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Thomas Taylor-Clark, PHD


Assoc Professor

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Email: ttaylorc@health.usf.edu
Phone: (813) 974-7749 ext. 81300
Office: MDC, 4046
Mailing address 12901 Bruce B Downs Blvd
Tampa, FL 33612
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  • PHD, Pharmacology, University College London, London, Uk - 2004.
    Interdisciplinary & Emerging Signature Programs
    Environmental & Global Health, Neuroscience, Pulmonary Physiology, Allergy, Immunology & Infectious Disease, Cardiovascular.
    Research Summary

    Our interests lie in the role of nociceptive (defensive) sensory nerves in health and disease. Aberrant nociceptor stimulation contributes to unpleasant/debilitating sensations and inappropriate reflexes. Our focus is primarily on the sensory nerves of the airways. Activation of these nerves leads to cough, mucus secretion, bronchospasm, wheeze. In addition, activation of airway nerves contributes to autonomic regulatory control of the heart. To gain understanding of these events we study the electrical excitability of sensory nerves, investigating the interaction of inflammation, oxidative stress and inhaled pollutants (e.g. particulate matter and ozone) on receptors and ion channels expressed on nociceptive sensory nerves. Using a combination of electrophysiological, imaging and molecular biological techniques we are able to study ion channel/receptor function and nerve activation at multiple levels, from single channels to single cells to intact tissue to preclinical models.


    Selected Publications
  • Hadley SH, Bahia PK, Taylor-Clark TE. Sensory nerve terminal mitochondrial dysfunction induces hyperexcitability in airway nociceptors via protein kinase C. Molecular pharmacology. 85(6) : 839-48, 2014.
  • Undem BJ, Taylor-Clark T. Mechanisms underlying the neuronal-based symptoms of allergy. The Journal of allergy and clinical immunology. 133(6) : 1521-34, 2014.
  • Nesuashvili L, Hadley SH, Bahia PK, Taylor-Clark TE. Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves via Transient Receptor Potential (TRP) Channels. Molecular pharmacology. 83(5) : 1007-19, 2013.
  • Hooper JS, Hadley SH, Mathews A, Taylor-Clark TE. Store-operated calcium entry in vagal sensory nerves is independent of Orai channels. Brain research. 1503: 7-15, 2013.
  • Bahia PK, Bennett ES, Taylor-Clark TE. Reductions in external divalent cations evoke novel voltage-gated currents in sensory neurons. PloS one. 7(2) : e31585, 2012.
  • Taylor-Clark TE, Undem BJ. Sensing pulmonary oxidative stress by lung vagal afferents. Respiratory physiology & neurobiology. 178(3) : 406-13, 2011.
  • Taylor-Clark T. Histamine in allergic rhinitis. Advances in experimental medicine and biology. 709: 33-41, 2011.
  • Brozmanova M, Ru F, Surdenikova L, Mazurova L, Taylor-Clark T, Kollarik M. Preferential activation of the vagal nodose nociceptive subtype by TRPA1 agonists in the guinea pig esophagus. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(10) : e437-45, 2011.
  • McAlexander MA, Taylor-Clark T. The role of transient receptor potential channels in respiratory symptoms and pathophysiology. Advances in experimental medicine and biology. 704: 969-86, 2011.
  • Taylor-Clark TE, Undem BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. The Journal of physiology. 588(Pt 3) : 423-33, 2010.
  • Nassenstein C, Taylor-Clark TE, Myers AC, Ru F, Nandigama R, Bettner W, Undem BJ. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. The Journal of physiology. 588(Pt 23) : 4769-83, 2010.
  • Taylor-Clark TE, Nassenstein C, McAlexander MA, Undem BJ. TRPA1: a potential target for anti-tussive therapy. Pulmonary pharmacology & therapeutics. 22(2) : 71-4, 2009.
  • Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA. Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. American journal of respiratory cell and molecular biology. 40(6) : 756-62, 2009.
  • Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Molecular pharmacology. 75(4) : 820-9, 2009.
  • Taylor-Clark TE, McAlexander MA, Nassenstein C, Sheardown SA, Wilson S, Thornton J, Carr MJ, Undem BJ. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. The Journal of physiology. 586(14) : 3447-59, 2008.
  • Taylor-Clark TE, Undem BJ, Macglashan DW, Ghatta S, Carr MJ, McAlexander MA. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Molecular pharmacology. 73(2) : 274-81, 2008.
  • Taylor-Clark TE, Nassenstein C, Undem BJ. Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. British journal of pharmacology. 154(6) : 1359-68, 2008.
  • Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, Braun A, Undem BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. The Journal of physiology. 586(6) : 1595-604, 2008.
  • Taylor-Clark TE. Insights into the mechanisms of histamine-induced inflammation in the nasal mucosa. Pulmonary pharmacology & therapeutics. 21(3) : 455-60, 2008.
  • Taylor-Clark T, Undem BJ. Transduction mechanisms in airway sensory nerves. Journal of applied physiology (Bethesda, Md. : 1985). 101(3) : 950-9, 2006.
  • Taylor-Clark T, Sodha R, Warner B, Foreman J. Histamine receptors that influence blockage of the normal human nasal airway. British journal of pharmacology. 144(6) : 867-74, 2005.
  • Taylor-Clark T, Foreman J. Histamine-mediated mechanisms in the human nasal airway. Current opinion in pharmacology. 5(3) : 214-20, 2005.
  • Taylor-Clark TE, Kollarik M, MacGlashan DW, Undem BJ. Nasal sensory nerve populations responding to histamine and capsaicin. The Journal of allergy and clinical immunology. 116(6) : 1282-8, 2005.

  • Lectures
  • "Airway sensory nerve activation by endogenous activators of TRPA1 channels" Department of Integrative Biology and Pharmacology, University of Texas Health Science Center . TX, United States - 2009.
  • "Airway sensory nerve activation by endogenous activators of TRPA1 channels" Department of Pharmacology, University of Texas Health Science Center. TX, United States - 2009.
  • "Airway sensory nerve activation by endogenous activators of TRPA1 channels" Ion Channel Research Group, Duke University. NC, United States - 2009.

  • Profile last modified on 11/03/2014