J.C., Borysov, S.I., Jones, J.R, Li, Q., Koren, J. III, Abisambra, J.F., Vestal, G.D., Lawson, L.Y., Johnson, A.G., Blair, L.J., Jin, Y., Miyata, Y., Gestwicki, J.E., and Dickey, C.A. Hsc70 rapidly engages tau after microtubule destabilization
The Journal of Biological Chemistry. (): , 2010.
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Koren, J., Jinwal, U.K., Jin, Y., O’Leary, J., Jones, J.R., Johnson, A.G., Blair, L.J., Abisambra, J.F., Chang, L., Miyata, Y., Cheng, A.M., Guo, J., Cheng, J.Q., Gestwicki, J.E., Dickey, C.A. Facilitating Akt clearance via manipulation of Hsp70 activity and levels
The Journal of Biological Chemistry. (): , 2010.
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Lebson, L., Nash, N., Kamath, S., Herber, D., Carty, C., Lee, D., Li, Q., Szekeres, K., Jinwal, U., Koren, J., Dickey, C.A., Gottschall, P., Morgan, D. and Gordon, M.N. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid depositing transgenic mice
The Journal of Neuroscience. (): , 2010.
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Jinwal, U.K., Koren, J. III, Borysov, S.I., Schmid, A.B., Abisambra, J.F., Blair, L.J., Johnson, A.G., Jones, J.R, Shults, C., O’Leary, J. III, Jin, Y., Buchner, J., Cox, M.B., and Dickey, C.A. The Hsp90 co-chaperone, FKBP51, increases tau stability and polymerizes microtubules
The Journal of Neuroscience. (): , 2010.
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Jinwal, U.K., Koren, J. III, O’Leary, Jones, J.R, Abisambra, J.F., and Dickey, C.A. Hsp70 ATPase modulators as therapeutics for Alzheimer’s and other neurodegenerative diseases
Molecular and Cellular Pharmacology. (): , 2010.
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Abisambra, J.F., Blair, L.J., Hill, S.E., Jones, J.R, Kraft, C., Rogers, J., Koren, J. III, Jinwal, U.K., Lawson L., Johnson, A.G., Wilcock, D., O’Leary, J.C., Jansen-west, K., Muschol, M., Golde, T.E., Weeber, E.J., Banko, J. and Dickey, C.A. Phosphorylation dynamics regulates Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
The Journal of Neuroscience. (): , 2010.
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O’Leary, J.C., Li, Q., Marinec, P., Blair, L.J., Congdon, E.E., Johnson, A.G., Jinwal, U.K., Koren, J. III, Jones, J.R., Kraft, C., Peters, M., Abisambra, J.F., Duff, K.E., Weeber, E.J., Gestwicki, J.E., and Dickey, C.A. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
Molecular Neurodegeneration. (): , 2010.
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Jones, J.R., Leber, M., Jinwal, U.K., Abisambra, J.F., Koren, J. III, Blair, J., O’Leary, J.C., Trotter, J., Johnson, A.G., Weeber, E., Eckman, C.B., Baker, B., and Dickey, C.A. Myricanol derived from Myrica cerifera is a novel diarylheptanoid scaffold that destabilizes the microtubule associated protein tau
Journal of Natural Products. (): , 2010.
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Daily, J.L., Nash, K., Jinwal, U., Golde, T., Rogers, J., Peters, M.P., Burdine, R.D., Dickey, C., Banko, J.L., and Weeber, J.E. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome
PLoS ONE. (): , 2011.
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Evans, C.E., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E. Identification of dihydropyridines that reduce cellular tau levels
Chemical Communications. (): , 2011.
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Rousaki, A., Miyata, Y., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E., and Zuiderweg, E.R.P. Allosteric drugs: the interaction of anti-tumor compound MKT-077 with human Hsp70 chaperones
Journal of Molecular Biology. (): , 2011.
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Shen, Z., Zhang, X., Tang, J., Kasiappan, R., Jinwal, U., Li, P., Hann, S., Nicosia, S., Wu, J., Zhang, X., and Bai, W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells
Molecular and Cellular Endocrinology. (): , 2011.
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Trotter, J.H., Klein, M., Jinwal, U., Abisambra, J., Dickey, C., Tharkur, J., Masiulis, I., Ding, J., Locke, K., Rickman, C., Birch, D., Weeber, E.J. and Herz, J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity
The Journal of Neuroscience. (): , 2011.
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O’Leary, J.C., Dharia, S., Blair, L.J., Brady, S., Johnson, A.G., Peters, M., Cheung-Flynn, J., Cox, M. B., Erausquin, G., Weeber, E.J. Jinwal, U.K., and Dickey, C.A. Ablation of FKBP5/FKBP51 as a novel anti-depressive strategy
PLoS ONE. (): , 2011.
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Abisambra, J.F., Jinwal, U.K., Jones, J.R., Blair, L.J., Koren, J. III, and Dickey, C.A. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics
Current Neuropharmacology. (): , 2011.
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Jinwal, U.K. and Dickey, C.A. Cell-based assays for regulators of Tau Biology. “Alzheimer’s disease and frontotemporal dementia
Methods in molecular biology. (): , 2011.
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Jinwal, U.K., Trotter, J.H., Abisambra, J.F., Vestal, G.D., Koren, J. III, Lawson, L.Y., Vestal, G.D., O’Leary, J.C., Johnson, A.G., Jin, Y., Jones, J.R, Li, Q., Weeber, E.J. and Dickey, C.A. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability
The Journal of Biological Chemistry. (): , 2011.
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Koren, J. III, Jinwal, U.K., Davey, Z., Kiray, J., Aruselvam, K. and Dickey, C.A. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies
Molecular Neurobiology. (): , 2011.
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Calcul, L., Zhang, B., Jinwal, U.K., Dickey, C.A., Baker, B.J. products are a rich source of tau-targeting drugs for Alzheimer’s disease
Future Medicinal Chemistry. (): , 2012.
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Thompson, A. D., Scaglione, K.M., Presener, J., Gillies, A.T., Chinnaiyan, A., Paulson, H. L., Jinwal, U. K., Dickey, C. A., Gestwicki, J. E Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation
ACS Chemical Biology. (): , 2012.
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Jinwal, U.K., J.H., Abisambra, J.F., Zhang, J., Dharia, S., O’Leary, J.C., Patel, T., Braswell, K., Jani, T., Gestwicki, J.E., Dickey, C.A. Cdc37/ Hsp90 Complex disruption triggers an autophagic clearance cascade for TDP-43
The Journal of Biological Chemistry. (): , 2012.
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Abisambra, J.F., Jinwal, U.K., Suntharalingam, A., Arulselvam, K. Brady, S., Cockman, M.S., Jin, Y., Zhang, B., Dickey, C.A. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau
Journal of Molecular Biology. (): , 2012.
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Koren, J. III., Miyata, Y., Kiray, J., O’Leary, J.C., Nguyen, L., Guo, J., Blair, L.J., Jinwal, U.K., Cheng, J.Q., Gestwicki, J.E., Dickey, C.A. Rhodacyanine derivatives selectively targets cancer cells and overcomes tamoxifen resistance
PLoS ONE. (): , 2012.
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Positions Held
- Assistant Professor
(Department of Pharmaceutical Sciences, USF College of Pharmacy, University of South Florida 2011 -
Present)
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- Research Assistant Professor
(Department of Molecular Medicine, College of Medicine, University of South Florida 2010 -
2011)
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- Instructor & Postdoctoral Fellow
(USF health Byrd Alzheimer Institute, Department of Molecular Medicine , University of South Florida 2007 -
2010)
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- Postdoctoral Fellow
(Department of Cell Biology and Pathology, College of Medicine, University of South Florida 2006 -
2007)
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- Senior Research Associate
(Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences 2002 -
2006)
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- Senior Research Fellow
(Fermentation Technology Division, Central Drug Research Institute, India 2000 -
2002)
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Memberships
- The Alzheimer's Association International Society to Advance Alzheimer Research & Treatment.
(Member,
2010 -
Present)
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- American Society for Biochemistry and Molecular Biology
(Member,
2004 -
Present)
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- Association of Microbiologists, India
(Life Member,
1998 -
Present)
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- American Association of College of Pharmacy
(Member,
2011 -
2012)
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- The Society for Neuroscience
(Member,
2008 -
2012)
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- American Association for the Advancement of Science
(Member,
2007 -
2012)
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- American Mosquito Control Association
(Member,
2004 -
2006)
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Awards/Honors
- New Investigator Research Grant award
(Alzheimer’s Association - 2010)
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- Senior Research Fellowship award
(Council of Scientific and Industrial Research, New Delhi, India - 2000)
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- Fellowship for M.S.
(Department of Biotechnology, Ministry Of Science and Technology, Government of India - 1995)
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Grants
- BEHAVIORAL AND BIOCHEMICAL ANALYSIS OF MICE LACKING FKBP51
($50,001.00,
10/01/2010-03/31/2012)
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Lectures
- "Identification of novel drugs by using cell culture models" Drug Discovery in the Post Genomic Era Symposium, USF College of Pharmacy, University of South Florida.
FL,
United States - 2011.
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- "Deconstructing the tau/Hsp90 complex" Department of Molecular Medicine, University of South Florida.
FL,
United States - 2010.
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- "The Hsp90 co-chaperone FKBP51 regulates Tau biology" Department of Molecular Medicine, University of South Florida.
FL,
United States - 2009.
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- "FKBP51 Regulates Tau Phosphorylation and Degradation" The 14th Annual Midwest Stress Response and Molecular Chaperone Meeting. Northwestern University, Evanston.
FL,
United States - 2009.
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- "Female-specific Enhancer activity from a Mosquito Hexamerin gene" The Entomological Society of America annual meeting: “Sex, Bugs and Rock ‘n’ roll”.
FL,
United States - 2005.
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Profile last modified on 10/11/2012
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