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Thomas Freeman,  MD
Medical Director, Center of Excellence for Aging and Brain Repair
Consultant, Division of Neurosurgery
Professor, College of Medicine, Department of Neurosurgery and Brain Repair


Primary Department: COLLEGE OF MEDICINE NEUROSURGERY

Professor
COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Professor
COLLEGE OF MEDICINE NEUROSURGERY

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Contacts
Email: tfreeman@health.usf.edu
Phone: (813) 259-0889
Office: STC,
Mailing address 2 Tampa General Circle
Tampa, FL 33606
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Education
  • MD, Johns Hopkins University , United States - 1981.
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    Selected Publications
  • Sanchez-Ramos, J.Song, S.Dailey, M.Cardozo-Pelaez, F.Hazzi, C.Stedeford, T.Willing, A.Freeman, TB.Saporta, S.Zigova, T.Sanberg, PR.Snyder, EY. The X-gal caution in neural transplantation studies. Cell transplantation. 9(5): 657-67, .
  • Saporta, S.Borlongan, C.Moore, J.Mejia-Millan, E.Jones, SL.Bonness, P.Randall, TS.Allen, RC.Freeman, TB.Sanberg, PR. Microcarrier enhanced survival of human and rat fetal ventral mesencephalon cells implanted in the rat striatum. Cell transplantation. 6(6): 579-84, .
  • Kordower, JH.Styren, S.Clarke, M.DeKosky, ST.Olanow, CW.Freeman, TB. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell transplantation. 6(3): 213-9, .
  • Holt, DA.Nauert, GM.Othberg, AI.Randall, TS.Willing, AE.Widen, RH.Hauser, RA.Sanberg, PR.Olanow, CW.Freeman, TB. Infectious issues in human fetal neural transplantation. Cell transplantation. 6(6): 553-6, .
  • Othberg, AI.Willing, AE.Cameron, DF.Anton, A.Saporta, S.Freeman, TB.Sanberg, PR. Trophic effect of porcine Sertoli cells on rat and human ventral mesencephalic cells and hNT neurons in vitro. Cell transplantation. 7(2): 157-64, .
  • Cisbani, G.Freeman, TB.Soulet, D.Saint-Pierre, M.Gagnon, D.Parent, M.Hauser, RA.Barker, RA.Cicchetti, F. Striatal allografts in patients with Huntington's disease: impact of diminished astrocytes and vascularization on graft viability. Brain : a journal of neurology. 136(Pt 2): 433-43, 2013.
  • Galpern, WR.Corrigan-Curay, J.Lang, AE.Kahn, J.Tagle, D.Barker, RA.Freeman, TB.Goetz, CG.Kieburtz, K.Kim, SY.Piantadosi, S.Comstock Rick, A.Federoff, HJ. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet neurology. 11(7): 643-50, 2012.
  • Freeman, TB.Cicchetti, F.Bachoud-Lévi, AC.Dunnett, SB. Technical factors that influence neural transplant safety in Huntington's disease. Experimental neurology. 227(1): 1-9, 2011.
  • Sangala, JR.Nichols, T.Freeman, TB. Technique to minimize paraspinal muscle atrophy after posterior cervical fusion. Clinical neurology and neurosurgery. 113(1): 48-51, 2011.
  • Borlongan, CV.Glover, LE.Tajiri, N.Kaneko, Y.Freeman, TB. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Progress in neurobiology. 95(2): 213-28, 2011.
  • Phommachanh, V.Patil, YJ.McCaffrey, TV.Vale, F.Freeman, TB.Padhya, TA. Otolaryngologic management of delayed pharyngoesophageal perforation following anterior cervical spine surgery. The Laryngoscope. 120(5): 930-6, 2010.
  • Cicchetti, F.Saporta, S.Hauser, RA.Parent, M.Saint-Pierre, M.Sanberg, PR.Li, XJ.Parker, JR.Chu, Y.Mufson, EJ.Kordower, JH.Freeman, TB. Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 106(30): 12483-8, 2009.
  • Olanow, CW.Gracies, JM.Goetz, CG.Stoessl, AJ.Freeman, T.Kordower, JH.Godbold, J.Obeso, JA. Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis. Movement disorders : official journal of the Movement Disorder Society. 24(3): 336-43, 2009.
  • Kordower, JH.Chu, Y.Hauser, RA.Freeman, TB.Olanow, CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nature medicine. 14(5): 504-6, 2008.
  • Kordower, JH.Chu, Y.Hauser, RA.Olanow, CW.Freeman, TB. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Movement disorders : official journal of the Movement Disorder Society. 23(16): 2303-6, 2008.
  • Soderstrom, KE.Meredith, G.Freeman, TB.McGuire, SO.Collier, TJ.Sortwell, CE.Wu, Q.Steece-Collier, K. The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors. Neurobiology of disease. 32(2): 229-42, 2008.
  • Yantzer, BK.Freeman, TB.Lee, WE.Nichols, T.Inamasu, J.Guiot, B.Johnson, WM. Torsion-induced pressure distribution changes in human intervertebral discs: an in vitro study. Spine. 32(8): 881-4, 2007.
  • Prehn, AW.Vawter, DE.Gervais, KG.DeVries, RG.Garrett, JE.Freeman, TB.McIndoo, TQ. Studying neurosurgical implants for Parkinson disease: a question of design. Neurology. 67(8): 1503-5, 2006.
  • Furtado, S.Sossi, V.Hauser, RA.Samii, A.Schulzer, M.Murphy, CB.Freeman, TB.Stoessl, AJ. Positron emission tomography after fetal transplantation in Huntington's disease. Annals of neurology. 58(2): 331-7, 2005.
  • Vawter, DE.Gervais, KG.Freeman, TB. Strategies for achieving high-quality IRB review. The American journal of bioethics : AJOB. 4(3): 74-6; discussion W32, 2004.
  • Olanow, CW.Goetz, CG.Kordower, JH.Stoessl, AJ.Sossi, V.Brin, MF.Shannon, KM.Nauert, GM.Perl, DP.Godbold, J.Freeman, TB. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Annals of neurology. 54(3): 403-14, 2003.
  • Hauser, RA.Furtado, S.Cimino, CR.Delgado, H.Eichler, S.Schwartz, S.Scott, D.Nauert, GM.Soety, E.Sossi, V.Holt, DA.Sanberg, PR.Stoessl, AJ.Freeman, TB. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology. 58(5): 687-95, 2002.
  • Zigova, T.Willing, AE.Saporta, S.Daadi, MM.McGrogan, MP.Randall, TS.Freeman, TB.Sanchez-Ramos, J.Sanberg, PR. Apoptosis in cultured hNT neurons. Brain research. Developmental brain research. 127(1): 63-70, 2001.
  • Zigova, T.Barroso, LF.Willing, AE.Saporta, S.McGrogan, MP.Freeman, TB.Sanberg, PR. Dopaminergic phenotype of hNT cells in vitro. Brain research. Developmental brain research. 122(1): 87-90, 2000.
  • Freeman, TB.Cicchetti, F.Hauser, RA.Deacon, TW.Li, XJ.Hersch, SM.Nauert, GM.Sanberg, PR.Kordower, JH.Saporta, S.Isacson, O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. 97(25): 13877-82, 2000.
  • Sanchez-Ramos, J.Song, S.Cardozo-Pelaez, F.Hazzi, C.Stedeford, T.Willing, A.Freeman, TB.Saporta, S.Janssen, W.Patel, N.Cooper, DR.Sanberg, PR. Adult bone marrow stromal cells differentiate into neural cells in vitro. Experimental neurology. 164(2): 247-56, 2000.
  • Freeman, TB.Hauser, RA.Sanberg, PR.Saporta, S. Neural transplantation for the treatment of Huntington's disease. Progress in brain research. 127(): 405-11, 2000.
  • Willing, AE.Sudberry, JJ.Othberg, AI.Saporta, S.Poulos, SG.Cameron, DF.Freeman, TB.Sanberg, PR. Sertoli cells decrease microglial response and increase engraftment of human hNT neurons in the hemiparkinsonian rat striatum. Brain research bulletin. 48(4): 441-4, 1999.
  • Hauser, RA.Freeman, TB.Snow, BJ.Nauert, M.Gauger, L.Kordower, JH.Olanow, CW. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Archives of neurology. 56(2): 179-87, 1999.
  • Sanberg, PR.Borlongan, CV.Koutouzis, TK.Norgren, RB.Cahill, DW.Freeman, TB. Human fetal striatal transplantation in an excitotoxic lesioned model of Huntington's disease. Annals of the New York Academy of Sciences. 831(): 452-60, 1997.
  • Sanberg, PR.Borlongan, CV.Othberg, AI.Saporta, S.Freeman, TB.Cameron, DF. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Nature medicine. 3(10): 1129-32, 1997.
  • Sanberg, PR.Othberg, AI.Borlongan, CV.Saporta, S.Anton, A.Freeman, TB.Cahill, DW.Allen, RC.Cameron, DF. Transplantation of testis-derived Sertoli cells into the mammalian brain. Transplantation proceedings. 29(4): 1926-8, 1997.
  • Borlongan, CV.Koutouzis, TK.Freeman, TB.Hauser, RA.Cahill, DW.Sanberg, PR. Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model. Brain research. Brain research protocols. 1(3): 253-7, 1997.

  • Positions Held
  • Professor with tenure (Department of Pharmacology and Experimental Therapeutics, College of Medicine, University of South Florida 1999 - 2007)
  • Chief (Division of Neurosurgery, James A. Haley Veterans Hospital 1988 - 1992)


  • Memberships
  • American Association of Neurological Surgeons (Fellow, 2010 - Present)
  • Florida Medical Association (Member, 2005 - Present)
  • Congress of Neurological Surgeons (Member, 1997 - Present)
  • American College of Surgeons (Fellow, 1997 - Present)


  • Awards/Honors
  • The Molly & Bernard Sanberg Memorial Award (American Society of Neural Therapy and Repair - 2013)
  • Best Doctors in America (US News and World Reports - 2010)
  • Top 1% of Neurosurgeons in the U.S. (US News and World Reports - 2010)
  • USF Platinum Dean's Recognition Award for "Exemplary Service and Excellence in teaching and research (University of South Florida - 2010)
  • America's Top Doctors (stle Connolly Medical LTD - 2001)


  • Lectures
  • "The effect of Parkinson's and Huntington's disease on neural transplants" Cell Society 3rd Annual Clinical Meeting. CA, United States - 2013.
  • "Hip back sacroiliac-they are all a pain in the butt. How to diagnose and treat sacroiliac joint pain" University of South Florida- Residents Conference. FL, United States - 2013.
  • "SI joint fusion" Selby Spine Conference. UT, United States - 2013.
  • "Clinical trials for neurologic disease" University of South Florida. FL, United States - 2013.
  • "What has been achieved in strategies to repair the brain in Huntington's disease?" 17th International Congress of Parkinson's Disease and Movement Disorders. Australia - 2013.
  • "Correction of kyphotic deformity secondary to a thoracolumbar burst fracture" Spine Guard Symposium. CO, United States - 2011.
  • "Technique to minimize paraspinal muscle atrophy and posterior cervical fusion" Selby Spine Annual Meeting. UT, United States - 2011.
  • "Sham surgery and the history of ethics in surgical research" Neurological & Neurosurgical Therapeutics: Contemporary Diagnosis and Management. FL, United States - 2011.
  • "Mechanisms of disease-like degeneration of embryonic neural grafts" American Association of Neurological Surgeons Annual Meeting. PA, United States - 2010.
  • "The effects of disease and aging on neural grafts: implications for future stem cell therapies" American Academy of Neurological Surgeons. CA, United States - 2010.
  • "What have we learned from the Parkinson's disease trials?" National Institutes of Health- Office of Biotechnology Activities. FL, United States - 2010.
  • "Restorative approaches to neurological disorders" Neurological & Neurosurgical Therapeutics: Contemporary Diagnosis and Management. FL, United States - 2010.
  • "Mechanisms of disease-like degeneration of embryonic neural grafts" American Association of Neurological Surgeons Annual Meeting. PA, United States - 2010.
  • "Cell Transplantation in Neurosurgery" American Society for Stereotactic and Functional Neurosurgery Biennial Meeting. NY, United States - 2010.

  • Profile last modified on 01/20/2014