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Narasaiah Kolliputi, PhD
Associate Professor, Department of Internal Medicine

Primary Department: COLLEGE OF MEDICINE INTERNAL MEDICINE

Assoc Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor
COLLEGE OF MEDICINE PEDIATRICS

Assoc Professor
COP DEPT OF PHARMACEUTICAL SCIENCE

Associate Professor
COLLEGE OF MEDICINE INTERNAL MEDICINE

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Contacts
Email: nkollipu@health.usf.edu
Phone: (813) 974-5419
Office: MDC, 4134
Mailing address University of South Florida 12901 Bruce B. Downs Blvd
Tampa, FL 33612
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Education
  • PhD, Biochemistry, Osmania University, Hyderabad, India - 2005.
  • MS, Biochemistry, S V University, Thirupathi, India - 1999.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease.
     
    Links

    Lab Link:  http://www.usfinternalmedicine.com


    Selected Publications
  • Venugopal R, Galam L, Cox R, Fukumoto J, Cho Y, Parthasarathy PT, Lockey RF, Kolliputi N. Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1). Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 36(5) : 2012-24, 2015.
  • Leung J, Cho Y, Lockey RF, Kolliputi N. The Role of Aging in Idiopathic Pulmonary Fibrosis. Lung. 193(4) : 605-610, 2015.
  • Chapalamadugu KC, Panguluri SK, Bennett ES, Kolliputi N, Tipparaju SM. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation. Toxicology and applied pharmacology. 282(1) : 100-7, 2015.
  • Cox Jr R, Phillips O, Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Arias S, Cho Y, Lockey RF, Kolliputi N. Aspirin-Triggered Resolvin D1 Treatment Enhances Resolution of Hyperoxic Acute Lung Injury. American journal of respiratory cell and molecular biology. : , 2015.
  • Turn CS, Lockey RF, Kolliputi N. Putting the brakes on age-related idiopathic pulmonary fibrosis: can Nox4 inhibitors suppress IPF? Experimental gerontology. 63: 81-2, 2015.
  • Czachor A, Cho Y, Lockey RF, Kolliputi N. Kinases: a remote control in inflammasome activity. Journal of cell communication and signaling. : , 2015.
  • Galam L, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury. Free radical biology & medicine. 84: 196-205, 2015.
  • Sankineni S, Cho Y, Hosseinian N, Kolliputi N. Does pIgR down-regulation in COPD cause reprogramming of bronchial epithelium? Lung. 193(1) : 1-2, 2015.
  • Patel P, Lockey RF, Kolliputi N. Can inflammation regulate systemic aging? Experimental gerontology. 67: 1-2, 2015.
  • Hosseinian N, Cho Y, Lockey RF, Kolliputi N. The role of the NLRP3 inflammasome in pulmonary diseases. Therapeutic advances in respiratory disease. : , 2015.
  • Rajanbabu V, Galam L, Fukumoto J, Enciso J, Tadikonda P, Lane TN, Bandyopadhyay S, Parthasarathy PT, Cho Y, Cho SH, Lee YC, Lockey RF, Kolliputi N. Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2. Cellular immunology. : , 2015.
  • Czachor A, Krueger Z, Cho Y, Pathak S, Pathak Y, Kolliputi N. Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury. Current pharmaceutical design. : , 2015.
  • Saco TV, Parthasarathy PT, Cho Y, Lockey R, Kolliputi N. Micro RNAs: the future of idiopathic pulmonary fibrosis therapy. Cell biochemistry and biophysics. 71(1) : 509-11, 2015.
  • Swarnabala S, Gattu M, Perry B, Cho Y, Lockey RF, Kolliputi N. ROMO1 links oxidative stress to mitochondrial integrity. Journal of cell communication and signaling. 9(1) : 73-5, 2015.
  • Cho Y, Swarnabala S, Lockey RF, Kolliputi N. EZH2, the moderator in the discussion between methyltransferases at histone H3? Journal of cell communication and signaling. 9(1) : 77-9, 2015.
  • Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and its Association with Altered IL-6 Trans-signaling. American journal of respiratory cell and molecular biology. : , 2015.
  • Cox, Ruan, Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Stephen Arias, Young Cho, Richard Lockey, and Narasaiah Kolliputi. Hyperoxia exposure results in decreased expression of pro-resolution receptor ALX/FPR2 (1153.12) (meeting abstract) FASEB Journal. 28: 1153.12, 2014.
  • Jia-Wang Wang, Michelle A. Reiser, Kunyu Li, Eileen Rifkin, Bangmei Wang, Narasaiah Kolliputi, Richard F. Lockey. LRBA Causes Immunodeficiency and Autoimmunity By Deregulating NFkB-Mediated Multiple Immune Effectors Critical For B Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 133(2) : AB251, 2014.
  • Turn CS, Kolliputi N. Two Sides of a Coin: The Dual Roles of Chitinase 3-Like 1 in Idiopathic Pulmonary Fibrosis. Lung. : DOI 10.1007/s00408-014-9651-0, 2014.
  • Lagishetty V, Parthasarathy PT, Phillips O, Fukumoto J, Cho Y, Fukumoto I, Bao H, Cox R, Galam L, Lockey RF, Kolliputi N. Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury. American journal of physiology. Cell physiology. 306(11) : C999-C1007, 2014.
  • Parthasarathy PT, Cho Y, Lockey R, Kolliputi N. An Old Molecule with a New Role: Microtubules in Inflammasome Regulation. Cell biochemistry and biophysics. 70(1) : 697-8, 2014.
  • Saco T, Parthasarathy PT, Cho Y, Lockey RF, Kolliputi N. Inflammasome: a new trigger of Alzheimer's disease. Frontiers in aging neuroscience. 6: 80, 2014.
  • Saco TV, Parthasarathy PT, Cho Y, Lockey RF, Kolliputi N. Role of Epigenetics in Pulmonary Hypertension. American journal of physiology. Cell physiology. 306(12) : C1101-5, 2014.
  • Kalyan C. Chapalamadugu, Siva K. Panguluri, Eric S. Bennett, Narasaiah Kolliputi, Srinivas M. Tipparaju. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation Toxicology and Applied Pharmacology. : http://dx.doi.org/10.1016/j.taap.2014.10.019, 2014.
  • L Galam, S Bandyopadhyay, O Martinez, T Abuelenen, A Castillo, P Parthasarathy, V Lagishetty, R Lockey, and N Kolliputi. Diindolylmethane Attenuates TGF β Mediated Human Lung Fibroblast Proliferation (meeting abstract) FASEB Journal. 27: lb874, 2013.
  • Venu Lagishetty, Prasanna Tamarapu Parthasarathy, Bao Huynh, Jutaro Fukumoto, Ruan Cox, Jr, Richard Lockey and Narasaiah Kolliputi. Hyperoxia induced lung injury is associated with alterations in circadian clock genes in mice (meeting abstract) FASEB Journal. 27: 914.8, 2013.
  • Mehta Jyoti, Tamarapu Parthasarathy Prasanna, Lockey Richard F., Kolliputi Narasaiah. New hope for a microRNA therapy for pulmonary arterial hypertension Frontiers in Genetics. 4: DOI=10.3389/fgene.2013.00137, 2013.
  • J Fukumoto, I Fukumoto, B Huynh, RR Cox, PT Parthasarathy, GK Ramanathan, RB Venugopal, RF Lockey, and N Kolliputi. NLRP3-Deficient Mice Have an Enhanced Neutrophil Apoptosis and a Suppressed Inflammatory Response to Hyperoxia-Induced Acute Lung Injury (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB9, 2013.
  • Ruan Cox, Narasaiah Kolliputi. Mechanisims of asthma and allergic disease – 1081. Resolvin inhibits the cryopyrin/nalp3 inflammasome (meeting abstract) World Allergy Organ J. 6: P77, 2013.
  • Narasaiah Kolliputi. NLRP3-deficient mice have enhanced neutrophil apoptosis and suppressed inflammatory response to hyperoxia-induced acute lung injury (2nd international conference on Clinical & Cellular Immunology) J Clin Cell Immunol. 4: 5, 2013.
  • Phillips, O., J. Fukumoto, P. Tamarapu Parthasarathy, I. Fukumoto, T. Luong, N. Remsen, R. Lockey, N. Kolliputi, and R. R. Cox. Resolvin D1 Attenuates Hyperoxia Induced Acute Lung Injury (meeting abstract) Am J Respir Crit Care Med. 187: A4938, 2013.
  • Desai P, Tamarapu Parthasarathy P, Galam L, Lockey R, Kolliputi N. A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease. Frontiers in physiology. 4: 156, 2013.
  • Narasaiah Kolliputi. SOCS-1 gene therapy protects against hyperoxia- Induced acute lung injury and pulmonary edema (meeting abstract; 2nd international conference and exhibition on Cell & Gene Therapy) J Stem Cell Res Ther. 3: 5, 2013.
  • Bandyopadhyay S, Lane T, Venugopal R, Parthasarathy PT, Cho Y, Galam L, Lockey R, Kolliputi N. MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochemical and biophysical research communications. 439(3) : 407-12, 2013.
  • Fukumoto J, Lockey R, Kolliputi N. New hope for Nutlin-3a therapy for pulmonary arterial hypertension. Frontiers in pharmacology. 4: 87, 2013.
  • Qazi O, Parthasarathy PT, Lockey R, Kolliputi N. Can microRNAs keep inflammasomes in check? Frontiers in genetics. 4: 30, 2013.
  • Lane T, Flam B, Lockey R, Kolliputi N. TXNIP shuttling: missing link between oxidative stress and inflammasome activation. Frontiers in physiology. 4: 50, 2013.
  • RR Cox Jr., O Phillips, J Fukumoto, I Fukumoto, PT Parthasarathy, V Lagishetty, T Luong, N Remsen, R Lockey, and N Kolliputi. Resolvins play a role in the resolution of acute lung injury (meeting abstract) FASEB Journal. 27: 1143.4, 2013.
  • O Phillips, R Cox, J Fukumoto, I Fukumoto, PT Parthasarathy, V Delic, T Luong, R Lockey, and N Kolliputi. Epigallocatechin-3-Gallate inhibits the effects of TGF-Beta and IL-1B on ENaC expression in human alveolar epithelial cells (meeting abstract) FASEB Journal.. 27: 913.41, 2013.
  • Cox, Ruan R., Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi. Resolvin D1 Inhibits IL-1beta Induced Alveolar Epithelial Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB197, 2013.
  • PT Parthasarathy, T Luong, V Lagishetty, O Phillips, R Cox, A Castillo, T Abuelenen, R Lockey, and N Kolliputi. Overexpression of Circadian CLOCK genes alters proinflammatory cytokine production in human alveolar epithelial cells (meeting abstract) FASEB Journal. 27: 722.8, 2013.
  • J Fukumoto, I Fukumoto, O Phillips, R Cox, Jr, P Tamarapu Parthasarathy, V Lagishetty, R Lockey and N Kolliputi. ASC plays a role in alveolar epithelial integrity (meeting abstract) FASEB Journal. 27: 1143.5, 2013.
  • Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N. NLRP3 deletion protects from hyperoxia-induced acute lung injury. American journal of physiology. Cell physiology. 305(2) : C182-9, 2013.
  • Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013.
  • Grams D, Lockey R, Kolliputi N. Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing? Frontiers in aging neuroscience. 5: 40, 2013.
  • Phillips, Oluwakemi, Ruan R. Cox, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi. Inhibition of IL-1β Mediated Proinflammatory Cytokine Production by Epigallocatechin Gallate in Human Alveolar Epithelial Cells (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2) : AB11, 2013.
  • Sayantani Bandyopadhyay and Narasaiah Kolliputi. Viruses: Cofactors in Idiopathic Pulmonary Fibrosis Virology & Mycology. 1: 3, 2012.
  • Narasaiah Kolliputi. Adenovirus-mediated gene therapy of SOCS-1 protects against acute lung injury (international conference on Genetic Syndromes & Gene Therapy) J Ge n et Syndr Gene Ther. 3: 4, 2012.
  • Prasanna Tamarapu Parthasarathy, Oluwakemi Phillips and Narasaiah Kolliputi. Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research Journal of Biocatalysis & Biotransformation. : doi:10.4172/2324-9099.1000e107, 2012.
  • Jalali S, Ramanathan GK, Parthasarathy PT, Aljubran S, Galam L, Yunus A, Garcia S, Cox RR, Lockey RF, Kolliputi N. Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation. PloS one. 7(10) : e46808, 2012.
  • Tamarapu Parthasarathy P, Galam L, Huynh B, Yunus A, Abuelenen T, Castillo A, Kollongod Ramanathan G, Cox R, Kolliputi N. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochemical and biophysical research communications. 426(2) : 203-8, 2012.
  • Cox RR, Phillips O, Kolliputi N. Putting the brakes on acute lung injury: can resolvins suppress acute lung injury? Frontiers in physiology. 3: 445, 2012.
  • Aljubran SA, Cox R, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, Mohapatra SM, Lockey R, Kolliputi N. Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PloS one. 7(5) : e37712, 2012.
  • Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey RF. NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability. Journal of cellular physiology. 227(9) : 3310-6, 2012.
  • Kolliputi N, Shaik RS, Waxman AB. The inflammasome mediates hyperoxia-induced alveolar cell permeability. Journal of immunology (Baltimore, Md. : 1950). 184(10) : 5819-26, 2010.
  • Waxman AB, Kolliputi N. IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. American journal of respiratory cell and molecular biology. 41(4) : 385-96, 2009.
  • Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, Waxman AB. Interleukin-6 overexpression induces pulmonary hypertension. Circulation research. 104(2) : 236-44, 28p following 244, 2009.
  • Kolliputi N, Waxman AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation. American journal of physiology. Lung cellular and molecular physiology. 297(1) : L6-16, 2009.
  • Kolliputi N, Waxman AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. American journal of respiratory cell and molecular biology. 40(3) : 314-24, 2009.
  • Bhaskaran M, Kolliputi N, Wang Y, Gou D, Chintagari NR, Liu L. Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway. The Journal of biological chemistry. 282(6) : 3968-76, 2007.
  • Jin N, Kolliputi N, Gou D, Weng T, Liu L. A novel function of ionotropic gamma-aminobutyric acid receptors involving alveolar fluid homeostasis. The Journal of biological chemistry. 281(47) : 36012-20, 2006.
  • Narasaiah KV, Sashidhar RB, Subramanyam C. Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates. Mycopathologia. 162(3) : 179-89, 2006.
  • Jin N, Narasaraju T, Kolliputi N, Chen J, Liu L. Differential expression of GABAA receptor pi subunit in cultured rat alveolar epithelial cells. Cell and tissue research. 321(2) : 173-83, 2005.

  • Positions Held
  • Assistant Professor (Department of Internal Medicine, University of South Florida 2010 - 2013)
  • Research Scientist (Pulmonary & Critical Care, Massachusetts General , Harvard Medical School 2008 - 2010)
  • Postdoc (Pulmonary & Critical Care, Massachusetts General , Harvard Medical School 2006 - 2008)
  • Postoc (Department of Physiology, Oklahoma State University 2004 - 2006)


  • Memberships
  • " American Physiological Society (Member, 2008 - Present)
  • " The American Association for the Advancement of Science (Member, 2008 - Present)
  • " Society for Experimental Biology and Medicine (Member, 2008 - Present)
  • " American Thoracic Society (Member, 2006 - Present)


  • Awards/Honors
  • AHA Study Section member -Lung 2 (AHA - 2014)
  • VA Study Section Ad Hoc Review Member -Pulmonology ( VA - 2014)
  • NIH Study Section Ad Hoc Review Member -LCMI (NIH - 2013)
  • VA Study Section Ad Hoc Review Member -Pulmonology (VA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2012)
  • AHA Study Section member -Lung 2 (AHA - 2011)
  • Young Investigator Award (Society for Experimental Biology and Medicine - 2009)
  • Best Poster Award (International Society of Human and Animal Mycology (ISHAM) - 2004)


  • Lectures
  • "Invited Lecture" Emory University. GA, United States - 2011.
  • "American Physiological Society Featured Topic Session " Experimental Biology. CA, United States - 2010.
  • "American Physiological Society Featured Topic Session " Experimental Biology. CA, United States - 2008.

  • Profile last modified on 08/22/2015