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Thomas Freeman, MD
Medical Director, Center of Excellence for Aging and Brain Repair
Consultant, Division of Neurosurgery
Professor, College of Medicine, Department of Neurosurgery and Brain Repair

Primary Department: COLLEGE OF MEDICINE NEUROSURGERY

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Professor
COLLEGE OF MEDICINE NEUROSURGERY

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Contacts
Email: tfreeman@health.usf.edu
Phone: (813) 259-0889
Office: STC,
Mailing address 2 Tampa General Circle
Tampa, FL 33606
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Education
  • MD, Johns Hopkins University, United States - 1981.
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    Selected Publications
  • Saporta S, Borlongan C, Moore J, Mejia-Millan E, Jones SL, Bonness P, Randall TS, Allen RC, Freeman TB, Sanberg PR. Microcarrier enhanced survival of human and rat fetal ventral mesencephalon cells implanted in the rat striatum. Cell transplantation. 6(6) : 579-84, .
  • Kordower JH, Styren S, Clarke M, DeKosky ST, Olanow CW, Freeman TB. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell transplantation. 6(3) : 213-9, .
  • Holt DA, Nauert GM, Othberg AI, Randall TS, Willing AE, Widen RH, Hauser RA, Sanberg PR, Olanow CW, Freeman TB. Infectious issues in human fetal neural transplantation. Cell transplantation. 6(6) : 553-6, .
  • Othberg AI, Willing AE, Cameron DF, Anton A, Saporta S, Freeman TB, Sanberg PR. Trophic effect of porcine Sertoli cells on rat and human ventral mesencephalic cells and hNT neurons in vitro. Cell transplantation. 7(2) : 157-64, .
  • Sanchez-Ramos J, Song S, Dailey M, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Zigova T, Sanberg PR, Snyder EY. The X-gal caution in neural transplantation studies. Cell transplantation. 9(5) : 657-67, .
  • Cicchetti F, Lacroix S, Cisbani G, Vallières N, Saint-Pierre M, St-Amour I, Tolouei R, Skepper JN, Hauser RA, Mantovani D, Barker RA, Freeman TB. Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Annals of neurology. 76(1) : 31-42, 2014.
  • Cisbani G, Freeman TB, Soulet D, Saint-Pierre M, Gagnon D, Parent M, Hauser RA, Barker RA, Cicchetti F. Striatal allografts in patients with Huntington's disease: impact of diminished astrocytes and vascularization on graft viability. Brain : a journal of neurology. 136(Pt 2) : 433-43, 2013.
  • Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff HJ. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet neurology. 11(7) : 643-50, 2012.
  • Sangala JR, Nichols T, Freeman TB. Technique to minimize paraspinal muscle atrophy after posterior cervical fusion. Clinical neurology and neurosurgery. 113(1) : 48-51, 2011.
  • Freeman TB, Cicchetti F, Bachoud-Lévi AC, Dunnett SB. Technical factors that influence neural transplant safety in Huntington's disease. Experimental neurology. 227(1) : 1-9, 2011.
  • Borlongan CV, Glover LE, Tajiri N, Kaneko Y, Freeman TB. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Progress in neurobiology. 95(2) : 213-28, 2011.
  • Phommachanh V, Patil YJ, McCaffrey TV, Vale F, Freeman TB, Padhya TA. Otolaryngologic management of delayed pharyngoesophageal perforation following anterior cervical spine surgery. The Laryngoscope. 120(5) : 930-6, 2010.
  • Cicchetti F, Saporta S, Hauser RA, Parent M, Saint-Pierre M, Sanberg PR, Li XJ, Parker JR, Chu Y, Mufson EJ, Kordower JH, Freeman TB. Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 106(30) : 12483-8, 2009.
  • Olanow CW, Gracies JM, Goetz CG, Stoessl AJ, Freeman T, Kordower JH, Godbold J, Obeso JA. Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis. Movement disorders : official journal of the Movement Disorder Society. 24(3) : 336-43, 2009.
  • Kordower JH, Chu Y, Hauser RA, Olanow CW, Freeman TB. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Movement disorders : official journal of the Movement Disorder Society. 23(16) : 2303-6, 2008.
  • Soderstrom KE, Meredith G, Freeman TB, McGuire SO, Collier TJ, Sortwell CE, Wu Q, Steece-Collier K. The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors. Neurobiology of disease. 32(2) : 229-42, 2008.
  • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nature medicine. 14(5) : 504-6, 2008.
  • Yantzer BK, Freeman TB, Lee WE, Nichols T, Inamasu J, Guiot B, Johnson WM. Torsion-induced pressure distribution changes in human intervertebral discs: an in vitro study. Spine. 32(8) : 881-4, 2007.
  • Prehn AW, Vawter DE, Gervais KG, DeVries RG, Garrett JE, Freeman TB, McIndoo TQ. Studying neurosurgical implants for Parkinson disease: a question of design. Neurology. 67(8) : 1503-5, 2006.
  • Furtado S, Sossi V, Hauser RA, Samii A, Schulzer M, Murphy CB, Freeman TB, Stoessl AJ. Positron emission tomography after fetal transplantation in Huntington's disease. Annals of neurology. 58(2) : 331-7, 2005.
  • Vawter DE, Gervais KG, Freeman TB. Strategies for achieving high-quality IRB review. The American journal of bioethics : AJOB. 4(3) : 74-6; discussion W32, 2004.
  • Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Annals of neurology. 54(3) : 403-14, 2003.
  • Hauser RA, Furtado S, Cimino CR, Delgado H, Eichler S, Schwartz S, Scott D, Nauert GM, Soety E, Sossi V, Holt DA, Sanberg PR, Stoessl AJ, Freeman TB. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology. 58(5) : 687-95, 2002.
  • Zigova T, Willing AE, Saporta S, Daadi MM, McGrogan MP, Randall TS, Freeman TB, Sanchez-Ramos J, Sanberg PR. Apoptosis in cultured hNT neurons. Brain research. Developmental brain research. 127(1) : 63-70, 2001.
  • Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Janssen W, Patel N, Cooper DR, Sanberg PR. Adult bone marrow stromal cells differentiate into neural cells in vitro. Experimental neurology. 164(2) : 247-56, 2000.
  • Freeman TB, Hauser RA, Sanberg PR, Saporta S. Neural transplantation for the treatment of Huntington's disease. Progress in brain research. 127: 405-11, 2000.
  • Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. 97(25) : 13877-82, 2000.
  • Zigova T, Barroso LF, Willing AE, Saporta S, McGrogan MP, Freeman TB, Sanberg PR. Dopaminergic phenotype of hNT cells in vitro. Brain research. Developmental brain research. 122(1) : 87-90, 2000.
  • Willing AE, Sudberry JJ, Othberg AI, Saporta S, Poulos SG, Cameron DF, Freeman TB, Sanberg PR. Sertoli cells decrease microglial response and increase engraftment of human hNT neurons in the hemiparkinsonian rat striatum. Brain research bulletin. 48(4) : 441-4, 1999.
  • Hauser RA, Freeman TB, Snow BJ, Nauert M, Gauger L, Kordower JH, Olanow CW. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Archives of neurology. 56(2) : 179-87, 1999.
  • Sanberg PR, Othberg AI, Borlongan CV, Saporta S, Anton A, Freeman TB, Cahill DW, Allen RC, Cameron DF. Transplantation of testis-derived Sertoli cells into the mammalian brain. Transplantation proceedings. 29(4) : 1926-8, 1997.
  • Sanberg PR, Borlongan CV, Koutouzis TK, Norgren RB, Cahill DW, Freeman TB. Human fetal striatal transplantation in an excitotoxic lesioned model of Huntington's disease. Annals of the New York Academy of Sciences. 831: 452-60, 1997.
  • Borlongan CV, Koutouzis TK, Freeman TB, Hauser RA, Cahill DW, Sanberg PR. Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model. Brain research. Brain research protocols. 1(3) : 253-7, 1997.
  • Sanberg PR, Borlongan CV, Othberg AI, Saporta S, Freeman TB, Cameron DF. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Nature medicine. 3(10) : 1129-32, 1997.

  • Positions Held
  • Professor with tenure (Department of Pharmacology and Experimental Therapeutics, College of Medicine, University of South Florida 1999 - 2007)
  • Chief (Division of Neurosurgery, James A. Haley Veterans Hospital 1988 - 1992)


  • Memberships
  • American Association of Neurological Surgeons (Fellow, 2010 - Present)
  • Florida Medical Association (Member, 2005 - Present)
  • Congress of Neurological Surgeons (Member, 1997 - Present)
  • American College of Surgeons (Fellow, 1997 - Present)


  • Awards/Honors
  • The Molly & Bernard Sanberg Memorial Award (American Society of Neural Therapy and Repair - 2013)
  • Best Doctors in America (US News and World Reports - 2010)
  • Top 1% of Neurosurgeons in the U.S. (US News and World Reports - 2010)
  • USF Platinum Dean's Recognition Award for "Exemplary Service and Excellence in teaching and research (University of South Florida - 2010)
  • America's Top Doctors (stle Connolly Medical LTD - 2001)


  • Lectures
  • "The effect of Parkinson's and Huntington's disease on neural transplants" Cell Society 3rd Annual Clinical Meeting. CA, United States - 2013.
  • "Hip back sacroiliac-they are all a pain in the butt. How to diagnose and treat sacroiliac joint pain" University of South Florida- Residents Conference. FL, United States - 2013.
  • "SI joint fusion" Selby Spine Conference. UT, United States - 2013.
  • "Clinical trials for neurologic disease" University of South Florida. FL, United States - 2013.
  • "What has been achieved in strategies to repair the brain in Huntington's disease?" 17th International Congress of Parkinson's Disease and Movement Disorders. Australia - 2013.
  • "Correction of kyphotic deformity secondary to a thoracolumbar burst fracture" Spine Guard Symposium. CO, United States - 2011.
  • "Technique to minimize paraspinal muscle atrophy and posterior cervical fusion" Selby Spine Annual Meeting. UT, United States - 2011.
  • "Sham surgery and the history of ethics in surgical research" Neurological & Neurosurgical Therapeutics: Contemporary Diagnosis and Management. FL, United States - 2011.
  • "Mechanisms of disease-like degeneration of embryonic neural grafts" American Association of Neurological Surgeons Annual Meeting. PA, United States - 2010.
  • "The effects of disease and aging on neural grafts: implications for future stem cell therapies" American Academy of Neurological Surgeons. CA, United States - 2010.
  • "What have we learned from the Parkinson's disease trials?" National Institutes of Health- Office of Biotechnology Activities. FL, United States - 2010.
  • "Restorative approaches to neurological disorders" Neurological & Neurosurgical Therapeutics: Contemporary Diagnosis and Management. FL, United States - 2010.
  • "Mechanisms of disease-like degeneration of embryonic neural grafts" American Association of Neurological Surgeons Annual Meeting. PA, United States - 2010.
  • "Cell Transplantation in Neurosurgery" American Society for Stereotactic and Functional Neurosurgery Biennial Meeting. NY, United States - 2010.

  • Profile last modified on 12/09/2014