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Shengyan Xiang, PH.D.
Research Associate, Pathology and Cell Biology, College of Medicine

Primary Department: COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

Research Associate
COLLEGE OF MEDICINE PATHOLOGY & CELL BIOLOGY

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Contacts
Email: sxiang@health.usf.edu
Phone: (813) 974-1278
Office: SHR, 115
 
Education
  • Ph.D, Biochemistry and Molecular Biology, Peking University, Beijing, People's Republic of China - 2009.
  • PHD, Peking University, Health Science Center, China - 2007.
  • Bachelor of Medicine, Preventive Medicine, Peking University, Beijing, People's Republic of China - 2002.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cancer Biology.
     


    Selected Publications
  • Joshua Haakenson, Jheng-Yu Wu, Shengyan Xiang, Kendra A Williams, Wenlong Bai, Xiaohong Zhang. HDAC6-Dependent Functions in Tumor Cells: Crossroad with the MAPK Pathways. Critical Reviews™ in Oncogenesis. 20: 65, 2016.
  • Nadine Nelson, Shengyan Xiang, Xiaohong Zhang, Danielle Gilvary, Julie Djeu, Kazim Husain, Mokenge Malafa, Nasreen Vohra, Shari Pilon-Thomas, Tomar Ghansah. Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis PLoS one. 10(1) : e0115546, 2015.
  • Rangasudhagar Radhakrishnan, Yixuan Li, Shengyan Xiang, Fenghua Yuan, Zhigang Yuan, Elphine Telles, Jia Fang, Domenico Coppola, David Shibata, William S Lane, Yanbin Zhang, Xiaohong Zhang, Edward Seto. Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2. J Biol Chem. : M114.612945, 2015.
  • Mu Zhang*, Shengyan Xiang*, Heui-Yun Joo, Amanda Jones, Ryan Pavlovicz, Huiqin Dong, Patrick Matthias, Santo V. Nicosia, Jiandong Chen, Chenglong Li, Wenlong Bai, Hengbin Wang and Xiaohong Zhang. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα Molecular Cell. 55(1) : 31, 2014.
  • Kendra A. Williams, Mu Zhang, Shengyan Xiang, Chen Hu, Jheng-Yu Wu, Shengping Zhang, Meagan Ryan, Adrienne D. Cox, Channing J. Der, Bin Fang, John Koomen, Eric Haura, Gerold Bepler, Santo V. Nicosia, Patrick Matthias, Chuangui Wang, Wenlong Bai, and Xiaohong Zhang. Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration. J Biol Chem.. 15(288) : 33156, 2013.
  • Baozhen Zhang*, Shengyan Xiang*, Yanru Yin, Liankun Gu and Dajun Deng. C-terminal in Sp1-like artificial zinc-finger proteins plays crucial roles in determining their DNA binding affinity BMC Biotechnology. 13: 106, 2013.
  • Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia SV, Khochbin S, Bepler G, Zhang X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. 7(9) : e44265, 2012.
  • Zhang B, Xiang S, Zhong Q, Yin Y, Gu L, Deng D. The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors. Human gene therapy. 23(10) : 1071-81, 2012.
  • Yonghua Yang, A KW Tse, Pengfei Li, Qiuping Ma, Shengyan Xiang, Santo V Nicosia, Edward Seto, Xiaohong Zhang, Wenlong Bai. Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation Oncogene. 30(19) : 2207-2218, 2011.
  • Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J, Zhao RJ, Zhang X. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Frontiers in bioscience (Elite edition). 2: 221-30, 2010.
  • Xiang S, Liu Z, Zhang B, Zhou J, Zhu BD, Ji J, Deng D. Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas. BMC cancer. 10: 44, 2010.
  • Luo D, Zhang B, Lv L, Xiang S, Liu Y, Ji J, Deng D. Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas. Laboratory investigation; a journal of technical methods and pathology. 86(6) : 591-8, 2006.

  • Positions Held
  • Postdoctoral Fellow (Pathology and Cell Biology, College of Medicine, University of South Florida 2008 - 2012)


  • Memberships
  • AACR (Associate member, 2011 - Present)


  • Patents & Licensing
  • Synthetic single-zinc finger protein, two-zinc finger protein and four-zinc finger protein (Xiang Shengyan, Zhang Baozhen, Yin Yanru, Gu Liankun, Deng Dajun - 2007)


  • Profile last modified on 08/25/2015