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Narasaiah Kolliputi,  PhD
Associate Professor, Department of Internal Medicine


Primary Department: COLLEGE OF MEDICINE INTERNAL MEDICINE

Assoc Professor
COLLEGE OF MEDICINE MOLECULAR MEDICINE

Assoc Professor
COLLEGE OF MEDICINE PEDIATRICS

Assoc Professor
COP DEPT OF PHARMACEUTICAL SCIENCE

Associate Professor
COLLEGE OF MEDICINE INTERNAL MEDICINE

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Contacts
Email: nkollipu@health.usf.edu
Phone: (813) 974-5419
Office: MDC, 4134
Mailing address University of South Florida 12901 Bruce B. Downs Blvd
Tampa, FL 33612
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Education
  • PhD, Biochemistry, Osmania University , Hyderabad, India - 2005.
  • MS, Biochemistry, S V University , Thirupathi, India - 1999.
  •  
    Interdisciplinary & Emerging Signature Programs
    Allergy, Immunology & Infectious Disease.
     
    Links

    Lab Link:  http://www.usfinternalmedicine.com


    Selected Publications
  • Saco, TV.Parthasarathy, PT.Cho, Y.Lockey, R.Kolliputi, N. Micro RNAs: The Future of Idiopathic Pulmonary Fibrosis Therapy. Cell biochemistry and biophysics. (): DOI 10.1007/s12013-014-0217-9, 2014.
  • Turn, CS.Kolliputi, N. Two Sides of a Coin: The Dual Roles of Chitinase 3-Like 1 in Idiopathic Pulmonary Fibrosis. Lung. (): DOI 10.1007/s00408-014-9651-0, 2014.
  • Swarnabala, S.Gattu, M.Perry, B.Cho, Y.Lockey, RF.Kolliputi, N. ROMO1 links oxidative stress to mitochondrial integrity. Journal of cell communication and signaling. (): DOI 10.1007/s12079-014-0249-3, 2014.
  • Cho, Y.Swarnabala, S.Lockey, RF.Kolliputi, N. EZH2, the moderator in the discussion between methyltransferases at histone H3? Journal of cell communication and signaling. (): DOI: http://dx.doi.org/10.1007/s12079-014-0256-4, 2014.
  • Cox, Ruan, Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Stephen Arias, Young Cho, Richard Lockey, and Narasaiah Kolliputi Hyperoxia exposure results in decreased expression of pro-resolution receptor ALX/FPR2 (1153.12) (meeting abstract) FASEB Journal. 28(): 1153.12, 2014.
  • Lagishetty, V.Parthasarathy, PT.Phillips, O.Fukumoto, J.Cho, Y.Fukumoto, I.Bao, H.Cox, R.Galam, L.Lockey, RF.Kolliputi, N. Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury. American journal of physiology. Cell physiology. 306(11): C999-C1007, 2014.
  • Jia-Wang Wang, Michelle A. Reiser, Kunyu Li, Eileen Rifkin, Bangmei Wang, Narasaiah Kolliputi, Richard F. Lockey LRBA Causes Immunodeficiency and Autoimmunity By Deregulating NFkB-Mediated Multiple Immune Effectors Critical For B Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 133(2): AB251, 2014.
  • Saco, TV.Parthasarathy, PT.Cho, Y.Lockey, RF.Kolliputi, N. Role of Epigenetics in Pulmonary Hypertension. American journal of physiology. Cell physiology. 306(12): C1101-5, 2014.
  • Saco, T.Parthasarathy, PT.Cho, Y.Lockey, RF.Kolliputi, N. Inflammasome: a new trigger of Alzheimer's disease. Frontiers in aging neuroscience. 6(): 80, 2014.
  • Parthasarathy, PT.Cho, Y.Lockey, R.Kolliputi, N. An Old Molecule with a New Role: Microtubules in Inflammasome Regulation. Cell biochemistry and biophysics. 70(1): 697-8, 2014.
  • Kalyan C. Chapalamadugu, Siva K. Panguluri, Eric S. Bennett, Narasaiah Kolliputi, Srinivas M. Tipparaju High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation Toxicology and Applied Pharmacology. (): http://dx.doi.org/10.1016/j.taap.2014.10.019, 2014.
  • Grams, D.Lockey, R.Kolliputi, N. Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing? Frontiers in aging neuroscience. 5(): 40, 2013.
  • J Fukumoto, I Fukumoto, O Phillips, R Cox, Jr, P Tamarapu Parthasarathy, V Lagishetty, R Lockey and N Kolliputi ASC plays a role in alveolar epithelial integrity (meeting abstract) FASEB Journal. 27(): 1143.5, 2013.
  • PT Parthasarathy, T Luong, V Lagishetty, O Phillips, R Cox, A Castillo, T Abuelenen, R Lockey, and N Kolliputi Overexpression of Circadian CLOCK genes alters proinflammatory cytokine production in human alveolar epithelial cells (meeting abstract) FASEB Journal. 27(): 722.8, 2013.
  • Cox, Ruan R., Oluwakemi Phillips, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi Resolvin D1 Inhibits IL-1beta Induced Alveolar Epithelial Cell Activation (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2): AB197, 2013.
  • O Phillips, R Cox, J Fukumoto, I Fukumoto, PT Parthasarathy, V Delic, T Luong, R Lockey, and N Kolliputi Epigallocatechin-3-Gallate inhibits the effects of TGF-Beta and IL-1B on ENaC expression in human alveolar epithelial cells (meeting abstract) FASEB Journal.. 27(): 913.41, 2013.
  • RR Cox Jr., O Phillips, J Fukumoto, I Fukumoto, PT Parthasarathy, V Lagishetty, T Luong, N Remsen, R Lockey, and N Kolliputi Resolvins play a role in the resolution of acute lung injury (meeting abstract) FASEB Journal. 27(): 1143.4, 2013.
  • L Galam, S Bandyopadhyay, O Martinez, T Abuelenen, A Castillo, P Parthasarathy, V Lagishetty, R Lockey, and N Kolliputi Diindolylmethane Attenuates TGF β Mediated Human Lung Fibroblast Proliferation (meeting abstract) FASEB Journal. 27(): lb874, 2013.
  • Venu Lagishetty, Prasanna Tamarapu Parthasarathy, Bao Huynh, Jutaro Fukumoto, Ruan Cox, Jr, Richard Lockey and Narasaiah Kolliputi Hyperoxia induced lung injury is associated with alterations in circadian clock genes in mice (meeting abstract) FASEB Journal. 27(): 914.8, 2013.
  • Mehta Jyoti, Tamarapu Parthasarathy Prasanna, Lockey Richard F., Kolliputi Narasaiah New hope for a microRNA therapy for pulmonary arterial hypertension Frontiers in Genetics. 4(): DOI=10.3389/fgene.2013.00137, 2013.
  • J Fukumoto, I Fukumoto, B Huynh, RR Cox, PT Parthasarathy, GK Ramanathan, RB Venugopal, RF Lockey, and N Kolliputi NLRP3-Deficient Mice Have an Enhanced Neutrophil Apoptosis and a Suppressed Inflammatory Response to Hyperoxia-Induced Acute Lung Injury (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2): AB9, 2013.
  • Narasaiah Kolliputi SOCS-1 gene therapy protects against hyperoxia- Induced acute lung injury and pulmonary edema (meeting abstract; 2nd international conference and exhibition on Cell & Gene Therapy) J Stem Cell Res Ther. 3(): 5, 2013.
  • Bandyopadhyay, S.Lane, T.Venugopal, R.Parthasarathy, PT.Cho, Y.Galam, L.Lockey, R.Kolliputi, N. MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochemical and biophysical research communications. 439(3): 407-12, 2013.
  • Qazi, O.Parthasarathy, PT.Lockey, R.Kolliputi, N. Can microRNAs keep inflammasomes in check? Frontiers in genetics. 4(): 30, 2013.
  • Lane, T.Flam, B.Lockey, R.Kolliputi, N. TXNIP shuttling: missing link between oxidative stress and inflammasome activation. Frontiers in physiology. 4(): 50, 2013.
  • Panguluri, SK.Tur, J.Fukumoto, J.Deng, W.Sneed, KB.Kolliputi, N.Bennett, ES.Tipparaju, SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12): H1651-61, 2013.
  • Fukumoto, J.Fukumoto, I.Parthasarathy, PT.Cox, R.Huynh, B.Ramanathan, GK.Venugopal, RB.Allen-Gipson, DS.Lockey, RF.Kolliputi, N. NLRP3 deletion protects from hyperoxia-induced acute lung injury. American journal of physiology. Cell physiology. 305(2): C182-9, 2013.
  • Ruan Cox, Narasaiah Kolliputi Mechanisims of asthma and allergic disease – 1081. Resolvin inhibits the cryopyrin/nalp3 inflammasome (meeting abstract) World Allergy Organ J. 6(): P77, 2013.
  • Narasaiah Kolliputi NLRP3-deficient mice have enhanced neutrophil apoptosis and suppressed inflammatory response to hyperoxia-induced acute lung injury (2nd international conference on Clinical & Cellular Immunology) J Clin Cell Immunol. 4(): 5, 2013.
  • Phillips, O., J. Fukumoto, P. Tamarapu Parthasarathy, I. Fukumoto, T. Luong, N. Remsen, R. Lockey, N. Kolliputi, and R. R. Cox Resolvin D1 Attenuates Hyperoxia Induced Acute Lung Injury (meeting abstract) Am J Respir Crit Care Med. 187(): A4938, 2013.
  • Desai, P.Tamarapu Parthasarathy, P.Galam, L.Lockey, R.Kolliputi, N. A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease. Frontiers in physiology. 4(): 156, 2013.
  • Phillips, Oluwakemi, Ruan R. Cox, Jutaro Fukumoto, Itsuko Fukumoto, Prasanna Tamarapu, Tran Luong, Richard F. Lockey, and Narasaiah Kolliputi Inhibition of IL-1β Mediated Proinflammatory Cytokine Production by Epigallocatechin Gallate in Human Alveolar Epithelial Cells (meeting abstract) Journal of Allergy and Clinical Immunology. 131(2): AB11, 2013.
  • Fukumoto, J.Lockey, R.Kolliputi, N. New hope for Nutlin-3a therapy for pulmonary arterial hypertension. Frontiers in pharmacology. 4(): 87, 2013.
  • Narasaiah Kolliputi Adenovirus-mediated gene therapy of SOCS-1 protects against acute lung injury (international conference on Genetic Syndromes & Gene Therapy) J Ge n et Syndr Gene Ther. 3(): 4, 2012.
  • Prasanna Tamarapu Parthasarathy, Oluwakemi Phillips and Narasaiah Kolliputi Thioredoxin Catalysis and Inflammasome Regulation: Directions for Future Research Journal of Biocatalysis & Biotransformation. (): doi:10.4172/2324-9099.1000e107, 2012.
  • Jalali, S.Ramanathan, GK.Parthasarathy, PT.Aljubran, S.Galam, L.Yunus, A.Garcia, S.Cox, RR.Lockey, RF.Kolliputi, N. Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation. PloS one. 7(10): e46808, 2012.
  • Tamarapu Parthasarathy, P.Galam, L.Huynh, B.Yunus, A.Abuelenen, T.Castillo, A.Kollongod Ramanathan, G.Cox, R.Kolliputi, N. MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells. Biochemical and biophysical research communications. 426(2): 203-8, 2012.
  • Cox, RR.Phillips, O.Kolliputi, N. Putting the brakes on acute lung injury: can resolvins suppress acute lung injury? Frontiers in physiology. 3(): 445, 2012.
  • Aljubran, SA.Cox, R.Tamarapu Parthasarathy, P.Kollongod Ramanathan, G.Rajanbabu, V.Bao, H.Mohapatra, SM.Lockey, R.Kolliputi, N. Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation. PloS one. 7(5): e37712, 2012.
  • Kolliputi, N.Galam, L.Parthasarathy, PT.Tipparaju, SM.Lockey, RF. NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability. Journal of cellular physiology. 227(9): 3310-6, 2012.
  • Sayantani Bandyopadhyay and Narasaiah Kolliputi Viruses: Cofactors in Idiopathic Pulmonary Fibrosis Virology & Mycology. 1(): 3, 2012.
  • Kolliputi, N.Shaik, RS.Waxman, AB. The inflammasome mediates hyperoxia-induced alveolar cell permeability. Journal of immunology (Baltimore, Md. : 1950). 184(10): 5819-26, 2010.
  • Waxman, AB.Kolliputi, N. IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. American journal of respiratory cell and molecular biology. 41(4): 385-96, 2009.
  • Steiner, MK.Syrkina, OL.Kolliputi, N.Mark, EJ.Hales, CA.Waxman, AB. Interleukin-6 overexpression induces pulmonary hypertension. Circulation research. 104(2): 236-44, 28p following 244, 2009.
  • Kolliputi, N.Waxman, AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation. American journal of physiology. Lung cellular and molecular physiology. 297(1): L6-16, 2009.
  • Kolliputi, N.Waxman, AB. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. American journal of respiratory cell and molecular biology. 40(3): 314-24, 2009.
  • Bhaskaran, M.Kolliputi, N.Wang, Y.Gou, D.Chintagari, NR.Liu, L. Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway. The Journal of biological chemistry. 282(6): 3968-76, 2007.
  • Jin, N.Kolliputi, N.Gou, D.Weng, T.Liu, L. A novel function of ionotropic gamma-aminobutyric acid receptors involving alveolar fluid homeostasis. The Journal of biological chemistry. 281(47): 36012-20, 2006.
  • Narasaiah, KV.Sashidhar, RB.Subramanyam, C. Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates. Mycopathologia. 162(3): 179-89, 2006.
  • Jin, N.Narasaraju, T.Kolliputi, N.Chen, J.Liu, L. Differential expression of GABAA receptor pi subunit in cultured rat alveolar epithelial cells. Cell and tissue research. 321(2): 173-83, 2005.

  • Positions Held
  • Assistant Professor (Department of Internal Medicine, University of South Florida 2010 - 2013)
  • Research Scientist (Pulmonary & Critical Care, Massachusetts General , Harvard Medical School 2008 - 2010)
  • Postdoc (Pulmonary & Critical Care, Massachusetts General , Harvard Medical School 2006 - 2008)
  • Postoc (Department of Physiology, Oklahoma State University 2004 - 2006)


  • Memberships
  • " American Physiological Society (Member, 2008 - Present)
  • " The American Association for the Advancement of Science (Member, 2008 - Present)
  • " Society for Experimental Biology and Medicine (Member, 2008 - Present)
  • " American Thoracic Society (Member, 2006 - Present)


  • Awards/Honors
  • AHA Study Section member -Lung 2 (AHA - 2014)
  • VA Study Section Ad Hoc Review Member -Pulmonology ( VA - 2014)
  • NIH Study Section Ad Hoc Review Member -LCMI (NIH - 2013)
  • VA Study Section Ad Hoc Review Member -Pulmonology (VA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2013)
  • AHA Study Section member -Lung 2 (AHA - 2012)
  • AHA Study Section member -Lung 2 (AHA - 2011)
  • Young Investigator Award (Society for Experimental Biology and Medicine - 2009)
  • Best Poster Award (International Society of Human and Animal Mycology (ISHAM) - 2004)


  • Lectures
  • "Invited Lecture" Emory University. GA, United States - 2011.
  • "American Physiological Society Featured Topic Session " Experimental Biology. CA, United States - 2010.
  • "American Physiological Society Featured Topic Session " Experimental Biology. CA, United States - 2008.

  • Profile last modified on 11/14/2014