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Larry Dishaw, PhD


Assistant Professor

Assistant Professor

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Email: ldishaw@health.usf.edu
Office: CRI, 3008
  • PhD, Biological Sciences, Florida International University, Miami, United States - 2002.
    Research Summary

    The gut immune system maintains an intimate dialogue with gut microbiota. My research focus is centered on defining conserved phylogenetic signals revealing how host immunity and exogenous factors of the gut ecosystem shape the microbiome. I am particularly interested in how these events take place within the epithelium-associated mucus; dynamics of colonization. This work may contribute to our understanding of how disruption of this dynamic interaction (e.g., loss of homeostasis) at the mucosal surface of the gut relates to the onset of Inflammatory Bowel Disease (IBD) pathologies observed in humans. This work has allowed me to develop expertise in comparative microbiome studies, which also includes studies on how microbiomes shape host physiology. Our research is supported by the NSF, the NIH, and All Children's Hospital Johns Hopkins Medicine. Contact me for further info; CV upon request.

    Personal Page:   http://www.capote-dishaw.com/larry
    Lab Link:  http://www.invertegut.net/

    Selected Publications
  • Zhang L, Li L, Guo X, Litman GW, Dishaw LJ, Zhang G. Massive expansion and functional divergence of innate immune genes in a protostome. Scientific reports. 5: 8693, 2015.
  • Groer MW, Luciano AA, Dishaw LJ, Ashmeade TL, Miller E, Gilbert JA. Development of the preterm infant gut microbiome: a research priority. Microbiome. 2: 38, 2014.
  • Dishaw LJ, Flores-Torres J, Lax S, Gemayel K, Leigh B, Melillo D, Mueller MG, Natale L, Zucchetti I, De Santis R, Pinto MR, Litman GW, Gilbert JA. The gut of geographically disparate Ciona intestinalis harbors a core microbiota. PloS one. 9(4) : e93386, 2014.
  • Liberti A, Melillo D, Zucchetti I, Natale L, Dishaw LJ, Litman GW, De Santis R, Pinto MR. Expression of Ciona intestinalis variable region-containing chitin-binding proteins during development of the gastrointestinal tract and their role in host-microbe interactions. PloS one. 9(5) : e94984, 2014.
  • Dishaw LJ, Cannon JP, Litman GW, Parker W. Immune-directed support of rich microbial communities in the gut has ancient roots. Developmental and comparative immunology. 47(1) : 36-51, 2014.
  • Litman GW, Dishaw LJ. Histocompatibility: clarifying fusion confusion. Current biology : CB. 23(20) : R934-5, 2013.
  • Dishaw LJ, Litman GW. Changing views of the evolution of immunity. Frontiers in immunology. 4: 122, 2013.
  • Dishaw LJ, Haire RN, Litman GW. The amphioxus genome provides unique insight into the evolution of immunity. Briefings in functional genomics. 11(2) : 167-76, 2012.
  • Dishaw LJ, Flores-Torres JA, Mueller MG, Karrer CR, Skapura DP, Melillo D, Zucchetti I, De Santis R, Pinto MR, Litman GW. A Basal chordate model for studies of gut microbial immune interactions. Frontiers in immunology. 3: 96, 2012.
  • Dishaw LJ, Giacomelli S, Melillo D, Zucchetti I, Haire RN, Natale L, Russo NA, De Santis R, Litman GW, Pinto MR. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proceedings of the National Academy of Sciences of the United States of America. 108(40) : 16747-52, 2011.
  • Dishaw LJ, Mueller MG, Haire RN, Litman GW. Transfection-based genomic readout for identifying rare transcriptional splice variants. Methods in molecular biology (Clifton, N.J.). 748: 243-54, 2011.
  • Dishaw LJ, Ota T, Mueller MG, Cannon JP, Haire RN, Gwatney NR, Litman RT, Litman GW. The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus. Immunogenetics. 62(9) : 623-31, 2010.
  • Cannon JP, Dishaw LJ, Haire RN, Litman RT, Ostrov DA, Litman GW. Recognition of additional roles for immunoglobulin domains in immune function. Seminars in immunology. 22(1) : 17-24, 2010.
  • Dorsey MJ, Petrovic A, Morrow MR, Dishaw LJ, Sleasman JW. FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Immunologic research. 44(1-3) : 179-84, 2009.
  • Dishaw LJ, Litman GW. Invertebrate allorecognition: the origins of histocompatibility. Current biology : CB. 19(7) : R286-8, 2009.
  • Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N, Holland PW. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome research. 18(7) : 1100-11, 2008.
  • Zhang Q, Zmasek CM, Dishaw LJ, Mueller MG, Ye Y, Litman GW, Godzik A. Novel genes dramatically alter regulatory network topology in amphioxus. Genome biology. 9(8) : R123, 2008.
  • Dishaw LJ, Mueller MG, Gwatney N, Cannon JP, Haire RN, Litman RT, Amemiya CT, Ota T, Rowen L, Glusman G, Litman GW. Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. BMC genetics. 9: 78, 2008.
  • Litman GW, Dishaw LJ, Cannon JP, Haire RN, Rast JP. Alternative mechanisms of immune receptor diversity. Current opinion in immunology. 19(5) : 526-34, 2007.
  • Litman GW, Cannon JP, Dishaw LJ, Haire RN, Eason DD, Yoder JA, Prada JH, Ostrov DA. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic research. 38(1-3) : 294-304, 2007.
  • Dishaw LJ, Herrera ML, Bigger CH. Characterization and phylogenetic analysis of a cnidarian LMP X-like cDNA. Immunogenetics. 58(5-6) : 454-64, 2006.
  • Dishaw LJ, Smith SL, Bigger CH. Characterization of a C3-like cDNA in a coral: phylogenetic implications. Immunogenetics. 57(7) : 535-48, 2005.
  • Litman GW, Cannon JP, Dishaw LJ. Reconstructing immune phylogeny: new perspectives. Nature reviews. Immunology. 5(11) : 866-79, 2005.
  • Kozmik Z, Daube M, Frei E, Norman B, Kos L, Dishaw LJ, Noll M, Piatigorsky J. Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Developmental cell. 5(5) : 773-85, 2003.
  • Piatigorsky J, Norman B, Dishaw LJ, Kos L, Horwitz J, Steinbach PJ, Kozmik Z. J3-crystallin of the jellyfish lens: similarity to saposins. Proceedings of the National Academy of Sciences of the United States of America. 98(22) : 12362-7, 2001.

  • Memberships
  • American Association of Immunologists (Member, 2014 - Present)
  • American Society of Microbiologists (Member, 2011 - Present)

  • Profile last modified on 09/17/2015