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Jerome Breslin, PhD


Assoc Professor

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Email: jbreslin@health.usf.edu
Phone: (813) 974-7631
Office: MDC, 2024
Mailing address 12901 Bruce B Downs Blvd MDC8
Tampa, FL 33612
View My C.V.
  • PhD, Pharmacology & Physiology, University Of Medicine And Dentistry Of New Jersey, Newark, United States - 2002.
  • MS, Biology, Seton Hall Universtiy, USA - 1998.
  • BA, Biological Sciences, Rutgers University, USA - 1993.
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease, Cardiovascular, Cardiovascular Sciences, Cellular and Molecular Biology.
    Research Summary

    My research area of interest is inflammation, with emphasis on the mechanisms that underlie swelling of tissues, or edema. Our laboratory focuses on two phenomena: First, we aim to understand the molecular signaling pathways and effector molecules in endothelial cells that initiate, sustain, and regulate the increased microvascular permeability that accompanies inflammation. This is important for understanding how excess fluid can accumulate in tissues. Second, we are studying the molecular mechanisms that control the intrinsic pumping of lymphatic vessels, which contributes to removing excess fluids from tissues. Understanding how these processes work is important for developing better strategies for resuscitation of trauma patients, wound healing, and optimizing immune function.

    Personal Page:   https://twitter.com/JeromeBreslin
    Lab Link:  https://www.facebook.com/BreslinLab

    Selected Publications
  • Adderley SP.Lawrence, C.Madonia, E.Olubadewo, JO.Breslin, JW. Histamine activates p38 MAP kinase and alters local lamellipodia dynamics, reducing endothelial barrier integrity and eliciting central movement of actin fibers. Am J Physiol Cell Physiol. 309: C51-C59, .
  • Adderley, SP.Zhang, XE.Breslin, JW. Involvement of the H1 histamine receptor, p38 MAP kinase, MLCK, and Rho/ROCK in histamine-indcued endothelial barrier dysfunction. Microcirculation. 22(4) : 237-248, 2015.
  • Breslin, JW.Zhang, XE.Worthylake, RA.Souza-Smith, FM. Involvement of local lamellipodia in endothelial barrier function. PLOS One. 10: e0117970, 2015.
  • Kurtz KH, Souza-Smith FM, Moor AN, Breslin JW. Rho kinase enhances contractions of rat mesenteric collecting lymphatics. PloS one. 9(4) : e94082, 2014.
  • Doggett TM, Breslin JW. Acute alcohol intoxication-induced microvascular leakage. Alcoholism, clinical and experimental research. 38(9) : 2414-26, 2014.
  • Breslin JW. Mechanical forces and lymphatic transport. Microvascular research. 96: 46-54, 2014.
  • Kurtz KH, Moor AN, Souza-Smith FM, Breslin JW. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation. 21(7) : 593-605, 2014.
  • Souza-Smith FM, Molina PE, Breslin JW. Reduced RhoA Activity Mediates Acute Alcohol Intoxication-Induced Inhibition of Lymphatic Myogenic Constriction Despite Increased Cytosolic [Ca(2+) ]. Microcirculation (New York, N.Y. : 1994). 20(5) : 377-84, 2013.
  • Souza-Smith FM, Kurtz KM, Breslin JW. Measurement of cytosolic Ca2+ in isolated contractile lymphatics. Journal of visualized experiments : JoVE. (58) : , 2011.
  • Doggett TM, Breslin JW. Study of the actin cytoskeleton in live endothelial cells expressing GFP-actin. Journal of visualized experiments : JoVE. (57) : , 2011.
  • Breslin JW. ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction. Lymphatic research and biology. 9(1) : 3-11, 2011.
  • Durán WN, Breslin JW, Sánchez FA. The NO cascade, eNOS location, and microvascular permeability. Cardiovascular research. 87(2) : 254-61, 2010.
  • Souza-Smith FM, Kurtz KM, Molina PE, Breslin JW. Adaptation of mesenteric collecting lymphatic pump function following acute alcohol intoxication. Microcirculation (New York, N.Y. : 1994). 17(7) : 514-24, 2010.
  • Breslin JW, Kurtz KM. Lymphatic endothelial cells adapt their barrier function in response to changes in shear stress. Lymphatic research and biology. 7(4) : 229-37, 2009.

  • Memberships
  • Research Society on Alcoholism (Member, 2014 - Present)
  • American Heart Association (Member, 2007 - Present)
  • American Association for the Advancement of Science (Member, 2005 - Present)
  • American Society for Cell Biology (Member, 2003 - Present)
  • American Physiological Society (Member, 2001 - Present)
  • The Microcirculatory Society (Councilor, 2000 - Present)

  • Awards/Honors
  • Fellow (American Physiological Society Cardiovascular Section - 2015)
  • Travel Award for Outstanding Young Investigators (The Microcirculatory Society, Inc. - 2012)

  • Profile last modified on 08/07/2015