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Nikolay Malinin , PhD

Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Assistant Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY
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Contacts
Email: nmalinin@health.usf.edu
Phone: (813) 974--876
Office: MDC, 2532
Mailing address 12901 Bruce B. Downs Blvd. ,MDC8
Tampa, FL 33612-4799
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Education
  • PhD, Molecular Biology, Weizmann Institute Of Science* , Israel - 2000.
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  • PhD, Molecular Biology, Weizmann Institue of Science , Rehovot, Israel - 2000.
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    Interdisciplinary & Emerging Signature Programs
    Cardiovascular.
     


    Selected Publications
  • Davydova, EK.Malinin, NL.Ovchinnikov, LP. Ribosomes terminated in vitro are in a tight association with non-phosphorylated elongation factor 2 (eEF-2) and GDP. European journal of biochemistry / FEBS. 215(2): 291-6, 1993.
  • Rachamim, N.Latter, H.Malinin, N.Asher, C.Wald, H.Garty, H. Dexamethasone enhances expression of mitochondrial oxidative phosphorylation genes in rat distal colon. The American journal of physiology. 269(5 Pt 1): C1305-10, 1995.
  • Wallach, D.Boldin, M.Goncharov, T.Goltsev, Y.Mett, I.Malinin, N.Adar, R.Kovalenko, A.Varfolomeev, E. Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family. Behring Institute Mitteilungen. (97): 144-55, 1996.
  • Malinin, NL.Boldin, MP.Kovalenko, AV.Wallach, D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 385(6616): 540-4, 1997.
  • Sylla, BS.Hung, SC.Davidson, DM.Hatzivassiliou, E.Malinin, NL.Wallach, D.Gilmore, TD.Kieff, E.Mosialos, G. Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. Proceedings of the National Academy of Sciences of the United States of America. 95(17): 10106-11, 1998.
  • Carpentier, I.Declercq, W.Malinin, NL.Wallach, D.Fiers, W.Beyaert, R. TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways. FEBS letters. 425(2): 195-8, 1998.
  • Akiba, H.Nakano, H.Nishinaka, S.Shindo, M.Kobata, T.Atsuta, M.Morimoto, C.Ware, CF.Malinin, NL.Wallach, D.Yagita, H.Okumura, K. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. The Journal of biological chemistry. 273(21): 13353-8, 1998.
  • Wallach, D.Boldin, MP.Kovalenko, AV.Malinin, NL.Mett, IL.Camonis, JH. The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis. Current opinion in immunology. 10(2): 131-6, 1998.
  • Wallach, D.Varfolomeev, EE.Malinin, NL.Goltsev, YV.Kovalenko, AV.Boldin, MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annual review of immunology. 17(): 331-67, 1999.
  • Holtmann, H.Winzen, R.Holland, P.Eickemeier, S.Hoffmann, E.Wallach, D.Malinin, NL.Cooper, JA.Resch, K.Kracht, M. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Molecular and cellular biology. 19(10): 6742-53, 1999.
  • Malinin, NL.Wright, S.Seubert, P.Schenk, D.Griswold-Prenner, I. Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences of the United States of America. 102(8): 3058-63, 2005.
  • Zhao, WN.Malinin, N.Yang, FC.Staknis, D.Gekakis, N.Maier, B.Reischl, S.Kramer, A.Weitz, CJ. CIPC is a mammalian circadian clock protein without invertebrate homologues. Nature cell biology. 9(3): 268-75, 2007.
  • Wright, S.Malinin, NL.Powell, KA.Yednock, T.Rydel, RE.Griswold-Prenner, I. Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity. Neurobiology of aging. 28(2): 226-37, 2007.
  • Malinin, N.Byzova, T. CD40/TRAF6 switch in neointimal hyperplasia. Blood. 111(9): 4424, 2008.
  • Somanath, PR.Malinin, NL.Byzova, TV. Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis. 12(2): 177-85, 2009.
  • Malinin, NL.Zhang, L.Choi, J.Ciocea, A.Razorenova, O.Ma, YQ.Podrez, EA.Tosi, M.Lennon, DP.Caplan, AI.Shurin, SB.Plow, EF.Byzova, TV. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature medicine. 15(3): 313-8, 2009.
  • West, XZ.Malinin, NL.Merkulova, AA.Tischenko, M.Kerr, BA.Borden, EC.Podrez, EA.Salomon, RG.Byzova, TV. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 467(7318): 972-6, 2010.
  • Malinin, NL.Plow, EF.Byzova, TV. Kindlins in FERM adhesion. Blood. 115(20): 4011-7, 2010.
  • Bialkowska, K.Ma, YQ.Bledzka, K.Sossey-Alaoui, K.Izem, L.Zhang, X.Malinin, N.Qin, J.Byzova, T.Plow, EF. The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. The Journal of biological chemistry. 285(24): 18640-9, 2010.
  • Malinin, NL.West, XZ.Byzova, TV. Oxidation as "the stress of life". Aging. 3(9): 906-10, 2011.
  • West, XZ.Meller, N.Malinin, NL.Deshmukh, L.Meller, J.Mahabeleshwar, GH.Weber, ME.Kerr, BA.Vinogradova, O.Byzova, TV. Integrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch. PloS one. 7(2): e31071, 2012.
  • Zhao, Y.Malinin, NL.Meller, J.Ma, Y.West, XZ.Bledzka, K.Qin, J.Podrez, EA.Byzova, TV. Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain. The Journal of biological chemistry. 287(47): 40012-20, 2012.
  • Malinin, NL.Pluskota, E.Byzova, TV. Integrin signaling in vascular function. Current opinion in hematology. 19(3): 206-11, 2012.
  • Meller, J.Malinin, NL.Panigrahi, S.Kerr, BA.Patil, A.Ma, Y.Venkateswaran, L.Rogozin, IB.Mohandas, N.Ehlayel, MS.Podrez, EA.Chinen, J.Byzova, TV. Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III. Journal of thrombosis and haemostasis : JTH. 10(7): 1397-408, 2012.

    • Memberships
  • American Heart Association (regular member, 2013 - Present)
  • American Physiological Society (regular member, 2012 - Present)


    • Awards/Honors
  • Irving Page Award (Cleveland Clinic - 2009)
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  • Brooks Fund Postdoctoral Fellowship (Harvard Medical School - 2001)
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  • Award of distinction in Ph.D. studies, (Weizmann Institute of Science, Israel - 1998)
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  • MS Degree Honor Diploma (N.Novgorod State University , Russia - 1993)
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    Patents & Licensing
  • SIGNALING INTERMEDIATES IN AN IN VITRO MODEL OF ALZHEIMER'S DISEASE (Elan Pharmaceuticals - 2010)
  • Modulators of TNF receptor associated factor (TRAF), their preparation and use (Yeda Research and Development Co Ltd - 2009)
  • IREN protein, its preparation and use (Yeda Research and Development Co Ltd - 2008)
  • Modulators of intracellular inflammation, cell death and cell survival pathways (Yeda Research and Development Co Ltd - 2008)


    • Grants
  • KINDLIN-3 SPECIFIC REGULATION OF THE INSIDE-OUT SIGNALING ($15,129.00, 06/01/2012-06/30/2014)
  • KINDLIN-3 SPECIFIC REGULATION OF THE INSIDE-OUT SIGNALING ($77,000.00, 06/01/2012-06/30/2014)


    • Profile last modified on 03/01/2013
    SIGNATURE PROGRAMS
    Allergy, Immunology and Infectious Diseases Cancer Biology Cardiovascular Research Neuroscience Research
    New Collaborative
    USF Neuroscience Collaborative – NSC
    Emerging Areas
    of Interest
    Biomedical Engineering Nanomedicine Neuromusculoskeletal Disorders(NEW) Pharmacogenomics Regenerative Medicine Sports Medicine Women's Health
    COM Approved
    Centers/Institutes
    Archie A. & Mary-Louise Silver Child Development Center Byrd Alzheimer’s Institute Cardiac Hormone Center Center for Aging & Brain Repair Center for Hospice, Palliative Care & End of Life Studies Diabetes Center Florida Infectious Disease Center Institute for Research In Psychiatry and NeurosciencesJoy McCann Culverhouse Center for Swallowing Disorders Nanomedicine Research Center Pediatrics Epidemiology Center Suncoast Alzheimer's Clinic USF Parkinson's Disease and Movement Disorders Center, NPF Center of Excellence