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Umesh Jinwal, PHD



Assistant Professor, Department of Pharmaceutical Sciences, USF College of Pharmacy

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Email: ujinwal@health.usf.edu
Phone: (813) 396-0673
Office: ALZ, 308
Mailing address Pharmaceutical Sciences, USF College of Pharmacy, USF Health Byrd Alzheimer’s Institute, University of South Florida, 4001 E. Fletcher Ave, MDC36,
Tampa, FL 33613
  • PHD, Biotechnology, Institute Of Microbiology & Biotechnology, Barkatullah Univ, Bhopal, India - 2003.
Research Summary

My research interest includes Drug discovery, Molecular Chaperone proteins, Neurodegenerative Diseases and Cancer.


Selected Publications
  • Narayan M, Zhang J, Braswell K, Gibson C, Zitnyar A, Lee DC, Varghese-Gupta S, Jinwal UK. Withaferin A regulates LRRK2 levels by interfering with the Hsp90-Cdc37 chaperone complex. Current aging science. : , 2015.
  • Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. ACS chemical biology. 10(4) : 1099-109, 2015.
  • Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki JE, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. The Journal of biological chemistry. 290(21) : 13115-27, 2015.
  • Narayan M, Peralta DA, Gibson C, Zitnyar A, Jinwal UK. An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug. Journal of biotechnology. 207: 34-8, 2015.
  • Jinwal U, K Grover A, Narayan M, Hirani A, Sutariya V, B. Preparation and Characterization of MKT-077 Nanoparticles for brain-targeted treatment of Alzheimer’s disease and other Tauopathies Pharmaceutical Nanotechnology. 2: 217-226 , 2014.
  • Jinwal UK, Groshev A, Zhang J, Grover A, Sutariya VB. Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies. Current drug delivery. 11(4) : 541-50, 2014.
  • Jinwal UK, Koren J, Dickey CA. Reconstructing the Hsp90/Tau Machine. Current enzyme inhibition. 9(1) : 41-45, 2013.
  • Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(22) : 9498-507, 2013.
  • Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological psychiatry. 74(5) : 367-74, 2013.
  • Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS chemical neuroscience. 4(6) : 930-9, 2013.
  • Totten DC, Vuong M, Litvinova OV, Jinwal UK, Gulia-Nuss M, Harrell RA, Beneš H. Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes. Insect molecular biology. 22(1) : 18-30, 2013.
  • Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4) : 1450-9, 2013.
  • Abisambra, J.F., Jinwal, U.K., Suntharalingam, A., Arulselvam, K. Brady, S., Cockman, M.S., Jin, Y., Zhang, B., Dickey, C.A. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau Journal of Molecular Biology. : , 2012.
  • Koren, J. III., Miyata, Y., Kiray, J., O’Leary, J.C., Nguyen, L., Guo, J., Blair, L.J., Jinwal, U.K., Cheng, J.Q., Gestwicki, J.E., Dickey, C.A. Rhodacyanine derivatives selectively targets cancer cells and overcomes tamoxifen resistance PLoS ONE. : , 2012.
  • Calcul, L., Zhang, B., Jinwal, U.K., Dickey, C.A., Baker, B.J. products are a rich source of tau-targeting drugs for Alzheimer’s disease Future Medicinal Chemistry. : , 2012.
  • Jinwal, U.K., J.H., Abisambra, J.F., Zhang, J., Dharia, S., O’Leary, J.C., Patel, T., Braswell, K., Jani, T., Gestwicki, J.E., Dickey, C.A. Cdc37/ Hsp90 Complex disruption triggers an autophagic clearance cascade for TDP-43 The Journal of Biological Chemistry. : , 2012.
  • Thompson, A. D., Scaglione, K.M., Presener, J., Gillies, A.T., Chinnaiyan, A., Paulson, H. L., Jinwal, U. K., Dickey, C. A., Gestwicki, J. E. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation ACS Chemical Biology. : , 2012.
  • Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future medicinal chemistry. 4(13) : 1751-61, 2012.
  • Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of biological chemistry. 287(48) : 40661-9, 2012.
  • Kasiappan R, Shen Z, Tse AK, Jinwal U, Tang J, Lungchukiet P, Sun Y, Kruk P, Nicosia SV, Zhang X, Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. The Journal of biological chemistry. 287(49) : 41297-309, 2012.
  • Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chemistry & biology. 19(11) : 1391-9, 2012.
  • O’Leary, J.C., Dharia, S., Blair, L.J., Brady, S., Johnson, A.G., Peters, M., Cheung-Flynn, J., Cox, M. B., Erausquin, G., Weeber, E.J. Jinwal, U.K., and Dickey, C.A. Ablation of FKBP5/FKBP51 as a novel anti-depressive strategy PLoS ONE. : , 2011.
  • Trotter, J.H., Klein, M., Jinwal, U., Abisambra, J., Dickey, C., Tharkur, J., Masiulis, I., Ding, J., Locke, K., Rickman, C., Birch, D., Weeber, E.J. and Herz, J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity The Journal of Neuroscience. : , 2011.
  • Daily, J.L., Nash, K., Jinwal, U., Golde, T., Rogers, J., Peters, M.P., Burdine, R.D., Dickey, C., Banko, J.L., and Weeber, J.E. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome PLoS ONE. : , 2011.
  • Koren, J. III, Jinwal, U.K., Davey, Z., Kiray, J., Aruselvam, K. and Dickey, C.A. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies Molecular Neurobiology. : , 2011.
  • Evans, C.E., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E. Identification of dihydropyridines that reduce cellular tau levels Chemical Communications. : , 2011.
  • Jinwal, U.K. and Dickey, C.A. Cell-based assays for regulators of Tau Biology. “Alzheimer’s disease and frontotemporal dementia Methods in molecular biology. : , 2011.
  • Abisambra, J.F., Jinwal, U.K., Jones, J.R., Blair, L.J., Koren, J. III, and Dickey, C.A. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics Current Neuropharmacology. : , 2011.
  • Shen, Z., Zhang, X., Tang, J., Kasiappan, R., Jinwal, U., Li, P., Hann, S., Nicosia, S., Wu, J., Zhang, X., and Bai, W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells Molecular and Cellular Endocrinology. : , 2011.
  • Rousaki, A., Miyata, Y., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E., and Zuiderweg, E.R.P. Allosteric drugs: the interaction of anti-tumor compound MKT-077 with human Hsp70 chaperones Journal of Molecular Biology. : , 2011.
  • Jinwal, U.K., Trotter, J.H., Abisambra, J.F., Vestal, G.D., Koren, J. III, Lawson, L.Y., Vestal, G.D., O’Leary, J.C., Johnson, A.G., Jin, Y., Jones, J.R, Li, Q., Weeber, E.J. and Dickey, C.A. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability The Journal of Biological Chemistry. : , 2011.
  • Jinwal, U.K., O’Leary, J.C., Borysov, S.I., Jones, J.R, Li, Q., Koren, J. III, Abisambra, J.F., Vestal, G.D., Lawson, L.Y., Johnson, A.G., Blair, L.J., Jin, Y., Miyata, Y., Gestwicki, J.E., and Dickey, C.A. Hsc70 rapidly engages tau after microtubule destabilization The Journal of Biological Chemistry. : , 2010.
  • Jones, J.R., Leber, M., Jinwal, U.K., Abisambra, J.F., Koren, J. III, Blair, J., O’Leary, J.C., Trotter, J., Johnson, A.G., Weeber, E., Eckman, C.B., Baker, B., and Dickey, C.A. Myricanol derived from Myrica cerifera is a novel diarylheptanoid scaffold that destabilizes the microtubule associated protein tau Journal of Natural Products. : , 2010.
  • Koren, J., Jinwal, U.K., Jin, Y., O’Leary, J., Jones, J.R., Johnson, A.G., Blair, L.J., Abisambra, J.F., Chang, L., Miyata, Y., Cheng, A.M., Guo, J., Cheng, J.Q., Gestwicki, J.E., Dickey, C.A. Facilitating Akt clearance via manipulation of Hsp70 activity and levels The Journal of Biological Chemistry. : , 2010.
  • Abisambra, J.F., Blair, L.J., Hill, S.E., Jones, J.R, Kraft, C., Rogers, J., Koren, J. III, Jinwal, U.K., Lawson L., Johnson, A.G., Wilcock, D., O’Leary, J.C., Jansen-west, K., Muschol, M., Golde, T.E., Weeber, E.J., Banko, J. and Dickey, C.A. Phosphorylation dynamics regulates Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice The Journal of Neuroscience. : , 2010.
  • O’Leary, J.C., Li, Q., Marinec, P., Blair, L.J., Congdon, E.E., Johnson, A.G., Jinwal, U.K., Koren, J. III, Jones, J.R., Kraft, C., Peters, M., Abisambra, J.F., Duff, K.E., Weeber, E.J., Gestwicki, J.E., and Dickey, C.A. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden Molecular Neurodegeneration. : , 2010.
  • Jinwal, U.K., Koren, J. III, O’Leary, Jones, J.R, Abisambra, J.F., and Dickey, C.A. Hsp70 ATPase modulators as therapeutics for Alzheimer’s and other neurodegenerative diseases Molecular and Cellular Pharmacology. : , 2010.
  • Lebson, L., Nash, N., Kamath, S., Herber, D., Carty, C., Lee, D., Li, Q., Szekeres, K., Jinwal, U., Koren, J., Dickey, C.A., Gottschall, P., Morgan, D. and Gordon, M.N. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid depositing transgenic mice The Journal of Neuroscience. : , 2010.
  • Jinwal, U.K., Koren, J. III, Borysov, S.I., Schmid, A.B., Abisambra, J.F., Blair, L.J., Johnson, A.G., Jones, J.R, Shults, C., O’Leary, J. III, Jin, Y., Buchner, J., Cox, M.B., and Dickey, C.A. The Hsp90 co-chaperone, FKBP51, increases tau stability and polymerizes microtubules The Journal of Neuroscience. : , 2010.
  • Dickey, C. A., Kraft, C., Jinwal U.K., Koren, J., Johnson, A., Anderson, L., Lebson, L., Lee, D., Dickson, D., De Silva, R., Binder, L., I., Morgan, D. and Lewis, J. Aging analysis reveals slowed Tau turnover and enhanced stress response in Mouse model of Tauopathy American Journal of Pathology. : , 2009.
  • Dickey, C.A., Koren, J., Zhang, Y.J., Xu, Y.F., Jinwal, U.K., Birnbaum, M.J., Monks, B., Sun, M., Cheng, J.Q., Patterson, C., Bailey, R.M., Dunmore, J., Soresh, S., Leon, C., Morgan, D., Petrucelli, L. Akt and CHIP coregulate tau degradation through coordinated interactions Proceedings of the National Academy of Sciences of the United States of America. : , 2008.
  • Jinwal, U.K., Zakharkin, S.O., Litvinova, O.V., Jain, S., and H. Beneš. Sex, stage and tissue-specific regulation by a mosquito hexamerin promoter Insect Molecular Biology. : , 2006.

Positions Held
  • Research Assistant Professor (Department of Molecular Medicine, College of Medicine, University of South Florida 2010 - 2011)
  • Instructor & Postdoctoral Fellow (USF health Byrd Alzheimer Institute, Department of Molecular Medicine , University of South Florida 2007 - 2010)
  • Postdoctoral Fellow (Department of Cell Biology and Pathology, College of Medicine, University of South Florida 2006 - 2007)
  • Senior Research Associate (Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences 2002 - 2006)
  • Senior Research Fellow (Fermentation Technology Division, Central Drug Research Institute, India 2000 - 2002)

  • USF Chapter of the National Academy of Inventors (Member, 2015 - Present)
  • American Society for Biochemistry and Molecular Biology (Member, 2004 - Present)
  • Association of Microbiologists, India (Life Member, 1998 - Present)
  • American Association of College of Pharmacy (Member, 2011 - 2012)
  • The Alzheimer's Association International Society to Advance Alzheimer Research & Treatment. (Member, 2010 - 2012)
  • The Society for Neuroscience (Member, 2008 - 2012)
  • American Association for the Advancement of Science (Member, 2007 - 2012)
  • American Mosquito Control Association (Member, 2004 - 2006)

  • Excellence in Innovation Award (USF Research & Innovation , USF Chapter of the National Academy of Inventors - 2015)
  • Best Researcher Award (College of Pharmacy, USF-Health - 2015)
  • Associate Membership (Byrd Alzheimer’s Institute, USF-Health - 2014)
  • Certificate of appreciation (McKnight Doctoral Fellowship Program, Florida Education Fund - 2014)
  • Fellow (The Faculty of Leadership Academy, Center for Transformation and Innovation - 2013)
  • New Investigator Research Grant award (Alzheimer’s Association - 2010)
  • Senior Research Fellowship award (Council of Scientific and Industrial Research, New Delhi, India - 2000)
  • Fellowship for M.S. (Department of Biotechnology, Ministry Of Science and Technology, Government of India - 1995)

  • "Understanding the role of Cdc37 chaperone in neurodegenerative diseases using C. elegans" Florida Worm Meeting. FL, United States - 2015.
  • "Newly developed TDP-43 targeting ICW drug screening revealed B10 as a novel potent drug for treatmen" The American Society for Neural Therapy and Repair (ASNTR). FL, United States - 2015.
  • "Identification of novel drugs by using cell culture models" Drug Discovery in the Post Genomic Era Symposium, USF College of Pharmacy, University of South Florida. FL, United States - 2011.
  • "Deconstructing the tau/Hsp90 complex" Department of Molecular Medicine, University of South Florida. FL, United States - 2010.
  • "The Hsp90 co-chaperone FKBP51 regulates Tau biology" Department of Molecular Medicine, University of South Florida. FL, United States - 2009.
  • "FKBP51 Regulates Tau Phosphorylation and Degradation" The 14th Annual Midwest Stress Response and Molecular Chaperone Meeting. Northwestern University, Evanston. FL, United States - 2009.
  • "Female-specific Enhancer activity from a Mosquito Hexamerin gene" The Entomological Society of America annual meeting: “Sex, Bugs and Rock ‘n’ roll”. FL, United States - 2005.

Profile last modified on 09/01/2015