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Michael Teng, PhD
Associate Professor, Internal Medicine, Morsani College of Medicine

Primary Department: COLLEGE OF MEDICINE INTERNAL MEDICINE

Assoc Professor
COLLEGE OF MEDICINE INTERNAL MEDICINE

Assoc Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor
COLLEGE OF MEDICINE PEDIATRICS

Assoc Professor
COP DEPT OF PHARMACEUTICAL SCIENCE

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Contacts
Email: mteng@health.usf.edu
Phone: (813) 974-5184
Office: MDC, 3146
Mailing address 12901 Bruce B. Downs Blvd. MDC 19
Tampa, FL 33612
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Education
  • PhD, Immunology, University Of Chicago, Chicago, United States - 1993.
  • Ph.D., Immunology, University of Chicago, USA - 1993.
  • B.S., Life Sciences, MIT, USA - 1988.
  •  
    Interdisciplinary & Emerging Signature Programs
    Biomedical Engineering & Nanomedicine, Allergy, Immunology & Infectious Disease.
     
    Research Summary

    We study the role of host-virus interactions in viral pathogenesis. In particular, we are interested in how respiratory syncytial virus affects host signal transduction pathways to enhance viral replication. We use a combination of biochemical, molecular and cell biological, and virological techniques to examine these questions.

     
    Links

    Lab Link:  http://www.usfinternalmedicine.com


    Selected Publications
  • Bakre A, Wu W, Hiscox J, Spann K, Teng MN, Tripp RA. Respiratory Syncytial Virus (RSV) Non-Structural Protein-1 Modifies miR-24 Expression via TGF-beta. The Journal of general virology. : , 2015.
  • Webster Marketon JI, Corry J, Teng MN. The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation. Virology. 449: 62-9, 2014.
  • Jillian N. Whelan , Kim C. Tran , Ruan R. Cox Jr , Damian B. van Rossum , Randen L. Patterson , Michael Teng. Exploitation Of The Host Ubiquitin System By Respiratory Syncytial Virus Nonstructural Protein 2 Journal of Allergy and Clinical Immunology. 133(2) : AB283, 2014.
  • Phan SI, Chen Z, Xu P, Li Z, Gao X, Foster SL, Teng MN, Tripp RA, Sakamoto K, He B. A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5). Vaccine. 32(25) : 3050-7, 2014.
  • Michael Teng, David J. Fitzhugh, Kim Tran, Richard F. Lockey, Peter Collins. Functional Characterization of A Cis-Acting Temperature Sensitive Mutation From A Respiratory Syncytial Virus Vaccine Candidate Journal of Allergy and Clinical Immunology. 131(2) : AB11, 2013.
  • Tian B, Zhao Y, Kalita M, Edeh CB, Paessler S, Casola A, Teng MN, Garofalo RP, Brasier AR. CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells. Journal of virology. 87(12) : 7075-92, 2013.
  • Fuentes S, Crim RL, Beeler J, Teng MN, Golding H, Khurana S. Development of a simple, rapid, sensitive, high-throughput luciferase reporter based microneutralization test for measurement of virus neutralizing antibodies following Respiratory Syncytial Virus vaccination and infection. Vaccine. 31(37) : 3987-94, 2013.
  • Wu W, Tran KC, Teng MN, Heesom KJ, Matthews DA, Barr JN, Hiscox JA. The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology. Journal of virology. 86(15) : 7777-89, 2012.
  • Teng MN. The non-structural proteins of RSV: targeting interferon antagonists for vaccine development. Infectious disorders drug targets. 12(2) : 129-37, 2012.
  • Anne L. Hotard, Fyza Y. Shaikh, Sujin Lee, Dan Yan, Michael N. Teng, Richard K. Plemper, James E. Crowe Jr., Martin L. Moore. A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis Virology. 434(1) : 129–136, 2012.
  • Kim Tran, Sandra Fuentes, Biao He and Michael Teng. Inhibition of AKT Kinase Activity Decreases Replication of Human Respiratory Syncytial Virus World Allergy Organ J. (5) : S63–S64, 2012.
  • Abhijeet Bakre, Patricia Mitchell, Jonathan K. Coleman, Les P. Jones, Geraldine Saavedra, Michael Teng, S. Mark Tompkins,. Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication J Gen Virol. 93: 2346-2356, 2012.
  • Reena Ghildyal, Kim C. Tran, Michael N. Teng, Leon Caly, Hongmei Li, John Mills and David A. Jans. Nucleocytoplasmic trafficking of the matrix protein of respiratory syncytial virus: Role in infection J Antivir Antiretrovir. 4(4) : , 2012.
  • Sandhya Boyapalle, Terianne Wong, Julio Garay, Michael Teng, Homero San Juan-Vergara, Subhra Mohapatra, Shyam Mohapatra. Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection PLoS ONE. 7(2) : e29386, 2012.
  • Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R. Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation. Virology. 406(2) : 241-52, 2010.
  • Ghildyal R, Ho A, Dias M, Soegiyono L, Bardin PG, Tran KC, Teng MN, Jans DA. The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism. Journal of virology. 83(11) : 5353-62, 2009.
  • Ling Z, Tran KC, Teng MN. Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. Journal of virology. 83(8) : 3734-42, 2009.
  • Sun M, Fuentes SM, Timani K, Sun D, Murphy C, Lin Y, August A, Teng MN, He B. Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. Journal of virology. 82(1) : 105-14, 2008.
  • Ling Z, Tran KC, Arnold JJ, Teng MN. Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1. Protein expression and purification. 57(2) : 261-70, 2008.
  • Tran KC, He B, Teng MN. Replacement of the respiratory syncytial virus nonstructural proteins NS1 and NS2 by the V protein of parainfluenza virus 5. Virology. 368(1) : 73-82, 2007.
  • Fuentes S, Tran KC, Luthra P, Teng MN, He B. Function of the respiratory syncytial virus small hydrophobic protein. Journal of virology. 81(15) : 8361-6, 2007.
  • Ghildyal R, Li D, Peroulis I, Shields B, Bardin PG, Teng MN, Collins PL, Meanger J, Mills J. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. The Journal of general virology. 86(Pt 7) : 1879-84, 2005.
  • Tran KC, Collins PL, Teng MN. Effects of altering the transcription termination signals of respiratory syncytial virus on viral gene expression and growth in vitro and in vivo. Journal of virology. 78(2) : 692-9, 2004.
  • Johnson TR, Teng MN, Collins PL, Graham BS. Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV. Journal of virology. 78(11) : 6024-32, 2004.
  • Spann KM, Collins PL, Teng MN. Genetic recombination during coinfection of two mutants of human respiratory syncytial virus. Journal of virology. 77(20) : 11201-11, 2003.
  • Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, Kleeberger SR, Wills-Karp M, Karron RA. A role for immune complexes in enhanced respiratory syncytial virus disease. The Journal of experimental medicine. 196(6) : 859-65, 2002.
  • Teng MN, Collins PL. The central conserved cystine noose of the attachment G protein of human respiratory syncytial virus is not required for efficient viral infection in vitro or in vivo. Journal of virology. 76(12) : 6164-71, 2002.

  • Positions Held
  • Assistant Professor (Internal Medicine, College of Medicine, USF 2010 - 2012)
  • Assistant Professor (Biochemistry and Molecular Biology, Eberly College of Science, Pennsylvania State University 2002 - 2010)


  • Memberships
  • American Society for Virology (Member, 2004 - Present)
  • American Society for Microbiology (Member, 2000 - Present)
  • American Association for the Advancement of Science (Member, 1994 - Present)


  • Profile last modified on 08/22/2015