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Larry Dishaw,  PhD


Primary Department: COLLEGE OF MEDICINE PEDIATRICS

Assistant Professor
COLLEGE OF MEDICINE PEDIATRICS

Assistant Professor
NON USF HEALTH

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Contacts
Email: ldishaw@health.usf.edu
Office: CRI, 3008
 
Education
  • PhD, Biological Sciences, Florida International University , Miami, United States - 2002.
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    Research Summary

    The gut immune system maintains an intimate dialogue with gut microbiota. My research focus is centered on defining conserved phylogenetic signals revealing how host immunity and exogenous factors of the gut ecosystem shape the microbiome. I am particularly interested in how these events take place within the epithelium-associated mucus; dynamics of colonization. This work may contribute to our understanding of how disruption of this dynamic interaction (e.g., loss of homeostasis) at the mucosal surface of the gut relates to the onset of Inflammatory Bowel Disease (IBD) pathologies observed in humans. This work has allowed me to develop expertise in comparative microbiome studies, which also includes studies on how microbiomes shape host physiology. Contact me for further info; CV upon request.

     
    Links
    Personal Page:   http://www.capote-dishaw.com/larry


    Selected Publications
  • Zhang, L.Li, L.Guo, X.Litman, GW.Dishaw, LJ.Zhang, G. Massive expansion and functional divergence of innate immune genes in a protostome. Scientific reports. 5(): 8693, 2015.
  • Groer, MW.Luciano, AA.Dishaw, LJ.Ashmeade, TL.Miller, E.Gilbert, JA. Development of the preterm infant gut microbiome: a research priority. Microbiome. 2(): 38, 2014.
  • Dishaw, LJ.Flores-Torres, J.Lax, S.Gemayel, K.Leigh, B.Melillo, D.Mueller, MG.Natale, L.Zucchetti, I.De Santis, R.Pinto, MR.Litman, GW.Gilbert, JA. The gut of geographically disparate Ciona intestinalis harbors a core microbiota. PloS one. 9(4): e93386, 2014.
  • Liberti, A.Melillo, D.Zucchetti, I.Natale, L.Dishaw, LJ.Litman, GW.De Santis, R.Pinto, MR. Expression of Ciona intestinalis variable region-containing chitin-binding proteins during development of the gastrointestinal tract and their role in host-microbe interactions. PloS one. 9(5): e94984, 2014.
  • Dishaw, LJ.Cannon, JP.Litman, GW.Parker, W. Immune-directed support of rich microbial communities in the gut has ancient roots. Developmental and comparative immunology. 47(1): 36-51, 2014.
  • Litman, GW.Dishaw, LJ. Histocompatibility: clarifying fusion confusion. Current biology : CB. 23(20): R934-5, 2013.
  • Dishaw, LJ.Litman, GW. Changing views of the evolution of immunity. Frontiers in immunology. 4(): 122, 2013.
  • Dishaw, LJ.Haire, RN.Litman, GW. The amphioxus genome provides unique insight into the evolution of immunity. Briefings in functional genomics. 11(2): 167-76, 2012.
  • Dishaw, LJ.Flores-Torres, JA.Mueller, MG.Karrer, CR.Skapura, DP.Melillo, D.Zucchetti, I.De Santis, R.Pinto, MR.Litman, GW. A Basal chordate model for studies of gut microbial immune interactions. Frontiers in immunology. 3(): 96, 2012.
  • Dishaw, LJ.Giacomelli, S.Melillo, D.Zucchetti, I.Haire, RN.Natale, L.Russo, NA.De Santis, R.Litman, GW.Pinto, MR. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proceedings of the National Academy of Sciences of the United States of America. 108(40): 16747-52, 2011.
  • Dishaw, LJ.Mueller, MG.Haire, RN.Litman, GW. Transfection-based genomic readout for identifying rare transcriptional splice variants. Methods in molecular biology (Clifton, N.J.). 748(): 243-54, 2011.
  • Dishaw, LJ.Ota, T.Mueller, MG.Cannon, JP.Haire, RN.Gwatney, NR.Litman, RT.Litman, GW. The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus. Immunogenetics. 62(9): 623-31, 2010.
  • Cannon, JP.Dishaw, LJ.Haire, RN.Litman, RT.Ostrov, DA.Litman, GW. Recognition of additional roles for immunoglobulin domains in immune function. Seminars in immunology. 22(1): 17-24, 2010.
  • Dorsey, MJ.Petrovic, A.Morrow, MR.Dishaw, LJ.Sleasman, JW. FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Immunologic research. 44(1-3): 179-84, 2009.
  • Dishaw, LJ.Litman, GW. Invertebrate allorecognition: the origins of histocompatibility. Current biology : CB. 19(7): R286-8, 2009.
  • Holland, LZ.Albalat, R.Azumi, K.Benito-Gutiérrez, E.Blow, MJ.Bronner-Fraser, M.Brunet, F.Butts, T.Candiani, S.Dishaw, LJ.Ferrier, DE.Garcia-Fernàndez, J.Gibson-Brown, JJ.Gissi, C.Godzik, A.Hallböök, F.Hirose, D.Hosomichi, K.Ikuta, T.Inoko, H.Kasahara, M.Kasamatsu, J.Kawashima, T.Kimura, A.Kobayashi, M.Kozmik, Z.Kubokawa, K.Laudet, V.Litman, GW.McHardy, AC.Meulemans, D.Nonaka, M.Olinski, RP.Pancer, Z.Pennacchio, LA.Pestarino, M.Rast, JP.Rigoutsos, I.Robinson-Rechavi, M.Roch, G.Saiga, H.Sasakura, Y.Satake, M.Satou, Y.Schubert, M.Sherwood, N.Shiina, T.Takatori, N.Tello, J.Vopalensky, P.Wada, S.Xu, A.Ye, Y.Yoshida, K.Yoshizaki, F.Yu, JK.Zhang, Q.Zmasek, CM.de Jong, PJ.Osoegawa, K.Putnam, NH.Rokhsar, DS.Satoh, N.Holland, PW. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome research. 18(7): 1100-11, 2008.
  • Zhang, Q.Zmasek, CM.Dishaw, LJ.Mueller, MG.Ye, Y.Litman, GW.Godzik, A. Novel genes dramatically alter regulatory network topology in amphioxus. Genome biology. 9(8): R123, 2008.
  • Dishaw, LJ.Mueller, MG.Gwatney, N.Cannon, JP.Haire, RN.Litman, RT.Amemiya, CT.Ota, T.Rowen, L.Glusman, G.Litman, GW. Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. BMC genetics. 9(): 78, 2008.
  • Litman, GW.Dishaw, LJ.Cannon, JP.Haire, RN.Rast, JP. Alternative mechanisms of immune receptor diversity. Current opinion in immunology. 19(5): 526-34, 2007.
  • Litman, GW.Cannon, JP.Dishaw, LJ.Haire, RN.Eason, DD.Yoder, JA.Prada, JH.Ostrov, DA. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic research. 38(1-3): 294-304, 2007.
  • Dishaw, LJ.Herrera, ML.Bigger, CH. Characterization and phylogenetic analysis of a cnidarian LMP X-like cDNA. Immunogenetics. 58(5-6): 454-64, 2006.
  • Dishaw, LJ.Smith, SL.Bigger, CH. Characterization of a C3-like cDNA in a coral: phylogenetic implications. Immunogenetics. 57(7): 535-48, 2005.
  • Litman, GW.Cannon, JP.Dishaw, LJ. Reconstructing immune phylogeny: new perspectives. Nature reviews. Immunology. 5(11): 866-79, 2005.
  • Kozmik, Z.Daube, M.Frei, E.Norman, B.Kos, L.Dishaw, LJ.Noll, M.Piatigorsky, J. Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Developmental cell. 5(5): 773-85, 2003.
  • Piatigorsky, J.Norman, B.Dishaw, LJ.Kos, L.Horwitz, J.Steinbach, PJ.Kozmik, Z. J3-crystallin of the jellyfish lens: similarity to saposins. Proceedings of the National Academy of Sciences of the United States of America. 98(22): 12362-7, 2001.

  • Memberships
  • American Association of Immunologists (Member, 2014 - Present)
  • American Association of Microbiologists (Member, 2011 - Present)


  • Profile last modified on 03/30/2015