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Nikolay Malinin,  PhD


Primary Department: COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

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Contacts
Email: nmalinin@health.usf.edu
Phone: (813) 974-8763
Office: MDC, 2532
Mailing address 12901 Bruce B. Downs Blvd. MDC8
Tampa, FL 33612
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Education
  • PhD, Molecular Biology, Weizmann Institute Of Science* , Israel - 2000.
  • PhD, Molecular Biology, Weizmann Institue of Science , Rehovot, Israel - 2000.
  •  
    Interdisciplinary & Emerging Signature Programs
    Cardiovascular.
     


    Selected Publications
  • Kerr, BA.Ma, L.West, XZ.Ding, L.Malinin, NL.Weber, ME.Tischenko, M.Goc, A.Somanath, PR.Penn, MS.Podrez, EA.Byzova, TV. Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress. Science signaling. 6(287): ra67, 2013.
  • Meller, J.Malinin, NL.Panigrahi, S.Kerr, BA.Patil, A.Ma, Y.Venkateswaran, L.Rogozin, IB.Mohandas, N.Ehlayel, MS.Podrez, EA.Chinen, J.Byzova, TV. Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III. Journal of thrombosis and haemostasis : JTH. 10(7): 1397-408, 2012.
  • Malinin, NL.Pluskota, E.Byzova, TV. Integrin signaling in vascular function. Current opinion in hematology. 19(3): 206-11, 2012.
  • Zhao, Y.Malinin, NL.Meller, J.Ma, Y.West, XZ.Bledzka, K.Qin, J.Podrez, EA.Byzova, TV. Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain. The Journal of biological chemistry. 287(47): 40012-20, 2012.
  • West, XZ.Meller, N.Malinin, NL.Deshmukh, L.Meller, J.Mahabeleshwar, GH.Weber, ME.Kerr, BA.Vinogradova, O.Byzova, TV. Integrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch. PloS one. 7(2): e31071, 2012.
  • Malinin, NL.West, XZ.Byzova, TV. Oxidation as "the stress of life". Aging. 3(9): 906-10, 2011.
  • Malinin, NL.Plow, EF.Byzova, TV. Kindlins in FERM adhesion. Blood. 115(20): 4011-7, 2010.
  • West, XZ.Malinin, NL.Merkulova, AA.Tischenko, M.Kerr, BA.Borden, EC.Podrez, EA.Salomon, RG.Byzova, TV. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 467(7318): 972-6, 2010.
  • Bialkowska, K.Ma, YQ.Bledzka, K.Sossey-Alaoui, K.Izem, L.Zhang, X.Malinin, N.Qin, J.Byzova, T.Plow, EF. The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell. The Journal of biological chemistry. 285(24): 18640-9, 2010.
  • Malinin, NL.Zhang, L.Choi, J.Ciocea, A.Razorenova, O.Ma, YQ.Podrez, EA.Tosi, M.Lennon, DP.Caplan, AI.Shurin, SB.Plow, EF.Byzova, TV. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature medicine. 15(3): 313-8, 2009.
  • Somanath, PR.Malinin, NL.Byzova, TV. Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis. 12(2): 177-85, 2009.
  • Malinin, N.Byzova, T. CD40/TRAF6 switch in neointimal hyperplasia. Blood. 111(9): 4424, 2008.
  • Zhao, WN.Malinin, N.Yang, FC.Staknis, D.Gekakis, N.Maier, B.Reischl, S.Kramer, A.Weitz, CJ. CIPC is a mammalian circadian clock protein without invertebrate homologues. Nature cell biology. 9(3): 268-75, 2007.
  • Wright, S.Malinin, NL.Powell, KA.Yednock, T.Rydel, RE.Griswold-Prenner, I. Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity. Neurobiology of aging. 28(2): 226-37, 2007.
  • Malinin, NL.Wright, S.Seubert, P.Schenk, D.Griswold-Prenner, I. Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proceedings of the National Academy of Sciences of the United States of America. 102(8): 3058-63, 2005.
  • Wallach, D.Varfolomeev, EE.Malinin, NL.Goltsev, YV.Kovalenko, AV.Boldin, MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annual review of immunology. 17(): 331-67, 1999.
  • Holtmann, H.Winzen, R.Holland, P.Eickemeier, S.Hoffmann, E.Wallach, D.Malinin, NL.Cooper, JA.Resch, K.Kracht, M. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Molecular and cellular biology. 19(10): 6742-53, 1999.
  • Sylla, BS.Hung, SC.Davidson, DM.Hatzivassiliou, E.Malinin, NL.Wallach, D.Gilmore, TD.Kieff, E.Mosialos, G. Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta. Proceedings of the National Academy of Sciences of the United States of America. 95(17): 10106-11, 1998.
  • Carpentier, I.Declercq, W.Malinin, NL.Wallach, D.Fiers, W.Beyaert, R. TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways. FEBS letters. 425(2): 195-8, 1998.
  • Akiba, H.Nakano, H.Nishinaka, S.Shindo, M.Kobata, T.Atsuta, M.Morimoto, C.Ware, CF.Malinin, NL.Wallach, D.Yagita, H.Okumura, K. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. The Journal of biological chemistry. 273(21): 13353-8, 1998.
  • Wallach, D.Boldin, MP.Kovalenko, AV.Malinin, NL.Mett, IL.Camonis, JH. The yeast two-hybrid screening technique and its use in the study of protein-protein interactions in apoptosis. Current opinion in immunology. 10(2): 131-6, 1998.
  • Malinin, NL.Boldin, MP.Kovalenko, AV.Wallach, D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 385(6616): 540-4, 1997.
  • Wallach, D.Boldin, M.Goncharov, T.Goltsev, Y.Mett, I.Malinin, N.Adar, R.Kovalenko, A.Varfolomeev, E. Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family. Behring Institute Mitteilungen. (97): 144-55, 1996.
  • Rachamim, N.Latter, H.Malinin, N.Asher, C.Wald, H.Garty, H. Dexamethasone enhances expression of mitochondrial oxidative phosphorylation genes in rat distal colon. The American journal of physiology. 269(5 Pt 1): C1305-10, 1995.
  • Davydova, EK.Malinin, NL.Ovchinnikov, LP. Ribosomes terminated in vitro are in a tight association with non-phosphorylated elongation factor 2 (eEF-2) and GDP. European journal of biochemistry / FEBS. 215(2): 291-6, 1993.

  • Memberships
  • American Heart Association (regular member, 2013 - Present)
  • American Physiological Society (regular member, 2012 - Present)


  • Awards/Honors
  • Irving Page Award (Cleveland Clinic - 2009)
  • Brooks Fund Postdoctoral Fellowship (Harvard Medical School - 2001)
  • Award of distinction in Ph.D. studies, (Weizmann Institute of Science, Israel - 1998)
  • MS Degree Honor Diploma (N.Novgorod State University , Russia - 1993)


  • Patents & Licensing
  • SIGNALING INTERMEDIATES IN AN IN VITRO MODEL OF ALZHEIMER'S DISEASE (Elan Pharmaceuticals - 2010)
  • Modulators of TNF receptor associated factor (TRAF), their preparation and use (Yeda Research and Development Co Ltd - 2009)
  • Modulators of intracellular inflammation, cell death and cell survival pathways (Yeda Research and Development Co Ltd - 2008)
  • IREN protein, its preparation and use (Yeda Research and Development Co Ltd - 2008)


  • Profile last modified on 02/04/2014